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Chancroid

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Bacterial Infections of Humans

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Chancroid is caused by Haemophilus ducreyi, a gram-negative bacterium. Chancroid, a genital ulcerative sexually transmitted disease, is characterized by painful genital ulcers and inguinal lymphadenitis. Like other genital ulcerative diseases (GUD), chancroid facilitates the transmission and acquisition of human immune deficiency virus (HIV).(26) The concern over the synergy between HIV infection and chancroid has renewed the interest to understand the pathogenesis of the disease and to develop new diagnosticmethods.

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References

  1. Afonina, G., Leduc, I., Nepluev, I., Jeter, C., Routh, P., Almond, G., Orndorff, P. E., Hobbs, M., and Elkins, C. (2006). Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid, Infect. Immun. 74(4):2224–32.

    Article  PubMed  CAS  Google Scholar 

  2. Al-Tawfiq, J. A., Thornton, A. C., Katz, B. P., Fortney, K. R., Todd, K. D., Hood A. F., and Spinola, S. M. (1999). Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge, J. Infect. Dis. 179: 1283–1287.

    Article  PubMed  CAS  Google Scholar 

  3. Al-Tawfiq, J. A., Bauer, M. E., Fortney, K. R., Katz, B. P., Hood, A. F., Ketterer, M., Apicella, M. A., and Spinola, S. M. (2000). A pilus-deficient mutant of Haemophilus ducreyi is virulent in the human model of experimental infection, J. Infect. Dis. 181:1176–9.

    Article  PubMed  CAS  Google Scholar 

  4. Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C., and Spinola, S. M. (2000). An isogenic hemoglobin receptor deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection, J. Infect. Dis. 181:1049–1054.

    Article  Google Scholar 

  5. Al-Tawfiq, J. A., Harezlak, J., Katz, B. P., and Spinola, S. M. (2000). Cumulative experience with Haemophilus ducreyi 35000 in the human model of experimental infection, Sex Transm. Dis. 27(2): 111–4.

    Article  PubMed  CAS  Google Scholar 

  6. Al-Tawfiq, J. A., and Spinola, S. M. (2002). Haemophilus ducreyi: clinical disease and pathogenesis, Curr. Opin. Infect. Dis. 15(1):43–7.

    Article  PubMed  Google Scholar 

  7. Ballard, R. C., Ye, H., Matta, A., Dangor, Y., and Radebe, F. (1996). Treatment of chancroid with azithromycin, Int. J. STD AIDS. 7(1):9–12.

    Article  PubMed  Google Scholar 

  8. Bassereau, P. I. (1852). Traite de affections de la peau symptomatiques de la syphilis. J. B. Bailliere, Paris.

    Google Scholar 

  9. Bauer, M. E., Contain, M. P., Townsend, C. A., and Spinola, S. M. (2001). Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers, Infect. Immun. 69:2549–2557.

    Article  PubMed  CAS  Google Scholar 

  10. Bauer, M. E., Townsend, C. A., Ronald, A. R., and Spinola, S. M. (2006). Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers, Microbes Infect. 8(9–10):2465–8.

    Article  PubMed  CAS  Google Scholar 

  11. Bezancon, F., Griffin, V., and LeSourd, L. (1900). Culture du Bacille du Chancre Mou, CR Soc. Biol. 11:1048–1051.

    Google Scholar 

  12. Blackmore, C. A., Limpakarnjanarat, K., Rigau-Perez, J. G., Albritton, W. L., and Greenwood, J. R. (1985). An outbreak of chancroid in Orange County, California: descriptive epidemiology and disease-control measures, J. Infect. Dis. 151:840–44.

    Article  PubMed  CAS  Google Scholar 

  13. Bong, C. T., Thrum, R. E., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C., and Spinola, S. M (2001). A DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers, Infect. Immun. 69:1488–1491.

    Article  PubMed  CAS  Google Scholar 

  14. Bong, C. T. H., Harezlak, J., Katz, B. P., and Spinola S. M. (2002). Men are more susceptible to pustule formation than women in the experimental model of Haemophilus ducreyi infection, Sex. Transmit. Dis. 29:114–118.

