Skip to main content
SpringerLink
Log in

Lymphoma

  • Chapter
Book cover Practical FDG Imaging: A Teaching File

  • 133 Accesses

Abstract

Although the incidence of Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL) is only 8% of all malignancies, they are potentially curable malignancies. The extent of the disease is the most important factor influencing relapse-free and total survival of patients. Conventional methods for staging (CT and gallium imaging) have limitations. Although gallium plays a role in the evaluation of the presence of viable tumor in residual posttherapy masses, it is not superior to CT in initial staging of untreated lymphoma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jotti G, Bonandonna G: Prognostic factors in Hodgkin’s disease: Implications for modern treatment. Anticancer Res 1998;8:749–760.

    Google Scholar 

  2. Armitage JO: Drug therapy: Treatment of non-Hodgkin’s lymphoma. N Engl J Med 1993;328: 1023–1030.

    Article  PubMed  CAS  Google Scholar 

  3. Castellino RA, Blank N, Hoppe RT, Cho C: Hodgkin’s disease: Contribution of chest CT in the initial staging evaluation. Radiology 1986; 160:603–605.

    PubMed  CAS  Google Scholar 

  4. Newman JS, Francis IR, Kaminske MS, Wahl RL: Imaging of lymphoma with PET with 2-[f-18]fluoro-2-deoxyglucose: Correlation with CT. Radiology 1994;190:111–116.

    PubMed  CAS  Google Scholar 

  5. Neumann CH, Robert NJ, Canellos G, Rosenthal D: Computed tomography of the abdomen and pelvis in non-Hodgkin lymphoma. J Comput Assist Tomgr 1983;7:846–850.

    Article  CAS  Google Scholar 

  6. Munker R, Stengel A, Stabler A, Hiller E, Brehm G: Diagnostic accuracy of ultrasound and computed tomography in the staging of Hodgkin’s disease. Cancer 1995;76:1460–1466.

    Article  PubMed  CAS  Google Scholar 

  7. Front D, Bar-Shalom R, Epelbaum R, et al.: Early detection of lymphoma recurrence with gallium-67 scintigraphy. J Nucl Med 1993;34:2101–2104.

    PubMed  CAS  Google Scholar 

  8. Paul R: Comparison of fluorine-18-2-fluorodeoxyglucose and gallium-67 citrate imaging for detection of lymphoma. J Nucl Med 1987;28: 288–292.

    PubMed  CAS  Google Scholar 

  9. Okada J, Yoshikawa K, Imazeki K, et al.:The use of FDG-PET in the detection and management of malignant lymphoma: Correlation of uptake with prognosis. J Nucl Med 1991;32:686–691.

    PubMed  CAS  Google Scholar 

  10. Okada J, Yoshikawa K, Imazeki K, et al.: Positron emission tomography using fluorine-18fluorodeoxyglucose in malignant lymphoma: A comparison with proliferative activity. J Nucl Med 1992;33:325–329.

    PubMed  CAS  Google Scholar 

  11. Leskinen-Kallio S, Rudsalainen U, Nagren K, Teras M, Joensuu H: Uptake of carbon-11 methionine and fluorodeoxyglucose in non-Hodgkin’s lymphoma: A PET study. J Nucl Med 1991;32:1211–1218.

    PubMed  CAS  Google Scholar 

  12. Lapela M, Leskinen S, Minn HR, et al.: Increased glucose metabolism in untreated non-Hodgkin’s lymphoma: A study with positron emission tomography and fluorine-18 fluorodeoxyglucose. Blood 1995;86:3522–3527.

    PubMed  CAS  Google Scholar 

  13. Rodriguez M, Rehn S, Ahlström H, Sunolstrom C, Glimelius B: Predicting malignancy grade with PET in non-Hodgkin’s lymphoma. J Nucl Med 1995;36:1790–1796.

    PubMed  CAS  Google Scholar 

  14. Hoh CK, Gaspy J, Rosen P, et al.: Whole body FDG-PET imaging for staging of Hodgkin’s disease and lymphoma. J Nucl Med 1997;38: 343–348.

    PubMed  CAS  Google Scholar 

  15. Moog F, Bangerter M, Diedrichs CG, et al.: Lymphoma: Role of whole-body 2-deoxy-2-[F18]fluoro D-glucose (FDG) PET in nodal staging. Radiology 1997;203:795–800.

    PubMed  CAS  Google Scholar 

  16. Moog F, Bangerter M, Diedrichs CG, et al.: Extranodal malignant lymphoma: Detection with FDG-PET versus CT. Radiology 1998;206: 475–481.

