Abstract
Nanoshells are a new class of nanoparticles with tunable optical properties that have shown promise in a number of diagnostic and therapeutic applications. Conceived of over 50 years ago [1] but not realized until the 1990’s [3, 25, 48], metal nanoshells consist of spherical dielectric nanoparticles surrounded by a thin, conductive, metallic layer. By varying the composition and dimensions of the nanoparticles, nanoshells can be designed and fabricated with plasmon resonances from the visible to the mid-infrared regions of the spectrum [26]. For a given composition of core and metal shell, the plasmon resonances of the nanoparticle, which determines the particle’s optical absorption and scattering, may be tuned by changing the ratio of the nanoparticle’s core size to its shell thickness. Essentially, for a core of given diameter, metal shells of diminishing thickness (or higher core:shell ratios) will result in red shifting of the peak plasmon frequency (Figure 9.1).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
A.L. Aden and M. Kerker. J. Appl. Phys., 22:1242–1246, 1951.
Z. Amin, W. Thurrell, G.M. Spencer, S.A. Harries, W.E. Grant, S.G. Bown, and W.R. Lees. Invest. Radiol., 28:1148–1154, 1993.
R.D. Averitt, D. Sarkar, and N.J. Halas. Phys. Rev. Lett., 78:4217–4220, 1997.
R.D. Averitt, S.L. Westcott, and N.J. Halas. J. Opt. Soc. Am. B, 16:1824–1832, 1999.
C.F. Bohren and D.R. Huffman. A bsorption and Scattering of Light by Small Particles.Wiley-Interscience, New York, pp. 379, 1983.
K. Eichner. Int. Dent. J., 33:1–10, 1983.
J.G. Fujimoto, M.E. Brezinski, B.J. Tearney, S.A. Boppart, B. Bouma, M.R. Hee, J.F. Southern, and E.A. Swanson. Nat. Med., 1:970–972, 1995.
G.S. Gazelle, S.N. Goldberg, L. Solbiati, and T. Livraghi. Radiology, 217:633–646, 2000.
H. Hagman. Dent. Lab. Rev., 54:28–30, 1979.
G.D. Hale, J.B. Jackson, T.R. Lee, and N.J. Halas. Appl. Phys. Lett., 78:1502–1504, 2000.
I. Hilger, R. Hiergeist, R. Hergt, K. Winnefeld, H. Schubert,and W.A. Kaiser. Invest. Radiol., 37:580–586, 2002.
L.R. Hirsch, J.B. Jackson, A. Lee, N.J. Halas, and J.L. West. Analyt. Chem., 75:2377–2381, 2003.
L.R. Hirsch, R.J. Stafford, J.A. Bankson, S.R. Sershen, B. Rivera, R.E. Price, J.D. Hazle, N.J. Halas,, and J.L. West. Proc. Natl. Acad. Sci. U.S.A., 100:13549–13554, 2003.
M. Ho, M.J. Warrell, D.A. Warrel, D. Bidwell, and A. Voller. Toxicon, 24:211–221, 1986.
N. Holstrum, P. Nilsson, J. Carlsten, and S. Bowland. Biosens. Bioelectron., 13:1287–1295, 1998.
M. Horisberger and J. Rosset. J. Histochem. Cytochem., 25:295–305, 1977.
J.V. Houten, D. Benaron, S. Spilman, and D.K. Stevenson. Ped. Res., 39:470–476, 1996.
D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman,W.G. Stinson,W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto. Science, 254:1178–1181, 1991.
F.A. Jolesz and K. Hynynen. Cancer J., S1:100–112, 2002.
B.M. Kapur. Bull. Narcot., 45:116–154, 1993.
E. Kuun, M. Brashaw, and A.d.P. Heyns. Vox Sanguinis, 72:11–15, 1997.
B. Lindholm-Sethson, J.C. Gonzalez, and G. Puu. Langmuir, 14:6705–6708, 1998.
H. Maeda, T. Sawa, and T. Konno, J. Control. Rel., 74:46–61, 2001.
R.G. Nuzzo, F.A. Fusco, and D.L. Allara. J. Am. Chem. Soc., 109:2358–2368, 1987.
