Helicobacter pylori

  • Sharon Perry
  • Catherine de Martel
  • Julie Parsonnet

Helicobacter pylori, a corkscrew-shaped, gram-negative rod, resides in the mucous layer of the human stomach. Unrecognized until the 1980s, the organism is extraordinarily common, infecting at least half of the world’s population. Once acquired, infection persists chronically, typically continuing in the stomach throughout the host’s life. H. pylori infection invariably causes acute and chronic gastric inflammation, but in only a minority of cases does it result in overt clinical disease. Yet, the diseases attributed to H. pylori infection, peptic ulcer disease and gastric malignancy, are among the world’s most important causes of morbidity and mortality in adults. For this reason, the past 30 years have borne witness to furious activity concerning diagnosis, treatment, and prevention of this recently rediscovered pathogen.


Gastric Cancer Pylorus Infection Peptic Ulcer Disease Pylorus Eradication Breath Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank Jeremy Schneider and Luz Sanchez for their technical assistance.


  1. 1.
    Aebischer, T., Schmitt, A., Walduck, A. K., & Meyer, T. F. (2005). Helicobacter pylori vaccine development: facing the challenge. Int J Med Microbiol, 295(5), 343–353.PubMedGoogle Scholar
  2. 2.
    Aguemon, B. D., Struelens, M. J., Massougbodji, A., & Ouendo, E. M. (2005). Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations. Clin Microbiol Infect, 11(8), 611–617.PubMedGoogle Scholar
  3. 3.
    Akada, J. K., Shirai, M., Takeuchi, H., Tsuda, M., & Nakazawa, T. (2000). Identification of the urease operon in Helicobacter pylori and its control by mRNA decay in response to pH. Mol Microbiol, 36(5), 1071–1084.PubMedGoogle Scholar
  4. 4.
    Akopyanz, N., Bukanov, N. O., Westblom, T. U., & Berg, D. E. (1992). PCR-based RFLP analysis of DNA sequence diversity in the gastric pathogen Helicobacter pylori. Nucleic Acids Res, 20(23), 6221–6225.PubMedGoogle Scholar
  5. 5.
    Alm, R. A., Bina, J., Andrews, B. M., Doig, P., Hancock, R. E., & Trust, T. J. (2000). Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families. Infect Immun, 68(7), 4155–4168.PubMedGoogle Scholar
  6. 6.
    Alm, R. A., & Trust, T. J. (1999). Analysis of the genetic diversity of Helicobacter pylori: the tale of two genomes. J Mol Med, 77(12), 834–846.PubMedGoogle Scholar
  7. 7.
    Al-Moagel, M. A., et al. (1990). Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudia Arabia, and comparison of those with and without upper gastrointestinal symptoms. Am J Gastroenterol, 85(8), 944–948.Google Scholar
  8. 8.
    Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003). Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science, 300(5624), 1430–1434.PubMedGoogle Scholar
  9. 9.
    Andersen, L. P., Goodwin, C. S., & Worsley, B. W. (1993). The antibody response to Helicobacter pylori infection, and the value of serologic tests to detect H. pylori and for post-treatment monitoring. In Helicobacter pylori: Biology and Clinical Practice (pp. 285). Boca Raton: CRC Press.Google Scholar
  10. 10.
    Andrutis, K. A., Fox, J. G., Schauer, D. B., Marini, R. P., Murphy, J. C., Yan, L., et al. (1995). Inability of an isogenic urease-negative mutant stain of Helicobacter mustelae to colonize the ferret stomach. Infect Immun, 63(9), 3722–3725.PubMedGoogle Scholar
  11. 11.
    Arroyo, M. T., Forne, M., de Argila, C. M., Feu, F., Arenas, J., de la Vega, J., et al. (2004). The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter, 9(3), 249–254.PubMedGoogle Scholar
  12. 12.
    Ashorn, M., et al. (1995). Helicobacter pylori infection in Finnish children and adolescents. A serologic cross-sectional and follow-up study. Scand J Gastroenterol, 30(9), 876–879.Google Scholar
  13. 13.
    Ashorn, M., et al. (1996). Seroepidemiological study of Helicobacter pylori infection in infancy. Arch Dis Child Fetal Neonatal Ed, 74(2), F141–142.Google Scholar
  14. 14.
    Baker, S., Gummett, P. A., Whittaker, L., Schaufelberger, H. D., Johnson, P., Misiewicz, J. J., et al. (1994). A pilot study of the epidemiology of Helicobacter pylori in children from London using the 13 C-urea breath test. American Journal of Gastroenterology, 89, 1307.Google Scholar
  15. 15.
    Bamford, K. B., Bickley, J., Collins, J. S., Johnston, B. T., Potts, S., Boston, V., et al. (1993). Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection. Gut, 34(10), 1348–1350.PubMedGoogle Scholar
  16. 16.
    Banatvala, N., Clements, L., Abdi, Y., Graham, J. Y., Hardie, J. M., & Feldman, R. A. (1995). Migration and Helicobacter pylori seroprevalence: Bangladeshi migrants in the U.K. J Infect, 31(2), 133–135.PubMedGoogle Scholar
  17. 17.
    Baron, J. H., & Sonnenberg, A. (2002). Hospital admissions for peptic ulcer and indigestion in London and New York in the 19th and early 20th centuries. Gut, 50(4), 568–570.PubMedGoogle Scholar
  18. 18.
    Basso, D., & Plebani, M. (2004). H. pylori infection: bacterial virulence factors and cytokine gene polymorphisms as determinants of infection outcome. Crit Rev Clin Lab Sci, 41(3), 313–337.PubMedGoogle Scholar
  19. 19.
    Bellack, N. R., Koehoorn, M. W., MacNab, Y. C., & Morshed, M. G. (2006). A conceptual model of water’s role as a reservoir in Helicobacter pylori transmission: a review of the evidence. Epidemiol Infect, 134(3), 439–449.PubMedGoogle Scholar
  20. 20.
    Berkowicz, J., & Lee, A. (1987). Person-to-person transmission of Campylobacter pylori. Lancet, 2(8560), 680–681.PubMedGoogle Scholar
  21. 21.
    Bernstein, C. N., McKeown, I., Embil, J. M., Blanchard, J. F., Dawood, M., Kabani, A., et al. (1999). Seroprevalence of Helicobacter pylori, incidence of gastric cancer, and peptic ulcer-associated hospitalizations in a Canadian Indian population. Dig Dis Sci, 44(4), 668–674.PubMedGoogle Scholar
  22. 22.
    Bhat, N., Gaensbauer, J., Peek, R. M., Bloch, K., Tham, K. T., Blaser, M. J., et al. (2005). Local and systemic immune and inflammatory responses to Helicobacter pylori strains. Clin Diagn Lab Immunol, 12(12), 1393–1400.PubMedGoogle Scholar
  23. 23.
    Bizzozero, G. (1893). Uber die schlauchförmigen drüsen des Magendarmkanals und die Beziehungen ihres epithels zu dem oberflächen-epithel der schleimhaut. Arch Mickrosk Anat, 42.Google Scholar
  24. 24.
    Blaser, M. J. (2005). The biology of cag in the Helicobacter pylori-human interaction. Gastroenterology, 128(5), 1512–1515.PubMedGoogle Scholar
  25. 25.
    Blaser, M. J., & Atherton, J. C. (2004). Helicobacter pylori persistence: biology and disease. J Clin Invest, 113(3), 321–333.PubMedGoogle Scholar
  26. 26.
    Blaser, M. J., & Berg, D. E. (2001). Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest, 107(7), 767–773.PubMedGoogle Scholar
  27. 27.
    Blaser, M. J., & Parsonnet, J. (1994). Parasitism by the “slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest, 94(1), 4–8.PubMedGoogle Scholar
  28. 28.
    Blecker, U., Hauser, B., Lanciers, S., Peeters, S., Suys, B., & Vandenplas, Y. (1993). The prevalence of Helicobacter pylori-positive serology in asymptomatic children. J Pediatr Gastroenterol Nutr, 16(3), 252–256.PubMedGoogle Scholar
  29. 29.
    Blecker, U., Lanciers, S., Mehta, D. I., & Vandenplas, Y. (1994). Familial clustering of Helicobacter pylori infection. Clin Pediatr (Phila), 33(5), 307–308.Google Scholar
  30. 30.
    Bode, G., Mauch, F., & Malfertheiner, P. (1993). The coccoid forms of Helicobacter pylori. Criteria for their viability. Epidemiol Infect, 111(3), 483–490.PubMedGoogle Scholar
  31. 31.
    Bodhidatta, L., Hoge, C. W., Churnratanakul, S., Nirdnoy, W., Sampathanukul, P., Tungtaem, C., et al. (1993). Diagnosis of Helicobacter pylori infection in a developing country: comparison of two ELISAs and a seroprevalence study. J Infect Dis, 168(6), 1549–1553.PubMedGoogle Scholar
  32. 32.
    Bohmer, C. J., Klinkenberg-Knol, E. C., Kuipers, E. J., Niezen-de Boer, M. C., Schreuder, H., Schuckink-Kool, F., et al. (1997). The prevalence of Helicobacter pylori infection among inhabitants and healthy employees of institutes for the intellectually disabled. Am J Gastroenterol, 92(6), 1000–1004.PubMedGoogle Scholar
  33. 33.
    Boren, T., Falk, P., Roth, K. A., Larson, G., & Normark, S. (1993). Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science, 262(5141), 1892–1895.PubMedGoogle Scholar
  34. 34.
    Bravos, E. D., & Gilman, R. H. (2000). Accurate diagnosis of Helicobacter pylori. Other tests. Gastroenterol Clin North Am, 29(4), 925–929, xii.PubMedGoogle Scholar
  35. 35.
    Brown, K. E., & Peura, D. A. (1993). Diagnosis of Helicobacter pylori infection. Gastroenterol Clin North Am, 22(1), 105–115.PubMedGoogle Scholar
  36. 36.
    Brown, L. M. (2000). Helicobacter pylori: epidemiology and routes of transmission. Epidemiologic Reviews, 22(2), 283–297.PubMedGoogle Scholar
  37. 37.
    Brown, L. M., & Devesa, S. S. (2002). Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am, 11(2), 235–256.PubMedGoogle Scholar
  38. 38.
    Chey, W. D. (2000). Accurate diagnosis of Helicobacter pylori. 14C-urea breath test. Gastroenterol Clin North Am, 29(4), 895–902.PubMedGoogle Scholar
  39. 39.
    Chey, W. D., Metz, D. C., Shaw, S., Kearney, D., Montague, J., & Murthy, U. (2000). Appropriate timing of the 14C-urea breath test to establish eradication of Helicobacter pylori infection. Am J Gastroenterol, 95(5), 1171–1174.PubMedGoogle Scholar
  40. 40.
    Chong, J., Marshall, B. J., Barkin, J. S., McCallum, R. W., Reiner, D. K., Hoffman, S. R., et al. (1994). Occupational exposure to Helicobacter pylori for the endoscopy professional: a sera epidemiological study. Am J Gastroenterol, 89(11), 1987–1992.PubMedGoogle Scholar
  41. 41.
    Collett, J. A., et al. (1999). Seroprevalence of Helicobacter pylori in the adult population of Christchurch: risk factors and relationship to dyspeptic symptoms and iron studies. NZ Med J, 112(1093), 292–295.Google Scholar
  42. 42.
    Conference, N. C. (1994). NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA, 272(1), 65–69.Google Scholar
  43. 43.
