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Vascular Cell Responses to Fluid Shear Stress

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BioMEMS and Biomedical Nanotechnology

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Abstract

The development of several vascular diseases is linked to both blood flowproperties and cellular behavior in the arterial and venous systems. For instance, atherosclerosis development is dependent on the blood flow profile, shear stress rate, and resulting cellular responses in the arteries. Specifically, in regions of disturbed flow behavior, cells demonstrate both altered morphology and phenotype. Based on this clinical knowledge, in vitro fluid flow studies have been performed on vascular endothelial and smooth muscle cells to understand the process of disease initiation and development. Ultimately, results of such studies will provide knowledge regarding key pathways involved in disease progression. Moreover, this information will be critical when designing effective drug therapies in the clinical setting.

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Authors and Affiliations

  1. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907

    Jennifer A. McCann, Thomas J. Webster & Karen M. Haberstroh

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Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  5. Texas Alliance for NanoHealth, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  6. Purdue University, West Lafayette, Indiana

    Rashid Bashir  & Steve Wereley  & 

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McCann, J.A., Webster, T.J., Haberstroh, K.M. (2006). Vascular Cell Responses to Fluid Shear Stress. In: Ferrari, M., Bashir, R., Wereley, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25845-4_18

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