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AIDS in Asia pp 317-333 | Cite as

Transmission of HIV and Other Infections in Southeast Asia

Cultural and Genetic Factors
  • Chris Beyrer
  • Henry Stephens

Abstract

Southeast (SE) Asia is second only to Sub-Saharan Africa as the world’s most heavily HIV/AIDS affected region in terms of number of infections (UNAIDS, 2002). While epidemic spread of HIV-1 began relatively late in the region, largely in the 1988-1990 period, the virus has spread widely and rapidly, and affected many millions in this densely populated, ethnically variable and politically diverse region. SE Asia includes some of the world’s wealthier states (Singapore and Brunei), emerging economies (China, Thailand and Vietnam) and some of the poorest and most isolated nations (Burma and Laos). Its political spectrum spans emerging democracies, military dictatorships, Islamic Republics and three of the last five nominally communist states worldwide (China, Laos, and Vietnam). Also located in SE Asia are two of the world’s leading heroin exporters, Burma and Laos (Beyrer, et al., 2000). The ethnic and linguistic diversity of the region is extremely complex, as are the range of climates and ecologies—from rain forests and sparsely peopled mountains to overcrowded metropolises, with their associated socio-economic deprivations, poor housing and contaminated water supplies.

Keywords

Human Leukocyte Antigen Dengue Virus Human Leukocyte Antigen Class Dengue Hemorrhagic Fever Inject Drug User 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aguado, B., Bahram, S., Beck, S., Campbell, R.D., Forbes, S.A., Geraghty, D., Guillaudeux, T., Hood, L., Horton, R., Inoko, H., Janer, M., Jasoni, C., Madan, A., Milne, S., Neville, M., Oka, A., Qin, S., Ribas-Despuig, G., Rogers, J., Rowen, L., Shiina, T., Spies, T., Tamiya, G., Tashiro, H., Trowsdale, J., Vu, Q., Williams, L., and Yamazaki, M. (1999). Complete sequence and gene map of a human major histocompatibility complex. Nature 401: 921–923.CrossRefGoogle Scholar
  2. Artenstein, A.W., Hegerich, P.A., Beyrer, C., Rungruengthanakit, K., Michael, N.L., and Natrapan, C. (1996). Sequences and phylogenetic analysis of the nef gene from Thai subjects harboring subtype E HIV-1. AIDS Res Hum Retroviruses 12: 557–560.CrossRefGoogle Scholar
  3. Beasley, R.P., Hwang, L.-Y., Lin, C.-C., and Chien, C.-S. (1981). Hepatocellular carcinoma and hepatitis B vim s: A prospective study of 22,707 men in Taiwan. Lancet 2: 1129–1133.PubMedCrossRefGoogle Scholar
  4. Beyrer, C. (1998). War in the Blood: Sex, Politics, and AIDS in Southeast Asia. Zed Books, London. (Second Edition, 2000. Thai Language Edition, “Songkram Nai Luat, Chulalongkom University Press, Bangkok, 2002).)Google Scholar
  5. Beyrer, C., Artenstein, A., Rungpao, S., Stephens, H., VanCott, T., Robb, M., Rinkaew, M., Birx, D., Khamboonruang, C., Zimmerman, P., Nelson, K.E., and Natpratan, C. (1999). Epidemiologic and biologic characterization of a cohort of HIV-1 highly exposed, persistently seronegative commercial sex workers in Northern Thailand. JID 179: 59–67.PubMedCrossRefGoogle Scholar