    Cover, T. L., & Blanke, S. R. (2005). Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol, 3(4), 320–332.PubMedGoogle Scholar
  44. 44.
    Cover, T. L., Cao, P., Murthy, U. K., Sipple, M. S., & Blaser, M. J. (1992). Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori. J Clin Invest, 90(3), 913–918.PubMedGoogle Scholar
  45. 45.
    Cover, T. L., Dooley, C. P., & Blaser, M. J. (1990). Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun, 58(3), 603–610.PubMedGoogle Scholar
  46. 46.
    Cover, T. L., Glupczynski, Y., Lage, A. P., Burette, A., Tummuru, M. K., Perez-Perez, G. I., et al. (1995). Serologic detection of infection with cagA+ Helicobacter pylori strains. J Clin Microbiol, 33(6), 1496–1500.PubMedGoogle Scholar
  47. 47.
    Cullen, D. J., et al. (1993). When is Helicobacter pylori infection acquired? Gut, 34(12), 1681–1682.Google Scholar
  48. 48.
    Cutler, A., Schubert, A., & Schubert, T. (1993). Role of Helicobacter pylori serology in evaluating treatment success. Dig Dis Sci, 38(12), 2262–2266.PubMedGoogle Scholar
  49. 49.
    Cutler, A. F., & Schubert, T. T. (1993). Patient factors affecting Helicobacter pylori eradication with triple therapy. Am J Gastroenterol, 88(4), 505–509.PubMedGoogle Scholar
  50. 50.
    Czinn, S. J., Carr, H. S., & Speck, W. T. (1991). Diagnosis of gastritis caused by Helicobacter pylori in children by means of an ELISA. Rev Infect Dis, 13 Suppl 8, S700–703.PubMedGoogle Scholar
  51. 51.
    Davies, G. R., Simmonds, N. J., Stevens, T. R., Sheaff, M. T., Banatvala, N., Laurenson, I. F., et al. (1994). Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut, 35(2), 179–185.PubMedGoogle Scholar
  52. 52.
    De Arruda, S. M., Passaro, D. J., & Parsonnet, J. (2001). Variability of serologic testing for H. pylori using U.S. and Peruvian antigens. Gastroenterology, 120(1), 325–326.PubMedGoogle Scholar
  53. 53.
    de Martel, C., Llosa, A. E., Farr, S. M., Friedman, G. D., Vogelman, J. H., Orentreich, N., et al. (2005). Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma. J Infect Dis, 191(5), 761–767.PubMedGoogle Scholar
  54. 54.
    de Martel, C., & Parsonnet, J. (2006). Helicobacter pylori infection and gender: a meta-analysis of population-based prevalence surveys. Digestive Diseases & Sciences, In press.Google Scholar
  55. 55.
    de Oliveira, A. M., Rocha, G. A., Queiroz, D. M., Mendes, E. N., de Carvalho, A. S., Ferrari, T. C., et al. (1999). Evaluation of enzyme-linked immunosorbent assay for the diagnosis of Helicobacter pylori infection in children from different age groups with and without duodenal ulcer. J Pediatr Gastroenterol Nutr, 28(2), 157–161.PubMedGoogle Scholar
  56. 56.
    Delaney, B., & McColl, K. (2005). Review article: Helicobacter pylori and gastro-oesophageal reflux disease. Aliment Pharmacol Ther, 22 Suppl 1, 32–40.PubMedGoogle Scholar
  57. 57.
    Doenges, J. L. (1938). Spirochaetes in gastric glands of macacus rhesus and humans without defined history of related disease. Proc Soc Exp Biol Med, 38, 536.Google Scholar
  58. 58.
    Doglioni, C., Wotherspoon, A. C., Moschini, A., de Boni, M., & Isaacson, P. G. (1992). High incidence of primary gastric lymphoma in northeastern Italy. Lancet, 339(8797), 834–835.PubMedGoogle Scholar
  59. 59.
    Dominici, P., Bellentani, S., Di Biase, A. R., Saccoccio, G., Le Rose, A., Masutti, F., et al. (1999). Familial clustering of Helicobacter pylori infection: population based study. Bmj, 319(7209), 537–540.PubMedGoogle Scholar
  60. 60.
    Drumm, B., Perez-Perez, G. I., Blaser, M. J., & Sherman, P. M. (1990). Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med, 322(6), 359–363.PubMedGoogle Scholar
  61. 61.
    Dubois, A., Berg, D. E., Incecik, E. T., Fiala, N., Heman-Ackah, L. M., Perez-Perez, G. I., et al. (1996). Transient and persistent experimental infection of nonhuman primates with Helicobacter pylori: implications for human disease. Infect Immun, 64(8), 2885–2891.PubMedGoogle Scholar
  62. 62.
    Dwyer, B., Kaldor, J., Tee, W., Marakowski, E., & Raios, K. (1988). Antibody response to Campylobacter pylori in diverse ethnic groups. Scand J Infect Dis, 20(3), 349–350.PubMedGoogle Scholar
  63. 63.
    Eaton, K. A., Brooks, C. L., Morgan, D. R., & Krakowka, S. (1991). Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun, 59(7), 2470–2475.PubMedGoogle Scholar
  64. 64.
    Eaton, K. A., Catrenich, C. E., Makin, K. M., & Krakowka, S. (1995). Virulence of coccoid and bacillary forms of Helicobacter pylori in gnotobiotic piglets. J Infect Dis, 171(2), 459–462.PubMedGoogle Scholar
  65. 65.
    Eaton, K. A., Suerbaum, S., Josenhans, C., & Krakowka, S. (1996). Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes. Infect Immun, 64(7), 2445–2448.PubMedGoogle Scholar
  66. 66.
    EUROGAST. (1993). An international association between Helicobacter pylori infection and gastric cancer. The EUROGAST Study Group. Lancet, 341(8857), 1359–1362.Google Scholar
  67. 67.
    Evans, D. J., Jr., et al. (1989). A sensitive and specific serologic test for detection of Campylobacter pylori infection. Gastroenterology, 96(4), 1004–1008.Google Scholar
  68. 68.
    Everhart, J. E., Kruszon-Moran, D., Perez-Perez, G. I., Tralka, T. S., & McQuillan, G. (2000). Seroprevalence and ethnic differences in Helicobacter pylori infection among adults in the United States. J Infect Dis, 181(4), 1359–1363.PubMedGoogle Scholar
  69. 69.
    Faigel, D. O., et al. (2000). Evaluation of rapid antibody tests for the diagnosis of Helicobacter pylori infection. Am J Gastroenterol, 95(1), 72–77.Google Scholar
  70. 70.
    Falush, D., Wirth, T., Linz, B., Pritchard, J. K., Stephens, M., Kidd, M., et al. (2003). Traces of human migrations in Helicobacter pylori populations. Science, 299(5612), 1582–1585.PubMedGoogle Scholar
  71. 71.
    Fantry, G. T., Zheng, Q. X., & James, S. P. (1995). Conventional cleaning and disinfection techniques eliminate the risk of endoscopic transmission of Helicobacter pylori. Am J Gastroenterol, 90(2), 227–232.PubMedGoogle Scholar
  72. 72.
    Farrell, S., Doherty, G. M., Milliken, I., Shield, M. D., & McCallion, W. A. (2005). Risk factors for Helicobacter pylori infection in children: an examination of the role played by intrafamilial bed sharing. Pediatr Infect Dis J, 24(2), 149–152.PubMedGoogle Scholar
  73. 73.
    Feldman, R. A., Deeks, J. J., & Evans, S. J. (1995). Multi-laboratory comparison of eight commercially available Helicobacter pylori serology kits. Helicobacter pylori Serology Study Group. Eur J Clin Microbiol Infect Dis, 14(5), 428–433.PubMedGoogle Scholar
  74. 74.
    Ferguson, D. A., Jr., Li, C., Patel, N. R., Mayberry, W. R., Chi, D. S., & Thomas, E. (1993). Isolation of Helicobacter pylori from saliva. J Clin Microbiol, 31(10), 2802–2804.PubMedGoogle Scholar
  75. 75.
    Ferlay, J., Bray, F., Pisani, P., & Parkin, D. M. (2004). GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide (Publication. Retrieved 1/16/2005, from IARC Press:Google Scholar
  76. 76.
    Fiedorek, S. C., Malaty, H. M., Evans, D. L., Pumphrey, C. L., Casteel, H. B., Evans, D. J., Jr., et al. (1991). Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics, 88(3), 578–582.PubMedGoogle Scholar
  77. 77.
    Figura, N. (1996). Mouth-to-mouth resuscitation and Helicobacter pylori infection. Lancet, 347(9011), 1342.PubMedGoogle Scholar
  78. 78.
    Fitzgerald, O., & Murphy, P. (1950). Studies of the physiological chemistry and clinical significance of urease and urea with special reference to the human stomach. Ir J Med Sci, 292, 97.Google Scholar
  79. 79.
    Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T., & Moayyedi, P. (2005). A community screening program for Helicobacter pylori saves money: 10-year follow-up of a randomized controlled trial. Gastroenterology, 129(6), 1910–1917.PubMedGoogle Scholar
  80. 80.
    Ford, A. C., Qume, M., Moayyedi, P., Arents, N. L., Lassen, A. T., Logan, R. F., et al. (2005). Helicobacter pylori “test and treat" or endoscopy for managing dyspepsia: an individual patient data meta-analysis. Gastroenterology, 128(7), 1838–1844.PubMedGoogle Scholar
  81. 81.
    Forman, D., Sitas, F., Newell, D. G., Stacey, A. R., Boreham, J., Peto, R., et al. (1990). Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer, 46(4), 608–611.PubMedGoogle Scholar
  82. 82.
    Fox, J. G. (1995). Non-human reservoirs of Helicobacter pylori. Alimentary Pharmacology & Therapeutics, 9 Suppl 2, 93–103.Google Scholar
  83. 83.
    Fox, J. G. (2002). The non-H pylori helicobacters: their expanding role in gastrointestinal and systemic diseases. Gut, 50(2), 273–283.PubMedGoogle Scholar
  84. 84.
    Fraser, A. G., Scragg, R., Metcalf, P., McCullough, S., & Yeates, N. J. (1996). Prevalence of Helicobacter pylori infection in different ethnic groups in New Zealand children and adults. Aust N Z J Med, 26(5), 646–651.PubMedGoogle Scholar
  85. 85.
    Freedberg, A. S., & Barron, L. E. (1940). The presence of spirochaetes in human gastric mucosa. Am J Dig Dis, 38, 443.Google Scholar
  86. 86.
    Friis, L., Engstrand, L., & Edling, C. (1996). Prevalence of Helicobacter pylori infection among sewage workers. Scand J Work Environ Health, 22(5), 364–368.PubMedGoogle Scholar
  87. 87.
    Fung, W. P., Papadimitriou, J. M., & Matz, L. R. (1979). Endoscopic, histological and ultrastructural correlations in chronic gastritis. Am J Gastroenterol, 71(3), 269–279.PubMedGoogle Scholar
  88. 88.
    Ganga-Zandzou, P. S., Michaud, L., Vincent, P., Husson, M. O., Wizla-Derambure, N., Delassalle, E. M., et al. (1999). Natural outcome of Helicobacter pylori infection in asymptomatic children: a two-year follow-up study. Pediatrics, 104(2 Pt 1), 216–221.PubMedGoogle Scholar
  89. 89.
