Skip to main content
SpringerLink
Log in

Intracellular Trafficking of AMPA-Type Glutamate Receptors

  • Chapter
Molecular Mechanisms of Synaptogenesis

  • 659 Accesses

1. Summary

AMPA receptors are one of the most dynamic components of excitatory synapses. They are responsible for most excitatory transmission in the brain, and therefore, their presence at synapses is tightly controlled. We now know that AMPA receptors reach their synaptic targets after a complicated intracellular trafficking pathway, in which almost every step is subject to precise regulation. In particular, neuronal activity is able to trigger the addition or removal of AMPA receptors at synapses, leading to long-lasting forms of synaptic plasticity known as long-term potentiation (LTP) and long-term depression (LTD). This chapter summarizes our current knowledge of the intracellular trafficking of AMPA receptors, and its relation to synaptic function and plasticity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

10. References

  1. Shi, S., Hayashi, Y., Esteban, J.A., and Malinow, R. (2001) Cell 105, 331–343.

    Article  PubMed  CAS  Google Scholar 

  2. Bear, M.F., and Malenka, R.C. (1994) Curr Opin Neurobiol 4, 389–399.

    Article  PubMed  CAS  Google Scholar 

  3. Petralia, R.S., Esteban, J.A., Wang, Y.X., Partridge, J.G., Zhao, H.M., Wenthold, R.J., and Malinow, R. (1999) Nat Neurosci 2, 31–36.

    Article  PubMed  CAS  Google Scholar 

  4. Malinow, R., and Malenka, R.C. (2002) Annu Rev Neurosci 25, 103–126.

    Article  PubMed  CAS  Google Scholar 

  5. Ju, W., Morishita, W., Tsui, J., Gaietta, G., Deerinck, T.J., Adams, S.R., Garner, C.C., Tsien, R.Y., Ellisman, M.H., and Malenka, R.C. (2004) Nat Neurosci 7, 244–253.

    Article  PubMed  CAS  Google Scholar 

  6. Wenthold, R.J., Prybylowski, K., Standley, S., Sans, N., and Petralia, R.S. (2003) Annu Rev Pharmacol Toxicol 43, 335–358.

    Article  PubMed  CAS  Google Scholar 

  7. Rosenmund, C., Stern-Bach, Y., and Stevens, C.F. (1998) Science 280, 1596–1599.

    Article  PubMed  CAS  Google Scholar 

  8. Hollmann, M., and Heinemann, S. (1994) Annu Rev Neurosci 17, 31–108.

    Article  PubMed  CAS  Google Scholar 

  9. Wenthold, R.J., Petralia, R.S., Blahos, J., II, and Niedzielski, A.S. (1996) J Neurosci 16, 1982–1989.

    PubMed  CAS  Google Scholar 

  10. Zhu, J.J., Esteban, J.A., Hayashi, Y., and Malinow, R. (2000) Nat Neurosci 3, 1098–1106.

    Article  PubMed  CAS  Google Scholar 

  11. Leuschner, W.D., and Hoch, W. (1999) J Biol Chem 274, 16907–16916.

    Article  PubMed  CAS  Google Scholar 

  12. Greger, I.H., Khatri, L., Kong, X., and Ziff, E.B. (2003) Neuron 40, 763–774.

    Article  PubMed  CAS  Google Scholar 

  13. Greger, I.H., Khatri, L., and Ziff, E.B. (2002) Neuron 34, 759–772.

    Article  PubMed  CAS  Google Scholar 

  14. Rubio, M.E., and Wenthold, R.J. (1999) J Neurochem 73, 942–948.

    Article  PubMed  CAS  Google Scholar 

  15. Xia, J., Zhang, X., Staudinger, J., and Huganir, R.L. (1999) Neuron 22, 179–187.

    Article  PubMed  CAS  Google Scholar 

  16. Leonard, A.S., Davare, M.A., Horne, M.C., Garner, C.C., and Hell, J.W. (1998) J Biol Chem 273, 19518–19524.

    Article  PubMed  CAS  Google Scholar 

  17. Sans, N., Racca, C., Petralia, R.S., Wang, Y.X., McCallum, J., and Wenthold, R.J. (2001) J Neurosci 21, 7506–7516.

    PubMed  CAS  Google Scholar 

  18. Tomita, S., Chen, L., Kawasaki, Y., Petralia, R.S., Wenthold, R.J., Nicoll, R.A., and Bredt, D.S. (2003) J Cell Biol 161, 805–816.

