Signaling from Synapse to Nucleus and Back

  • Imbritt König
  • Michael R. Kreutz

1. Summary

Long-lasting changes in neuronal excitability and synapto-dendritic cytoarchitecture require gene transcription and it is thought that synaptic activity by itself triggers signaling pathways to the nucleus that will eventually control transcriptional regulation. Signaling from the synapse to the nucleus might therefore directly control the making of proteins involved in processes broadly referred to as synaptic plasticity. At present relatively little is known about the exact role of plasticity related genes and how their expression is regulated at the cellular level. Moreover, it is largely unclear how this process affects synaptic transmission and whether there is any specific feedback between the nucleus and activated synapses that drive transcriptional regulation. These questions are of pivotal importance to understand how the wiring of the brain is brought about during development and how long-term use-dependent changes of synaptic efficacy are mediated at the molecular level.


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10. References

  1. 1.
    Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J.C., Chen, M., Bailey, C.H., and Kandel, E.R. (1997) Cell 91, 927–938.PubMedCrossRefGoogle Scholar
  2. 2.
    Martin, K.C., Michael, D., Rose, J.C., Barad, M., Casadio, A., Zhu, H., and Kandel, E.R. (1997) Neuron 18, 899–912.PubMedCrossRefGoogle Scholar
  3. 3.
    Graef, I.A., Mermelstein, P.G., Stankunas, K., Neilson, J.R., Deisseroth, K., Tsien, R.W., and Crabtree, G.R. (1999) Nature 401, 703–708.PubMedCrossRefGoogle Scholar
  4. 4.
    Deisseroth, K., Bito, H., and Tsien, R.W. (1996) Neuron 16, 89–101.PubMedCrossRefGoogle Scholar
  5. 5.
    Deisseroth, K., Bito, H., and Tsien, R.W. (2003) Curr Opin Neurobiol 13, 354–365.PubMedCrossRefGoogle Scholar
  6. 6.
    Dolmetsch, R.E., Pajvani, U., Fife, K., Spotts, J.M., and Greenberg, M.E. (2001) Science 294, 333–339.PubMedCrossRefGoogle Scholar
  7. 7.
    West, A.E., Griffith, E.C., and Greenberg, M.E. (2002) Nat Rev Neurosci 3, 921–931.PubMedCrossRefGoogle Scholar
  8. 8.
    Hardingham, G.E., Arnold, F.J., and Bading, H. (2001) Nat Neurosci 4, 261–267.PubMedCrossRefGoogle Scholar
  9. 9.
    Carrion, A.M., Link, W.A., Ledo, F., Mellstrom, B., and Naranjo, J.R. (1999) Nature 398, 80–84.PubMedCrossRefGoogle Scholar
  10. 10.
    Osawa, M., Dace, A., Tong, K.I., Valiveti, A., Ikura, M., and Ames, J.B. (2005) J Biol Chem 280, 18008–18014.PubMedCrossRefGoogle Scholar
  11. 11.
    Guerrini, L., Blasi, F., and Denis-Donini, S. (1995) Proc Natl Acad Sci U S A 92, 9077–9081.PubMedCrossRefGoogle Scholar
  12. 12.
    Kaltschmidt, C., Kaltschmidt, B., and Baeuerle, P.A. (1995) Proc Natl Acad Sci U S A 92, 9618–9622.PubMedCrossRefGoogle Scholar