    Garg, P. K., Perry, S., Sanchez, L., & Parsonnet, J. (2006). Concordance of Helicobacter pylori infection among children in extended-family homes. Epidemiol Infect, 134(3), 450–459.PubMedGoogle Scholar
  90. 90.
    Garner, R. M., Fulkerson, J., Jr., & Mobley, H. L. (1998). Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulation. Infect Immun, 66(5), 1839–1847.PubMedGoogle Scholar
  91. 91.
    Gebert, B., Fischer, W., & Haas, R. (2004). The Helicobacter pylori vacuolating cytotoxin: from cellular vacuolation to immunosuppressive activities. Rev Physiol Biochem Pharmacol, 152, 205–220.PubMedGoogle Scholar
  92. 92.
    Genta, R. M., & Graham, D. Y. (1993). Intestinal metaplasia, not atrophy or achlorhydria, creates a hostile environment for Helicobacter pylori. Scand J Gastroenterol, 28(10), 924–928.PubMedGoogle Scholar
  93. 93.
    Genta, R. M., Hamner, H. W., & Graham, D. Y. (1993). Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum Pathol, 24(6), 577–583.PubMedGoogle Scholar
  94. 94.
    Gisbert, J. P., de la Morena, F., & Abraira, V. (2006). Accuracy of Monoclonal Stool Antigen Test for the Diagnosis of H. pylori Infection: A Systematic Review and Meta-Analysis. Am J Gastroenterol.Google Scholar
  95. 95.
    Gisbert, J. P., & Pajares, J. M. (2004a). Review article: C-urea breath test in the diagnosis of Helicobacter pylori infection — a critical review. Aliment Pharmacol Ther, 20(10), 1001–1017.PubMedGoogle Scholar
  96. 96.
    Gisbert, J. P., & Pajares, J. M. (2004b). Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. Helicobacter, 9(4), 347–368.PubMedGoogle Scholar
  97. 97.
    Gisbert, J. P., Trapero, M., & Pajares, J. M. (2005). Evaluation of 3 different tests for the detection of stool antigens to confirm Helicobacter pylori eradication after treatment. A pilot study. Gastroenterol Hepatol, 28(10), 615–618.PubMedGoogle Scholar
  98. 98.
    Gledhill, T., Leicester, R. J., Addis, B., Lightfoot, N., Barnard, J., Viney, N., et al. (1985). Epidemic hypochlorhydria. Br Med J (Clin Res Ed), 290(6479), 1383–1386.Google Scholar
  99. 99.
    Glupczynski, Y., Bourdeaux, L., Verhas, M., DePrez, C., DeVos, D., & Devreker, T. (1992). Use of a urea breath test versus invasive methods to determine the prevalence of Helicobacter pylori in Zaire. Eur J Clin Microbiol Infect Dis, 11(4), 322–327.PubMedGoogle Scholar
  100. 100.
    Glynn, M. K., Friedman, C. R., Gold, B. D., Khanna, B., Hutwagner, L., Iihoshi, N., et al. (2002). Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: acquisition and analysis of possible risk factors. Clin Infect Dis, 35(9), 1059–1065.PubMedGoogle Scholar
  101. 101.
    Gobert, A. P., Mersey, B. D., Cheng, Y., Blumberg, D. R., Newton, J. C., & Wilson, K. T. (2002). Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. J Immunol, 168(12), 6002–6006.PubMedGoogle Scholar
  102. 102.
    Goh, K. L., & Parasakthi, N. (2001). The racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial South-East Asian country. Eur J Gastroenterol Hepatol, 13(2), 177–183.PubMedGoogle Scholar
  103. 103.
    Goodman, K. J., & Correa, P. (2000). Transmission of Helicobacter pylori among siblings. Lancet, 355(9201), 358–362.PubMedGoogle Scholar
  104. 104.
    Goodman, K. J., O’Rourke, K., Day, R. S., Wang, C., Nurgalieva, Z., Phillips, C. V., et al. (2005). Dynamics of Helicobacter pylori infection in a US-Mexico cohort during the first two years of life. Int J Epidemiol, 34(6), 1348–1355.PubMedGoogle Scholar
  105. 105.
    Goodwin, C. S. (1988). Duodenal ulcer, Campylobacter pylori, and the “leaking roof" concept. Lancet, 2(8626–8627), 1467–1469.PubMedGoogle Scholar
  106. 106.
    Graham, D. Y., Alpert, L. C., Smith, J. L., & Yoshimura, H. H. (1988). Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol, 83(9), 974–980.PubMedGoogle Scholar
  107. 107.
    Graham, D. Y., and Klein, P. D. (2000). Accurate diagnosis of Helicobacter pylori. 13C-urea breath test. Gastroenterol Clin North Am, 29(4), 885–893, x.Google Scholar
  108. 108.
    Graham, D. Y., Lew, G. M., Klein, P. D., Evans, D. G., Evans, D. J., Jr., Saeed, Z. A., et al. (1992). Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized, controlled study. Ann Intern Med, 116(9), 705–708.PubMedGoogle Scholar
  109. 109.
    Graham, D. Y., Malaty, H. M., Evans, D. G., Evans, D. J., Jr., Klein, P. D., & Adam, E. (1991). Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology, 100(6), 1495–1501.PubMedGoogle Scholar
  110. 110.
    Graham, D. Y., Opekun, A. R., Jogi, M., Yamaoka, Y., Lu, H., Reddy, R., et al. (2004). False negative urea breath tests with H2-receptor antagonists: interactions between Helicobacter pylori density and pH. Helicobacter, 9(1), 17–27.PubMedGoogle Scholar
  111. 111.
    Graham, D. Y., Opekun, A. R., Osato, M. S., El-Zimaity, H. M., Lee, C. K., Yamaoka, Y., et al. (2004). Challenge model for Helicobacter pylori infection in human volunteers. Gut, 53(9), 1235–1243.PubMedGoogle Scholar
  112. 112.
    Graham, D. Y., & Uemura, N. (2006). Natural history of gastric cancer after Helicobacter pylori eradication in Japan: after endoscopic resection, after treatment of the general population, and naturally. Helicobacter, 11(3), 139–143.PubMedGoogle Scholar
  113. 113.
    Granstrom, M., Tindberg, Y., & Blennow, M. (1997). Seroepidemiology of Helicobacter pylori infection in a cohort of children monitored from 6 months to 11 years of age. J Clin Microbiol, 35(2), 468–470.PubMedGoogle Scholar
  114. 114.
    Greiner, A., Marx, A., Heesemann, J., Leebmann, J., Schmausser, B., & Muller-Hermelink, H. K. (1994). Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis. Lab Invest, 70(4), 572–578.PubMedGoogle Scholar
  115. 115.
    Gressmann, H., Linz, B., Ghai, R., Pleissner, K. P., Schlapbach, R., Yamaoka, Y., et al. (2005). Gain and loss of multiple genes during the evolution of Helicobacter pylori. PLoS Genet, 1(4), e43.PubMedGoogle Scholar
  116. 116.
    Grubel, P., Hoffman, J. S., Chong, F. K., Burstein, N. A., Mepani, C., & Cave, D. R. (1997). Vector potential of houseflies (Musca domestica) for Helicobacter pylori. J Clin Microbiol, 35(6), 1300–1303.PubMedGoogle Scholar
  117. 117.
    Ha, N. C., Oh, S. T., Sung, J. Y., Cha, K. A., Lee, M. H., & Oh, B. H. (2001). Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Biol, 8(6), 505–509.PubMedGoogle Scholar
  118. 118.
    Haggerty, T. D., Perry, S., Sanchez, L., Perez-Perez, G., & Parsonnet, J. (2005). Significance of transiently positive enzyme-linked immunosorbent assay results in detection of Helicobacter pylori in stool samples from children. J Clin Microbiol, 43(5), 2220–2223.PubMedGoogle Scholar
  119. 119.
    Hahn, M., Fennerty, M. B., Corless, C. L., Magaret, N., Lieberman, D. A., & Faigel, D. O. (2000). Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection. Gastrointest Endosc, 52(1), 20–26.PubMedGoogle Scholar
  120. 120.
    Han, S. R., Zschausch, H. C., Meyer, H. G., Schneider, T., Loos, M., Bhakdi, S., et al. (2000). Helicobacter pylori: clonal population structure and restricted transmission within families revealed by molecular typing. J Clin Microbiol, 38(10), 3646–3651.PubMedGoogle Scholar
  121. 121.
    Handt, L. K., Fox, J. G., Dewhirst, F. E., Fraser, G. J., Paster, B. J., Yan, L. L., et al. (1994). Helicobacter pylori isolated from the domestic cat: public health implications. Infect Immun, 62(6), 2367–2374.PubMedGoogle Scholar
  122. 122.
    Harris, P., Perez-Perez, G., Zylberberg, A., Rollan, A., Serrano, C., Riera, F., et al. (2005). Relevance of adjusted cut-off values in commercial serological immunoassays for Helicobacter pylori infection in children. Dig Dis Sci, 50(11), 2103–2109.PubMedGoogle Scholar
  123. 123.
    Hazell, S. L., Goodwin, C. S., & Worsley, B. W. (1993). Cultural techniques for the growth and isolation of Helicobacter pylori In Helicobacter pylori: biology and clinical practice (pp. 273). Boca Raton: CRC Press.Google Scholar
  124. 124.
    Hennig, E. E., Allen, J. M., & Cover, T. L. (2006). Multiple chromosomal loci for the babA gene in Helicobacter pylori. Infect Immun, 74(5), 3046–3051.PubMedGoogle Scholar
  125. 125.
    Henrik Siman, J., Forsgren, A., Berglund, G., & Floren, C. H. (2001). Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms. Helicobacter, 6(4), 310–316.PubMedGoogle Scholar
  126. 126.
    Hentschel, E., Brandstatter, G., Dragosics, B., Hirschl, A. M., Nemec, H., Schutze, K., et al. (1993). Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. N Engl J Med, 328(5), 308–312.PubMedGoogle Scholar
  127. 127.
    Holtmann, G., Goebell, H., Holtmann, M., & Talley, N. J. (1994). Dyspepsia in healthy blood donors. Pattern of symptoms and association with Helicobacter pylori. Dig Dis Sci, 39(5), 1090–1098.PubMedGoogle Scholar
  128. 128.
    Hooton, C., Keohane, J., Clair, J., Azam, M., O’Mahony, S., Crosbie, O., et al. (2006). Comparison of three stool antigen assays with the 13C- urea breath test for the primary diagnosis of Helicobacter pylori infection and monitoring treatment outcome. Eur J Gastroenterol Hepatol, 18(6), 595–599.PubMedGoogle Scholar
  129. 129.
    Hopkins, R. J., Russell, R. G., O’Donnoghue, J. M., Wasserman, S. S., Lefkowitz, A., & Morris, J. G., Jr. (1990). Seroprevalence of Helicobacter pylori in Seventh-Day Adventists and other groups in Maryland. Lack of association with diet. Arch Intern Med, 150(11), 2347–2348.PubMedGoogle Scholar
  130. 130.
    Hopkins, R. J., Vial, P. A., Ferreccio, C., Ovalle, J., Prado, P., Sotomayor, V., et al. (1993). Seroprevalence of Helicobacter pylori in Chile: vegetables may serve as one route of transmission. J Infect Dis, 168(1), 222–226.PubMedGoogle Scholar
  131. 131.
    Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., et al. (2004). Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568–1571.PubMedGoogle Scholar
  132. 132.