    Article  PubMed  CAS  Google Scholar 

  19. Chen, L., Chetkovich, D.M., Petralia, R.S., Sweeney, N.T., Kawasaki, Y., Wenthold, R.J., Bredt, D.S., and Nicoll, R.A. (2000) Nature 408, 936–943.

    Article  PubMed  CAS  Google Scholar 

  20. Vandenberghe, W., Nicoll, R.A., and Bredt, D.S. (2005) Proc Natl Acad Sci U S A 102, 485–490

    Article  PubMed  CAS  Google Scholar 

  21. Fukata, Y., Tzingounis, A.V., Trinidad, J.C., Fukata, M., Burlingame, A.L., Nicoll, R.A., and Bredt, D.S. (2005) J Cell Biol 169, 399–404.

    Article  PubMed  CAS  Google Scholar 

  22. Goldstein, L.S., and Yang, Z. (2000) Annu Rev Neurosci 23, 39–71.

    Article  PubMed  CAS  Google Scholar 

  23. Setou, M., Seog, D.H., Tanaka, Y., Kanai, Y., Takei, Y., Kawagishi, M., and Hirokawa, N. (2002) Nature 417, 83–87.

    Article  PubMed  CAS  Google Scholar 

  24. Dong, H., O’Brien, R.J., Fung, E.T., Lanahan, A.A., Worley, P.F., and Huganir, R.L. (1997) Nature 386, 279–284.

    Article  PubMed  CAS  Google Scholar 

  25. Wyszynski, M., Kim, E., Dunah, A.W., Passafaro, M., Valtschanoff, J.G., Serra-Pages, C., Streuli, M., Weinberg, R.J., and Sheng, M. (2002) Neuron 34, 39–52.

    Article  PubMed  CAS  Google Scholar 

  26. Shin, H., Wyszynski, M., Huh, K.H., Valtschanoff, J.G., Lee, J.R., Ko, J., Streuli, M., Weinberg, R.J., Sheng, M., and Kim, E. (2003) J Biol Chem 278, 11393–11401.

    Article  PubMed  CAS  Google Scholar 

  27. Allison, D.W., Gelfand, V.I., Spector, I., and Craig, A.M. (1998) J Neurosci 18, 2423–2436.

    PubMed  CAS  Google Scholar 

  28. Hoover, K.B., and Bryant, P.J. (2000) Curr Opin Cell Biol 12, 229–234.

    Article  PubMed  CAS  Google Scholar 

  29. Shen, L., Liang, F., Walensky, L.D., and Huganir, R.L. (2000) J Neurosci 20, 7932–7940.

    PubMed  CAS  Google Scholar 

  30. Coleman, S.K., Cai, C., Mottershead, D.G., Haapalahti, J.P., and Keinanen, K. (2003) J Neurosci 23, 798–806.

    PubMed  CAS  Google Scholar 

  31. Schulz, T.W., Nakagawa, T., Licznerski, P., Pawlak, V., Kolleker, A., Rozov, A., Kim, J., Dittgen, T., Kohr, G., Sheng, M., Seeburg, P.H., and Osten, P. (2004) J Neurosci 24, 8584–8594.

    Article  PubMed  CAS  Google Scholar 

  32. Osterweil, E., Wells, D.G., and Mooseker, M.S. (2005) J Cell Biol 168, 329–338.

    Article  PubMed  CAS  Google Scholar 

  33. Wu, H., Nash, J.E., Zamorano, P., and Garner, C.C. (2002) J Biol Chem 277, 30928–30934.

    Article  PubMed  CAS  Google Scholar 

  34. Passafaro, M., Piech, V., and Sheng, M. (2001) Nat Neurosci 4, 917–926.

    Article  PubMed  CAS  Google Scholar 

  35. Malinow, R., Mainen, Z.F., and Hayashi, Y. (2000) Curr Opin Neurobiol 10, 352–357.

    Article  PubMed  CAS  Google Scholar 

  36. Nishimune, A., Isaac, J.T., Molnar, E., Noel, J., Nash, S.R., Tagaya, M., Collingridge, G.L., Nakanishi, S., and Henley, J.M. (1998) Neuron 21, 87–97.