    PubMed  CAS  Google Scholar 

  17. Carr R, Barrington SF, Madan B, et al.: Detection of lymphoma in bone marrow by whole-body positron emission tomography. Blood 1998;91:3340–3346.

    PubMed  CAS  Google Scholar 

  18. Moog F, Bangerter M, Kotzerke J, Guhlmann A, Frickhofen N, Reske SN: 18-F fluorodeoxyglucose-positron emission tomography as a new approach to detect lymphomatous bone marrow. J Clin Oncol 1998;16:603–609.

    PubMed  CAS  Google Scholar 

  19. Stumpe KD, Urbinelli M, Steinert HC, Glanzmann C, Buck A, von Schulthess GK: Whole-body positron emission tomography using fluorodeoxyglucose for staging of lymphoma: Effectiveness and comparison with computed tomography. Eur J Nucl Med 1998;25:721–728.

    Article  PubMed  CAS  Google Scholar 

  20. De Wit M, Bumann D, Beyer W, Herbst K, Clausen M, Hossfeld DK: Whole-body positron emission tomography (PET) for diagnoses of residual mass in patients with lymphoma. Ann Oncol 1997;8(Suppl):57–60.

    Google Scholar 

  21. Romer W, Hanauske AR, Ziegler S, et al.: Positron emission tomography in non-Hodgkin’s lymphoma: Assessment of chemotherapy with fluorodeoxyglucose. Blood 1998;91:4464–4471.

    PubMed  CAS  Google Scholar 

  22. Brunning RD, Bloomfield CD, McKenna RW, Peterson L: Bilateral trephine bone marrow biopsies in lymphoma and other neoplastic disease. Ann Intern Med 1975;82:375.

    Google Scholar 

  23. Ebie N, Loew JM, Gregory SA: Bilateral trephine bone marrow biopsies for staging non-Hodgkin’s lymphoma: A second look. Hematol Pathol 1989;3:29.

    PubMed  CAS  Google Scholar 

  24. Haddy TB, Parker RI, Magrath IT: Bone marrow involvement in young patients with non-Hodgkin’s lymphoma: The importance of multiple bone marrow samples for accurate staging. Med Pediatr Oncol 1989;17:418.

    Article  PubMed  CAS  Google Scholar 

  25. Juneja SK, Wolf MM, Cooper IA: Value of bilateral bone marrow biopsy specimens in non-Hodgkin’s lymphoma. J Clin Pathol 1990;43:630.

    PubMed  CAS  Google Scholar 

  26. Landgren O, Axdorph U, Jacobson H, et al.: Routine bone scintigraphy is of limited value in the clinical assessment of untreated patients with Hodgkin’s disease. Med Oncol 2000;17:174–178.

    PubMed  CAS  Google Scholar 

  27. Orzel J, Sawaf NW, Richardson ML: Lymphoma of the skeleton: Scintigraphic evaluation: Am J Rehabil 1988;150:1095–1099.

    CAS  Google Scholar 

  28. Schechter JP, Jones SE, Woolfenden JM, et al.: Bone scanning in lymphoma. Cancer 1976;38: 1142–1146.

    Article  PubMed  CAS  Google Scholar 

  29. Ferrant A, Rodhain J, Michaux JL, Piret L, Maldaque B, Sokal G: Detection of skeletal involvement in Hodgkin’s disease: A comparison of radiography, bone scanning, and bone marrow biopsy in 38 patients. Cancer 1975;35: 1346–1353.

    Article  PubMed  CAS  Google Scholar 

  30. Shields AF, Porter BA, Olson DO, et al.: The detection of bone marrow involvement by lymphoma using magnetic resonance imaging. J Clin Oncol 1987;5:225–230.

    PubMed  CAS  Google Scholar 

  31. Altenhoefer C, Blum U, Bathmann J, et al.: Comparative diagnostic accuracy of magnetic resonance imaging and immunoscintigraphy for detection of bone marrow involvement in patients with malignant lymphoma. J Clin Oncol 1997;15:1754–1760.

    Google Scholar 

  32. Delbeke D, Kovalsky E, Cerci R, Martin WH, Kinney M, Greer J: 18F-fluorodeoxyglucose imaging with positron emission tomography for initial staging of Hodgkin’s disease and lymphoma. J Nucl Med 2000;41:275P.

    Google Scholar 

  33. Moog F, Kotzerke J, Reske SN: FDG PET can replace bone scintigraphy in primary staging of malignant lymphoma. J Nucl Med 1999;40: 1407–1413.

    PubMed  CAS  Google Scholar 

  34. Bangerter M, Moog F, Buchmann I, et al.: Whole-body 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) for accurate staging of Hodgkin’s disease. Ann Oncol 1998; 9(10):1117–1122.