  6. Beyrer, C., Razak, MH., Lisam, K., Wei, L., Chen, J., and Yu, X.F. (2000). Overland heroin trafficking routes and HIV spread in South and SE Asia. AIDS 14: 1–9.CrossRefGoogle Scholar
  7. Beyrer, C., Juttiwutikarn, J., Teokul, W., Razak, M.H., Suriyanon, V., Srirak, N., Pripaipan, T., Vonchuk, T., Tovanabutra, S., Sripaipan, T., and Celentano, D.D. (2003a). Drug use, increasing incarceration rates, and prison associated HIV risks in Thailand. AIDS & Behavior 2 (7): 153–161.CrossRefGoogle Scholar
  8. Beyrer, C., Razak, M.H., Labrique, A., and Brookmeyer, R. (2003b). Assessing the magnitude of the HIV/AIDS epidemic in Burma. J AIDS 32: 311–317.Google Scholar
  9. Buson, M., Vu Trieu, A., Labelle, P., Phan-Van, K., HoQuang, H., Bouteiller, A.M., Bieux, H., Charron, D., and Hors, J. (2002). HLA-DRB 1 and DQB1 allele distribution in the Muong population exposed to malaria in Vietnam. Tissue Antigens 59: 470474.Google Scholar
  10. Carrington, M. and Norman, P. (2003). The KIR gene Cluster. led. National Library of Medicine, National Center for Biotechnology Information, Vol. 2003.Google Scholar
  11. Carrington, M., Nelson, G.W., Martin, M.P., Kissner, T., Vlahov, D., Goedert, J.J., Kaslow, R., Buchbinder, S., Hoots, K., and O’Brien, S.J. (1999). HLA and HIV-1: Heterozgote advantage and B*35-Cw*04 disadvantage. Science 283: 1748–1752.PubMedCrossRefGoogle Scholar
  12. Cavalli-Sforza, L.L. (2000). Genes, Peoples, and Languages. North Point Press, New York.Google Scholar
  13. Cavalli-Sforza, L.L., Piazza, A., Menozzi, M., and Mountain, J. (1988). Reconstruction of human evolution: Bringing together genetic, archeological, and linguistic data. Proc Natl Acad Sci. USA 85: 60026006.Google Scholar
  14. Chandanayingyong, D., Stephens, H.A.F., Fan. L.A., Sirkong, M., Longta, P., Vangseratthana, R., Lekmak, S., Longta, K., Bejrachandra, S., and Rungruang, E. (1994). HLA-DP polymorphism in the Thais of Southeast Asia. Hum Immunol. 40: 20–24.PubMedCrossRefGoogle Scholar
  15. Chandanayingyong, D., Stephens, H.A.F., Klaythong, R., Sirkong, M., Udee, S., Longta, P., Chantangpol, R., Bejrachandra, S., and Runruang, E. (1997). HLAA, -B, -DRB1, -DQA1 and DQB 1 polymorphism in Thais. Hum Immunol. 53: 174–182.PubMedCrossRefGoogle Scholar
  16. Chareonviriyaphap, T., Bangs, M.J., and Ratanatham, S. (2001). Status of malaria in Thailand. Southeast Asian J. Trop. Med. & Public Health 31: 225–235.Google Scholar
  17. Chariyalertsak, S., Sirisanthana, T., Saengwonloey, O., and Nelson, K.E. (2001). Clinical presentation and risk behaviors of AIDS patients in Thailand, 19941998: Regional variation and temporal trends. Clinical Infect Dis. 32 (6): 955–962.CrossRefGoogle Scholar
  18. Chazee’, L. (1999). The Peoples of Laos: Rural and Ethnic Diversities. White Lotus Press, Bangkok. Choopanya, K., Vanichseni, S., Des Jarlais, D.J., Plangsringgarm, K., Sonchai, W., Carballo, M., 331 Friedmann, P., and Friedman, S.R. (1991). Risk factors and HIV seropositivity among injecting drug users in Bangkok. AIDS 5: 1509–1513.Google Scholar
  19. Choopanya, K., Des Jarlais, D.C., Vanichseni, S., Kitayaporn, D., Mock, P.A., Raktham, S., Hireanras, K., Heyward, W.L., Sujarita, S., and Mastro, T.D. (2002). Incarceration and risk for HIV infection among injection drug users in Bangkok. JAIDS 29: 86–94.PubMedGoogle Scholar
