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The Biology of Echinostomes pp 185–206Cite as

Immunology and pathology of echinostome infections in the definitive host.

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Abstract

This chapter examines the salient literature on the immunology and pathology of members of the family Echinostomatidae in their definitive hosts, with emphasis on experimental studies that may provide useful information on factors that determine resistance to the parasites. For this purpose, several topics such as manifestations and mechanisms of resistance to infection, experimental strategies, and antigenic characterization of echinostomes are covered. Moreover, other topics such as immunodiagnosis are also analyzed. The analysis is focused on members of the genus Echinostoma. Although some of the nomenclature for echinostome species is disputed, the names used are those currently accepted.

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References

  • Agger, M.K., Simonsen, P.E., and Vennervald, B.J. 1993. The antibody response in serum, intestinal wall and intestinal lumen of NMRI mice infected with Echinostoma caproni. Journal of Helminthology 67: 169–178.

    Article  CAS  PubMed  Google Scholar 

  • Andresen, K., Simonsen, P.E., Andersen, B.J., and Birch-Andersen, A. 1989. Echinostoma caproni in mice, shedding of antigens from the surface of an intestinal trematode. International Journal for Parasitology 19: 111–118.

    Article  CAS  PubMed  Google Scholar 

  • Baek, J., Simonsen, P.E., Friis, H., and Christensen, N.Ø.. 1996Zinc deficiency and host response to helminth infection: Echinostoma caproni infections in CBA mice. Journal of Helminthology 70: 7–12.

    Article  CAS  PubMed  Google Scholar 

  • Balic, A., Bowles, V.M., and Meeusen, E.N. 2000. The immunobiology of gastrointestinal nematode infections in ruminants. Advances in Parasitology 45: 181–241.

    Article  CAS  PubMed  Google Scholar 

  • Balic, A., Cunningham. C.P., and Meeusen, E.N. 2006. Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tract. Parasite Immunology 28: 107–15.

    Article  CAS  PubMed  Google Scholar 

  • Bindseil, E., and Christensen, N.Ø. (1984). Thymus-independent crypt hyperplasia and villous atrophy in the small intestine of mice infected with the trematode Echinostoma revolutum. Parasitology 88: 431–438.

    Article  PubMed  Google Scholar 

  • Bischoff, S.C., and Krämer, S. 2007. Human mast cells, bacteria, and intestinal immunity. Immunological Reviews 217: 329–337.

    Article  CAS  PubMed  Google Scholar 

  • Brunet, L.R., Joseph, S., Dunne, D.W., and Fried, B. 2000. Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni. Parasitology 120: 565–571.

    Article  PubMed  Google Scholar 

  • Carpena, I., Espert A., Muñoz-Antoli, C., Marcilla, A., Esteban, J.G., and Toledo, R. 2007. Antigenic characterization of Echinostoma friedi (Trematoda) in hamsters and rats experimentally infected. Revista Ibérica de Parasitología 67: 127–124.

    Google Scholar 

  • Cho, Y.K., Ryang, Y.S., Kim, I.S., Park, S.K., Im, J.A., and Lee, K.J. 2007. Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN mice. Parasitology Research 100: 1053–1061.

    Article  PubMed  Google Scholar 

  • Christensen, N.Ø., Knudsen, J., Fagbemi, B.O., and Nansen, P. 1985. Impairment of primary expulsion of Echinostoma revolutum in mice concurrently infected with Schistosoma mansoni. Journal of Helminthology 59: 333–335.

    Article  CAS  PubMed  Google Scholar 

  • Christensen, N.Ø., Knudsen, J., and Andreassen, J. 1986. Echinostoma revolutum: resistance to secondary and superimposed infections in mice. Experimental Parasitology 61: 311–318.

    Article  CAS  PubMed  Google Scholar 

  • Else, K.J., and Finkelman, F.D. 1998. Intestinal nematode parasites, cytokines and effector mechanisms. International Journal for Parasitology 28: 1145–1158.

