Abstract
Over the last three decades considerable advances have marked the field of drug delivery technology, resulting in many breakthroughs in clinical medicine. However, major unmet needs remain. Among these are broad categories of: 1) Continuous release of therapeutic agents over extended time periods and in accordance to a pre-determined temporal profile [38, 60]; 2) Local delivery at a constant rate to the tumor microenvironment, to overcome much of the systemic toxicity and improve anti-tumor efficacy; 3) Improved ease of administration, increasing patient compliance, while minimizing the needed intervention of healthcare personnel and decreasing the length of hospital stays [6, 46]. Success in addressing some or all of these challenges would potentially lead to improvements in efficacy and patient compliance, as well as minimization of side effects [66].
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Desai, T.A. et al. (2006). Nanoporous Implants for Controlled Drug Delivery. In: Ferrari, M., Desai, T., Bhatia, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25844-7_15
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