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Evoked Potentials in the Diagnosis of Brain Death

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Brain Death and Disorders of Consciousness

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 550))

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Abstract

Brain death (BD) is a by-product of the modern intensive care: since the report on coma depassé by Mollaret and Goulon in 19591 and the new criterion of death on neurological grounds published by the Harvard Medical School Ad Hoc Committee in 1968,2 both the definition and diagnostic of BD criteria have undergone a substantial evolution. Nowadays, most of the problems, dilemmas, and polemics raised in the past regarding the concept of BD, by terminological confusion, and by the grave responsibility of declaring dead a corpse with a still beating heart, are definitively overcome. However, despite the fact that BD is now widely accepted all over the world and regardless the certainty of its diagnosis when carefully formulated, its definition as well as diagnostic criteria are far from perfect and need further adjustments.

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References

  1. Mollaret P, Goulon M. Le coma depassé. Rev Neurol 1959; 101: 3–15.

    PubMed  CAS  Google Scholar 

  2. Harvard Medical School ad Hoc Committee to examine the definition of brain death: a definition of irreversible coma. DAMA 1968;205:337–340.

    Google Scholar 

  3. Machado C. Consciousness as a definition of death: Its appeal and complexity. Clin Electroencephalogr 1999; 30: 156–164.

    PubMed  CAS  Google Scholar 

  4. Legge 29 Dicembre 1993 n.578. Norme per l’accertamento e le certificazione di morte. Gazzetta Ufficiale della Repubblica Italiana 8/1/1994;5:4–5.

    Google Scholar 

  5. Ministero della Sanità. Regolamento recante le modalità per l’accertamento e la certificazione di morte. Decreto 1994;22/8/1994 n. 582.

    Google Scholar 

  6. Report of the Medical Consultants on the Diagnosis of Death to the President’s Commission on the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Guidelines for the determination of death. DAMA 1981; 246; 2184–2186.

    Google Scholar 

  7. Royal Colleges and Faculties of the United Kingdom. Diagnosis of brain death. Br Med J 1976; 2: 1187 1188.

    Google Scholar 

  8. Le Ministre Delegue charge de la Sante. Decree n° 90–844 du 24 septembre 1990. 1990.

    Google Scholar 

  9. Wissenschaftlicher Beirat der Bundesärtzekammer. Kriterien des Hirntodes. Dtsch Artzebl Mitteilg 1991; 87: 2855–2860.

    Google Scholar 

  10. Korein J. The problem of brain death: development and history. Ann N YAcad Sci 1978; 315: 19–38.

    Article  CAS  Google Scholar 

  11. Machado C. Is the concept of brain death secure? In: Zeman A, Emanuel L, eds. Ethical Dilemmas in Neurology. London: W. B. Saunders Company, 2000; Vol 36: 193–212.

    Google Scholar 

  12. Machado C. Una nueva formulación de la muerte: Definición-criterio-pruebas confirmatorias. Rev Neurol 1998; 26 (154): 1040–1047.

    Google Scholar 

  13. Beecher HK. After the definition of irreversible coma. N Engl J Med 1969; 281: 1070–1071.

    Article  PubMed  CAS  Google Scholar 

  14. Pallis C. Prognostic value of brain stem lesion. Lancet 1981; 1: 379.

    Article  PubMed  CAS  Google Scholar 

  15. Pallis C. ABC of brain stem death. The arguments about the EEG. Br Med J 1983; 286: 284–287.

    Google Scholar 

  16. Egol AB, Guntupalli KK. Intravenous infusion device artifacts in the EEG-confusion in the diagnosis of electrocerebral silence. Intensive Care Med 1983; 9: 29–32.

    Article  PubMed  CAS  Google Scholar 

  17. Spudis EV, Penry JK, Link SL. Paradoxical contribution of EEG during protracted dying. Arch Neurol 1984; 41: 153–156.

    Article  PubMed  CAS  Google Scholar 

  18. Buchner H, Schuchardt V. Reliability of electroencephalogram in the diagnosis of brain death. Eur Neurol 1990; 30 (3): 138–141.

    Article  PubMed  CAS  Google Scholar 

  19. Nau R, Prange HW, Klingelhofer J, Kukowski B, Sander D, Tchorsch R, et al. Results of four technical investigations in fifty clinically brain dead patients. Intensive Care Med 1992; 18 (2): 82–88.