    Article  Google Scholar 

  15. Bruisten, S. M., Cairo, I., Fennema, H., Pijl, A., Buimer, M., Peerbooms, P. G., Van Dyck, E., Meijer, A., Ossewaarde, J. M., and van Doornum, G. J. (2001). Diagnosing genital ulcer disease in a clinic for sexually transmitted diseases in Amsterdam, The Netherlands, J Clin Microbial 2001 39:601–605.

    Article  CAS  Google Scholar 

  16. Centers for Disease Control and Prevention (1999). Summary of notifiable diseases, United States, 1998, MMWR, 47(53):1–93.

    Google Scholar 

  17. Centers for Disease Control and Prevention. (2002). Sexually Transmitted Diseases Treatment Guidelines - 2002 MMWR 51(RR-6):1–80.

    Google Scholar 

  18. Centers for Disease Control and Prevention (2004). Summary of notifiable diseases, United States, 2002, MMWR 51(53):1–84.

    Google Scholar 

  19. Chen, C. Y., Bollard, R. C., Beck-Sague, C. M., Dangor, Y., Radebe, F., Schmid, S., Weiss, J. B., Tshabalala, V., Fehler, G., Htun, Y., and Morse, S. A. (2000). Human immunodeficiency virus infection and genital ulcer disease in South Africa: the herpetic connection, Sex Trans. Dis. 27:21–290.

    Article  CAS  Google Scholar 

  20. Chen, C. Y., Mertz, K. J., Spinola, S. M., and Morse, S. A. (1997). Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States, J. Infect. Dis. 175:1390–5.

    Article  PubMed  CAS  Google Scholar 

  21. De Ley, J., Mannheim, W., Mutters, R., Piechulla, K., Tytgat, R., Segars, P., Bisgaard, M., Frederikson, W., Hinz, K. H., and Vanhoucke, M. (1990). Inter and intrafamilial similarities of the rRNA cistrons of the Pasteurellaceae, Int. J. Syst. Bacteriol. 40: 126–137.

    Article  PubMed  Google Scholar 

  22. Dewhirst, F. E., Paster, B. I., Olsen, I., and Fraser, G. J. (1992). Phylogeny of 54 representative strains of species in the family Pasteurellaceae as determined by comparison of 16S rRNA Sequences, J. Bacteriol. 174:2002–2013.

    PubMed  CAS  Google Scholar 

  23. Diaz-Mitoma, F., Benningen, G., Slutchuk M., Ronald A. R., and Brunham R. C. (1987). Etiology of nonvesicular genital ulcers in Winnipeg. Sex. Transm. Dis. 14:33–36.

    Article  PubMed  CAS  Google Scholar 

  24. Dorman C. J., (1991). DNA supercoiling and environmental regulation of gene expression in pathogenic bacteria, Infect. Immun. 59: 745–749.

    PubMed  CAS  Google Scholar 

  25. Elkins, C., Yi, K., Olsen, B., Thomas, C., Thomas, K., and Morse, S. (2000). Development of a serological test for Haemophilus ducreyi for seroprevalence studies, J. Clin. Microbiol. 38:1520–6.

    PubMed  CAS  Google Scholar 

  26. Fleming, D. T. and Wasserheit, J. N. (1999). From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Trans. Infect. 75(1):3–17.

    Article  CAS  Google Scholar 

  27. Fortney, K. R., Young, R. S., Bauer, M. E., Katz, B. P., Hood, A. F., Munson, R. S. Jr., and Spinola, S. M (2000). Expression of peptidoglycan-associated lipoprotein is required for virulence in the human model of Haemophilus ducreyi infection, Infect. Immun. 68:6441–6448.

    Article  PubMed  CAS  Google Scholar 

  28. Fulcher, R. A., Cole, L. E., Janowicz, D. M., Toffer, K. L., Fortney, K. R., Katz, B. P., Orndorff, P. E., Spinola, S. M., and Kawula, T. H. (2006). Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid, Infect. Immun. 74(5):2651–8.

