Abstract
Abnormalities in the regulation of meiosis can lead to several disastrous outcomes, including infertility, birth defects, and teratocarcinogensis. This chapter will discuss abnormalities in oocyte meiosis that lead to the formation of spontaneous ovarian teratomas. Emphasis is placed on ovarian teratocarcinogenesis in strain LT mice, and related strains. The word teratoma is derived from the Greek teras, meaning monster, because the tumors are composed of a variety of differentiated cell and tissue types including skin, glandular tissue, bone, muscle, neural tissue, and even hair and teeth, which is assembled into a highly disorganized, sometimes bizarre, mass. Ovarian teratomas in both mice and humans often arise from oocytes that undergo parthenogenetic embryo development without ovulation.
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Eppig, J.J., Hampl, A., Hirao, Y. (2000). Ovarian Teratocarcinogenesis: A Consequence of Abnormal Regulation of Meiosis. In: Adashi, E.Y. (eds) Ovulation. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21508-2_5
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DOI: https://doi.org/10.1007/978-0-387-21508-2_5
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4899-0521-5
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