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Clinical PET pp 372-386 | Cite as

Lymphoma

  • E. Edmund Kim
  • Franklin C. L. Wong

Abstract

The term lymphoma identifies two distinct groups of tumors: Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL). Since the late 1970s, significant progress has been made in the elucidation of the pathogenesis of NHL as a clonal malignant expansion of B or T cells. B lymphocytes are generated in the bone marrow as a result of a multistep differentiation process. On entering the germinal center (GC), B cells activate into centroblasts, proliferate, and mature into centrocytes. Cells that have exited the GC have two fates: differentiation into either plasma cells or memory B cells. Based on the absence or presence of somatic immunoglobulin (Ig) hypermutation, B-cell NHL may be distinguished into two broad histogenetic categories: One derived from pre-GC B cells and devoid of Ig mutations (mantle cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma), and the other derived from B cells that have transited through the GC and harbor 1g mutations (follicular lymphoma, lymphoplasmacytoid lymphoma, mucosa-associated lymphoid tissue lymphoma, diffuse large cell lymphoma, Burkitt’s lymphoma). The pathogenesis of lymphoma represents a multistep process involving the progressive and clonal accumulation of multiple genetic lesions affecting proto-oncogenes and tumor suppressor genes. The genome of lymphoma cells is relatively stable and is characterized by few nonrandom chromosomal abnormalities, commonly represented by chromosomal translocations.

Keywords

Positron Emission Tomography Standard Uptake Value Germinal Center Mantle Cell Lymphoma Meet Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • E. Edmund Kim
  • Franklin C. L. Wong

There are no affiliations available

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