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Leptin and Immune Function, Inflammation and Angiognenesis

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Leptin

Part of the book series: Endocrine Updates ((ENDO,volume 25))

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Abstract

Over the last few years the intricate interaction between immunity and metabolism has been recognized. Indeed, it has been suggested that adipose tissue is not merely the site of energy storage, but can be considered as an “immune-related” organ producing a series of molecules named “adipocytokines.” Among these, leptin seems to play a pivotal role in the regulation of several neuroendocrine and immune functions. In this chapter, we describe the effects of leptin on innate/adaptive immunity and angiogenesis and speculate on the possible modulation of the leptin axis in novel therapeutic settings.

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Author information

Authors and Affiliations

  1. Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Italy

    Giuseppe Matarese, Claudio Procaccini & Veronica De Rosa

  2. Consiglio Nazionale delle Ricerche c/o Laboratorio di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II, Napoli, Italy

    Giuseppe Matarese, Claudio Procaccini & Veronica De Rosa

Authors
  1. Giuseppe Matarese
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  2. Claudio Procaccini
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  3. Veronica De Rosa
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Editor information

Editors and Affiliations

  1. Texas Tech University School of Medicine, Lubbock, Texas, USA

    V. Daniel Castracane PhD (Professor Emeritus and Director of Laboratory Operations) (Professor Emeritus and Director of Laboratory Operations)

  2. Foundation for Blood Research, P. O. Box 190, Scarborough, ME, USA

    V. Daniel Castracane PhD (Professor Emeritus and Director of Laboratory Operations) (Professor Emeritus and Director of Laboratory Operations)

  3. Department of Biological Sciences, Purdue University Calumet, Hammond, Indiana, USA

    Michael C. Henson PhD (Professor and Head) (Professor and Head)

  4. Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, LA, USA

    Michael C. Henson PhD (Professor and Head) (Professor and Head)

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Matarese, G., Procaccini, C., De Rosa, V. (2006). Leptin and Immune Function, Inflammation and Angiognenesis. In: Castracane, V.D., Henson, M.C. (eds) Leptin. Endocrine Updates, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-31416-7_7

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  • DOI: https://doi.org/10.1007/978-0-387-31416-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-31415-0

  • Online ISBN: 978-0-387-31416-7

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