Biomaterials pp 113-122 | Cite as
Degradable Phosphazene Polymers and Blends for Biomedical Applications
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Abstract
In the biomaterials science, bioresorbable polymeric materials are of great importance in the case of short-term applications that need a temporary presence of implant. It has been known for many years that polymer scaf-folds are useful materials for initial cell attachment and subsequent tissue formation both in vitro and in vivo. A number of requirements should be met for a proper use of polymer scaffolds, such as biodegradability with a con-trollable degradation rate, structure, porosity and surface properties to allow cells to be seeded for a successful growth and differentiation. Mechanical properties comparable to those of the natural extracellular matrices are also desirable.
Keywords
Mass Loss Glycolic Acid Ring Opening Polymerization Polymer Scaffold Amino Acid EsterPreview
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References
- 1.Thomson, C., Wake, M.C., Yaszemski, M.J., and Mikos, A.G., 1995, Biodegradable polymer scaffolds to regenerate organs. Adv. Polym. Sci. 122: 245–274.CrossRefGoogle Scholar
- 2.Kim, B.-S., and Mooney, D.J., 1998, Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol. 16: 224–230.CrossRefGoogle Scholar
- 3.Fambri, L., Migliaresi, C., Kesenci, K., Piskin, E., 2002, Biodegradabile Polymers. In Integrated Biomaterials Science (R. Barbucci, ed.), Kluwer Plenum, New York, pp. 119–187.CrossRefGoogle Scholar
- 4.Allcock, H.R., Fuller, T.J., Mack, D.P., Matsumura, K., and Smeltz, K.M., 1977, Synthesis of poly[(amino acid alkyl ester)phosphazenes]. Macromolecules 10: 824–830.CrossRefGoogle Scholar
- 5.Laurencin, C.T., Norman, M.E., Elgendy, H.M., El-Amin, S.F., Allcock, H.R., Pucher, S.R., and Ambrosio, A.A., 1993, Use of polyphosphazenes for skeletal tissue regeneration. J. Biomed. Mater. Res. 27: 963–973.CrossRefGoogle Scholar
- 6.Neilson, R.H., and Wisian-Neilson, P., 1988, Poly(alkyl/arylphosphazenes) and their pre-cursors. Chem. Rev. 88: 541–562.CrossRefGoogle Scholar
- 7.Sulkowski, W.W., 2003, Some Aspects of Synthesis and Investigation of Poly(diorganophosphazene)s. In Phosphazenes — A Worldwide Insight (M. Gleria and R. DeJaeger, eds.), Nova Science, New York, pp. 69–106.Google Scholar
- 8.Lakshmi, S., Katti, D.S., Laurencin, C.T., 2003, Biodegradable polyphosphazenes for drug delivery applications. Adv. Drug Deliv. Rev. 55: 467–482.CrossRefGoogle Scholar
- 9.Crommen, J., Vandorpe, J., and Schacht, E., 1993, Degradable polyphosphazenes for bio-medical applications. J. Controlled Release 24: 167–180.CrossRefGoogle Scholar
- 10.Crommen, J.H.L., Schacht, E.H., and Mense, E.H.G.,1992, Biodegradable polymers. I. Synthesis of hydrolysis-sensitive poly[(organo)phosphazenes]. Biomaterials 13: 511–520.CrossRefGoogle Scholar
- 11.Ibim, S.E.M., Ambrosio, A.M.A., Kwon, M.S., El-Amin, S.F., Allcock, H.R., and Laurencin, C.T., 1997, Novel polyphosphazene/poly(lactide-co-glycolide) blends: miscibility and degradation studies. Biomaterials 18: 1565–1569.Google Scholar
- 12.Ambrosio, A.M.A., Allcock, H.R., Katti, D.S., and Laurencin, C.T., 2002, Degradable polyphosphazene/poly(a-hydroxyester) blends: degradation studies. Biomaterials 23: 1667–1672.CrossRefGoogle Scholar
- 13.Qiu, L. Y., and Zhu, K.J., 2000, Novel blends of poly[bis(glycine ethyl ester)phosphazene] and polyesters or polyanhydrides: compatibility and degradation characteristics in vitro. Polym. Int. 49: 1283–1288.CrossRefGoogle Scholar