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Magnetic Nanoparticles for MR Imaging

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BioMEMS and Biomedical Nanotechnology

Abstract

The combination of a nonmaterial, magnetic nanoparticles, with magnetic resonance imaging, is yielding major advances in diverse areas of biology and medicine. This review will present a short history of iron oxide based nanoparticles, and review important new developments in the fields of magnetic nanoparticles and MRI. Magnetic nanoparticles are currently used in approved MRI contrast agents for imaging hepatic metastases and show considerable potential in clinical testing for imaging nodal metastases. New applications of magnetic nanoparticles include (i) ex-vivo labeling of cells with nanoparticles, followed by MR imaging in vivo, (ii) magnetic nanoparticles as biosensors termed magnetic relaxation switches, to measure a wide range of analytes in vitro, (iii) magneto/optical nanoparticles providing a fluorescent signal in addition to their magnetic character and (iv) biomolecule targeted magnetic nanoparticles for the imaging of specific molecular targets by MRI. This review will cover each of these diverse developments.

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Author information

Authors and Affiliations

  1. Center for Molecular Imaging Research, Massachusetts General Hospital/Harvard Medical School, Building 149, 13th Street, Charlestown, MA, 02129

    Lee Josephson

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  1. Lee Josephson
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  5. Texas Alliance for NanoHealth, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  6. Biomedical Engineering, University of California, Irvine

    Abraham P. Lee

  7. Chemical and Biomolecular Engineering, The Ohio State University, USA

    L. James Lee

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© 2006 Springer Science + Business Media, LLC

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Josephson, L. (2006). Magnetic Nanoparticles for MR Imaging. In: Ferrari, M., Lee, A.P., Lee, L.J. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25842-3_8

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  • DOI: https://doi.org/10.1007/978-0-387-25842-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25563-7

  • Online ISBN: 978-0-387-25842-3

  • eBook Packages: EngineeringEngineering (R0)

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