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Analyses of Intracellular Signal Transduction Pathways in CNS Progenitor Cells

  • Elena Cattaneo
  • Luciano Conti

Abstract

Growth factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet derived growth factor (PDGF), and the neurotrophins and cytokines, such as interleukines and interferons, have a profound influence on the proliferation, survival, and differentiation of central nervous system (CNS) cells. They exert their roles by binding to their respective membrane-bound receptors and stimulating phosphorylation cascades (4). These receptors have been classified into two major groups: (i) receptors that have an intrinsic tyrosine kinase domain. These are also known as receptor protein tyrosine kinases (RPTK)and are exemplified by the epidermal growth factor receptor (EGFR) and neurotrophin receptors; and (ii) receptors such as those for the interleukins, which lack a kinase domain and use cytoplasmic tyrosine kinases.

Keywords

Epidermal Growth Factor Receptor Sodium Dodecyl Sulfate Kinase Assay Sodium Orthovanadate Central Nervous System Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 2002

Authors and Affiliations

  • Elena Cattaneo
    • 1
  • Luciano Conti
    • 1
  1. 1.Institute of Pharmacological SciencesUniversity of MilanoMilanoItaly, EU

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