    Article  CAS  PubMed  Google Scholar 

  • Franco, J., Huffman, J.E., and Fried, B. 1986. Infectivity, growth and development of Echinostoma revolutum (Digenea: Echinostomatidae) in the golden hamster, Mesocricetus auratus. Journal of Parasitology 72: 142–147.

    Article  CAS  PubMed  Google Scholar 

  • Frazer, B.A., Fried, B., Fujino, T., and Sleckman, B.P. 1999. Host-parasite relationships between Echinostoma caproni and RAG-2-deficient mice. Parasitology Research 85: 337–342.

    Article  CAS  PubMed  Google Scholar 

  • Fried, B., and Peoples, R.C. 2007. Longevity of Echinostoma caproni in Balb/c mice. Journal of Helminthology 82: 95–96.

    PubMed  Google Scholar 

  • Fried, B., Huffman, J.E, and Weiss, P.M. 1990. Single and multiple worm infections of Echinostoma caproni (Trematoda) in the golden hamster. Journal of Helminthology 64: 75–78.

    Article  CAS  PubMed  Google Scholar 

  • Fried, B., Nanni, T.J., Reddy, A., and Fujino, T. 1997. Maintenance of the life cycle of Echinostoma trivolvis (Trematoda) in dexamethasone-treated ICR mice and laboratory-raised helisoma trivolvis (Gastropoda). Parasitology Research 83: 16–19.

    Article  CAS  PubMed  Google Scholar 

  • Fujino, T., and Fried, B. 1993a. Expulsion of Echinostoma trivolvis (Cort, 1914) Kanev, 1985 and retention of E. caproni Richard, 1964 (Trematoda, Echinostomatidae) in C3H mice: pathological, ultrastructural, and cytochemical effects on the host intestine. Parasitology Research 79: 286–292.

    Article  CAS  Google Scholar 

  • Fujino, T., and Fried, B. 1993b. Echinostoma caproni and E. trivolvis alter the binding of glycoconjugates in the intestinal mucosa of C3H mice as determined by lectin histochemistry. Journal of Helminthology 67: 179–188.

    Article  CAS  Google Scholar 

  • Fujino, T., and Fried, B. 1996. The expulsion of Echinostoma trivolvis from C3H mice: differences in glycoconjugates in mouse versus hamster small intestinal mucosa during infection. Journal of Helminthology 70: 115–121.

    Article  CAS  PubMed  Google Scholar 

  • Fujino, T., Fried, B., and Tada, I. 1993. The expulsion of Echinostoma trivolvis: worm kinetics and intestinal cytopathology in conventional and congenitally athymic BALB/c mice. Parasitology 106: 297–304.

    Article  PubMed  Google Scholar 

  • Fujino, T., Ichikawa, H., Fried, B., and Fukuda, K. 1996a. The expulsion of Echinostoma trivolvis: suppressive effects of dexamethasone on goblet cell hyperplasia and worm rejection in C3H/HeN mice. Parasite 3: 283–289.

    CAS  Google Scholar 

  • Fujino, T., Fried, B., Ichikawa, H., and Tada, I. 1996b. Rapid expulsion of the intestinal trematodes Echinostoma trivolvis and E. caproni from C3H mice by trapping with increased goblet cell mucins. International Journal for Parasitology26: 319–324.

    Article  CAS  Google Scholar 

  • Fujino, T., Yamada,M., Ichikawa, H., Fried, B., Arizono, N., and Tada, I. 1996c. Rapid expulsion of the intestinal trematodes Echinostoma trivolvis and E. caproni from C3H/HeN mice after infection with Nippostrongylus brasiliensis. Parasitology Research 82: 577–579.

