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Rodent Models of Diabetes

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Principles of Diabetes Mellitus

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Abstract

Animal models have been used extensively to study the pathophysiology of type 1 and type 2 diabetes. These models have been invaluable in the development of therapeutic agents to treat the diseases and associated complications. Rodents, primarily mice and rats, are the predominant animals used as models of diabetes. The use of these animals is relatively inexpensive and practical. The importance of mouse models has increased after the introduction of advanced methods for genetic manipulation, such as tissue-specific transgenic expression and targeted gene knockout.

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Authors and Affiliations

  1. Takeda San Diego, Inc., San Diego, CA, 92121, USA

    Ronald J. Christopher

  2. Pharmacology Research Laboratories, Takeda Pharmaceutical Company Limited, Osaka, Japan

    Koji Takeuchi Ph.D.

  3. Takeda San Diego, Inc., San Diego, CA, USA

    Bumsup Lee D.V.M., Ph.D.

Authors
  1. Ronald J. Christopher
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  2. Koji Takeuchi Ph.D.
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  3. Bumsup Lee D.V.M., Ph.D.
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Corresponding author

Correspondence to Ronald J. Christopher .

Editor information

Editors and Affiliations

  1. Div. Endocrinology & Metabolism, Beth Israel Medical Center, East 17th Street 317, New York, 10003, U.S.A.

    Leonid Poretsky

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Christopher, R.J., Takeuchi, K., Lee, B. (2010). Rodent Models of Diabetes. In: Poretsky, L. (eds) Principles of Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09841-8_11

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  • DOI: https://doi.org/10.1007/978-0-387-09841-8_11

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  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-0-387-09841-8

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