S.J. Oldenberg, R.D. Averitt, S.L. Westcott, and N.J. Halas. Chem. Phys. Lett., 28:243–247, 1998.
S.J. Oldenberg, S.L. Westcott, R.D. Averitt, and N.J. Halas. J. Chem. Phys., 111:4729–4735, 1999.
D.P. O’Neal, L.R. Hirsch, N.J. Halas, J.D. Payne, J.L. West. Cancer Lett., (In Press), 2004.
M. Pourbaix. Biomaterials, 5:122–134, 1984.
J.H. Priest, S.L. Murray, R.J. Nelson, and A.S. Hoffman. Revers. Polym. Gels Related Syst., 350:255–264, 1987.
E. Prodan, C. Radloff, N. Halas, and P. Nordlander. Science, 302:419–422, 2003.
M. Quinten. Appl. Phys. B, 73:317–326, 2001.
M. Rajadhyaksha, S. González, J.M. Zavislan, R.R. Anderson, and R.H. Webb. J. Investig. Dermatol., 113:203–303, 1999.
C. Ruan, R. Yang, X. Chen, and J. Deng. J. Electroanalyt. Chem., 455:121–125, 1998.
S. Sasaki, H. Kawasaki, and H. Maeda. Macromolecules, 30:1847–1848.
T. Seki, M. Wakabayashi, T. Nakagawa, M. Imamura, T. Tamai, A. Nishimura, N. Yamashiki, A. Okamura, and K. Inoue. Cancer, 85:1694–1702, 1999.
S. Sershen and J. West. Adv. Drug Del. Rev., 54:1225–1235, 2002.
S.R. Sershen, J.L. Westcott, J.L. West, and N.J. Halas. Appl. Phys. B, 73:379–381, 2001.
S.R. Sershen, S.L. Westcott, N.J. Halas, and J.L. West, J. Biomed. Mater. Res., 51:293–298, 2000.
S.R. Sershen, S.L. Westcott, N.J. Halas, and J.L. West, Appl. Phys. Lett., 80:4609–4611, 2002.
K. Sokolov, M. Follen, I. Pavolva, A. Malpica, R. Lotan, and R. Richards-Kortum. Cancer Res., 63:1999–2004, 2003.
W. Stober and A. Fink. J. Colloid. Interf. Sci., 26:62–69, 1968.
N. Tanaka, S. Matsukawa, H. Kuroso, and I. Ando. Polymer, 39:4703–4706, 1998.
A. Vogel. Phys. Med. Biol., 42:895–912, 1997. [44] T.J. Vogl, M.G. Mack, R. Straub, K. Engelmann, S. Zangos, and K. Eichler. Radiologe, 39:764-771, 1999.
R. Weissleder. Nat. Biotech., 19:316–317, 2001.
A. Welch and M. van Gemert (eds.). Optical-Thermal Response of Laser-Irradiated Tissue, P enum Press, New York, 1995.
R. Yoshida, K. Sakai, T. Okano, and Y. Sakurai. J. Biomat. Sci. Polym. Ed., 6:585–598, 1994.
H.S. Zhou, I. Honma, and H. Komiyama. Phys. Rev. B, 50:12052–12056, 1994
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science + Business Media, LLC
About this chapter
Cite this chapter
Hirsch, L.R., Drezek, R.A., Halas, N.J., West, J.L. (2006). Diagnostic and Therapeutic Applications of Metal Nanoshells. In: Ferrari, M., Desai, T., Bhatia, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25844-7_9
Download citation
DOI: https://doi.org/10.1007/978-0-387-25844-7_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25565-1
Online ISBN: 978-0-387-25844-7
eBook Packages: EngineeringEngineering (R0)