  20. Chu J.Y., Huang W, Kuang S.Q, (et al)?. (1998). Genetic relationship of populations in China. Proc NatlAcad Sci. 95: 11763–11768.Google Scholar
  21. Coedes, G. (1975). The Indianized States of Southeast Asia. University of Hawaii Press, Honolulu. Cohen, J. (2003). AIDS In Asia. Science 301 (5640): 1613–1796.Google Scholar
  22. Collins, K. L., Chen, B.K., Kalams, S.A., Walker, B.D., and Baltimore, D. (1998). HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391: 397–401.PubMedCrossRefGoogle Scholar
  23. Coullin, I., Culmann-Penciolelli, B., Gomard, E., Chop-pin, J., Levy, J.-P., Guillet, J.-G., and Saragosti, S. (1994). Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein. J Exp Med. 180: 1129–1134.CrossRefGoogle Scholar
  24. Crofts, N., Reid, G., and Deany, P. (1998). Injecting drug use and HIV infection in Asia. The Asian Harm Reduction Network. AIDS 12 Suppl B: S69–78.Google Scholar
  25. Darakul, T., Vejbaeysa, S., Chaowagul, W., Luangtrakool, P., Stephens, H.A. E, and Sirirurg, S. (1998). HLADR and DQ associations with Meliodosis. Hum Immunol. 59: 580–586.CrossRefGoogle Scholar
  26. Des Jarlais, D.C., and Friedman, S.R. (1998). Fifteen years of research on preventing HIV infection among injecting drug users: What we have learned, what we have not learned, what we have done, what we have not done. Public Health Rep. 113 Suppl 1: 182–188.Google Scholar
  27. De Souza, M.S., Karnasuta, C., Brown A.E., Markowitz, L.E., Nitayaphan, S., Garner, R.P., McNeil, J.G., Birx, D.L., and Cox, J.H. (2000). A comparative study of the impact of HIV infection on natural killer cell number and function in Thais and North Americans AIDS Res Hum Retroviruses 16: 1061–1066.PubMedCrossRefGoogle Scholar
  28. Dunstan, S.J., Stephens, H.A.F., Blackwell J.M., Duc, C.M., Lanh, M. N., Dudbridge, E, Phuong, C.X.T., Luxemberger, C., Wain, J., Ho V.A., Hien, T.T., Farrar, J., and Dougan, G. (2001). Genes of the Class II and Class III Major Histocompatibility Complex are associated with typhoid fever in Vietnam. J. Inf. Dis. 183: 261–268.CrossRefGoogle Scholar
  29. Flores-Villanueva, P.O., Hendel, H., Caillat-Zucman, S., Rappaport, J., Burgos-Tiburcio, A., Bertin-Maghit, S., Ruiz-Morales, J.A., Teran, M.E., Rodriguez-Google Scholar
  30. Tafur, J., and Zagury, J.-F. (2003). Associations of MHC ancestral haplotypes with resistance/susceptibility to AIDS disease development. J Immunol. 170: 1925–1929.Google Scholar
  31. Gao, F., Balles, E., Robertson, D.L., ChenY., Rodenburg, C.M., Michael, S., Cummins, L.B., Arthur, L.O., Peeters, M., Shaw, G.M., Sharp, P.M., and Hahn, B. (1999). Origin of HIV-1 in the chimpanzee Pan trogolodytes trogolodytes. Nature 397: 436–441.CrossRefGoogle Scholar
  32. Gao, X., and Serjeantson, S.W. (1991). Heterogeneity of HLA-DR2-related DR, DQ haplotypes in eight populations of Asia-Oceania. Immunogenetics 34: 40 1407.Google Scholar
  33. Gao, X., Nelson, G.W., Karacki, P., Martin, M., P., Phair, J., Kaslow, R., Goedert, J.J., Buchbinder, S., HootsGoogle Scholar