    Hulten, K., Enroth, H., Nystrom, T., & Engstrand, L. (1998). Presence of Helicobacter species DNA in Swedish water. J Appl Microbiol, 85(2), 282–286.PubMedGoogle Scholar
  133. 133.
    Hurtado, A., Chahal, B., Owen, R. J., & Smith, A. W. (1994). Genetic diversity of the Helicobacter pylori haemagglutinin/protease (hap) gene. FEMS Microbiol Lett, 123(1–2), 173–178.PubMedGoogle Scholar
  134. 134.
    Hwang, S. W., Wong, S. Y., & Bargh, G. J. (2006). Dyspepsia in homeless adults. J Clin Gastroenterol, 40(5), 416–420.PubMedGoogle Scholar
  135. 135.
    IARC. (1994). Helicobacter pylori Paper presented at the Schistosomes, Liver Flukes and Helicobacter pylori: views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Lyon.Google Scholar
  136. 136.
    Isaacson, P. G. (1992). Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol, 76, 14–23.PubMedGoogle Scholar
  137. 137.
    Isaacson, P. G., & Du, M. Q. (2005). Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol, 205(2), 255–274.PubMedGoogle Scholar
  138. 138.
    Isenbarger, D. W., Bodhidatta, L., Hoge, C. W., Nirdnoy, W., Pitarangsi, C., Umpawasiri, U., et al. (1998). Prospective study of the incidence of diarrheal disease and Helicobacter pylori infection among children in an orphanage in Thailand. Am J Trop Med Hyg, 59(5), 796–800.PubMedGoogle Scholar
  139. 139.
    Israel, D. A., Salama, N., Krishna, U., Rieger, U. M., Atherton, J. C., Falkow, S., et al. (2001). Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A, 98(25), 14625–14630.PubMedGoogle Scholar
  140. 140.
    Jeggli, S., Steiner, D., Joller, H., Tschopp, A., Steffen, R., & Hotz, P. (2004). Hepatitis E, Helicobacter pylori, and gastrointestinal symptoms in workers exposed to waste water. Occup Environ Med, 61(7), 622–627.PubMedGoogle Scholar
  141. 141.
    Jennings, D. (1940). Perforated peptic ulcer: Changes in age-incidence and sex-distribution in the last 150 years (Part I). Lancet, i, 395.Google Scholar
  142. 142.
    Karita, M., Teramukai, S., & Matsumoto, S. (2003). Risk of Helicobacter pylori transmission from drinking well water is higher than that from infected intrafamilial members in Japan. Dig Dis Sci, 48(6), 1062–1067.PubMedGoogle Scholar
  143. 143.
    Kato, S., Furuyama, N., Ozawa, K., Ohnuma, K., & Iinuma, K. (1999). Long-term follow-up study of serum immunoglobulin G and immunoglobulin A antibodies after Helicobacter pylori eradication. Pediatrics, 104(2), e22.PubMedGoogle Scholar
  144. 144.
    Katoh, M., Saito, D., Noda, T., Yoshida, S., Oguro, Y., Yazaki, Y., et al. (1993). Helicobacter pylori may be transmitted through gastrofiberscope even after manual Hyamine washing. Jpn J Cancer Res, 84(2), 117–119.PubMedGoogle Scholar
  145. 145.
    Kawasaki, M., Kawasaki, T., Ogaki, T., Itoh, K., Kobayashi, S., Yoshimizu, Y., et al. (1998). Seroprevalence of Helicobacter pylori infection in Nepal: low prevalence in an isolated rural village. Eur J Gastroenterol Hepatol, 10(1), 47–50.PubMedGoogle Scholar
  146. 146.
    Kelly, S. M., Pitcher, M. C., Farmery, S. M., & Gibson, G. R. (1994). Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology, 107(6), 1671–1674.PubMedGoogle Scholar
  147. 147.
    Kersulyte, D., Mukhopadhyay, A. K., Velapatino, B., Su, W., Pan, Z., Garcia, C., et al. (2000). Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol, 182(11), 3210–3218.PubMedGoogle Scholar
  148. 148.
    Khanna, B. (1998). Use caution with serologic testing for helicobacter pylori infection in children. Journal of Infectious Disease, 178, 460.Google Scholar
  149. 149.
    Kimura, A., Matsubasa, T., Kinoshita, H., Kuriya, N., Yamashita, Y., Fujisawa, T., et al. (1999). Helicobacter pylori seropositivity in patients with severe neurologic impairment. Brain Dev, 21(2), 113–117.PubMedGoogle Scholar
  150. 150.
    Kivi, M., Johansson, A. L., Reilly, M., & Tindberg, Y. (2005). Helicobacter pylori status in family members as risk factors for infection in children. Epidemiol Infect, 133(4), 645–652.PubMedGoogle Scholar
  151. 151.
    Kivi, M., & Tindberg, Y. (2006). Helicobacter pylori occurrence and transmission: A family affair? Scand J Infect Dis, 38(6), 407–417.PubMedGoogle Scholar
  152. 152.
    Kivi, M., Tindberg, Y., Sorberg, M., Casswall, T. H., Befrits, R., Hellstrom, P. M., et al. (2003). Concordance of Helicobacter pylori strains within families. J Clin Microbiol, 41(12), 5604–5608.PubMedGoogle Scholar
  153. 153.
    Klein, P. D., Gilman, R. H., Leon-Barua, R., Diaz, F., Smith, E. O., & Graham, D. Y. (1994). The epidemiology of Helicobacter pylori in Peruvian children between 6 and 30 months of age. Am J Gastroenterol, 89(12), 2196–2200.PubMedGoogle Scholar
  154. 154.
    Klein, P. D., Graham, D. Y., Gaillour, A., Opekun, A. R., & Smith, E. O. (1991). Water source as risk factor for Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group. Lancet, 337(8756), 1503–1506.PubMedGoogle Scholar
  155. 155.
    Klein, P. D., Malaty, H. M., Czinn, S. J., Emmons, S. C., Martin, R. F., & Graham, D. Y. (1999). Normalizing results of 13C-urea breath testing for CO2 production rates in children. J Pediatr Gastroenterol Nutr, 29(3), 297–301.PubMedGoogle Scholar
  156. 156.
    Klein, P. D., Malaty, H. M., Martin, R. F., Graham, K. S., Genta, R. M., & Graham, D. Y. (1996). Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. Am J Gastroenterol, 91(4), 690–694.PubMedGoogle Scholar
  157. 157.
    Kobayashi, T., Kikuchi, S., Lin, Y., Yagyu, K., Obata, Y., Ogihara, A., et al. (2004). Trends in the incidence of gastric cancer in Japan and their associations with Helicobacter pylori infection and gastric mucosal atrophy. Gastric Cancer, 7(4), 233–239.PubMedGoogle Scholar
  158. 158.
    Kokkola, A., Kosunen, T. U., Puolakkainen, P., Sipponen, P., Harkonen, M., Laxen, F., et al. (2003). Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis. Apmis, 111(6), 619–624.PubMedGoogle Scholar
  159. 159.
    Konno, M., Fujii, N., Yokota, S., Sato, K., Takahashi, M., Sato, K., et al. (2005). Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method. J Clin Microbiol, 43(5), 2246–2250.PubMedGoogle Scholar
  160. 160.
    Kosunen, T. U., Aromaa, A., Knekt, P., Salomaa, A., Rautelin, H., Lohi, P., et al. (1997). Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland. Epidemiol Infect, 119(1), 29–34.PubMedGoogle Scholar
  161. 161.
    Kosunen, T. U., Seppala, K., Sarna, S., & Sipponen, P. (1992). Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori. Lancet, 339(8798), 893–895.PubMedGoogle Scholar
  162. 162.
    Krajden, S., Fuksa, M., Anderson, J., Kempston, J., Boccia, A., Petrea, C., et al. (1989). Examination of human stomach biopsies, saliva, and dental plaque for Campylobacter pylori. J Clin Microbiol, 27(6), 1397–1398.PubMedGoogle Scholar
  163. 163.
    Kreinitz, W. (1906). Ueber das Auftreten von Spirochaeten verschiedener Form im Mageninhalt bei Carcinoma ventriculi. Deutsche Medizinische Wochenschrift, 32, 872.Google Scholar
  164. 164.
    Kuipers, E. J., et al. (1993). Seroconversion for Helicobacter pylori. Lancet, 342(8867), 328–331.Google Scholar
  165. 165.
    Kumagai, T., Malaty, H. M., Graham, D. Y., Hosogaya, S., Misawa, K., Furihata, K., et al. (1998). Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study. J Infect Dis, 178(3), 717–721.PubMedGoogle Scholar
  166. 166.
    Kurata, J. H., Elashoff, J. D., Haile, B. M., & Honda, G. D. (1983). A reappraisal of time trends in ulcer disease: factors related to changes in ulcer hospitalization and mortality rates. Am J Public Health, 73(9), 1066–1072.PubMedGoogle Scholar
  167. 167.
    Laine, L., Lewin, D., Naritoku, W., Estrada, R., & Cohen, H. (1996). Prospective comparison of commercially available rapid urease tests for the diagnosis of Helicobacter pylori. Gastrointest Endosc, 44(5), 523–526.PubMedGoogle Scholar
  168. 168.
    Lambert, J. R. (1993). The role of Helicobacter pylori in nonulcer dyspepsia. A debate—for. Gastroenterol Clin North Am, 22(1), 141–151.PubMedGoogle Scholar
  169. 169.
    Lambert, J. R., Lin, S. K., Sievert, W., Nicholson, L., Schembri, M., & Guest, C. (1995). High prevalence of Helicobacter pylori antibodies in an institutionalized population: evidence for person-to-person transmission. Am J Gastroenterol, 90(12), 2167–2171.PubMedGoogle Scholar
  170. 170.
    Lane, J. A., Murray, L. J., Noble, S., Egger, M., Harvey, I. M., Donovan, J. L., et al. (2006). Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial. Bmj, 332(7535), 199–204.PubMedGoogle Scholar
  171. 171.
    Langenberg, W., Rauws, E. A., Houthoff, H. J., Oudbier, J. H., van Bohemen, C. G., Tytgat, G. N., et al. (1988). Follow-up study of individuals with untreated Campylobacter pylori-associated gastritis and of noninfected persons with non-ulcer dyspepsia. J Infect Dis, 157(6), 1245–1249.PubMedGoogle Scholar
  172. 172.
    Langenberg, W., Rauws, E. A., Oudbier, J. H., & Tytgat, G. N. (1990). Patient-to-patient transmission of Campylobacter pylori infection by fiberoptic gastroduodenoscopy and biopsy. J Infect Dis, 161(3), 507–511.PubMedGoogle Scholar
  173. 173.
    Langenberg, W., Rauws, E. A., Widjojokusumo, A., Tytgat, G. N., & Zanen, H. C. (1986). Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J Clin Microbiol, 24(3), 414–417.PubMedGoogle Scholar
  174. 174.
    Laporte, R., Pernes, P., Pronnier, P., Gottrand, F., & Vincent, P. (2004). Acquisition of Helicobacter pylori infection after outbreaks of gastroenteritis: prospective cohort survey in institutionalised young people. Bmj, 329(7459), 204–205.PubMedGoogle Scholar
  175. 175.
    Lee, N., Lee, T. T., & Fang, K. M. (1994). Assessment of four rapid urease test systems for detection of Helicobacter pylori in gastric biopsy specimens. Diagn Microbiol Infect Dis, 18(2), 69–74.PubMedGoogle Scholar
  176. 176.