    Article  PubMed  CAS  Google Scholar 

  29. Hammond, G. W., Slutchuk, M., Scatliff, J., Sherman, E., Wilt, J. C., and Ronald, A. R. (1980). Epidemiologic, clinical, laboratory and therapeutic features of an urban outbreak of chancroid in North America, Rev. Infect. Dis. 2: 867–879.

    Article  PubMed  CAS  Google Scholar 

  30. Hanenberg, R. S., Rojanapithayakorn, W., Kunasol, P., and Sokal, D. C. (1994). Impact of Thailand’s HIV control programme as indicated by the decline of sexually transmitted diseases, Lancet 344: 243–245.

    Article  PubMed  CAS  Google Scholar 

  31. Humphreys, T. L., Schnizlein-Bick, C. T., Katz, B. P., Baldridge, L. A., Hood, A. F., Hromas, R. A., and Spinola, S. M. (2002) Evolution of the cutaneous immune response to experimental Haemophilus ducreyi infection and its relevance to HIV-1 acquisition, J. Immunol. 169(11):6316–23.

    PubMed  CAS  Google Scholar 

  32. Janowicz, D. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Deng, K., Hansen, E. J., and Spinola, S. M. (2004) Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers, Infect. Immun. 72(8):4528–33.

    Article  PubMed  CAS  Google Scholar 

  33. Janowicz, D. M., Tenner-Racz, K., Racz, P., Humphreys, T. L., Schnizlein-Bick, C., Fortney, K. R., Zwickl, B., Katz, B. P., Campbell, J. J., Ho, D. D., Spinola, S. M. (2007) Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication, J. Infect. Dis. 195(10):1443–51.

    Article  PubMed  CAS  Google Scholar 

  34. Jones, C., Rosen, T., Clarridge, J., and Collins, S. (1990). Chancroid: Results from an outbreak in Houston, Texas. South Med. J. 83: 1384–1389.

    Article  CAS  Google Scholar 

  35. Kilian, M. and Biberstein, E. L. (1984). Genus II. Haemophilus, pp. 558–569. In N. R. Krieg and J. G. Holt (ed.), Bergey’s manual of systematic bacteriology, vol. 1. The Williams & Wilkins Co., Baltimore.

    Google Scholar 

  36. King, R., Choudhri, S. H., Nasio, J., Gough, J., Nagelkerke, N. J., Plummer, F. A., Ndinya-Achola, J. O., and Ronald, A. R. (1998). Clinical and in situ cellular responses to Haemophilus ducreyi in the presence or absence of HIV infection, Int. J. STD AIDS. 9:531–536.

    Article  PubMed  CAS  Google Scholar 

  37. Lagergård, T., Lundqvist, A., Wising, C., Gabrielsson, V., and Ahlman, K. (2007 May 4) Formaldehyde treatment increases the immunogenicity and decreases the toxicity of Haemophilus ducreyi cytolethal distending toxin, Vaccine 25(18):3606–14.

    Article  PubMed  Google Scholar 

  38. Lewis, D. A. (2000). Diagnostic tests for chancroid. Sex Trans. Infect. 76(2):137–41.

    Article  CAS  Google Scholar 

  39. Malonza, I. M., Tyndall, M. W., Ndinya-Achola, J. O., Maclean, I., Omar, S., MacDonald, K. S., Perriens, J., Orle, K., Plummer, F. A., Ronald, A. R., and Moses, S. (1999). A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya, J. Infect. Dis. 180:1886–1893.

    Article  PubMed  CAS  Google Scholar 

  40. Mertz, K. J., Trees, D., Levine, W. C., Lewis, J. S., Litchfield, B., Pettus, K. S., Morse, S. A., St Louis, M. E., Weiss, J. B., Schwebke, J., Dickes, J., Kee, R., Reynolds, J., Hutcheson, D., Green, D., Dyer, I., Richwald, G. A., Novotny, J., Weisfuse, I., Goldberg, M., O’Donnell, J. A., and Knaup, R. (1998). Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities, J. Infect. Dis. 178:1795–8.