    Article  CAS  Google Scholar 

  • Fujino, T., Ichikawa, H., Fried, B., and Fukuda, K. 1997. The expulsion of Echinostoma trivolvis: worm kinetics and intestinal reactions in C3H/HeN mice treated with dexamethasone. Journal of Helminthology 71: 257–259.

    Article  CAS  PubMed  Google Scholar 

  • Fujino T., Ichikawa H., and Fried, B. 1998a. The immunosuppressive compound FK506 does not affect expulsion of Echinostoma trivolvis in C3H mice. Parasitology Research 84: 519–521.

    Article  CAS  Google Scholar 

  • Fujino T., Ichikawa H, Fukuda, K., and Fried, B. 1998b. The expulsion of Echinostoma trivolvis caused by goblet cell hyperplasia in severe combined immunodeficient (SCID) mice. Parasite 5: 219–222.

    CAS  Google Scholar 

  • Graczyk, T.K., and Fried, B. 1994. ELISA method for detecting anti-Echinostoma caproni (Trematoda: Echinostomatidae) immunoglobulins in experimentally infected ICR mice. Journal of Parasitology 80: 544–549.

    Article  CAS  PubMed  Google Scholar 

  • Graczyk, T.K., and Fried, B. 1995. An enzyme-linked immunosorbent assay for detecting anti-Echinostoma trivolvis (Trematoda) IgG in experimentally infected ICR mice. Cross-reactivity with E. caproni. Parasitology Research81: 710–712.

    Article  CAS  PubMed  Google Scholar 

  • Hansen, K., Nielsen, J.W., Hindsbo, O., and Christensen, N.Ø. 1991. Echinostoma caproni in rats: worm population dynamics and host blood eosinophilia during primary infections with 6, 25 and 50 metacercariae and resistance to secondary and superimposed infections. Parasitology Research 77: 686–690.

    Article  CAS  PubMed  Google Scholar 

  • Hosier, D.W., and Fried, B. 1986. Infectivity, growth, and distribution of Echinostoma revolutum (Trematoda) in Swiss webster and ICR mouse. Proceedings of the Helminthological Society of Washington. 53: 173–176.

    Google Scholar 

  • Hosier, D.W., and Fried, B. 1991. Infectivity, growth, and distribution of Echinostoma caproni (Trematoda) in the ICR mouse. Journal of Parasitology 77: 640–642.

    Article  CAS  PubMed  Google Scholar 

  • Hosier, D.W., Fried, B., and Szewczak, J.P. (1988). Homologous and heterologous resistance of Echinostoma revolutum and E. liei in ICR mice. Journal of Parasitology 74: 89–92.

    Article  CAS  PubMed  Google Scholar 

  • Huffman, J.E., and Fried, B. 1990. Echinostoma and echinostomiasis. Advances in Parasitology 29: 215–269

    Article  CAS  PubMed  Google Scholar 

  • Huffman, J.E., Iglesias, D., and Fried, B. 1988. Echinostoma revolutum: pathology of extraintestinal infection in the golden hamster. International Journal for Parasitology 18: 873–874.

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa, N., Horii, Y., and Nawa, Y. 1993. Immune-mediated alteration of the terminal sugars of goblet cell mucins in the small intestine of Nippostrongylus brasiliensis-infected rats. Immunology 78: 303–307.

    CAS  PubMed  Google Scholar 

  • Ishikawa, N., Horii, Y., Oinuma, T., Suganuma, T., and Nawa Y. 1994. Goblet cell mucins as the selective barrier for the intestinal helminths: T-cell-independent alteration of goblet cell mucins by immunologically ‘damaged’ Nippostrongylus brasiliensis worms and its significance on the challenge infection with homologous and heterologous parasites. Immunology 81: 480–486.

    CAS  PubMed  Google Scholar 

  • Kim, I., Im, J.A., Lee, K.J., and Ryang, Y.S. 2000. Mucosal mast cell responses in the small intestine of rats infected with Echinostoma hortense. The Korean Journal of Parasitology 38: 139–143.