    Leong, R. W., Lee, C. C., Ling, T. K., Leung, W. K., & Sung, J. J. (2003). Evaluation of the string test for the detection of Helicobacter pylori. World J Gastroenterol, 9(2), 309–311.PubMedGoogle Scholar
  177. 177.
    Leung, W. K., Siu, K. L., Kwok, C. K., Chan, S. Y., Sung, R., & Sung, J. J. (1999). Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission. Am J Gastroenterol, 94(10), 2881–2884.PubMedGoogle Scholar
  178. 178.
    Lieber, C. S., & Lefevre, A. (1959). Ammonia as a source of gastric hypoacidity in patients with uremia. J Clin Invest, 38(8), 1271–1277.PubMedGoogle Scholar
  179. 179.
    Lin, S. K., Lambert, J. R., Schembri, M. A., Nicholson, L., & Korman, M. G. (1994). Helicobacter pylori prevalence in endoscopy and medical staff. Journal of Gastroenterology & Hepatology, 9(4), 319–324.Google Scholar
  180. 180.
    Lindkvist, P., et al. (1999). Helicobacter pylori infection in Ethiopian children: a cohort study. Scand J Infect Dis, 31(5), 475–480.Google Scholar
  181. 181.
    Lingwood, C. A., Wasfy, G., Han, H., & Huesca, M. (1993). Receptor affinity purification of a lipid-binding adhesin from Helicobacter pylori. Infect Immun, 61(6), 2474–2478.PubMedGoogle Scholar
  182. 182.
    Loy, C. T., Irwig, L. M., Katelaris, P. H., & Talley, N. J. (1996). Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis. Am J Gastroenterol, 91(6), 1138–1144.PubMedGoogle Scholar
  183. 183.
    Lu, Y., Redlinger, T. E., Avitia, R., Galindo, A., & Goodman, K. (2002). Isolation and genotyping of Helicobacter pylori from untreated municipal wastewater. Appl Environ Microbiol, 68(3), 1436–1439.PubMedGoogle Scholar
  184. 184.
    Luman, W., Zhao, Y., Ng, H. S., & Ling, K. L. (2002). Helicobacter pylori infection is unlikely to be transmitted between partners: evidence from genotypic study in partners of infected patients. Eur J Gastroenterol Hepatol, 14(5), 521–528.PubMedGoogle Scholar
  185. 185.
    Luzza, F., Mancuso, M., Imeneo, M., Contaldo, A., Giancotti, L., Pensabene, L., et al. (2000). Evidence favouring the gastro-oral route in the transmission of Helicobacter pylori infection in children. Eur J Gastroenterol Hepatol, 12(6), 623–627.PubMedGoogle Scholar
  186. 186.
    Lynch, D. A., Mapstone, N. P., Clarke, A. M., Sobala, G. M., Jackson, P., Morrison, L., et al. (1995). Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut, 36(3), 346–350.PubMedGoogle Scholar
  187. 187.
    Mahdavi, J., Sonden, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., et al. (2002). Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science, 297(5581), 573–578.PubMedGoogle Scholar
  188. 188.
    Malaty, H. M., El-Kasabany, A., Graham, D. Y., Miller, C. C., Reddy, S. G., Srinivasan, S. R., et al. (2002). Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet, 359(9310), 931–935.PubMedGoogle Scholar
  189. 189.
    Malaty, H. M., Engstrand, L., Pedersen, N. L., & Graham, D. Y. (1994). Helicobacter pylori infection: genetic and environmental influences. A study of twins. Ann Intern Med, 120(12), 982–986.PubMedGoogle Scholar
  190. 190.
    Malaty, H. M., Evans, D. J., Jr., Abramovitch, K., Evans, D. G., & Graham, D. Y. (1992). Helicobacter pylori infection in dental workers: a seroepidemiology study. Am J Gastroenterol, 87(12), 1728–1731.PubMedGoogle Scholar
  191. 191.
    Malaty, H. M., & Graham, D. Y. (1994). Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection. Gut, 35(6), 742–745.PubMedGoogle Scholar
  192. 192.
    Malaty, H. M., Graham, D. Y., Klein, P. D., Evans, D. G., Adam, E., & Evans, D. J. (1991). Transmission of Helicobacter pylori infection. Studies in families of healthy individuals. Scand J Gastroenterol, 26(9), 927–932.PubMedGoogle Scholar
  193. 193.
    Malaty, H. M., Kim, J. G., Kim, S. D., & Graham, D. Y. (1996). Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults. Am J Epidemiol, 143(3), 257–262.PubMedGoogle Scholar
  194. 194.
    Malaty, H. M., et al. (1999). Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. Clin Infect Diseases, 28(2), 279–282.Google Scholar
  195. 195.
    Malaty, H. M., Kumagai, T., Tanaka, E., Ota, H., Kiyosawa, K., Graham, D. Y., et al. (2000). Evidence from a nine-year birth cohort study in Japan of transmission pathways of Helicobacter pylori infection. J Clin Microbiol, 38(5), 1971–1973.PubMedGoogle Scholar
  196. 196.
    Malaty, H. M., Paykov, V., Bykova, O., Ross, A., Graham, D. P., Anneger, J. F., et al. (1996). Helicobacter pylori and socioeconomic factors in Russia. Helicobacter, 1(2), 82–87.PubMedGoogle Scholar
  197. 197.
    Malfertheiner, P., Megraud, F., O’Morain, C., Hungin, A. P., Jones, R., Axon, A., et al. (2002). Current concepts in the management of Helicobacter pylori infection—the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther, 16(2), 167–180.PubMedGoogle Scholar
  198. 198.
    Malfertheiner, P. Megraud, F., O’Morain, C. (2005). Guidelines for the management of Helicobacter pylori infection: Summary of the Maastricht-3 2005 Consensus Report. In Business Briefing: European Gastroenterology Review, 2005 (pp. 59–60). London: TouchBriefings.Google Scholar
  199. 199.
    Mapstone, N. P., Lynch, D. A., Lewis, F. A., Axon, A. T., Tompkins, D. S., Dixon, M. F., et al. (1993). Identification of Helicobacter pylori DNA in the mouths and stomachs of patients with gastritis using PCR. J Clin Pathol, 46(6), 540–543.PubMedGoogle Scholar
  200. 200.
    Marchetti, M., Arico, B., Burroni, D., Figura, N., Rappuoli, R., & Ghiara, P. (1995). Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science, 267(5204), 1655–1658.PubMedGoogle Scholar
  201. 201.
    Marcus, E. A., & Scott, D. R. (2001). Cell lysis is responsible for the appearance of extracellular urease in Helicobacter pylori. Helicobacter, 6(2), 93–99.PubMedGoogle Scholar
  202. 202.
    Marshall, B. J. (Ed.). (2002). Helicobacter pioneers: Firsthand accounts from the scientists who discovered helicobacters. Victoria: Blackwell.Google Scholar
  203. 203.
    Marshall, B. J., Armstrong, J. A., McGechie, D. B., & Glancy, R. J. (1985). Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Aust, 142(8), 436–439.PubMedGoogle Scholar
  204. 204.
    Marshall, B. J., Barrett, L. J., Prakash, C., McCallum, R. W., & Guerrant, R. L. (1990). Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastroenterology, 99(3), 697–702.PubMedGoogle Scholar
  205. 205.
    Marshall, B. J., & Blaser, M. J. (1989). History of the discovery of C. pylori InCampylobacter pylori in gastritis and peptic ulcer disease (pp. 7). New York: Igaku-Shoin.Google Scholar
  206. 206.
    Marshall, B. J., Warren, J. R., Francis, G. J., Langton, S. R., Goodwin, C. S., & Blincow, E. D. (1987). Rapid urease test in the management of Campylobacter pyloridis-associated gastritis. Am J Gastroenterol, 82(3), 200–210.PubMedGoogle Scholar
  207. 207.
    Matsuda, R., & Morizane, T. (2005). Helicobacter pylori infection in dental professionals: a 6-year prospective study. Helicobacter, 10(4), 307–311.PubMedGoogle Scholar
  208. 208.
    McNulty, C. A., Dent, J. C., Uff, J. S., Gear, M. W., & Wilkinson, S. P. (1989). Detection of Campylobacter pylori by the biopsy urease test: an assessment in 1445 patients. Gut, 30(8), 1058–1062.PubMedGoogle Scholar
  209. 209.
    Megraud, F. (2004). H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut, 53(9), 1374–1384.PubMedGoogle Scholar
  210. 210.
    Megraud, F., et al. (1989). Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol, 27(8), 1870–1873.Google Scholar
  211. 211.
    Mendall, M. A., Goggin, P. M., Molineaux, N., Levy, J., Toosy, T., Strachan, D., et al. (1992). Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet, 339(8798), 896–897.PubMedGoogle Scholar
  212. 212.
    Midolo, P., & Marshall, B. J. (2000). Accurate diagnosis of Helicobacter pylori. Urease tests. Gastroenterol Clin North Am, 29(4), 871–878.PubMedGoogle Scholar
  213. 213.
    Mitchell, H. M., Bohane, T., Hawkes, R. A., & Lee, A. (1993). Helicobacter pylori infection within families. Zentralbl Bakteriol, 280(1–2), 128–136.PubMedGoogle Scholar
  214. 214.
    Mitchell, J. D., Mitchell, H. M., & Tobias, V. (1992). Acute Helicobacter pylori infection in an infant, associated with gastric ulceration and serological evidence of intra-familial transmission. Am J Gastroenterol, 87(3), 382–386.PubMedGoogle Scholar
  215. 215.
    Miyazaki, M., Kato, M., Takata, T., & Une, H. (2002). Intrafamilial transmission of Helicobacter pylori: the association between a parent and an offspring with respect to the presence of anti-CagA antibody. J Infect Chemother, 8(1), 70–75.PubMedGoogle Scholar
  216. 216.
    Moayyedi, P., Soo, S., Deeks, J., Delaney, B., Harris, A., Innes, M., et al. (2006). Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev (2), CD002096.Google Scholar
  217. 217.
    Moayyedi, P., Talley, N. J., Fennerty, M. B., & Vakil, N. (2006). Can the clinical history distinguish between organic and functional dyspepsia? Jama, 295(13), 1566–1576.PubMedGoogle Scholar
  218. 218.
    Mobley, H. L., Hu, L. T., & Foxal, P. A. (1991). Helicobacter pylori urease: properties and role in pathogenesis. Scand J Gastroenterol Suppl, 187, 39–46.PubMedGoogle Scholar
  219. 219.
    Mobley, H. L. T., Mendez, G. L., & Hazell, S. L. (2001). Helicobacter pylori: Physiology and Genetics. Washington, D.C.: ASM Press.Google Scholar
  220. 220.
    Morris, A., Ali, M. R., Brown, P., Lane, M., & Patton, K. (1989). Campylobacter pylori infection in biopsy specimens of gastric antrum: laboratory diagnosis and estimation of sampling error. J Clin Pathol, 42(7), 727–732.PubMedGoogle Scholar
  221. 221.
    Morris, A., & Nicholson, G. (1987). Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol, 82(3), 192–199.PubMedGoogle Scholar
  222. 222.
    Morris, A., Nicholson, G., Lloyd, G., Haines, D., Rogers, A., & Taylor, D. (1986). Seroepidemiology of Campylobacter pyloridis. N Z Med J, 99(809), 657–659.PubMedGoogle Scholar
  223. 223.