    Article  PubMed  CAS  Google Scholar 

  20. Bennett DR. The EEG in the determination of brain death. Ann N YAcad Sci 1978; 315: 110–119.

    Article  CAS  Google Scholar 

  21. Goldie WD, Chiappa KH. Brainstem auditory and short latency somatosensory evoked responses in brain death. Neurology 1981; 31: 248–256.

    Article  PubMed  CAS  Google Scholar 

  22. Mauguière F, Grand C, Fischer C, Courjon J. Aspects of early somatosensory and auditory evoked potentials in neurologic comas and brain death. Rev Electroencephalogr Neurophysiol Clin 1982;12(3): 280–285.

    Google Scholar 

  23. Facco E, Caputo P, Casartelli LM, Munari M, Toffoletto F, Fabiani F, et al. Auditory and somatosensory evoked potentials in brain-dead patients. Riv Neurol 1988; 58: 140–145.

    PubMed  CAS  Google Scholar 

  24. Ganes T, Lundar T. EEG and evoked potentials in comatose patients with severe brain damage. Electroencephalogr Clin Neurophysiol 1988; 69(1): 6–13.

    Article  PubMed  CAS  Google Scholar 

  25. Facco E, Casartelli LM, Munari M, Toffoletto F, Baratto F, Giron GP. Short latency evoked potentials: new criteria for brain death? JNeurol Neurosurg Psychiatry 1990; 53(4): 351–353.

    Article  CAS  Google Scholar 

  26. Wagner W. SEP testing in deeply comatose and brain dead patients: the role of nasopharyngeal, scalp and earlobe derivations in recording the P14 potential. Electroencephalogr Clin Neurophysiol 1991; 80(5): 352–363.

    Article  PubMed  CAS  Google Scholar 

  27. Wagner W. SEP testing in deeply comatose and brain dead patients: the role of nasopharyngeal, scalp and earlobe derivations in recording the P14 potential. Electroencephalogr Clin Neurophysiol 1991; 80(5): 352–363.

    Article  PubMed  CAS  Google Scholar 

  28. Firsching R, Frowein RA, Wilhelms S, Buchholz F. Brain death: practicability of evoked potentials. Neurosurg Rev 1992; 15(4): 249–254.

    PubMed  CAS  Google Scholar 

  29. Guérit JM. Evoked potentials: a safe brain-death confirmatory tool? Eur J Med 1992; 1(4): 233–243.

    PubMed  Google Scholar 

  30. Machado C, Valdés P, Garcia O, Coutin P, Miranda J, Roman J. Short latency somatosensory evoked potentials in brain-dead patients using restricted low cut filter setting. J Neurosurg Sci 1993;37(3):133140.

    Google Scholar 

  31. Machado C. Multimodality evoked potentials and electroretinography in a test battery for an early diagnosis of brain death. JNeurosurg Sci 1993; 37(3): 125–131.

    CAS  Google Scholar 

  32. Facco E, Munari M, Baratto F, Giron GP. Role of the somatosensory evoked potentials in the diagnosis of brain death. In: Machado C, ed. Brain Death. Amsterdam: Elsevier Science Publishers B.V., 1995:135-139.

    Google Scholar 

  33. Guérit JM, de Tourtchaninoff M, Hantson P, Mahieu P. Multimodality evoked potentials in the differential diagnosis of brain death. In: Machado C, ed. Brain Death. Amsterdam: Elsevier Science Publishers B.V., 1995: 119–126.

    Google Scholar 

  34. Shiogai T, Takeuchi K. Diagnostic reliability in loss of brainstem function evaluated by brainstem auditory evoked potentials and somatosensory evoked potentials in impending brain death. In: Machado C, ed. Brain Death. Amsterdam: Elsevier Science Publishers B.V., 1995: 111–118.

    Google Scholar 

  35. Wagner W. Scalp, earlobe and nasopharyngeal recordings of the median nerve somatosensory evoked P14 potential in coma and brain death. Detailed latency and amplitude analysis in 181 patients. Brain 1996; 119(Pt 5): 1507–1521.

    Article  Google Scholar 

  36. Facco E, Baratto F, Munari M, Behr AU, Volpin SM, Gallo F, et al. Short latency evoked potentials in the diagnosis of brain death. Electroencephalogr Clin Neurophysiol 1997; 103 (1): 106.

    Google Scholar 

  37. Machado-Curbelo C, Roman-Murga JM. [Usefulness of multimodal evoked potentials and the electroretinogram in the early diagnosis of brain death]. Rev Neurol 1998; 27 (159): 809–817.