  34. K., Vlahov, D., O’Brien, S.J., and Carrington, M. (2001). Effect of a single amino acid change in MHC class I molecules on the rate of progession of AIDS N Engl J Med. 344: 1668–1675.CrossRefGoogle Scholar
  35. Gavioli, R., Mang, Q-J., and Masucci, M.G. (1996). FILA-A 1 1-mediated protection from NK cell-mediated lysis. Role of HLA-A11-presented peptides. Hum Immunol 49: 1–12.PubMedCrossRefGoogle Scholar
  36. Goldfield, A.E., Delgado, J.C., Thim, S., Bozon, M.V., Uglialoro, A.M., Turbay, D., Cohen, C., and Yunis, E.J. (1998). Association of an HLA-DQ allele with clinical tuberculosis. JA MA. 279: 226–228.Google Scholar
  37. Hendel, H., Caillat-Zucman, S., Lebuanec, H., Carrington, M., O’Brien, S., Andrieu, J.M., Schachter, F., Zagury, D., Rappaport, J., Winkler, C., Nelson, G.W., and Zagury, J.-F. (1999). New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. Jlmmunol. 162: 69426946.Google Scholar
  38. Hirayama, K., Zaidi, A.S., Lokman Hakim, S., Kimura, A., Ong, K.J., Kikuchi, M., Nasuruddin, H.A., Kojima, S., and Mak, J.W. (1996). Molecular analysis of HLA-B in Malaysian aborigines. Tissue Antigens 48: 692–697.PubMedCrossRefGoogle Scholar
  39. Kato, K., Shiino, T., and Kusagawa, S. (1999). Genetic similarity of HIV-1 subtype E in a recent outbreak among injecting drug users in Northern Vietnam to strains in Guangxi Province of Southern China. AIDS Res & Hum Retroviruses 15 (13): 1157–1168.Google Scholar
  40. Khomenko, A.G., Litvinov, V.I., Chukanova, VP, and Pospelov, L.E. (1990). Tuberculosis in patients with various HLA phenotypes. Tubercle 71:187–192.Google Scholar
  41. Kidson, C., Singhasivanon, P., Supavey, S. (eds.). (1999). Mekong Malaria. Malaria, multi-drug resistance and economic development in the Greater Mekong subregion of Southeast Asia. SE Asian J Trop Med Public Health, 30 (Suppl.).Google Scholar
  42. Korber, B., Brander, B., Moore, J., D’Souza, P., Walker, B., Koup, R., Haynes, B., and Myers, G. (eds.). (1996). HIV Molecular Immunology Database 1996. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico. LA-UR 97–1150.Google Scholar
  43. Korber, B.T.M., Brander, B., Haynes, B.F., Koup, R., Kuiken, C., Moore, J.P., Walker, B.D., and Watkins, D.I. (eds.). (2002). HIV Molecular Immunology 2002. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico. LA-UR 03–5816.Google Scholar
  44. Langlade-Demoyen, P., Ngo-Giang-Huong, N., Ferchal., F., and Oksenhendler, E. (1994). Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J Clin Invest. 93: 1293 1297.Google Scholar
  45. Lawlor, D., Ward, F., Ennis, P., Jackson, A., and Parham, P. (1988). HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. Nature 335: 268–271.PubMedCrossRefGoogle Scholar
  46. Li, L., Promadej, N., McNicholl, J.M., and Bouvier, J. (2002). Crystallization and preliminary X-ray crystallographic studies of HLA-A*1101 complexed with an HIV-1 decapeptide. Acta Cryst. D58: 1195 1197.Google Scholar
  47. Lintner, B. (1994). Burma in Revolt: Opium and Insur- gency since 1948. Westview Press, Boulder, CO.Google Scholar
  48. MacDonald, K.S., Fowke, K.R., Kimani, J., Dunand, V.A., Nagelkerte, N.J. D., BalI.T., B., Oyugi, J., Njagi, E., Gaur, L.K., Brunham, R.C., Wade, J., Luscher, M.A., Kraus, P., Rowland-Jones, S., Ngugi, E., Bwayo, J.J., and Plummer, F.A. (2000). Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. J Inf Dis. 181: 1581–1589.CrossRefGoogle Scholar
