A Case Study in Model-driven Synthetic Biology
- Cite this paper as:
- Gilbert D., Heiner M., Rosser S., Fulton R., Gu X., Trybilo M. (2008) A Case Study in Model-driven Synthetic Biology. In: Hinchey M., Pagnoni A., Rammig F.J., Schmeck H. (eds) Biologically-Inspired Collaborative Computing. IFIP – The International Federation for Information Processing, vol 268. Springer, Boston, MA
We report on a case study in synthetic biology, demonstrating the model-driven design of a self-powering electrochemical biosensor. An essential result of the design process is a general template of a biosensor, which can be instantiated to be adapted to specific pollutants. This template represents a gene expression network extended by metabolic activity. We illustrate the model-based analysis of this template using qualitative, stochastic and continuous Petri nets and related analysis techniques, contributing to a reliable and robust design.