    PubMed  CAS  Google Scholar 

  38. Roncucci P, Lepori P, Mok MS, Bayat A, Logi F, Marino A. Nasopharyngeal electrode recording of somatosensory evoked potentials as an indicator in brain death. Anaesth Intensive Care 1999; 27 (1): 20–25.

    PubMed  CAS  Google Scholar 

  39. Ruiz-Lopez MJ, Martinez dA, Serrano A, Casado-Flores J. Brain death and evoked potentials in pediatric patients [see comments]. Crit Care Med 1999; 27 (2): 412–416.

    CAS  Google Scholar 

  40. Sonoo M, Tsai-Shozawa Y, Aoki M, Nakatani T, Hatanaka Y, Mochizuki A, et al. N18 in median somatosensory evoked potentials: a new indicator of medullary function useful for the diagnosis of brain death…/ Neurol Neurosurg Psychiatry 1999; 67 (3): 374–378.

    Article  CAS  Google Scholar 

  41. Facco E, Munari M, Gallo F, Volpin SM, Behr AU, Baratto F, et al. Role of short latency evoked potentials in the diagnosis of brain death. Clin Neurophysiol 2002; 113 (11): 1855–1866.

    Article  PubMed  Google Scholar 

  42. Arfel G. Visual stimuli and cerebral silence. Electroencephalogr Clin Neurophysiol 1967; 23 (2): 172–175.

    Article  PubMed  CAS  Google Scholar 

  43. Arfel G. Problemes electroencéphalographiques de la mort. Paris: Masson, 1970.

    Google Scholar 

  44. Reilly EL, Kondo C, Brunberg JA, Doty DB. Visual evoked potentials during hypothermia and prolonged circulatory arrest. Electroencephalogr Clin Neurophysiol 1978; 45 (1): 100–106.

    Article  PubMed  CAS  Google Scholar 

  45. Trojaborg W, Jorgensen EO. Evoked cortical potentials in patients with “isoelectric” EEGs. Electroencephalogr Clin Neurophysiol 1973;35(3):301–309.

    Google Scholar 

  46. Wilkus RJ, Chatrian GE, Lettich E. The electroretinogram during terminal anoxia in humans. Electroencephalogr Clin Neurophysiol 1971; 31 (6): 537–546.

    Article  PubMed  CAS  Google Scholar 

  47. Walter S, Arfel G. Responses to visual stimuli in acute and chronic coma states. Electroencephalogr Clin Neurophysiol 1972; 32 (1): 27–41.

    Article  PubMed  CAS  Google Scholar 

  48. Cobb WA, Dawson. The latency and form in man of the occipital potentials evoked by bright flashes. J Physiol 1960; 152: 108–121.

    PubMed  CAS  Google Scholar 

  49. Machado C, et al. Visual evoked potentials and electroretinography in brain-dead patients. Doc Ophthalmol 1993; 84: 89–96.

    Article  PubMed  CAS  Google Scholar 

  50. Ferbert A, Buchner H, Bruckmann H, Zeumer H, Hacke W. Evoked potentials in basilar artery thrombosis: correlation with clinical and angiographic findings. Electroencephalogr Clin Neurophysiol 1988; 69 (2): 136–147.

    Article  PubMed  CAS  Google Scholar 

  51. Anziska BJ, Cracco RQ. Short latency SEPs to median nerve stimulation: comparison of recording methods and origin of components. Electroencephalogr Clin Neurophysiol 1981; 52 (6): 531–539.

    Article  PubMed  CAS  Google Scholar 

  52. Chiappa KH. Evoked potentials in clinical medicine. New York: Raven Press, 1989.

    Google Scholar 

  53. Guérit J, Mathieu P. Are evoked potentials a valuable tool for the diagnosis of brain death? Transplant Proc 1986; 18: 38–67.

    Google Scholar 

  54. Machado C. A multimodal evoked potential and electroretinography test battery for the early diagnosis of brain death. lnt J Neurosci 1989; 49: 241–242.

    Google Scholar 

  55. Machado C, Valdes P, Garcia-Tigera J, Virues T, Biscay R, Miranda J, et al. Brain-stem auditory evoked potentials and brain death. Electroencephalogr Clin Neurophysiol 1991; 80 (5): 392–398.

