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Kinetic Proofreading Model

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Multichain Immune Recognition Receptor Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 640))

Abstract

Kinetic proofreading is an intrinsic property of the cell signaling process. It arises as a consequence of the multiple interactions that occur after a ligand triggers a receptor to initiate a signaling cascade and it ensures that false signals do not propagate to completion. In order for an aaive signaling complex to form after a ligand binds to a cell surface receptor, a sequence of binding and phosphorylation events must occur that are rapidly reversed if the ligand dissociates from the receptor. This gives rise to a mechanism by which cells can discriminate among ligands that bind to the same receptor but form ligand-receptor complexes with different lifetimes. We review experiments designed to test for kinetic proofreading and models that exhibit kinetic proofreading.

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Author information

Authors and Affiliations

  1. Theoretical Division, Los Alamos National Laboratory, Theoretical Biology and Biophysics Group, T-10 MSK710, Los Alamos, NM, 875435, USA

    Byron Goldstein, Daniel Coombs, James R. Faeder & William S. Hlavacek

Authors
  1. Byron Goldstein
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  2. Daniel Coombs
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  3. James R. Faeder
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  4. William S. Hlavacek
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Alexander B. Sigalov PhD

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© 2008 Landes Bioscience and Springer Science+Business Media

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Goldstein, B., Coombs, D., Faeder, J.R., Hlavacek, W.S. (2008). Kinetic Proofreading Model. In: Sigalov, A.B. (eds) Multichain Immune Recognition Receptor Signaling. Advances in Experimental Medicine and Biology, vol 640. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09789-3_8

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