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Diversity in Phagocytic Signaling

A Story of Greed, Sharing, and Exploitation

  • Chapter
Molecular Mechanisms of Phagocytosis

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

Phagocytosis is the process whereby cells engulf large particles. Phagocytosis is triggered by the interaction of opsonins covering the surface of a phagocytic target with specific phagocyte receptors. In multicellular organisms phagocytosis participates in tissue remodeling and contributes to homeostasis. Higher organisms possess various phagocytic systems. Each system is composed of a series of ligands, specific receptors, and signaling pathways that culminate in particle internalization and destruction. The best studied phagocytic system is that of the receptors that bind to the Fc portion of immunoglobulins. Other phagocytic systems include phagocytosis of complement-opsonized particles, and phagocytosis of apoptotic cells. The signaling pathways elicited by many phagocytic receptors are complex and diverse. Comparison between the signaling pathways elicited by many phagocytic receptors shows that phagocytic signaling pathways share many elements. Shared signaling molecules include tyrosine kinases, lipid kinases, phospholipases, and serine/threonine kinases. Additionally, all phagocytic signaling pathways activate cytoskeleton-remodeling molecules. The dynamic nature of the cytoskeleton is thus exploited by all phagocytic systems to achieve particle internalization. In this review I will discuss the connections between the various signaling pathways of different phagocytic systems, and the regulation of cytoskeleton dynamics as a means to achieve particle internalization.

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  1. Immunology Department, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Erick García-García

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García-García, E. (2005). Diversity in Phagocytic Signaling. In: Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-28669-3_1

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