    Article  PubMed  CAS  Google Scholar 

  41. Morse S. A. (1989). Chancroid and Haemophilus ducreyi, Clin. Microbiol. Rev. 2:137–157.

    PubMed  CAS  Google Scholar 

  42. Morse, S. A., Trees, D. L., Htun, Y., Radebe, F., Orle, K. A., Dangor, Y., Beck-Sague, C. M., Schmid, S., Fehler, G., Weiss, J. B., and Ballard, R. C. (1997). Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: association with human immunodeficiency virus infection, J. Infect. Dis. 175:583–9.

    Article  PubMed  CAS  Google Scholar 

  43. Nsanze, H., Plummer, F. A., Maggwa, A. B. N., Maitha, G., Dylewski, J., Piot, P., and Ronald, A. R. (1984). Comparison of media for the primary isolation of Haemophilus ducreyi, Sex. Transm. Dis. 11:6–9

    Article  PubMed  CAS  Google Scholar 

  44. Orle, K. A., Gates, C. A., Martin, D. H., Body, B. A., and Weiss, J. B. (1996). Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and Herpes Simplex Virus types 1 and 2 from genital ulcers, J. Clin. Microbiol. 34:49–54.

    PubMed  CAS  Google Scholar 

  45. Ortiz-Zepeda, C., Hernandez-Perez, E., and Marroquin-Burgos, R. (1994). Gross and microscopic features in chancroid: a study in 200 new culture proven cases in San Salvador, Sex. Transm. Dis. 21:112–117.

    Article  PubMed  CAS  Google Scholar 

  46. Palmer, K. L., Thornton, A. C., Fortney, K. R., Hood, A. F., Munson, R. S. Jr., and Spinola, S. M. (1998). Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection, J. Infect. Dis. 1998 178:191–199.

    Article  PubMed  CAS  Google Scholar 

  47. Plummer, F. A., D’Costa, L. J., Nsanze, H., Karasira, P., MacLean, I. W., Piot, P., and Ronald, A. R. (1985). Clinical and microbiological studies of genital ulcers in Kenyan women, Sex. Transm. Dis. 12:193–197

    Article  PubMed  CAS  Google Scholar 

  48. Post, D. M., Gibson, B. W. (2007) Proposed second class of Haemophilus ducreyi strains show altered protein and lipooligosaccharide profiles. Proteomics. 7(17):3131–42.

    Google Scholar 

  49. Ronald, A. R., and Albritton, W. L. (1984). Chancroid and Haemophilus ducreyi, pp. 385–393. In Holmes, K. K., Mardh, P. A., Sparling, P. F., and Wiesner, P. J. (ed.), Sexually Transmitted diseases. McGraw-Hill Book Co., New York.

    Google Scholar 

  50. Singh, K. G., Joshi, M. K., and Bajaj, A. K. (1990). Pattern of sexually transmitted diseases in Allahabad, Indian J. Sex. Transm. Dis. 11(1):6–8.

    PubMed  CAS  Google Scholar 

  51. Spinola, S. M., Bauer, M. E., and Munson, R. S., Jr. (2002). Immunopathogenesis of Haemophilus ducreyi infection (chancroid), Infect. Immun. 70:1667–1676.

    Article  PubMed  CAS  Google Scholar 

  52. Spinola, S. M., Bong, C. T., Faber, A. L., Fortney, K. R., Bennett, S. L., Townsend, C. A., Zwickl, B. E., Billings, S. D., Humphreys, T. L., Bauer, M. E., and Katz, B. P. (2003). Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection, Infect. Immun. 71:6658–6663.

    Article  PubMed  CAS  Google Scholar 

  53. Spinola, S. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Mock, J. R., Vakevainen, M., and Hansen, E. J. (2003) Haemophilus ducreyi requires an intact flp gene cluster for virulence in humans, Infect. Immun. 71(12):7178–82.

    Article  PubMed  CAS  Google Scholar 

  54. Steen, R. (2001). Eradicating chancroid, Bull. World Health Organ. 79(9): 818–26.

    PubMed  CAS  Google Scholar 

  55. Sullivan, M. (1940). Chancroid, Am. J. Syph. Gonorrhea Vener. Dis. 24:482–521.

    Google Scholar 

  56. Thornton, A. C., O’Mara, E. M. Jr., Sorensen, S. J., Hiltke, T. J., Fortney, K., Katz, B., Shoup, R. E., Hood, A. F., and Spinola, S. M. (1998). Prevention of experimental Haemophilus ducreyi infection: a randomized, controlled clinical trial, J. Infect. Dis. 177:1606–1613.