  13. 13.
    Meffert, M.K., Chang, J.M., Wiltgen, B.J., Fanselow, M.S., and Baltimore, D. (2003) Nat. Neurosci 6, 1072–1078.PubMedCrossRefGoogle Scholar
  14. 14.
    Lilienbaum, A., and Israel, A. (2003) Mol Cell Biol 23, 2680–2698.PubMedCrossRefGoogle Scholar
  15. 15.
    Wellmann, H., Kaltschmidt, B., and Kaltschmidt, C. (2001) J Biol Chem 276, 11821–11829.PubMedCrossRefGoogle Scholar
  16. 16.
    Hsueh, Y.P., Wang, T.F., Yang, F.C., and Sheng, M. (2002) Nature 404, 298–302.Google Scholar
  17. 17.
    Wang, G.S., Hong, C.J., Yen, T.Y., Huang, H.Y., Ou, Y., Huang, T.N., Jung, W.G., Kuo, T.Y., Sheng, M., Wang, T.F., and Hsueh, Y.P. (2004) Neuron 42, 113–128.PubMedCrossRefGoogle Scholar
  18. 18.
    Wang, T.F., Ding, C.N., Wang, G.S., Luo, S.C., Lin, Y.L., Ruan, Y., Hevner, R., Rubenstein, J.L., and Hsueh, Y.P. (2004) J Neurochem 91, 1483–1492.PubMedCrossRefGoogle Scholar
  19. 19.
    Bao, J., Lin, H., Ouyang, Y., Lei, D., Osman, A., Kim, T.W., Mei, L., Dai, P., Ohlemiller, K.K., and Ambron, R.T. (2004) Nat Neurosci 7, 1250–1258.PubMedCrossRefGoogle Scholar
  20. 20.
    Redmond, L., Oh, S.R., Hicks, C., Weinmaster, G., and Ghosh, A. (2000) Nat Neurosci 3, 30–40.PubMedCrossRefGoogle Scholar
  21. 21.
    McKenzie, G.J., Stevenson, P., Ward, G., Papadia, S., Bading, H., Chawla, S., Privalsky, M., and Hardingham, G.E. (2005) J Neurochem 93, 171–185.PubMedCrossRefGoogle Scholar
  22. 22.
    Wang, Y., Chan, S.L., Miele, L., Yao, P.J., Mackes, J., Ingram, D.K., Mattson, M.P., and Furukawa, K. (2004) Proc Natl Acad Sci U S A 101, 9458–9462.PubMedCrossRefGoogle Scholar
  23. 23.
    Cao, X., and Südhof, T.C. (2001) Science 293, 115–120.PubMedCrossRefGoogle Scholar
  24. 24.
    Ni, C.Y., Murphy, M.P., Golde, T.E., and Carpenter, G. (2001) Science 294, 2179–2181.PubMedCrossRefGoogle Scholar
  25. 25.
    Thompson, K.R., Otis, K.O., Chen, D.Y., Zhao, Y., O’Dell, T.J., and Martin, K.C. (2004) Neuron 44, 997–1009.PubMedGoogle Scholar
  26. 26.
    Hardingham, G.E., Arnold, F.J., and Bading, H. (2001) Nat Neurosci 4, 565–566.PubMedCrossRefGoogle Scholar
  27. 27.
    Mao, L., Yang, L., Tang, Q., Samdani, S., Zhang, G., and Wang, J.Q. (2005) J Neurosci 25, 2741–2752.PubMedCrossRefGoogle Scholar
  28. 28.
    Takasu, M.A., Dalva, M.B., Zigmond, R.E., and Greenberg, M.E. (2002) Science 295, 491–495.PubMedCrossRefGoogle Scholar
  29. 29.
    Yang, L., Mao, L., Tang, Q., Samdani, S., Liu, Z., and Wang, J.Q. (2004) J Neurosci 24, 10846–10857.PubMedCrossRefGoogle Scholar
  30. 30.
    Hardingham, G.E., Fukunaga, Y., and Bading, H. (2002) Nat Neurosci 5, 405–414.PubMedGoogle Scholar
  31. 31.
    Fields, R.D., Lee, P.R., and Cohen, J.E. (2005) Cell Calcium 37, 433–442.PubMedCrossRefGoogle Scholar
  32. 32.
    Shieh, P.B., Hu, S.C., Bobb, K., Timmusk, T., and Ghosh, A. (1998) Neuron 20, 727–740.PubMedCrossRefGoogle Scholar
