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Reviews in Fluorescence 2004 pp 1–19Cite as

Arenedicarboximides as Versatile Building Blocks for Fluorescent Photoinduced Electron Transfer Saccharide Sensors

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Part of the book series: Reviews in Fluorescence 2004 ((RFLU,volume 2004))

Abstract

Within the last decade a considerable amount of effort has been directed towards the detection of saccharides by fluorescent chemosensors.1–3 Such studies have shown that the response which signals an interaction between carbohydrate and receptor is frequently communicated by changes in fluorescence intensity either through chelation enhanced-quenching (CHEQ) or chelation-enhanced fluorescence (CHEF).4,5 While significant advances continue in the areas of chemosensors for saccharides, invariably, one or more of the requisite conditions necessary for biologists to measure these analytes goes unmet. For carbohydrate measurements, conditions such as neutral pH as well as selectivity in an aqueous testing environment are essential. In addition to these physiological requirements, for effective photoinduced electron transfer (PET), the signaling properties of the chemosensor must also meet certain criteria. Three critical prerequisites of the fluorescent sensor that must be satisfied for carbohydrate recognition have been outlined by Shinkai: strong fluorescence intensity, large pH dependent change in I max, and shift of the pH-I max profile to lower pH region in the presence of saccharides.6

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Author information

Authors and Affiliations

  1. Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico, USA, 87801, Jones Hall Rm 259

    Michael D. Heagy

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  1. Michael D. Heagy
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Editors and Affiliations

  1. Institute of Fluorescence, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA

    Chris D. Geddes

  2. Center for Fluorescence Spectroscopy, University of Maryland, Baltimore, Maryland, USA

    Joseph R. Lakowicz

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Heagy, M.D. (2004). Arenedicarboximides as Versatile Building Blocks for Fluorescent Photoinduced Electron Transfer Saccharide Sensors. In: Geddes, C.D., Lakowicz, J.R. (eds) Reviews in Fluorescence 2004. Reviews in Fluorescence 2004, vol 2004. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-48672-2_1

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  • DOI: https://doi.org/10.1007/978-0-306-48672-2_1

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