    Article  CAS  PubMed  Google Scholar 

  • Lamkhioued, B., Gounni, A.S., Gruart, V., Pierce, A., Capron, A., and Capron M. 1995. Human eosinophils express a receptor for secretory component. Role in secretory IgA-dependent activation. European Journal of Immunology 25: 117–125.

    Article  CAS  PubMed  Google Scholar 

  • Lantz, C.S., Boesiger, J., Song, C.H., Mach, N., Kobayashi, T., Mulligan, R.C., Nawa, Y., Dranoff, G., and Galli, S.J. 1998. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 392: 90–93.

    Article  CAS  PubMed  Google Scholar 

  • Lawrence, C.E. 2003. Is there a common mechanism of gastrointestinal nematode expulsion? Parasite Immunology 25: 271–281.

    Article  CAS  PubMed  Google Scholar 

  • Mabus, J., Huffman, J.E., and Fried, B. 1988. Humoral and cellular response to infection with Echinostoma revolutum in the golden hamster, Mesocricetus auratus. Journal of Helminthology. 62: 127–132.

    Article  CAS  PubMed  Google Scholar 

  • McKenzie, G.J., Bancroft, A., Grencis, R.K., and McKenzie. A.N. 1998. A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Current Biology 8: 339–342.

    Article  CAS  PubMed  Google Scholar 

  • McMaster, R.P., Huffman, J.E., Fried. B. 1995. The effect of dexamethasone on the course of Echinostoma caproni and E. trivolvis infections in the golden hamster (Mesocricetus auratus). Parasitology Research 81: 518–521.

    Article  CAS  PubMed  Google Scholar 

  • Muñoz-Antoli, C., Carpena, I., Espert, A., Esteban, J.G., and Toledo R. 2004. The effect of host species on the development of Echinostoma friedi (Trematoda: Echinostomatidae) adult worms. Revista Ibérica de Parasitología 64: 81–87.

    Google Scholar 

  • Muñoz-Antoli, C., Sotillo, J., Monteagudo, C., Fried, B., Marcilla, A., and Toledo, R. 2007. Development and pathology of Echinostoma caproni in experimentally infected mice. Journal of Parasitology 93: 854–859.

    Article  PubMed  Google Scholar 

  • Nawa, Y., Ishikawa, N., Tsuchiya, K., Horii, Y., Abe, T., Khan, A.I., Bing-Shi, Itoh, H., Ide, H., and Uchiyama, F. 1994. Selective effector mechanisms for the expulsion of intestinal helminths. Parasite Immunology 16: 333–338.

    Article  CAS  PubMed  Google Scholar 

  • Noland, G.S., Urban, J.F., Fried B., Kumar, N. 2008. Counter-regulatory anti parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice. Experimental Parasitology 119: 272–278.

    Article  CAS  PubMed  Google Scholar 

  • Odaibo, A.B., Christensen, N.Ø., and Ukoli, F.M.A. 1988. Establishment, survival and fecundity in Echinostoma caproni (Trematoda) infections in NMRI mice. Proceedings of the Helminthological Society of Washington 55: 265–269.

    Google Scholar 

  • Odaibo, A.B., Christensen, N.Ø., and Ukoli, F.M.A. 1989. Further studies on the population regulation in Echinostoma caproni infections in NMRI mice. Proceedings of the Helminthological Society of Washington 56: 192–198.

    Google Scholar 

  • Park, K.Y., Lee, K.J., Kim, I.S., Yang, E.J., Lim, S.J., Lim, B.H., and Ryang, Y.S. 2005. Reaction of mast cells and goblet cells in the small intestine of C57BL/6 and C3H/HeN mice infected with Echinostoma hortense. The Korean Journal of Biomedical Laboratory Sciences 11: 259–266.

    Google Scholar 

  • Ramsay, A.J. 1995. Genetic approaches to the study of cytokine regulation of mucosal immunity. Immunology and Cell Biology 73: 484–488.

