Two Loci

  • Warren J. Ewens
Part of the Interdisciplinary Applied Mathematics book series (IAM, volume 27)


Most of the theory of this book so far has assumed that the fitness of any individual depends on his genetic make-up at a single locus. Although for certain specific purposes this assumption may give reasonable approximations, it is in general a gross simplification, in particular when epistatic, that is interactive, effects arise between loci. In this chapter we suppose that the fitness of any individual depends on his genetic constitution at two (or sometimes three) loci. Although this assumption is hardly less realistic than the previous one, it does allow substantial advance to be made, as has been noted in Section 2.10, on assessing the evolutionary effect of recombination between loci. It also allows us to assess the extent to which two-locus behavior is predictable from combining two single-locus analyses. We shall also see later in this chapter that it allows an investigation of the effects of modifier genes.


Linkage Disequilibrium Equilibrium Point Modifier Locus Selective Sweep Recombination Fraction 
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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Warren J. Ewens
    • 1
  1. 1.Department of BiologyUniversity of PennsylvaniaPhiladelphiaUSA

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