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Congenital Melanocytic Nevi and Associated Neoplasms, Congenital and Childhood Melanoma

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Abstract

By definition, the term congenital nevus denotes presence at birth (1,2) (Table 6-1). However, congenital melanocytic nevi (CMN) are also defined by striking differences from common acquired nevi. In general, these differences include (a) overall size, (b) depth of involvement by nevus cells, (c) adnexal or vascular involvement, and (d) diversity of neurocristic differentiation (3). Most melanocytic nevi > 1.5 cm in diameter are probably congenital (1), if not acquired atypical (dysplastic) nevi or melanoma. However, smaller CMN may be indistinguishable from acquired nevi (2,4–6). Thus documentation at birth by reliable means such as physicians, parents, photography, or medical records is necessary to confirm a congenital onset for nevi > 1.5 cm. The larger CMN are distinctive because of their size (1,6–8). A small subset of nevi are remarkable for clinical and histologic features that are indistinguishable from typical CMN but are associated with an onset at several months to 2 years after birth. Such nevi have been termed congenital nevi tardive (9).

Keywords

  • Melanocytic Nevus
  • Melanoma Risk
  • Reticular Dermis
  • Nevus Cell
  • Associate Neoplasm

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Barnhill, R.L. (2004). Congenital Melanocytic Nevi and Associated Neoplasms, Congenital and Childhood Melanoma. In: Barnhill, R.L., Piepkorn, M., Busam, K.J. (eds) Pathology of Melanocytic Nevi and Malignant Melanoma. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21619-5_6

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