  33. 33.
    Tao, X., Finkbeiner, S., Arnold, D.B., Shaywitz, A.J., and Greenberg, M.E. (1998) Neuron 20, 709–726.PubMedCrossRefGoogle Scholar
  34. 34.
    Tao, X., West, A.E., Chen, W.G., Corfas, G., and Greenberg, M.E. (2002) Neuron 3, 383–395.CrossRefGoogle Scholar
  35. 35.
    Chen, W.G., West, A.E., Tao, X., Corfas, G., Szentirmay, M.N., Sawadogo, M., Vinson, C., and Greenberg, M.E. (2003) J Neurosci 23, 2572–2581.PubMedGoogle Scholar
  36. 36.
    Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R., and Greenberg, M.E. (2003) Science 302, 885–889.PubMedCrossRefGoogle Scholar
  37. 37.
    Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., and Sun, Y.E. (2003) Science 302, 890–893.PubMedCrossRefGoogle Scholar
  38. 38.
    Levenson, J.M., and Sweatt, J.D. (2005) Nat Rev Neurosci 6, 108–118.PubMedCrossRefGoogle Scholar
  39. 39.
    Santos-Rosa, H., and Caldas, C. (2005) Eur J Cancer 41, 2381–2402.PubMedCrossRefGoogle Scholar
  40. 40.
    Levenson, J.M., O’Riordan, K.J., Brown, K.D., Trinh, M.A., Molfese, D.L., and Sweatt, J.D. (2004) J Biol Chem 279, 40545–40559.PubMedCrossRefGoogle Scholar
  41. 41.
    Crosio, C., Heitz, E., Allis, C.D., Borrelli, E., and Sassone-Corsi, P. (2003) J Cell Sci 116, 4905–4914.PubMedCrossRefGoogle Scholar
  42. 42.
    Pak, D.T., and Sheng, M. (2003) Science 302, 1368–1373.PubMedCrossRefGoogle Scholar
  43. 43.
    O’Brien, R.J., Xu, D., Petralia, R.S., Steward, O., Huganir, R.L., and Worley, P. (1999) Neuron 23, 309–323.PubMedCrossRefGoogle Scholar
  44. 44.
    Xu, D., Hopf, C., Reddy, R., Cho, R.W., Guo, L., Lanahan, A., Petralia, R.S., Wenthold, R.J., O’Brien, R.J., and Worley, P. (2003) Neuron 39, 513–528.PubMedCrossRefGoogle Scholar
  45. 45.
    Bramham, C.R., and Messaoudi, E. (2005) Prog Neurobiol 76, 99–125.PubMedCrossRefGoogle Scholar
  46. 46.
    Cantallops, I, Haas, K., and Cline, H.T. (2000) Nat Neurosci 3, 1004–1011.PubMedCrossRefGoogle Scholar
  47. 47.
    Sala, C., Futai, K., Yamamoto, K., Worley, P.F., Hayashi, Y., and Sheng, M. (2003) J Neurosci 23, 6327–6337.PubMedGoogle Scholar
  48. 48.
    Frey, U., and Morris, R.G. (1998) Trends Neurosci 21, 181–188.PubMedCrossRefGoogle Scholar
  49. 49.
    Dudek, S.M., and Fields, R.D. (2002) Proc Nat Acad Sci U S A, 99, 3962–3967.CrossRefGoogle Scholar
  50. 50.
    Adams, J.P., and Dudek, S.M. (2005) Nat Rev Neurosci 6, 737–743.PubMedCrossRefGoogle Scholar
  51. 51.
    Guzowski, J.F., McNaughton, B.L., Barnes, C.A., and Worley, P.F. (1999) Nat Neurosci 2, 1120–1124.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Imbritt König
    • 1
  • Michael R. Kreutz
    • 1
  1. 1.Department of Neurochemistry/Mol. Biology, Leibniz Institute for NeurobiologyAG ‘Molecular Mechanisms of Plasticity’MagdeburgGermany

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