    Article  PubMed  CAS  Google Scholar 

  37. Hanley, J.G., Khatri, L., Hanson, P.I., and Ziff, E.B. (2002) Neuron 34, 53–67.

    Article  PubMed  CAS  Google Scholar 

  38. Gerges, N.Z., Tran, I.C., Backos, D.S., Harrell, J.M., Chinkers, M., Pratt, W.B., and Esteban, J.A. (2004) J Neurosci 24, 4758–4766.

    Article  PubMed  CAS  Google Scholar 

  39. Gerges, N.Z., Backos, D.S., and Esteban, J.A. (2004) J Biol Chem 279, 43870–43878.

    Article  PubMed  CAS  Google Scholar 

  40. Zerial, M., and McBride, H. (2001) Nat Rev Mol Cell Biol 2, 107–117.

    Article  PubMed  CAS  Google Scholar 

  41. Brown, T.C., Tran, I.C., Backos, D.S., and Esteban, J.A. (2005) Neuron 45, 81–94.

    Article  PubMed  CAS  Google Scholar 

  42. Hayashi, Y., Shi, S.H., Esteban, J.A., Piccini, A., Poncer, J.C., and Malinow, R. (2000) Science 287, 2262–2267.

    Article  PubMed  CAS  Google Scholar 

  43. Kolleker, A., Zhu, J.J., Schupp, B.J., Qin, Y., Mack, V., Borchardt, T., Kohr, G., Malinow, R., Seeburg, P.H., and Osten, P. (2003) Neuron 40, 1199–1212.

    Article  PubMed  CAS  Google Scholar 

  44. Malenka, R.C., and Bear, M.F. (2004) Neuron 44, 5–21.

    Article  PubMed  CAS  Google Scholar 

  45. Zhu, J.J., Qin, Y., Zhao, M., Van Aelst, L., and Malinow, R. (2002) Cell 110, 443–455.

    Article  PubMed  CAS  Google Scholar 

  46. Qin, Y., Zhu, Y., Baumgart, J.P., Stornetta, R.L., Seidenman, K., Mack, V., van Aelst, L., and Zhu, J.J. (2005) Genes Dev 19, 2000–2015.

    Article  PubMed  CAS  Google Scholar 

  47. Esteban, J.A., Shi, S.H., Wilson, C., Nuriya, M., Huganir, R.L., and Malinow, R. (2003) Nat Neurosci 6, 136–143.

    Article  PubMed  CAS  Google Scholar 

  48. Lee, H.K., Barbarosie, M., Kameyama, K., Bear, M.F., and Huganir, R.L. (2000) Nature 405, 955–959.

    Article  PubMed  CAS  Google Scholar 

  49. Boehm, J., Kang, M., Esteban, J.A., Huganir, R.L., and Malinow, R. (2005) in Annual Meeting of the Society for Neuroscience, Washington, DC.

    Google Scholar 

  50. Letts, V.A., Felix, R., Biddlecome, G.H., Arikkath, J., Mahaffey, C.L., Valenzuela, A., Bartlett, F.S., 2nd, Mori, Y., Campbell, K.P., and Frankel, W.N. (1998) Nat Genet 19, 340–347.

    Article  PubMed  CAS  Google Scholar 

  51. Rouach, N., Byrd, K., Petralia, R.S., Elias, G.M., Adesnik, H., Tomita, S., Karimzadegan, S., Kealey, C., Bredt, D.S., and Nicoll, R.A. (2005) Nat Neurosci 8, 1525–1533.

    Article  PubMed  CAS  Google Scholar 

  52. Borgdorff, A.J., and Choquet, D. (2002) Nature 417, 649–653.

    Article  PubMed  CAS  Google Scholar 

  53. El-Husseini, A.E., Schnell, E., Chetkovich, D.M., Nicoll, R.A., and Bredt, D.S. (2000) Science 290, 1364–1368.

    PubMed  CAS  Google Scholar 

  54. El-Husseini Ael, D., Schnell, E., Dakoji, S., Sweeney, N., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R.A., and Bredt, D.S. (2002) Cell 108, 849–863.