    Article  PubMed  CAS  Google Scholar 

  56. Machado C. Muerte encefâlica. Criterios diagnósticos. Rev Cubana Med 1991; 30: 181–206.

    Google Scholar 

  57. Brunko E, Delecluse F, Herbaut AG, Levivier M, Zegers dB. Unusual pattern of somatosensory and brain-stem auditory evoked potentials after cardio-respiratory arrest. Electroencephalogr Clin Neurophysiol 1985; 62 (5): 338–342.

    Article  PubMed  CAS  Google Scholar 

  58. Fauvage B, Combes P. Isoelectric electroencephalogram and loss of evoked potentials in a patient who survived cardiac arrest. Crit Care Med 1993; 21 (3): 472–475.

    Article  PubMed  CAS  Google Scholar 

  59. Ferbert A, Buchner H, Zeumer H, Hacke W. Evoked potentials in basilar artery thrombosis: correlation with clinical and angiographic findings. Electroencephalogr Clin Neurophysiol 1988; 69 (136): 147.

    Google Scholar 

  60. Barelli A, Della CF, Calimici R, Sandroni C, Proietti R, Magalini SI. Do brainstem auditory evoked potentials detect the actual cessation of cerebral functions in brain dead patients? Crit Care Med 1990; 18 (3): 322–323.

    Article  PubMed  CAS  Google Scholar 

  61. Chandler JM, Brilli RJ. Brainstem encephalitis imitating brain death. Crit Care Med 1991; 19 (7): 977–979.

    Article  PubMed  CAS  Google Scholar 

  62. Hantson P, Guerit JM, de Tourtchaninoff M, Deconinck B, Mahieu P, Dooms G et al. Rabies encephalitis mimicking the electrophysiological pattern of brain death. A case report. Eur Neurol 1993; 33(3):212–217.

    Google Scholar 

  63. Martin WH, Pratt H, Schwegler JW. The origin of the human auditory brain-stem response wave II. Electroencephalogr Clin Neurophysiol 1995; 96 (4): 357–370.

    Article  PubMed  CAS  Google Scholar 

  64. Facco E, Munari M, Gallo F, Volpin SM, Behr AU, Baratto F, et al. Role of short latency evoked potentials in the diagnosis of brain death. Clin Neurophysiol 2002; 113 (11): 1855–1866.

    Article  PubMed  Google Scholar 

  65. Hall JW, Mackey-Hargadine JR, Kim EE. Auditory brain-stem response in determination of brain death. Arch Otolaryngol 1985; 111 (9): 613–620.

    Article  PubMed  Google Scholar 

  66. Paniagua-Soto M, PifeiroBenitez M, GarciaJiménez MA, RodriguezElvira M. Evoked potentials in brain death. Electroencephalogr Clin Neurophysiol 1987; 67 (42P): 43 P.

    Google Scholar 

  67. Machado C, Valdes P, Garcia-Tigera J, Virues T, Biscay R, Miranda J, et al. Brain-stem auditory evoked potentials and brain death. Electroencephalogr Clin Neurophysiol 1991; 80 (5): 392–398.

    Article  PubMed  CAS  Google Scholar 

  68. de la Torre JC. Evaluation of brain death using somatosensory evoked potentials. Biol Psychiatry 1981; 16 (10): 931–935.

    PubMed  Google Scholar 

  69. Mauguière F, Grand C, Fischer C, Courjon J. [Aspects of early somatosensory and auditory evoked potentials in neurologic comas and brain death]. Rev Electroencephalogr Neurophysiol Clin 1982; 12 (3): 280–285.

    Article  PubMed  Google Scholar 

  70. Fotiou F, Tsitsopoulos P, Sitzoglou K, Fekas L, Tavridis G. Evaluation of the somatosensory evoked potentials in brain death. Electromyogr Clin Neurophysiol 1987; 27 (1): 55–60.

    PubMed  CAS  Google Scholar 

  71. Stohr M, Riffel B, Trost E, Ullrich A. Short-latency somatosensory evoked potentials in brain death. J Neurol 1987; 234 (4): 211–214.

    Article  PubMed  CAS  Google Scholar 

  72. Besser R, Dillmann U, Henn M. Somatosensory evoked potentials aiding the diagnosis of brain death. Neurosurg Rev 1988; 11 (2): 171–175.

    Article  PubMed  CAS  Google Scholar 

  73. Buchner H, Ferbert A, Hacke W. Serial recording of median nerve stimulated subcortical somatosensory evoked potentials (SEPs) in developing brain death. Electroencephalogr Clin Neurophysiol 1988; 69 (1): 14–23.