    Morris, A. J., Ali, M. R., Nicholson, G. I., Perez-Perez, G. I., & Blaser, M. J. (1991). Long-term follow-up of voluntary ingestion of Helicobacter pylori. Ann Intern Med, 114(8), 662–663.PubMedGoogle Scholar
  224. 224.
    Naumann, M. (2005). Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells. Int J Med Microbiol, 295(5), 335–341.PubMedGoogle Scholar
  225. 225.
    Ndip, R. N., MacKay, W. G., Farthing, M. J., & Weaver, L. T. (2003). Culturing Helicobacter pylori from clinical specimens: review of microbiologic methods. J Pediatr Gastroenterol Nutr, 36(5), 616–622.PubMedGoogle Scholar
  226. 226.
    Nedenskov-Sorensen, P., Aase, S., Bjorneklett, A., Fausa, O., & Bukholm, G. (1991). Sampling efficiency in the diagnosis of Helicobacter pylori infection and chronic active gastritis. J Clin Microbiol, 29(4), 672–675.PubMedGoogle Scholar
  227. 227.
    Ng, B. L., Ng, H. C., Goh, K. T., & Ho, B. (2001). Helicobacter pylori in familial clusters based on antibody profile. FEMS Immunol Med Microbiol, 30(2), 139–142.PubMedGoogle Scholar
  228. 228.
    Nguyen, A. M., Engstrand, L., Genta, R. M., Graham, D. Y., & el-Zaatari, F. A. (1993). Detection of Helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. J Clin Microbiol, 31(4), 783–787.PubMedGoogle Scholar
  229. 229.
    Nguyen, V. B., Nguyen, G. K., Phung, D. C., Okrainec, K., Raymond, J., Dupond, C., et al. (2006). Intra-familial Transmission of Helicobacter pylori Infection in Children of Households with Multiple Generations in Vietnam. Eur J Epidemiol.Google Scholar
  230. 230.
    Nomura, A., Stemmermann, G. N., Chyou, P. H., Kato, I., Perez-Perez, G. I., & Blaser, M. J. (1991). Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med, 325(16), 1132–1136.PubMedGoogle Scholar
  231. 231.
    Nomura, A. M., Perez-Perez, G. I., Lee, J., Stemmermann, G., & Blaser, M. J. (2002). Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am J Epidemiol, 155(11), 1054–1059.PubMedGoogle Scholar
  232. 232.
    Noone, P. A., Waclawski, E. R., & Watt, A. D. (2006). Are endoscopy nurses at risk of infection with Helicobacter pylori from their work? Occup Med (Lond), 56(2), 122–128.Google Scholar
  233. 233.
    Nowak, R. (1995). Getting the bugs worked out. Science, 267(5195), 172–174.PubMedGoogle Scholar
  234. 234.
    Nugalieva, Z. Z., Opekun, A. R., & Graham, D. Y. (2006). Problem of distinguishing false-positive tests from acute or transient Helicobacter pylori infections. Helicobacter, 11(2), 69–74.PubMedGoogle Scholar
  235. 235.
    Nurnberg, M., Schulz, H. J., Ruden, H., & Vogt, K. (2003). Do conventional cleaning and disinfection techniques avoid the risk of endoscopic Helicobacter pylori transmission? Endoscopy, 35(4), 295–299.PubMedGoogle Scholar
  236. 236.
    O’Rourke, K., Goodman, K. J., Grazioplene, M., Redlinger, T., & Day, R. S. (2003). Determinants of geographic variation in Helicobacter pylori infection among children on the US-Mexico border. Am J Epidemiol, 158(8), 816–824.PubMedGoogle Scholar
  237. 237.
    Odenbreit, S. (2005). Adherence properties of Helicobacter pylori: impact on pathogenesis and adaptation to the host. Int J Med Microbiol, 295(5), 317–324.PubMedGoogle Scholar
  238. 238.
    Odenbreit, S., Puls, J., Sedlmaier, B., Gerland, E., Fischer, W., & Haas, R. (2000). Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science, 287(5457), 1497–1500.PubMedGoogle Scholar
  239. 239.
    Palmer, E. D. (1954). Investigation of the gastric mucosa spirochetes of the human. Gastroenterology, 27(2), 218–220.PubMedGoogle Scholar
  240. 240.
    Pardo-Mindan, F. J., Joly, M., Robledo, C., Sola, J., & Valerdiz, S. (1989). Duodenal ulcer “epidemic" in a pathology department. Lancet, 1(8630), 153.PubMedGoogle Scholar
  241. 241.
    Parkin, D. M. (2006). The global health burden of infection-associated cancers in the year 2002. Int J Cancer, 118(12), 3030–3044.PubMedGoogle Scholar
  242. 242.
    Parsonnet, J. (1995). The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther, 9 Suppl 2, 45–51.PubMedGoogle Scholar
  243. 243.
    Parsonnet, J. (2003). What is the Helicobacter pylori global reinfection rate? Can J Gastroenterol, 17 Suppl B, 46B–48B.PubMedGoogle Scholar
  244. 244.
    Parsonnet, J. (2005). Clinician-discoverers—Marshall, Warren, and H. pylori. N Engl J Med, 353(23), 2421–2423.PubMedGoogle Scholar
  245. 245.
    Parsonnet, J., Blaser, M. J., Perez-Perez, G. I., Hargrett-Bean, N., & Tauxe, R. V. (1992). Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology, 102(1), 41–46.PubMedGoogle Scholar
  246. 246.
    Parsonnet, J., Friedman, G. D., Vandersteen, D. P., Chang, Y., Vogelman, J. H., Orentreich, N., et al. (1991). Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med, 325(16), 1127–1131.PubMedGoogle Scholar
  247. 247.
    Parsonnet, J., Hansen, S., Rodriguez, L., Gelb, A. B., Warnke, R. A., Jellum, E., et al. (1994). Helicobacter pylori infection and gastric lymphoma. N Engl J Med, 330(18), 1267–1271.PubMedGoogle Scholar
  248. 248.
    Parsonnet, J., Shmuely, H., & Haggerty, T. (1999). Fecal and oral shedding of Helicobacter pylori from healthy infected adults. Jama, 282(23), 2240–2245.PubMedGoogle Scholar
  249. 249.
    Passaro, D. J., Taylor, D. N., Meza, R., Cabrera, L., Gilman, R. H., & Parsonnet, J. (2001). Acute Helicobacter pylori infection is followed by an increase in diarrheal disease among Peruvian children. Pediatrics, 108(5), E87.PubMedGoogle Scholar
  250. 250.
    Peek, R. M., Jr. (2004). Clandestine intracellular delivery of Helicobacter pylori CagA: guess who’s coming to dinner? Gastroenterology, 127(2), 669–672.PubMedGoogle Scholar
  251. 251.
    Peek, R. M., Jr. (2005). Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA. Sci STKE, 2005(277), pe14.Google Scholar
  252. 252.
    Peek, R. M., Jr., & Blaser, M. J. (2002). Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer, 2(1), 28–37.PubMedGoogle Scholar
  253. 253.
    Pel, P. (1899). Ziekten van de maag. De Erven F. Bohn, Amsterdam.Google Scholar
  254. 254.
    Perez-Perez, G. I., Bhat, N., Gaensbauer, J., Fraser, A., Taylor, D. N., Kuipers, E. J., et al. (1997). Country-specific constancy by age in cagA+ proportion of Helicobacter pylori infections. Int J Cancer, 72(3), 453–456.PubMedGoogle Scholar
  255. 255.
    Perez-Perez, G. I., Olivares, A. Z., Foo, F. Y., Foo, S., Neusy, A. J., Ng, C., et al. (2005). Seroprevalence of Helicobacter pylori in New York City populations originating in East Asia. J Urban Health, 82(3), 510–516.PubMedGoogle Scholar
  256. 256.
    Perez-Perez, G. I., Sack, R. B., Reid, R., Santosham, M., Croll, J., & Blaser, M. J. (2003). Transient and persistent Helicobacter pylori colonization in Native American children. J Clin Microbiol, 41(6), 2401–2407.PubMedGoogle Scholar
  257. 257.
    Perez-Perez, G. I., Taylor, D. N., Bodhidatta, L., Wongsrichanalai, J., Baze, W. B., Dunn, B. E., et al. (1990). Seroprevalence of Helicobacter pylori infections in Thailand. Journal of Infectious Diseases, 161(6), 1237–1241.PubMedGoogle Scholar
  258. 258.
    Perez-Perez, G. I., Witkin, S. S., Decker, M. D., & Blaser, M. J. (1991). Seroprevalence of helicobacter pylori infection in couples. J Clin Microbiol, 29(3), 642–644.PubMedGoogle Scholar
  259. 259.
    Perry, S., de la Luz Sanchez, M., Hurst, P. K., & Parsonnet, J. (2005). Household transmission of gastroenteritis. Emerg Infect Dis, 11(7), 1093–1096.PubMedGoogle Scholar
  260. 260.
    Perry, S., & Parsonnet, J. (2005). Commentary: H. pylori infection in early life and the problem of imperfect tests. Int J Epidemiol, 34(6), 1356–1358.PubMedGoogle Scholar
  261. 261.
    Perry, S., Sanchez, L., Yang, S., Haggerty, T. D., Hurst, P., Perez-Perez, G., et al. (2006). New H. pylori infection is associated with gastroenteritis in H. pylori-infected household contacts. Emerging Inf Dis (in press).Google Scholar
  262. 262.
    Pflock, M., Kennard, S., Finsterer, N., & Beier, D. (2006). Acid-responsive gene regulation in the human pathogen Helicobacter pylori. J Biotechnol.Google Scholar
  263. 263.
    Phadnis, S. H., Ilver, D., Janzon, L., Normark, S., & Westblom, T. U. (1994). Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun, 62(5), 1557–1565.PubMedGoogle Scholar
  264. 264.
    Price, A. B. (1991). The Sydney System: histological division. J Gastroenterol Hepatol, 6(3), 209–222.PubMedGoogle Scholar
  265. 265.
    Quan, C., & Talley, N. J. (2002). Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs. Am J Gastroenterol, 97(12), 2950–2961.PubMedGoogle Scholar
  266. 266.
    Rad, R., Dossumbekova, A., Neu, B., Lang, R., Bauer, S., Saur, D., et al. (2004). Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut, 53(8),1082–1089.PubMedGoogle Scholar
  267. 267.
    Rad, R., Gerhard, M., Lang, R., Schoniger, M., Rosch, T., Schepp, W., et al. (2002). The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J Immunol, 168(6), 3033–3041.PubMedGoogle Scholar
  268. 268.
    Raghunath, A., Hungin, A. P., Wooff, D., & Childs, S. (2003). Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. Bmj, 326(7392), 737.PubMedGoogle Scholar
  269. 269.
    Raguza, D., Granato, C. F., & Kawakami, E. (2005). Evaluation of the stool antigen test for Helicobacter pylori in children and adolescents. Dig Dis Sci, 50(3), 453–457.PubMedGoogle Scholar
  270. 270.
    Ramsey, E. J., Carey, K. V., Peterson, W. L., Jackson, J. J., Murphy, F. K., Read, N. W., et al. (1979). Epidemic gastritis with hypochlorhydria. Gastroenterology, 76(6), 1449–1457.PubMedGoogle Scholar
  271. 271.
    Raymond, J., Thiberg, J. M., Chevalier, C., Kalach, N., Bergeret, M., Labigne, A., et al. (2004). Genetic and transmission analysis of Helicobacter pylori strains within a family. Emerg Infect Dis, 10(10), 1816–1821.PubMedGoogle Scholar
  272. 272.