    Article  Google Scholar 

  55. Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D.S., and Nicoll, R.A. (2002) Proc Natl Acad Sci U S A 99, 13902–13907.

    Article  PubMed  CAS  Google Scholar 

  56. Park, M., Penick, E.C., Edwards, J.G., Kauer, J.A., and Ehlers, M.D. (2004) Science 305, 1972–1975.

    Article  PubMed  CAS  Google Scholar 

  57. Shi, S.H., Hayashi, Y., Petralia, R.S., Zaman, S.H., Wenthold, R.J., Svoboda, K., and Malinow, R. (1999) Science 284, 1811–1816.

    Article  PubMed  CAS  Google Scholar 

  58. TerBush, D.R., Maurice, T., Roth, D., and Novick, P. (1996) EMBO J 15, 6483–6494.

    PubMed  CAS  Google Scholar 

  59. Gerges, N.Z., Backos, D.S., and Esteban, J.A. (2005) in Annual Meeting of the Society for Neuroscience, Washington, DC.

    Google Scholar 

  60. Meng, Y., Zhang, Y., and Jia, Z. (2003) Neuron 39, 163–176.

    Article  PubMed  CAS  Google Scholar 

  61. Perez, J.L., Khatri, L., Chang, C., Srivastava, S., Osten, P., and Ziff, E.B. (2001) J Neurosci 21, 5417–5428.

    PubMed  CAS  Google Scholar 

  62. Kim, C.H., Chung, H.J., Lee, H.K., and Huganir, R.L. (2001) Proc Natl Acad Sci U S A 98, 11725–11730.

    Article  PubMed  CAS  Google Scholar 

  63. Beattie, E.C., Carroll, R.C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., and Malenka, R.C. (2000) Nat Neurosci 3, 1291–1300.

    Article  PubMed  CAS  Google Scholar 

  64. Lin, J.W., Ju, W., Foster, K., Lee, S.H., Ahmadian, G., Wyszynski, M., Wang, Y.T., and Sheng, M. (2000) Nat Neurosci 3, 1282–1290.

    Article  PubMed  CAS  Google Scholar 

  65. Lee, S.H., Simonetta, A., and Sheng, M. (2004) Neuron 43, 221–236.

    Article  PubMed  CAS  Google Scholar 

  66. Man, H.Y., Lin, J.W., Ju, W.H., Ahmadian, G., Liu, L., Becker, L.E., Sheng, M., and Wang, Y.T. (2000) Neuron 25, 649–662.

    Article  PubMed  CAS  Google Scholar 

  67. Chung, H.J., Steinberg, J.P., Huganir, R.L., and Linden, D.J. (2003) Science 300, 1751–1755.

    Article  PubMed  CAS  Google Scholar 

  68. Lu, W., and Ziff, E.B. (2005) Neuron 47, 407–421.

    Article  PubMed  CAS  Google Scholar 

  69. Lee, H.K., Kameyama, K., Huganir, R.L., and Bear, M.F. (1998) Neuron 21, 1151–1162.

    Article  PubMed  CAS  Google Scholar 

  70. Ehlers, M.D. (2000) Neuron 28, 511–525.

    Article  PubMed  CAS  Google Scholar 

  71. Mulkey, R.M., Herron, C.E., and Malenka, R.C. (1993) Science 261, 1051–1055.

    Article  PubMed  CAS  Google Scholar 

  72. Blanpied, T.A., Scott, D.B., and Ehlers, M.D. (2002) Neuron 36, 435–449.

    Article  PubMed  CAS  Google Scholar 

  73. Petralia, R.S., Wang, Y.X., and Wenthold, R.J. (2003) Eur J Neurosci 18, 3207–3217.

    Article  PubMed  Google Scholar 

  74. Wang, Y.T., and Linden, D.J. (2000) Neuron 25, 635–647.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Dr., Ann Arbor, MI, 48109, USA

    José A. Esteban

Authors
  1. José A. Esteban
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Esteban, J.A. (2006). Intracellular Trafficking of AMPA-Type Glutamate Receptors. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_25

Download citation

Publish with us

Policies and ethics

Search

Navigation