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Constructing a Patient-Specific Model Heart from CT Data

  • D. M. McQueen
  • T. O’Donnell
  • B. E. Griffith
  • C. S. Peskin

Abstract

The goal of our work is to predict the patterns of blood flow in a model of the human heart using the Immersed Boundary method. In this method, fluid is moved by forces associated with the deformation of flexible boundaries which are immersed in, and interacting with, the fluid. In the present work the boundary is comprised of the muscular walls and valve leaflets of the heart. The method benefits by having an anatomically correct model of the heart. This report describes the construction of a model based on CT data from a particular individual, opening up the possibility of simulating interventions in an individual for clinical purposes.

Notes

Acknowledgements

The authors are grateful to Arthur E. Stillman, M.D., Ph.D., and Randolph M. Setser, D.Sc. of The Cleveland Clinic Foundation, Cleveland, Ohio for providing the CT images on which this work was based. We are also deeply grateful to “Mr. C.”, the patient whose heart was imaged.

We thank Nikos Paragios for organizing the collaboration between the Cleveland Clinic, Siemens Corporate Research and NYU that made possible the present work.

References

  1. 1.
    D. M. McQueen and C. S. Peskin. A three-dimensional computer model of the human heart for studying cardiac fluid dynamics. Computer Graphics, 34:56–60, 2000.CrossRefGoogle Scholar
  2. 2.
    D. M. McQueen and C. S. Peskin. Heart simulation by an immersed boundary method with formal second-order accuracy and reduced numerical viscosity. In H. Aref and J. Phillips, editors, Mechanics for a New Millennium, Proceedings of the International Conference on Theoretical and Applied Mechanics (ICTAM) 2000, pages 429–444. Kluwer Academic Publishers, 2001.Google Scholar
  3. 3.
    C. S. Peskin. Fiber-architecture of the left ventricular wall: an asymptotic analysis. Commun. Pure and Appl. Math., 42:79–113, 1989.CrossRefMATHMathSciNetGoogle Scholar
  4. 4.
    C. S. Peskin. The immersed boundary method. Acta Numerica, 11:479–517, 2002.CrossRefMATHMathSciNetGoogle Scholar
  5. 5.
    C. S. Peskin and D. M. McQueen. Mechanical equilibrium determines the fractal fiber architecture of the aortic heart valve leaflets. Am J. Physiol, 266:H319–H328, 1994.Google Scholar
  6. 6.
    D. D. Streeter, W. E. Powers, A. Ross, and F. Torrent-Guasp. Three-dimensional fiber orientation in the mammalian left ventricular wall. In J. Baan, A. Noordergraaf, and J. Raines, editors, Cardiovascular System Dynamics, pages 73–84. MIT Press, 1978.Google Scholar
  7. 7.
    D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick. Fiber orientation in the canine left ventricle during diastole and systole. Circ. Res., 24:339–347, 1969.CrossRefGoogle Scholar
  8. 8.
    C. E. Thomas. The muscular architecture of the ventricles of hog and dog hearts. Am. J. Anat., 101:17–57, 1957.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • D. M. McQueen
    • 1
    • 2
  • T. O’Donnell
    • 3
  • B. E. Griffith
    • 4
    • 5
  • C. S. Peskin
    • 5
  1. 1.Department of MathematicsUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.University of North CarolinaChapel HillUSA
  3. 3.Siemens Medical SolutionsMalvernUSA
  4. 4.Leon H. Charney Division of Cardiology, Department of MedicineNew York University School of MedicineNew YorkUSA
  5. 5.Courant Institute of Mathematical SciencesNew York UniversityNew YorkUSA

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