    Article  PubMed  CAS  Google Scholar 

  74. Facco E, Caputo P, Casartelli LM, Munari M, Toffoletto F, Fabiani F, et al. Auditory and somatosensory evoked potentials in brain-dead patients. Riv Neurol 1988; 58 (4): 140–145.

    PubMed  CAS  Google Scholar 

  75. Chancellor AM, Frith RW, Shaw NA. Somatosensory evoked potentials following severe head injury: loss of the thalamic potential with brain death. JNeurol Sci 1988; 87 (2–3): 255–263.

    Article  CAS  Google Scholar 

  76. Buchner H, Ferbert A, Hacke W. Serial recording of median nerve stimulated somatosensory evoked potentials in brain death. Neurosurg Rev 1989; 12 (Suppl 1): 349–352.

    Article  PubMed  Google Scholar 

  77. Haupt WF. Evoked potentials in non-traumatic brain death. Neurosurg Rev 1989; 12 (Suppl 1): 369–374.

    Article  PubMed  Google Scholar 

  78. Facco E, Casartelli LM, Munari M, Toffoletto F, Baratto F, Giron GP. Short latency evoked potentials: new criteria for brain death JNeurol Neurosurg Psychiatry 1990;53(4):351–353.

    Google Scholar 

  79. Machado C. Multimodality evoked potentials and electroretinography in a test battery for an early diagnosis of brain death. JNeurosurg Sci 1993; 37 (3): 125–131.

    CAS  Google Scholar 

  80. Facco E, Giron GP. Multimodality evoked potentials in coma and brain death. Minerva Anestesiol 1994; 60 (10): 593–599.

    PubMed  CAS  Google Scholar 

  81. Wagner W. Scalp, earlobe and nasopharyngeal recordings of the median nerve somatosensory evoked P14 potential in coma and brain death. Detailed latency and amplitude analysis in 181 patients. Brain 1996; 119 (Pt 5): 1507–1521.

    Article  Google Scholar 

  82. Tornita Y, Fukuda C, Maegaki Y, Hanaki K, Kitagawa K, Sanpei M. Re-evaluation of short latency somatosensory evoked potentials (P13, P14 and N18) for brainstem function in children who once suffered from deep coma. Brain Dev 2003; 25 (5): 352–356.

    Article  Google Scholar 

  83. Sonoo M, Tsai-Shozawa Y, Aoki M, Nakatani T, Hatanaka Y, Mochizuki A, et al. N18 in median somatosensory evoked potentials: a new indicator of medullary function useful for the diagnosis of brain death. JNeurol Neurosurg Psychiatry 1999; 67 (3): 374–378.

    Article  CAS  Google Scholar 

  84. Facco E. Review: the diagnosis of brain death–role of short latency evoked potentials. J Audiol Med 2001; 10: 1–19.

    Google Scholar 

  85. Desmedt JE, Cheron G. Prevertebral (oesophageal) recording of subcortical somatosensory evoked potentials in man: the spinal P13 component and the dual nature of the spinal generators. Electroencephalogr Clin Neurophysiol 1981; 52 (4): 257–275.

    Article  PubMed  CAS  Google Scholar 

  86. Mauguière F. Cervical somatosensory evoked potentials in the healthy subject: analysis of the effect of the location of the reference electrode on aspects of the responses. Rev Electroencephalogr Neurophysiol Clin 1983; 13 (3): 259–272.

    Article  PubMed  Google Scholar 

  87. Desmedt JE. Critical neuromonitoring at spinal and brainstem levels by somatosensory evoked potentials. Cent New Syst Trauma 1985; 2 (3): 169–186.

    CAS  Google Scholar 

  88. Mauguière F, Ibanez V. The dissociation of early SEP components in lesions of the cervico-medullary junction: a cue for routine interpretation of abnormal cervical responses to median nerve stimulation. Electroencephalogr Clin Neurophysiol 1985; 62 (6): 406–420.

    Article  PubMed  Google Scholar 

  89. MSller AR, Jannetta PJ, Burgess JE. Neural generators of the somatosensory evoked potentials: recording from the cuneate nucleus in man and monkeys. Electroencephalogr Clin Neurophysiol 1986; 65(4):241248.

    Google Scholar 

  90. Morioka T, Tobimatsu S, Fujii K, Fukui M, Kato M, Matsubara T. Origin and distribution of brain-stem somatosensory evoked potentials in humans. Electroencephalogr Clin Neurophysiol 1991; 80 (3): 221–227.