    Reiff, A., Jacobs, E., & Kist, M. (1989). Seroepidemiological study of the immune response to Campylobacter pylori in potential risk groups. Eur J Clin Microbiol Infect Dis, 8(7), 592–596.PubMedGoogle Scholar
  273. 273.
    Replogle, M. L., Glaser, S. L., Hiatt, R. A., & Parsonnet, J. (1995). Biologic sex as a risk factor for Helicobacter pylori infection in healthy young adults. Am J Epidemiol, 142(8), 856–863.PubMedGoogle Scholar
  274. 274.
    Robinson, L. G., Black, F. L., Lee, F. K., Sousa, A. O., Owens, M., Danielsson, D., et al. (2002). Helicobacter pylori prevalence among indigenous peoples of South America. J Infect Dis, 186(8), 1131–1137.PubMedGoogle Scholar
  275. 275.
    Rocha, G. A., Rocha, A. M., Silva, L. D., Santos, A., Bocewicz, A. C., Queiroz Rd Rde, M., et al. (2003). Transmission of Helicobacter pylori infection in families of preschool-aged children from Minas Gerais, Brazil. Trop Med Int Health, 8(11), 987–991.PubMedGoogle Scholar
  276. 276.
    Rosenstock, S., Jorgensen, T., Andersen, L., & Bonnevie, O. (2000). Seroconversion and seroreversion in IgG antibodies to Helicobacter pylori: a serology based prospective cohort study. J Epidemiol Community Health, 54(6), 444–450.PubMedGoogle Scholar
  277. 277.
    Rothenbacher, D., Bode, G., & Brenner, H. (2002). Dynamics of Helicobacter pylori infection in early childhood in a high-risk group living in Germany: loss of infection higher than acquisition. Aliment Pharmacol Ther, 16(9), 1663–1668.PubMedGoogle Scholar
  278. 278.
    Rothenbacher, D., Inceoglu, J., Bode, G., & Brenner, H. (2000). Acquisition of Helicobacter pylori infection in a high-risk population occurs within the first 2 years of life. J Pediatr, 136(6), 744–748.PubMedGoogle Scholar
  279. 279.
    Rothenbacher, D., Winkler, M., Gonser, T., Adler, G., & Brenner, H. (2002). Role of infected parents in transmission of helicobacter pylori to their children. Pediatr Infect Dis J, 21(7), 674–679.PubMedGoogle Scholar
  280. 280.
    Rowland, M., Daly, L., Vaughan, M., Higgins, A., Bourke, B., & Drumm, B. (2006). Age-specific incidence of Helicobacter pylori. Gastroenterology, 130(1), 65–72; quiz 211.PubMedGoogle Scholar
  281. 281.
    Sachs, G., Weeks, D. L., Melchers, K., & Scott, D. R. (2003). The gastric biology of Helicobacter pylori. Annu Rev Physiol, 65, 349–369.PubMedGoogle Scholar
  282. 282.
    Sachs, G., Weeks, D. L., Wen, Y., Marcus, E. A., Scott, D. R., & Melchers, K. (2005). Acid acclimation by Helicobacter pylori. Physiology (Bethesda), 20, 429–438.Google Scholar
  283. 283.
    Saito, N., Konishi, K., Sato, F., Kato, M., Takeda, H., Sugiyama, T., et al. (2003). Plural transformation-processes from spiral to coccoid Helicobacter pylori and its viability. J Infect, 46(1), 49–55.PubMedGoogle Scholar
  284. 284.
    Samuels, A. L., Windsor, H. M., Ho, G. Y., Goodwin, L. D., & Marshall, B. J. (2000). Culture of Helicobacter pylori from a gastric string may be an alternative to endoscopic biopsy. J Clin Microbiol, 38(6), 2438–2439.PubMedGoogle Scholar
  285. 285.
    Schmitt, W., & Haas, R. (1994). Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol, 12(2), 307–319.PubMedGoogle Scholar
  286. 286.
    Scott, D. R., Marcus, E. A., Weeks, D. L., Lee, A., Melchers, K., & Sachs, G. (2000). Expression of the Helicobacter pylori ureI gene is required for acidic pH activation of cytoplasmic urease. Infect Immun, 68(2), 470–477.PubMedGoogle Scholar
  287. 287.
    Segal, E. D., Cha, J., Lo, J., Falkow, S., & Tompkins, L. S. (1999). Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A, 96(25), 14559–14564.PubMedGoogle Scholar
  288. 288.
    Seher, C., Thierfelder, W., and Dortschy, R. (2000). [Helicobacter pylori–prevalence in the German population]. Gesundheitswesen, 62(11), 598–603.Google Scholar
  289. 289.
    Severson, R. K., & Davis, S. (1990). Increasing incidence of primary gastric lymphoma. Cancer, 66(6), 1283–1287.PubMedGoogle Scholar
  290. 290.
    Shepherd, A. J., Williams, C. L., Doherty, C. P., Hossack, M., Preston, T., McColl, K. E., et al. (2000). Comparison of an enzyme immunoassay for the detection of Helicobacter pylori antigens in the faeces with the urea breath test. Arch Dis Child, 83(3), 268–270.PubMedGoogle Scholar
  291. 291.
    Sheu, B. S., Sheu, S. M., Yang, H. B., Huang, A. H., & Wu, J. J. (2003). Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection. Gut, 52(7), 927–932.PubMedGoogle Scholar
  292. 292.
    Sinha, S. K., Martin, B., Sargent, M., McConnell, J. P., & Bernstein, C. N. (2002). Age at acquisition of Helicobacter pylori in a pediatric Canadian First Nations population. Helicobacter, 7(2), 76–85.PubMedGoogle Scholar
  293. 293.
    Sipponen, P. (1992). Natural history of gastritis and its relationship to peptic ulcer disease. Digestion, 51 Suppl 1, 70–75.PubMedGoogle Scholar
  294. 294.
    Sipponen, P. (2001). Update on the pathologic approach to the diagnosis of gastritis, gastric atrophy, and Helicobacter pylori and its sequelae. J Clin Gastroenterol, 32(3), 196–202.PubMedGoogle Scholar
  295. 295.
    Sipponen, P., Aarynen, M., Kaariainen, I., Kettunen, P., Helske, T., & Seppala, K. (1989). Chronic antral gastritis, Lewis(a+) phenotype, and male sex as factors in predicting coexisting duodenal ulcer. Scand J Gastroenterol, 24(5), 581–588.PubMedGoogle Scholar
  296. 296.
    Sipponen, P., Kekki, M., Haapakoski, J., Ihamaki, T., & Siurala, M. (1985). Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer, 35(2), 173–177.PubMedGoogle Scholar
  297. 297.
    Sipponen, P., et al. (1996). Rate of Helicobacter pylori acquisition among Finnish adults: a fifteen year follow–up. Scand J Gastroenterol, 31(3), 229–232.Google Scholar
  298. 298.
    Sipponen, P., & Seppala, K. (1992). Gastric carcinoma: failed adaptation to Helicobacter pylori. Scand J Gastroenterol Suppl, 193, 33–38.PubMedGoogle Scholar
  299. 299.
    Sonnenberg, A. (1984). Occurrence of a cohort phenomenon in peptic ulcer mortality from Switzerland. Gastroenterology, 86(3), 398–401.PubMedGoogle Scholar
  300. 300.
    Sonnenberg, A. (2006). Causes underlying the birth-cohort phenomenon of peptic ulcer: analysis of mortality data 1911–2000, England and Wales. Int J Epidemiol, 35(4), 1090–1097.Google Scholar
  301. 301.
    Sonnenberg, A., & Fritsch, A. (1983). Changing mortality of peptic ulcer disease in Germany. Gastroenterology, 84(6), 1553–1557.PubMedGoogle Scholar
  302. 302.
    Steer, H. W. (1975). Ultrastructure of cell migration through the gastric epithelium and its relationship to bacteria. J Clin Pathol, 28(8), 639–646.PubMedGoogle Scholar
  303. 303.
    Steer, H. W., & Colin-Jones, D. G. (1975). Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut, 16(8), 590–597.PubMedGoogle Scholar
  304. 304.
    Stingl, K., & De Reuse, H. (2005). Staying alive overdosed: how does Helicobacter pylori control urease activity? Int J Med Microbiol, 295(5), 307–315.PubMedGoogle Scholar
  305. 305.
    Stingl, K., Uhlemann, E. M., Schmid, R., Altendorf, K., & Bakker, E. P. (2002). Energetics of Helicobacter pylori and its implications for the mechanism of urease-dependent acid tolerance at pH 1. J Bacteriol, 184(11), 3053–3060.PubMedGoogle Scholar
  306. 306.
    Stolte, M., Bayerdorffer, E., Morgner, A., Alpen, B., Wundisch, T., Thiede, C., et al. (2002). Helicobacter and gastric MALT lymphoma. Gut, 50 Suppl 3, III19–24.PubMedGoogle Scholar
  307. 307.
    Suerbaum, S., & Michetti, P. (2002). Helicobacter pylori infection. N Engl J Med, 347(15), 1175–1186.PubMedGoogle Scholar
  308. 308.
    Suzuki, J., Muraoka, H., Kobayasi, I., Fujita, T., & Mine, T. (1999). Rare incidence of interspousal transmission of Helicobacter pylori in asymptomatic individuals in Japan. J Clin Microbiol, 37(12), 4174–4176.PubMedGoogle Scholar
  309. 309.
    Take, S., Mizuno, M., Ishiki, K., Nagahara, Y., Yoshida, T., Yokota, K., et al. (2005). The effect of eradicating helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease. Am J Gastroenterol, 100(5), 1037–1042.PubMedGoogle Scholar
  310. 310.
    Talley, N. J. (1993). The role of Helicobacter pylori in nonulcer dyspepsia. A debate—against. Gastroenterol Clin North Am, 22(1), 153–167.PubMedGoogle Scholar
  311. 311.
    Talley, N. J., Zinsmeister, A. R., Weaver, A., DiMagno, E. P., Carpenter, H. A., Perez-Perez, G. I., et al. (1991). Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst, 83(23), 1734–1739.PubMedGoogle Scholar
  312. 312.
    Tanaka, A., Watanabe, K., Tokunaga, K., Hoshiya, S., Imase, K., Sugano, H., et al. (2003). Evaluation of Helicobacter pylori stool antigen test before and after eradication therapy. J Gastroenterol Hepatol, 18(6), 732–738.PubMedGoogle Scholar
  313. 313.
    Tarnasky, P. R., Kovacs, T. O., Sytnik, B., & Walsh, J. H. (1993). Asymptomatic H. pylori infection impairs pH inhibition of gastrin and acid secretion during second hour of peptone meal stimulation. Dig Dis Sci, 38(9), 1681–1687.PubMedGoogle Scholar
  314. 314.
    Taylor, D. E., Eaton, M., Chang, N., & Salama, S. M. (1992). Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level. J Bacteriol, 174(21), 6800–6806.PubMedGoogle Scholar
  315. 315.
    Taylor, D. N., Parsonnet, J., Blaser, M. J., Smith, P. D., Ravdin, J. I., Greenberg, H. B., et al. (1995). The epidemiology and natural history of Helicobacter pylori infection. In Infections of the Gastrointestinal Tract (Vol. 1). New York: Raven Press.Google Scholar
  316. 316.
