Abstract
Research has led to a better understanding of soft-tissue tumors and to improvements in the multidisciplinary care of patients with rhabdomyosarcoma, nonrhabdomyosarcomatous soft-tissue sarcoma, aggressive fibromatosis, and neurofibromas. This chapter outlines the diagnostic and therapeutic strategies used at M. D. Anderson Cancer Center in the treatment of children and adolescents with these 4 types of soft-tissue tumors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Suggested Readings
Ayala AG, Ro JY, Goepfert H, et al. Desmoid fibromatosis: a clinicopathologic study of 25 children. Semin Diagn Pathol 1986;3:138–150.
Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer 1981;48:1807–1818.
Cosetti M, Wexler LH, Calleja E, et al. Irinotecan for pediatric solid tumors: The Memorial Sloan-Kettering experience. J Pediatr Hematol Oncol 2002;24:101–105.
Crist W, Gehan EA, Ragab AH, et al. The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol 1995;13:610–630.
Crist WM, Anderson JR, Meza JL, et al. Intergroup Rhabdomyosarcoma Study-IV: results for patients with nonmetastatic disease. J Clin Oncol 2001;19:3091–3102.
Donaldson SS, Meza J, Breneman JC, et al. Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma—A report from the IRSG. Int J Radiat Oncol Biol Phys 2001;51:718–728.
Heyn RM, Holland R, Newton WA, Jr, et al. The role of combined chemotherapy in the treatment of rhabdomyosarcoma in children. Cancer 1974;34:2128–2142.
Izes JK, Zinman LN, Larsen CR. Regression of large pelvic desmoid tumor by tamoxifen and sulindac. Urology 1996;47:756–759.
Kelly KM, Womer RB, Sorensen PHB, et al. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol 1997;15:1831–1836.
Kinzler KW, Nilbert MC, Su LK, et al. Identification of FAP locus genes from chromosome 5q21. Science 1991;253:661–665.
McClay EF. Epidemiology of bone and soft tissue sarcomas. Semin Oncol 1989;16:264–272.
Michalski JM, Sur RK, Harms WB, et al. Three-dimensional conformal radiation therapy in pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys 1995;33:985–991.
Neville HL, Andrassy RJ, Lally KP, et al. Lymphatic mapping with sentinel node biopsy in pediatric patients. J Pediatr Surg 2000;35:961–964.
Okçu MF, Despa S, Choroszy M, et al. Synovial sarcoma in children and adolescents: thirty three years of experience with multimodal therapy. Med Pediatr Oncol 2001;37:90–96.
Okçu MF, Munsell M, Treuner J, et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J Clin Oncol 2003; 21:1602–1611.
Pappo AS, Lyden E, Breneman J, et al. Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: An Intergroup Rhabdomyosarcoma Study. J Clin Oncol 2001;19:213–219.
Qualman SJ, Coffin CM, Newton WA, et al. Intergroup Rhabdomyosarcoma Study: Update for pathologists. Pediatr Dev Pathol 1998;1:463–474.
Raney B. Soft-tissue sarcoma in adolescents. In: Tebbi CK, ed. Major Topics in Adolescent Oncology. Mount Kisco, NY: Futura Publishing Company, Inc; 1987: 221–240.
Raney B, Evans A, Granowetter L, et al. Nonsurgical management of children with recurrent or unresectable fibromatosis. Pediatrics 1987;79:394–398.
Raney RB, Maurer HM, Anderson JR, et al. The Intergroup Rhabdomyosarcoma Study Group (IRSG): major lessons from the IRS-I through IRS-IV studies as background for the current IRS-V treatment protocols. Sarcoma 2001;5:9–15.
Raney RB, Meza J, Anderson JR, et al. Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group Protocols IRS-II through-IV, 1978–1997. Med Pediatr Oncol 2002;38:22–32.
Ries LAG, Smith MA, Gurney JG, et al. Cancer Incidence and Survival Among Children and Adolescents. Bethesda, MD: National Institutes of Health, National Cancer Institute; 1999. Report No.: NIH-NCI-99-4649.
Skapek SX, Hawk BJ, Hoffer FA, et al. Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children. J Clin Oncol 1998;16:3021–3027.
Wiener ES, Anderson JR, Ojimba JI, et al. Controversies in the management of paratesticular rhabdomyosarcoma: is staging retroperitoneal lymph node dissection necessary for adolescents with resected paratesticular rhabdomyosarcoma? Semin Pediatr Surg 2001;10:146–152.
Wolden SL, Anderson JR, Crist WM, et al. Indications for radiotherapy and chemotherapy after complete resection in rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Studies I to III. J Clin Oncol 1999;17:3468–3475.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this chapter
Cite this chapter
Raney, R.B., Andrassy, R.J., Blakely, M., Fanning, T.V., Maor, M.H., Stewart, J. (2005). Soft-Tissue Tumors. In: Chan, K.W., Raney, R.B. (eds) Pediatric Oncology. M.D. Anderson Cancer Care Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-24472-3_7
Download citation
DOI: https://doi.org/10.1007/978-0-387-24472-3_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-24470-9
Online ISBN: 978-0-387-24472-3
eBook Packages: MedicineMedicine (R0)