    Article  PubMed  CAS  Google Scholar 

  35. Mikhaeel NG, Timothy AR, Hain SF, O’Doherty MJ: 18-FDG-PET for the assessment of residual masses on CT following treatment of lymphomas. Ann Oncol 2000;11(Suppl):147–150.

    Article  PubMed  Google Scholar 

  36. Jerusalem G, Beguin Y, Fassotte MF, et al.: Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin’s lymphoma. Haematologica2000;85(6):613–618.

    PubMed  CAS  Google Scholar 

  37. Delbeke D, Kovalsky E, Cerci R, Martin WH, Kinney M, Greer J: 18F-fluorodeoxyglucose imaging with positron emission tomography in the follow-up of patients with lymphoma. J Nucl Med 2000;41:70P.

    Google Scholar 

Reference

  1. Delbeke D, Martin WH, Patton JA, Sandler MP: Value of iterative reconstruction, attenuation correction, and image fusion in the interpretation of FDG PET images with an integrated dual-head coincidence camera and x-ray-based attenuation maps. Radiology 2000;218:163–171.

    Google Scholar 

Reference

  1. Powles T, Matthews G, Bower M: AIDS related systemic non-Hodgkin’s lymphoma. Sex Transm Infect 2000;76:335–341.

    Article  PubMed  CAS  Google Scholar 

Reference

  1. Zangwill SD, Kichuk MR, Garvin JH, et al.: Incidence and outcome of primary Epstein-Barr virus infection and lymphoproliferative disease in pediatric heart transplant recipients. J Heart Lung Transplant 1998;17:1161–1166.

    PubMed  CAS  Google Scholar 

Reference

  1. Kostakoglu L, Goldsmith SJ: Fluorine-18 fluorodeoxyglucose positron emission tomography in the staging and follow-up of lymphoma: Is it time to shift gears? Eur J Nucl Med 2000;27(10): 1564–1578.

    Article  PubMed  CAS  Google Scholar 

References

  1. Janicek M, Kaplan W, Neuberg D, Canellos GP, Shulman LN, Shipp MA: Early restaging gallium scans predict outcome in poor-prognosis patients with aggressive non-Hodgkin’s lymphoma treated with high-dose CHOP chemotherapy. J Clin Oncol 1997;15(4):1631–1637.

    PubMed  CAS  Google Scholar 

  2. Romer W, Hanauske AR, Ziegler S, et al.: Positron emission tomography in non-Hodgkin’s lymphoma: Assessment of chemotherapy with fluorodeoxyglucose. Blood 1998;91:4464–4471.

    PubMed  CAS  Google Scholar 

  3. Jerusalem G, Beguin Y, Fassotte MF, et al.: Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin’s lymphoma. Haematologica 2000;85(6):613–618.

    PubMed  CAS  Google Scholar 

  4. De Wit M, Bumann D, Beyer W, Herbst K, Clausen M, Hossfeld DK: Whole-body positron emission tomography (PET) for diagnoses of residual mass in patients with lymphoma. Ann Oncol 1997;8(Suppl):57–60.

    Google Scholar 

  5. Stumpe KD, Urbinelli M, Steinert HC, Glanzmann C, Buck A, von Schulthess GK: Whole-body positron emission tomography using fluorodeoxyglucose for staging of lymphoma: Effectiveness and comparison with computed tomography. Eur J Nucl Med 1998;25:721–728.

    Article  PubMed  CAS  Google Scholar 

  6. Delbeke D, Kovalsky E, Cerci R, Martin WH, Kinney M, Greer J: 18F-fluorodeoxyglucose imaging with positron emission tomography in the follow-up of patients with lymphoma. J Nucl Med 2000;41:70P.

    Google Scholar 

  7. Mikhaeel NG, Timothy AR, Hain SF, O’Doherty MJ: 18-FDG-PET for the assessment of residual masses on CT following treatment of lymphomas. Ann Oncol 2000;11(Suppl):147–150.

    Article  PubMed  Google Scholar 

Download references

Authors
  1. William H. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amy B. Gibson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dominique Delbeke
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    Dominique Delbeke MD, PhD , William H. Martin MD , James A. Patton PhD  & Martin P. Sandler MD , ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Martin, W.H., Gibson, A.B., Delbeke, D. (2002). Lymphoma. In: Delbeke, D., Martin, W.H., Patton, J.A., Sandler, M.P. (eds) Practical FDG Imaging: A Teaching File. Springer, New York, NY. https://doi.org/10.1007/978-0-387-22453-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-22453-4_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95292-5

  • Online ISBN: 978-0-387-22453-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation