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Designer Self-Assembling Peptide Nanofiber Scaffolds

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Nanotechnology for Biology and Medicine

Part of the book series: Fundamental Biomedical Technologies ((FBMT))

Abstract

Biomedical researchers have become increasingly aware of the limitations of the conventional two-dimensional (2-D) tissue cell cultures where most tissue cell studies have been carried out. They are now searching and testing three-dimensional (3-D) cell culture systems, something between a Petri dish and an animal, such as a mouse. The important implications of 3-D tissue cell cultures for basic cell biology, high-content drug screening, and regenerative medicine and beyond are far-reaching. How can nanobiotechnology truly advance traditional cell biology and emerging regenerative medicine? Why nanometer scale is important in biomedical research and medical science? Of course, a nanometer is 1,000 times smaller than a micrometer, but why it matters in biology? This chapter addresses these questions. It has become more and more apparent that 3-D cell culture offers a more realistic local environment through the nanofiber scaffolds where the functional properties of cells can be observed and manipulated. A new class of designer self-assembling peptide nanofiber scaffolds now provides an ideally alternative system not only for 3-D tissue culture but also for regenerative medicine and beyond.

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Acknowledgments

We gratefully acknowledge the supports by grants from Olympus Corp., Japan; Menicon, Ltd, Japan and fellowship to FG from Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy.

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Authors and Affiliations

  1. Center for Biomedical Engineering, Center for Bits & Atoms Massachusetts Institute of Technology, Cambridge, MA, USA

    Shuguang Zhang, Hidenori Yokoi, Fabrizio Gelain & Akihiro Horii

Authors
  1. Shuguang Zhang
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  2. Hidenori Yokoi
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  3. Fabrizio Gelain
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  4. Akihiro Horii
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Corresponding author

Correspondence to Shuguang Zhang .

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Editors and Affiliations

  1. Jacobs Retina Center, University of California - San Diego, Campus Point Drive 9415, La Jolla, 92037-0946, California, USA

    Gabriel A. Silva

  2. Center for Glial Biology in Medicine, University of Alabama, Birmingham, 6th Avenue South 1719, Birmingham, 35294-0021, Alabama, USA

    Vladimir Parpura

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Zhang, S., Yokoi, H., Gelain, F., Horii, A. (2012). Designer Self-Assembling Peptide Nanofiber Scaffolds. In: Silva, G., Parpura, V. (eds) Nanotechnology for Biology and Medicine. Fundamental Biomedical Technologies. Springer, New York, NY. https://doi.org/10.1007/978-0-387-31296-5_6

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