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Historical Overview of Glycosaminoglycans (GAGs) and their Potential Value in the Treatment of Alzheimer’s Disease

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Mapping the Progress of Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 51))

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Abstract

“Dies annorum nostrum sunt septaginta anni aut in valentibus octoginta anni et maior pars eorum labor et dolor….” [1]. The years in our life are seventy, eighty for the more resistant, but most of them are work and pain. This is the translation of Psalm 89 recognizable as one of the oldest documents concerning duration of life; it is attributed to Moses and it was translated 1,300 years later from Hebrew into Latin. Not much has changed for the individual span of life: once a proper environment allows our genoma to express its potentialities, some of us can reach or even exceed the age of one hundred years. In this context senile dementia, and particularly Alzheimer’s disease (AD), shortens life and adds a substantial amount of pain to our days; that is why in every part of the world a lot of efforts are devoted to understand all the possible mechanisms that may bring our brain to the loss of life consciousness. The results of these efforts are expressed by a quite variegate number of theories. One of these is related to glycosaminoglycans (GAGs) and proteoglycans (PGs).

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Authors and Affiliations

  1. Loyola University Stritch School of Medicine, Maywood, Illinois, 60153, USA

    I. Hanin & S. Lorens

  2. Neuro Cognitive Research Laboratories, Columbus, Ohio, 43212, USA

    R. Mervis

  3. 2nd Division Geriatric Hospital, University of Padova, 35100, Padua, Italy

    P. Piccolo

  4. Cornelli Consulting S.a.s., 20129, Milan, Italy

    M. Cornelli

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  1. U. Cornelli
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  1. Juntendo University School of Medicine, Tokyo, Japan

    Yoshikuni Mizuno

  2. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher

  3. Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA

    Israel Hanin

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© 2002 Kluwer Academic / Plenum Publishers, New York

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Cornelli, U. et al. (2002). Historical Overview of Glycosaminoglycans (GAGs) and their Potential Value in the Treatment of Alzheimer’s Disease. In: Mizuno, Y., Fisher, A., Hanin, I. (eds) Mapping the Progress of Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-47593-1_25

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  • DOI: https://doi.org/10.1007/978-0-306-47593-1_25

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