    Article  CAS  PubMed  Google Scholar 

  • Ryang, Y.S., Yang, E.J., Kim, J.L., Lee, K.J., Sung, H.J., Kim, J.B., and Kim, I.S. 2007. Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense. Parasitology Research 101: 1103–1110.

    Article  PubMed  Google Scholar 

  • Sayed, B.A., and Brown, M.A. 2007. Mast cells as modulators of T-cell responses. Immunological Reviews 217: 53–64.

    Article  CAS  PubMed  Google Scholar 

  • Simonsen, P.E., and Andersen, B.J. 1986. Echinostoma revolutum in mice; dynamics of the antibody attack to the surface of an intestinal trematode. International Journal for Parasitology 16: 475–482.

    Article  CAS  PubMed  Google Scholar 

  • Simonsen, P.E., Vennervald, B.J., and Birch-Andersen, A. 1990. Echinostoma caproni in mice: ultrastructural studies on the formation of immune complexes on the surface of an intestinal trematode. International Journal for Parasitology 20: 935–491.

    Article  CAS  PubMed  Google Scholar 

  • Simonsen, P.E., Estambale, B.B., and Agger, M. 1991. Antibodies in the serum of golden hamsters experimentally infected with the intestinal trematode Echinostoma caproni. Journal of Helminthology 65: 239–247.

    Article  CAS  PubMed  Google Scholar 

  • Sirag, S.B., Christensen, N.Ø., Frandsen, F., Monrad. J., and Nansen, P. 1980. Homologous and heterologous resistance in Echinostoma revolutum infections in mice. Parasitology 80: 479–486.

    Article  CAS  PubMed  Google Scholar 

  • Snapper, C.M., McIntyre, T.M., Mandler, R., Pecanha, L.M.T., Finkelman, F.D., and Mond, J.J. 1992. Induction of IgG3 secretion by interferon-γ: a model for T cell-independent class switching in response to T cell-independent Type 2 antigens. Journal of Experimental Medicine 175: 1367–1371.

    Article  CAS  PubMed  Google Scholar 

  • Sotillo, J., Munoz-Antoli, C., Marcilla, A., Fried, B., Esteban, J.G. and Toledo, R. 2007. Echinostoma caproni: Kinetics of IgM, IgA and IgG subclasses in the serum and intestine of experimentally infected rats and mice. Experimental Parasitology 116: 390–398.

    Article  CAS  PubMed  Google Scholar 

  • Sotillo, J., Valero, L., Sánchez del Pino, M.M., Fried, B., Esteban, J.G., Marcilla, A., and Toledo, R. 2008. Identification of antigenic proteins from Echinostoma caproni (Trematoda: Echinostomatidae) recognized by mouse immunoglobulins M, A and G using an immunoproteomic approach. Parasite Immunology 30: 271–279.

    Article  CAS  PubMed  Google Scholar 

  • Specian, R.D., and Oliver, M.G. 1991. Functional biology of intestinal goblet cells. American Journal of Physiology 260: C183–C193.

    CAS  PubMed  Google Scholar 

  • Tani, S., and Yoshimura K. 1988. Spontaneous expulsion of Echinostoma hortense Asada, 1926 (Trematoda: Echinostomatidae) in mice. Parasitology Research 74: 495–497.

    Article  CAS  PubMed  Google Scholar 

  • Toledo, R., and Fried, B. 2005. Echinostomes as experimental models in adult parasite-vertebrate host interactions. Trends in Parasitology 21: 251–254.

    Article  PubMed  Google Scholar 

  • Toledo, R., Espert, A., Carpena, I., Muñoz-Antoli, C., and Esteban, J.G. 2003a. An experimental study of the reproductive success of Echinostoma friedi (Trematoda: Echinostomatidae) in the golden hamster. Parasitology 126: 433–441.