    Article  Google Scholar 

  57. Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Slaughter, C. A., Hansen, E. J., and Spinola, S. M. (2000). Evaluation of an isogenic MOMP deficient mutant in the human model of Haemophilus ducreyi infection, Infect. Immun. 68:2602–7.

    Article  PubMed  CAS  Google Scholar 

  58. Totten, P. A., Kuypers, J. M., Chen, C. Y., Alfa, M. J., Parsons, L. M., Dutro, S. M., Morse, S. A., and Kiviat, N. B. (2000). Etiology of genital ulcer disease in Dakar, Senegal, and comparison of PCR and serologic assays for detection of Haemophilus ducreyi, J. Clin. Microbiol. 38:268–273.

    PubMed  CAS  Google Scholar 

  59. Trees, D. L. and Morse, S. A. (1995). Chancroid and Haemophilus ducreyi: An update, Clin. Microbiol. Rev. 8:357–375.

    PubMed  CAS  Google Scholar 

  60. Tyndall, M., Malisa, M., Plummer, F. A., Ombetti, J., Ndinya-Achola, J. O., and Ronald, A. R. (1993). Ceftriaxone no longer predictably cures chancroid in Kenya, J. Infect. Dis. 167:469–471.

    Article  PubMed  CAS  Google Scholar 

  61. Ussher, J. E., Wilson, E., Campanella, S., Taylor, S. L., and Roberts, S. A. (2007 May 15) Haemophilus ducreyi causing chronic skin ulceration in children visiting Samoa, Clin. Infect. Dis. 44(10):e85–7.

    Article  PubMed  Google Scholar 

  62. Young, R. S., Fortney, K., Haley, J. C., Hood, A. F., Campagnari, A. A., Wang, J., Bozue, J. A., Munson, R. S. Jr., and Spinola, S. M. (1999). Expression of sialylated or paragloboside-like lipooligosaccharides are not required for pustule formation by Haemophilus ducreyi in human volunteers, Infect. Immun. 67:6335–6340.

    PubMed  CAS  Google Scholar 

  63. Young, R. S., Filiatrault, M. J., Fortney, K. R, Hood, A. F., Katz, B. P., Munson, R. S. Jr., Campagnari, A. A., and Spinola, S. M. (2001). Haemophilus ducreyi lipooligosaccharide mutant defective in expression of beta-l,4-glucosyltransferase is virulent in humans, Infect. Immun. 69:4810–4814.

    Google Scholar 

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  2. Bong, C. T., Bauer, M. E., and Spinola, S. M. (2002) Haemophilus ducreyi: clinical features, epidemiology, and prospects for disease control, Microbes Infect. 4(11):1141–8.

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  3. Lewis, D. A. (2003). Chancroid: clinical manifestations, diagnosis, and management, Sex. Transm. Infect. 79(1):68–71.

    Article  PubMed  CAS  Google Scholar 

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    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Internal Medicine Services Division, Internal Medicine and Infectious Diseases, Dhahran Health Center, Saudi Aramco Medical Services Organization, Saudi Arameo, Dhahran, Saudi Arabia

    Jaffar A. Al-Tawfiq MD, FACP

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  1. Jaffar A. Al-Tawfiq MD, FACP
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Correspondence to Jaffar A. Al-Tawfiq MD, FACP .

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  1. Rollins School of Public Health, Emory University, Clifton Road NE., 1518, Atlanta, 30322, U.S.A.

    Philip S. Brachman

  2. College of Medicine, Office of Faculty Affairs, Drexel University, Race Street 1505, Philadelphia, 19102, U.S.A.

    Elias Abrutyn

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Al-Tawfiq, J.A. (2009). Chancroid. In: Brachman, P., Abrutyn, E. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09843-2_10

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