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In modeling whole cells we try to understand complex properties of cells by combining interlocking transport and regulatory mechanisms. We use a modular approach and develop models of each individual process separately using available experimental data. We then construct progressively more complete models by combining components to understand how they work together. Sometimes, we proceed in the opposite order, beginning with a comprehensive model, which we simplify in order to determine the minimal essential elements. One particularly useful simplification technique is to exploit separation of time scales to set fast processes to equilibrium as described in Chapter 4.
KeywordsEndoplasmic Reticulum Hopf Bifurcation Bifurcation Diagram Homoclinic Orbit Endoplasmic Reticulum Membrane
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