    Article  CAS  Google Scholar 

  • Toledo, R., Espert, A., Muñoz-Antoli, C., Marcilla, A., Fried, B., and Esteban, J.G. 2003b. Development of an antibody-based capture enzyme-linked immunosorbent assay for detecting Echinostoma caproni (Trematoda) in experimentally infected rats: kinetics of coproantigen excretion. Journal of Parasitology 89: 1227–1231.

    Article  Google Scholar 

  • Toledo, R., Espert, A., Carpena, I., Muñoz-Antoli, C., Fried, B and Esteban, J.G. 2004a. The comparative development of Echinostoma caproni (Trematoda: Echinostomatidae) adults in experimentally infected hamsters and rats. Parasitology Research 93: 439–444.

    Article  Google Scholar 

  • Toledo, R., Espert, A., Muñoz-Antoli, C., Marcilla, A., Fried, B., and Esteban, J.G.. 2004b. Kinetics of Echinostoma caproni (Trematoda: Echinostomatidae) antigens in feces and serum of experimentally infected hamsters and rats. Journal of Parasitology 90: 752–758.

    Article  Google Scholar 

  • Toledo, R., Espert, A., Muñoz-Antoli, C., Fried, B., and Esteban, J.G. 2004c. Immunological characterization of somatic and excretory/secretory antigens of Echinostoma caproni (Trematoda: Echinostomatidae) in experimentally infected rats. Comparative Parasitology 71: 42–48.

    Article  Google Scholar 

  • Toledo, R., Espert, A., Muñoz-Antoli, C., Marcilla, A., Fried, B., and Esteban, J.G. 2005. Kinetics of antibodies and antigens in serum of mice experimentally infected with Echinostoma caproni (Trematoda: Echinostomatidae). Journal of Parasitology 91: 978–980.

    Article  CAS  PubMed  Google Scholar 

  • Toledo, R., Carpena, I., Espert, A., Sotillo, J., Muñoz-Antoli, C., and Esteban JG. 2006a. A quantitative approach to the experimental transmission success of Echinostoma friedi (Trematoda: Echinostomatidae) in rats. Journal of Parasitology 92: 16–20.

    Article  Google Scholar 

  • Toledo, R., Monteagudo, C., Espert, A., Fried, B., Esteban J.G., and Marcilla, A. 2006b. Echinostoma caproni: intestinal pathology in the golden hamster, a highly compatible host, and the Wistar rat, a less compatible host. Experimental Parasitology 112: 164–171.

    Article  CAS  Google Scholar 

  • Toledo, R., Esteban, J.G., and Fried, B. 2006c. Immunology and pathology of intestinal trematodes in their definitive hosts. Advances in Parasitology 63: 285–365.

    Article  Google Scholar 

  • Weinstein, M.S., and Fried, B. 1991. The expulsion of Echinostoma trivolvis and retention of Echinostoma caproni in the ICR mouse: pathological effects. International Journal for Parasitology 21: 255–257.

    Article  CAS  PubMed  Google Scholar 

  • Weller, P.F. 1997. Human eosinophils. Journal of Allergy and Clinical Immunology 100: 283–287.

    Article  CAS  PubMed  Google Scholar 

  • Yoshimoto, T., and Nakanishi, K. 2006. Roles of IL-18 in basophils and mast cells. Allergology International 55: 105–13.

    Article  CAS  PubMed  Google Scholar 

  • Yu, L.C., and Perdue, M.H. 2001. Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress. Immunological Reviews 179: 61–73.

    Article  CAS  PubMed  Google Scholar 

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  1. Departamento de Biología Celular y Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andrés Estellés s/n, 46100, Burjassot-Valencia, Spain

    Rafael Toledo

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    Toledo, R. (2009). Immunology and pathology of echinostome infections in the definitive host.. In: Toledo, R., Fried, B. (eds) The Biology of Echinostomes. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09577-6_8

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