Abstract:
There has been a major increase in the scale of scientific activity devoted to the study of energy balance and obesity in the last 10 years. This explosion of interest has to a large extent been driven by the identification of genes responsible for murine obesity syndromes and the novel physiological pathways that have been delineated by these genetic discoveries. Several single gene defects causing severe human obesity have been identified. Many of these defects have been in molecules identical or similar to those identified as a cause of obesity in rodents. In this chapter, I will review two of the human monogenic obesity syndromes that have been characterized to date and discuss how far such observations support the physiological role of leptin in the regulation of human body weight and neuroendocrine function.
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Farooqi, I.S. (2006). Genetic Disorders Involving Leptin and the Leptin Receptor. In: Castracane, V.D., Henson, M.C. (eds) Leptin. Endocrine Updates, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-31416-7_15
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DOI: https://doi.org/10.1007/978-0-387-31416-7_15
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