    Article  PubMed  CAS  Google Scholar 

  91. Sonoo M, Shimpo T, Takeda K, Genba K, Nakano I, Mannen T. SEPs in two patients with localized lesions of the postcentral gyms. Electroencephalogr Clin Neurophysiol 1991; 80 (6): 536–546.

    Article  PubMed  CAS  Google Scholar 

  92. Sonoo M, Genba K, Zai W, Iwata M, Mannen T, Kanazawa I. Origin of the widespread N18 in median nerve SEP. Electroencephalogr Clin Neurophysiol 1992; 84 (5): 418–425.

    Article  PubMed  CAS  Google Scholar 

  93. Mavroudakis N, Brunko E, Delberghe X, Zegers dB. Dissociation of P13–P14 far-field potentials: clinical and MRI correlation. Electroencephalogr Clin Neurophysiol 1993; 88 (3): 240–242.

    Article  PubMed  CAS  Google Scholar 

  94. Raroque HG Jr, Batjer H, White C, Bell WL, Bowman G, Greenlee R Jr. Lower brain-stem origin of the median nerve N18 potential. Electroencephalogr Clin Neurophysiol 1994; 90 (2): 170–172.

    Article  PubMed  Google Scholar 

  95. Hashimoto T, Miyasaka M, Yanagisawa N. Short-latency somatosensory evoked potentials following median nerve stimulation in four patients with medial medullary infarction. Eur Neurol 1995;35(4):220225.

    Google Scholar 

  96. Restuccia D, Di Lazzaro V, Valeriani M, Conti G, Tonali P, Mauguière F. Origin and distribution of P13 and P14 far-field potentials after median nerve stimulation. Scalp, nasopharyngeal and neck recording in healthy subjects and in patients with cervical and cervico-medullary lesions. Electroencephalogr Clin Neurophysiol 1995; 96 (5): 371–384.

    Article  Google Scholar 

  97. Noel P, Ozaki I, Desmedt JE. Origin of N18 and P14 far-fields of median nerve somatosensory evoked potentials studied in patients with a brain-stem lesion. Electroencephalogr Clin Neurophysiol 1996; 98 (2): 167–170.

    Article  PubMed  CAS  Google Scholar 

  98. Sonoo M, Hagiwara H, Motoyoshi Y, Shimizu T. Preserved widespread N18 and progressive loss of P13/14 of median nerve SEPs in a patient with unilateral medial medullary syndrome. Electroencephalogr Clin Neurophysiol 1996; 100 (6): 488–492.

    Article  PubMed  CAS  Google Scholar 

  99. Sonoo M. Anatomic origin and clinical application of the widespread N18 potential in median nerve somatosensory evoked potentials. J Clin Neurophysiol 2000; 17 (3): 258–268.

    Article  PubMed  CAS  Google Scholar 

  100. Mauguière F, Desmedt JE, Courjon J. Neural generators of N18 and P14 far-field somatosensory evoked potentials studied in patients with lesion of thalamus or thalamo-cortical radiations. Electroencephalogr Clin Neurophysiol 1983; 56 (4): 283–292.

    Article  PubMed  Google Scholar 

  101. Urasaki E, Wada S, Kadoya C, Tokimura T, Yokota A, Yamamoto S, et al. Amplitude abnormalities in the scalp far-field N18 of SSEPs to median nerve stimulation in patients with midbrain-pontine lesion. Electroencephalogr Clin Neurophysiol 1992; 84 (3): 232–242.

    Article  PubMed  CAS  Google Scholar 

  102. Sonoo M, Tsai-Shozawa Y, Aoki M, Nakatani T, Hatanaka Y, Mochizuki A, et al. N18 in median somatosensory evoked potentials: a new indicator of medullary function useful for the diagnosis of brain death. J Neurol Neurosurg Psychiatry 1999; 67 (3): 374–378.

    Article  PubMed  CAS  Google Scholar 

  103. Sonoo M, Tsai-Shozawa Y, Aoki M, Nakatani T, Hatanaka Y, Mochizuki A, et al. N18 in median somatosensory evoked potentials: a new indicator of medullary function useful for the diagnosis of brain death. J Neurol Neurosurg Psychiatry 1999; 67 (3): 374–378.

    Article  PubMed  CAS  Google Scholar 

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Facco, E., Machado, C. (2004). Evoked Potentials in the Diagnosis of Brain Death. In: Machado, C., Shewmon, D.A. (eds) Brain Death and Disorders of Consciousness. Advances in Experimental Medicine and Biology, vol 550. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-48526-8_16

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