    Taylor, D. N., Sanchez, J. L., Smoak, B. L., & DeFraites, R. (1997). Helicobacter pylori infection in Desert Storm troops. Clin Infect Dis, 25(5), 979–982.PubMedGoogle Scholar
  317. 317.
    Teh, B. H., Lin, J. T., Pan, W. H., Lin, S. H., Wang, L. Y., Lee, T. K., et al. (1994). Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. Anticancer Res, 14(3B), 1389–1392.PubMedGoogle Scholar
  318. 318.
    Telford, J. L., Ghiara, P., Dell’Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., et al. (1994). Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med, 179(5), 1653–1658.PubMedGoogle Scholar
  319. 319.
    Thomas, J. E., Dale, A., Harding, M., Coward, W. A., Cole, T. J., Sullivan, P. B., et al. (1999). Interpreting the 13C-urea breath test among a large population of young children from a developing country. Pediatr Res, 46(2), 147–151.PubMedGoogle Scholar
  320. 320.
    Thomas, J. E., Dale, A., Harding, M., Coward, W. A., Cole, T. J., & Weaver, L. T. (1999). Helicobacter pylori colonization in early life. Pediatr Res, 45(2), 218–223.PubMedGoogle Scholar
  321. 321.
    Thomas, J. E., Gibson, G. R., Darboe, M. K., Dale, A., & Weaver, L. T. (1992). Isolation of Helicobacter pylori from human faeces. Lancet, 340(8829), 1194–1195.PubMedGoogle Scholar
  322. 322.
    Tilvis, R. S., Vuoristo, M., & Varis, K. (1987). Changed profile of peptic ulcer disease in hospital patients during 1969–1984 in Finland. Scand J Gastroenterol, 22(10), 1238–1244.PubMedGoogle Scholar
  323. 323.
    Tindberg, Y., Bengtsson, C., Granath, F., Blennow, M., Nyren, O., & Granstrom, M. (2001). Helicobacter pylori infection in Swedish school children: lack of evidence of child-to-child transmission outside the family. Gastroenterology, 121(2), 310–316.PubMedGoogle Scholar
  324. 324.
    Tomb, J. F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., et al. (1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature, 388(6642), 539–547.PubMedGoogle Scholar
  325. 325.
    Torres, J., Leal-Herrera, Y., Perez-Perez, G., Gomez, A., Camorlinga-Ponce, M., Cedillo-Rivera, R., et al. (1998). A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico. J Infect Dis, 178(4), 1089–1094.PubMedGoogle Scholar
  326. 326.
    Torres, J., Lopez, L., Lazcano, E., Camorlinga, M., Flores, L., & Munoz, O. (2005). Trends in Helicobacter pylori infection and gastric cancer in Mexico. Cancer Epidemiol Biomarkers Prev, 14(8), 1874–1877.PubMedGoogle Scholar
  327. 327.
    Tsai, C. J., Perry, S., Sanchez, L., & Parsonnet, J. (2005). Helicobacter pylori infection in different generations of Hispanics in the San Francisco Bay Area. Am J Epidemiol, 162(4), 351–357.PubMedGoogle Scholar
  328. 328.
    Tsuda, M., Karita, M., Morshed, M. G., Okita, K., & Nakazawa, T. (1994). A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun, 62(8), 3586–3589.PubMedGoogle Scholar
  329. 329.
    Turbett, G. R., Hoj, P. B., Horne, R., & Mee, B. J. (1992). Purification and characterization of the urease enzymes of Helicobacter species from humans and animals. Infect Immun, 60(12), 5259–5266.PubMedGoogle Scholar
  330. 330.
    Ueda, M., Kikuchi, S., Kasugai, T., Shunichi, T., & Miyake, C. (2003). Helicobacter pylori risk associated with childhood home environment. Cancer Sci, 94(10), 914–918.PubMedGoogle Scholar
  331. 331.
    Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., et al. (2001). Helicobacter pylori infection and the development of gastric cancer. N Engl J Med, 345(11), 784–789.PubMedGoogle Scholar
  332. 332.
    Vaira, D., Gatta, L., Ricci, C., & Miglioli, M. (2002). Review article: diagnosis of Helicobacter pylori infection. Aliment Pharmacol Ther, 16 Suppl 1, 16–23.PubMedGoogle Scholar
  333. 333.
    Vaira, D., Malfertheiner, P., Megraud, F., Axon, A. T., Deltenre, M., Gasbarrini, G., et al. (2000). Noninvasive antigen-based assay for assessing Helicobacter pylori eradication: a European multicenter study. The European Helicobacter pylori HpSA Study Group. Am J Gastroenterol, 95(4), 925–929.PubMedGoogle Scholar
  334. 334.
    Vakil, N. (2001). Review article: the cost of diagnosing Helicobacter pylori infection. Aliment Pharmacol Ther, 15 Suppl 1, 10–15.PubMedGoogle Scholar
  335. 335.
    Valkonen, K. H., Wadstrom, T., & Moran, A. P. (1994). Interaction of lipopolysaccharides of Helicobacter pylori with basement membrane protein laminin. Infect Immun, 62(9), 3640–3648.PubMedGoogle Scholar
  336. 336.
    van Amsterdam, K., van Vliet, A. H., Kusters, J. G., & van der Ende, A. (2006). Of microbe and man: determinants of Helicobacter pylori-related diseases. FEMS Microbiol Rev, 30(1), 131–156.PubMedGoogle Scholar
  337. 337.
    Velapatino, B., Balqui, J., Gilman, R. H., Bussalleu, A., Quino, W., Finger, S. A., et al. (2006). Validation of string test for diagnosis of Helicobacter pylori infections. J Clin Microbiol, 44(3), 976–980.PubMedGoogle Scholar
  338. 338.
    Veldhuyzen van Zanten, S. J., et al. (1994). Increasing prevalence of Helicobacter pylori infection with age: continuous risk of infection in adults rather than cohort effect. J Infect Dis, 169(2), 434–437.Google Scholar
  339. 339.
    Wang, J. T., Sheu, J. C., Lin, J. T., Wang, T. H., & Wu, M. S. (1993). Direct DNA amplification and restriction pattern analysis of Helicobacter pylori in patients with duodenal ulcer and their families. J Infect Dis, 168(6), 1544–1548.PubMedGoogle Scholar
  340. 340.
    Wang, P., & Adair, R. (1999). Helicobacter pylori in immigrants from East Africa. J Gen Intern Med, 14(9), 567–568.PubMedGoogle Scholar
  341. 341.
    Watson, C. L., Owen, R. J., Said, B., Lai, S., Lee, J. V., Surman-Lee, S., et al. (2004). Detection of Helicobacter pylori by PCR but not culture in water and biofilm samples from drinking water distribution systems in England. J Appl Microbiol, 97(4), 690–698.PubMedGoogle Scholar
  342. 342.
    Webb, P. M., Knight, T., Greaves, S., Wilson, A., Newell, D. G., Elder, J., et al. (1994). Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. Bmj, 308(6931), 750–753.PubMedGoogle Scholar
  343. 343.
    Webberley, M. J., Webberley, J. M., Newell, D. G., Lowe, P., & Melikian, V. (1992). Seroepidemiology of Helicobacter pylori infection in vegans and meat-eaters. Epidemiol Infect, 108(3), 457–462.PubMedGoogle Scholar
  344. 344.
    Weeks, D. L., Eskandari, S., Scott, D. R., & Sachs, G. (2000). A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science, 287(5452), 482–485.PubMedGoogle Scholar
  345. 345.
    Wen, Y., Marcus, E. A., Matrubutham, U., Gleeson, M. A., Scott, D. R., & Sachs, G. (2003). Acid-adaptive genes of Helicobacter pylori. Infect Immun, 71(10), 5921–5939.PubMedGoogle Scholar
  346. 346.
    Whary, M. T., & Fox, J. G. (2004). Natural and experimental Helicobacter infections. Comp Med, 54(2), 128–158.PubMedGoogle Scholar
  347. 347.
    Williams, C. L., Preston, T., Hossack, M., Slater, C., & McColl, K. E. (1996). Helicobacter pylori utilises urea for amino acid synthesis. FEMS Immunol Med Microbiol, 13(1), 87–94.PubMedGoogle Scholar
  348. 348.
    Windsor, H. M., Abioye-Kuteyi, E. A., Leber, J. M., Morrow, S. D., Bulsara, M. K., & Marshall, B. J. (2005). Prevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations. Med J Aust, 182(5), 210–213.PubMedGoogle Scholar
  349. 349.
    Wizla-Derambure, N., Michaud, L., Ategbo, S., Vincent, P., Ganga-Zandzou, S., Turck, D., et al. (2001). Familial and community environmental risk factors for Helicobacter pylori infection in children and adolescents. J Pediatr Gastroenterol Nutr, 33(1), 58–63.PubMedGoogle Scholar
  350. 350.
    Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T. T., Feng, R. E., et al. (2004). Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. Jama, 291(2), 187–194.PubMedGoogle Scholar
  351. 351.
    Wotherspoon, A. C., Ortiz-Hidalgo, C., Falzon, M. R., & Isaacson, P. G. (1991). Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet, 338(8776), 1175–1176.PubMedGoogle Scholar
  352. 352.
    Wu, A. H., Crabtree, J. E., Bernstein, L., Hawtin, P., Cockburn, M., Tseng, C. C., et al. (2003). Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus. Int J Cancer, 103(6), 815–821.PubMedGoogle Scholar
  353. 353.
    Wu, D. C., Wu, I. C., Lee, J. M., Hsu, H. K., Kao, E. L., Chou, S. H., et al. (2005). Helicobacter pylori infection: a protective factor for esophageal squamous cell carcinoma in a Taiwanese population. Am J Gastroenterol, 100(3), 588–593.PubMedGoogle Scholar
  354. 354.
    Wundisch, T., Thiede, C., Morgner, A., Dempfle, A., Gunther, A., Liu, H., et al. (2005). Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication. J Clin Oncol, 23(31), 8018–8024.PubMedGoogle Scholar
  355. 355.
    Yang, L., Parkin, D. M., Whelan, S., Zhang, S., Chen, Y., Lu, F., et al. (2005). Statistics on cancer in China: cancer registration in 2002. Eur J Cancer Prev, 14(4), 329–335.PubMedGoogle Scholar
  356. 356.
    Ye, W., Held, M., Lagergren, J., Engstrand, L., Blot, W. J., McLaughlin, J. K., et al. (2004). Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia. J Natl Cancer Inst, 96(5), 388–396.PubMedGoogle Scholar
  357. 357.
    Young, J. L., Percy, C. L., Asire, A. J., Berg, J. W., Cusano, M. M., Gloekler, L. A., et al. (1981). Surveillance, Epidemiology and End Results: Incidence and Mortality Data, 1973–1977. Natl Cancer Inst Monogr 57, 1–187.Google Scholar
  358. 358.
    Young, K. A., Akyon, Y., Rampton, D. S., Barton, S. G., Allaker, R. P., Hardie, J. M., et al. (2000). Quantitative culture of Helicobacter pylori from gastric juice: the potential for transmission. J Med Microbiol, 49(4), 343–347.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sharon Perry
    • 1
  • Catherine de Martel
    • 2
  • Julie Parsonnet
    • 3
  1. 1.Department of MedicineStanford University School of MedicineCaliforniaUSA
  2. 2.Department of MedicineStanford University School of MedicineCaliforniaUSA
  3. 3.Department of MedicineStanford University School of MedicineCaliforniaUSA

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