  49. Marsh, S.G.E., Parham, P., Dupont, B., Geraghty, D.E., Trowsdale, J., Middleton, D., Vilches, C., Carrington, M., Witt, C., Guethlein, L.A., Shilling, H., Garcia, C.A., Hsu, K.C., and Wain, H. (2003). Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Tissue Antigens 62: 79–86.PubMedCrossRefGoogle Scholar
  50. Martin, M.P., Gao, X., Lee, J-H, Nelson G.W., De-tels, R., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Trowsdale, J., Wilson, M., O’Brien, S.J., and Carrington, M. (2002). Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nature Genetics 31: 429–434.PubMedGoogle Scholar
  51. McCutchan, F.E., Carr, J.K., Murphy, D., Piyasirisilp, S., Gao, F., Hahn, B., Yu, X.F., Beyrer, C., and Birx, D.L. (2002). Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. AIDS Res Hum Retroviruses. 18(15):113540.Google Scholar
  52. Middleton, D., Curran, M., and Maxwell, L. (2002). Natural killer cells and their receptors. Transplant Immunology 10: 147–164.PubMedCrossRefGoogle Scholar
  53. Mongkolsapaya, J., Dejinirattisai, W., Xu, X., Vasanawathana, S., Tangthawornchaikul, N.Google Scholar
  54. Chairunsri, A., Sawasdivom, S., Duangchinda, T., Dong, T., Rowland-Jones, S., Yenchitsomanus, P., McMichael, A., Malasit, P., and Screaton, G. (2003). Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nature Medicine 9: 921–927.PubMedCrossRefGoogle Scholar
  55. Moore, C.B., John, M., James, I.R., Christiansen, F.T. Witt, C., and Mallal, S.A. (2002). Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296: 1439–1443.Google Scholar
  56. Nelson, K.E., and Thomas, D.L. (2001). Viral Hepatitis: In Nelson, Williams, and Graham. Infectious Disease Epidemiology. Aspen Publishers, Gaithersberg, pp. 582–588.Google Scholar
  57. Nihei, N., Hashida, Y., Kobayashi, M., and Ishii, A. (2002). Analysis of malaria endemic areas on the Indochinese Peninsula using remote sensing. Jpn J Infect Dis. 55: 160–166.PubMedGoogle Scholar
  58. Norman, P.J., Stephens, H.A.F., Verity, D.H., Chandanayingyong, D., and Vaughan R.W. (2001). Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups. Immunogenetics 52: 195–205.PubMedCrossRefGoogle Scholar
  59. Norman, P.J. Carrington, C.V.F., Byng, M., Curran, M.D., Stephens, H.A. F., Chandanayingyong, D., Verity, D.H., Hameed, K., Ramdath, D.D. and Vaughan, R.W. (2002). Natural killer cell immunoglobulinlike receptor (KIR) locus profiles in African and South Asian populations. Genes and Immunity 3: 8695.Google Scholar
  60. Owens, K., and King, M.-C. (1999). Genomic views of human history. Science 286: 451–453.PubMedCrossRefGoogle Scholar
  61. Parham, P. (2003). Immunogenetics of killer-cell immunoglobulin-like receptors. Tissue Antigens 62: 194–200.PubMedCrossRefGoogle Scholar
  62. Pende, D., Biassoni, R., Cantoni, C., Verdiani, S., Falco, M., di Donato, C., Accame, L., Bottino, C., Moretta, A., and Moretta, L. (1996). The natural killer cell receptor specific for HLA-A allotypes: A novel memeber of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J. Exp. Med. 184: 505–515.PubMedCrossRefGoogle Scholar
