Infant Morbidity

  • Melisa M. AdamsEmail author

While epidemiologic research occasionally results in identification of novel associations between exposures and disease, more often it is the astute clinician who makes the initial observations that begin the process. Such was the case in the late 1950s, when a German pediatrician, Dr. Widikund Lenz, began to observe a very unusual pattern of birth defects involving phocomelia. Fetuses affected by this extremely rare condition have limb reduction defects including the absence of hands and/or feet, together with other abnormalities. Dr. Lenz queried colleagues, and compiled a case series with more than 50 cases by late 1961. The common exposure was the use of a new anti-nausea medication, thalidomide. Additional studies demonstrated the power teratogenic effect of this drug, and the timing of fetal development during which its effects were most pronounced. Thalidomide was removed for the market for several decades, but is now prescribed for patients suffering terminal illness.

Rajkumar (


Neonatal Intensive Care Unit Birth Certificate Congenital Toxoplasmosis Congenital Rubella Syndrome Congenital Syphilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



bronchopulmonary dysplasia


Centers for Disease Control and Prevention




congenital rubella syndrome


Children with Special Health Care Needs




Group B Streptococcus


intrauterine growth restriction


intraventricular hemorrhage


necrotizing enterocolitis




periventricular leukomalacia


retinopathy of prematurity


retrosynctial virus


small-for-gestational age


neonatal intensive care unit


Special Supplemental Food Program for Women, Infants and Children


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.AtlantaUSA

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