  63. Piazza A. (1998). Human evolution: Towards a genetic history of China. Nature 395: 636–639.PubMedCrossRefGoogle Scholar
  64. Picard, Al., Wongsrichanalai, C., Purfeild, A., Kamwendo, D., Emery, K., Zalewski, C., Kawamoto, F., Miller, R.S., Meshnick, S.R. (2003). Resistance to antimalarials in SE Asia and genetic polymorphisms in pfmdrl. Antimicrob. Agnts. & Chemother. 47 (8): 2418–2423.CrossRefGoogle Scholar
  65. Piriyasilip, S., McCutchan, F., Can, J.K., Sanders-Buell, E., Liu, W., Chen, J., Wagner, R., Wolf, H., Shao, Y., Lai, S., Beyrer, C., and Yu, X.-E (2000). A recent outbreak of HIV-1 infection in Southern China was initiated by two highly homogenous, geographically separated strains: Circulating recombinant for AE and a novel BC recombinant. J Virology 74 (23): 11286–11295.CrossRefGoogle Scholar
  66. Plummer, F.A., Fowke, K., Nagelkerke, N.J.D., Simonsen, J.N., Bwayo, J., and Ngugi, E. (1993). Evidence of resistance to HIV among continuously exposed prostitutes in Nairobi, Kenya [Abstract WS-A07–3]. In: Program and abstracts: IX International Conference on AIDS/IV World STD Congress, Berlin. London: Wellcome Foundation, p. 23.Google Scholar
  67. Razak, M.H., Jittiwutikarn, J., Suriyanon, V., Vongchak, T., Srirak, N., Beyrer, C., Kawichai, S., Tovanabutra, S., Rungruengthanakit, K., Sawanpanyalert, P., and Celentano, D.D. (2003). HIV prevalence and risks among injection and non-injection drug users in Northern Thailand: Need for comprehensive HIV prevention programs. J AIDS 33 (2): 259–266.Google Scholar
  68. Rowland-Jones, S., Sutton, J., Ariyoshi, K., Dong, T., Gotch, E, McAdam, S., Whitby, D., Sabally, S.S., Gallimore, A., Corrah, T., Takiguchi, M., Schultz, T., McMichael, A., and Whittle, H. (1995). HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat Med. 1: 59–64.PubMedCrossRefGoogle Scholar
  69. Schliesinger, J. (2000). Ethnic Groups of Thailand: NonTai-Speaking Peoples. White Lotus Press, BangkokGoogle Scholar
  70. Sidney, J., Grey, H.M., Kubo, R.T., and Sette, A. (1996). Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs. Immunology Today 17: 261–266.PubMedCrossRefGoogle Scholar
  71. Sriwanthana, B., Hodge, T., Mastro, T.D., Dezzutti, C.S. Bond, K., Stephens, H.A.F., Kostrikis, L.G., Limpakarnjanarat, K., Young, N.L., Qari, S.H., Lal, R.B., Chandanayingyong, D., and McNicholl, J.M. (2001). HIV-specific cytotoxic T lymphocytes, HLA-A11 and chemokine related factors may act synergistically to determine HIV resistance in CCR5 delta-32 negative female sex workers in Chiang Rai, northern Thailand. AIDS Res Hum Retroviruses 17: 719–734.Google Scholar
  72. Stephens, H.A.F., Brown, A.E., Chandanayingyong, D., Webster, H.K., Sirikong, M., Longta, P., Vangseratthana, R., Gordon, D.M., Lekmak, S., and Rungruang, E. (1995). The presence of the HLA class H allele DPB 1 *0501 in ethnic Thais correlates with an enhanced vaccine-induced antibody response to a malaria sporozoite vaccine. Eur Jlmmuol. 25: 31423147.Google Scholar
  73. Stephens, H.A.F., Kunachiwa, W., Sirikong, M., Longta, K., Maneemaroj, R., Wongkuttiya, D., Rungruang, E., Sittisombut, N., and Chandanayingyong, D. (2000). A comparison of molecular HLA-DR and DQ allele profiles forming DR51, DR52 and DR53related haplotypes in five ethnic Thai populations from mainland Southeast Asia. Hum Immunol. 61: 1039–1047.PubMedCrossRefGoogle Scholar
  74. Stephens, H.A.F., Klaythong R., Sirikong, M., Vaughn, D.W., Green, S., Kalayanarooj, S., Endy, T.P., Libraty, D.H., Nisalak, A., Innis, B. L., Rothman, A.L., Ennis, F.A., and Chandanayingyong, D. (2002). Class I HLA-A and B allele associations with secondary infections, correlate with disease severity and the infecting dengue virus serotype in ethnic Thais. Tissue Antigens 60: 309–318.PubMedCrossRefGoogle Scholar
  75. Takebe, Y., Motomura, K., Tatsumi, M., Lwin, H.H., Zaw, M., and Kusagawa, S. (2003). High prevalence of diverse forms of HIV-1 intersubtype recombinants in Central Myanmar: Geographical hot spot of extensive recombination. AIDS 17 (14): 2077–2087.PubMedCrossRefGoogle Scholar
  76. Ugoloni, S., and Vivier, E. (2001). Mutifaceted roles of MHC class I and MHC class I-like molecules in T cell activation. Nature Immunol. 2: 198–200.CrossRefGoogle Scholar
  77. UNAIDS. (2002). Report on the Global HIV/AIDS Epidemic, 2002. UNAIDS, Geneva.Google Scholar
  78. United States Department of State. (2003). International Narcotics Strategy Control Report, 2002. U.S. Dept. of State, Washington, DC.Google Scholar
  79. Vejbaesya, S., Songsivilai, S., Tanawandee, T., Rachaibun, S., Chantangpol, R., and Dharakul, T. (2000). HLA association with hepatitis C virus infection. Hum Immunol. 61: 348–353.PubMedCrossRefGoogle Scholar
  80. Vejbaesya, S., Chierakul, N., Luangtrakool, K., and Stephens, H.A.F. (2002). Associations of HLA class II alleles with pulmonary tuberculosis in Thais. Eur J Immunogenet. 29: 431–434.PubMedCrossRefGoogle Scholar
  81. Vu-Trieu, A., Djoulah, S., Tran-Thi, C., Ngyuyen-Thanh, T., Le Monnier de Gouville, I., Hors, J., and Sanchez-Mazas, A. (1997). HLA-DR and-DQB1 DNA polymorphisms in a Vietnamese Kinh population from Hanoi. Eur J Immunogenet. 24: 345–356.Google Scholar
  82. Wongsrichanalai, C., Pickard, A.L., Wernsdorfer, W.H., and Meshnick, S.R. (2002). Epidemiology of drug-resistant malaria. Lancet Infect Dis. 2: 209–218.PubMedCrossRefGoogle Scholar
  83. Yanai, H., Uthaivoravit, W., Panich, V., Sawanpanyalert, P., Chaimanee, B., Akarasewi, P., Limpakarnjanarat, K., Nieburg, P., and Mastro, T.D. (1996). Rapid increase in HIV-related tuberculosis, Chiang Rai, Thailand, 1990–1994. AIDS 10: 527–531.PubMedCrossRefGoogle Scholar
  84. Yu X.F., Chen J., Shao Y, Beyrer C., Wang Z., Liu B., Wang Z., Liu W., Yang J., Liang S., Viscidi R.P., Gu J., Gum-Glass G., and Lai S. (1999). Emerging HIV infections with distinct subtypes of HIV-1 among injection drug users from geographically separated locations in Guangxi Province, China. JAIDS 22: 180–188.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Chris Beyrer
    • 1
  • Henry Stephens
    • 2
  1. 1.Departments of Epidemiology and International HealthJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  2. 2.Institute of Urology and Nephrology, University College LondonThe Middlesex HospitalLondonUK

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