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Synthetic peptide libraries

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Annual Reports in Combinatorial Chemistry and Molecular Diversity

Part of the book series: Annual Reports in Combinatorial Chemistry and Molecular Diversity ((ARCC,volume 1))

Abstract

Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead. Most pharmaceutical companies have been focusing their efforts on small-molecule library development because drug leads discovered from these libraries are more likely to be able to cross cellular membranes. Therefore, for intracellular targets, small-molecule libraries are preferred. However, for extracellular targets, particularly those with larger natural ligands such as insulin, growth factors, and cytokines, peptide or oligomeric non-peptide libraries may sometimes be very useful, since it is unlikely that a small molecule (e.g., MW 300–600) can bind to these receptors with high affinity. Peptide libraries are also useful for the development of drug leads for enzymes that use peptides as a substrate, e.g., protease, and protein kinase. These peptide drug leads can then be converted to active peptidomimetics. The development of drugs for peptide hormone receptors, and vaccines for both humoral and cellular immunity certainly are two additional areas where peptide libraries will play an important role.

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References

  1. Geysen, H.M., Meloen, R. and Barteling, S., Proc. Natl. Acad. Sci. USA, 81 (1984) 3998.

    Article  CAS  Google Scholar 

  2. Geysen, H.M., Rodda, H.M. and Mason, T.J., Mol. Immunol., 23 (1986) 709.

    Article  PubMed  CAS  Google Scholar 

  3. Cwirla, S.E., Peters, E.A., Barrett, R.W. and Dower, W.J., Proc. Natl. Acad. Sci. USA, 87 (1990) 6378.

    Article  CAS  Google Scholar 

  4. Devlin, J.J., Panganiban, L.C. and Devlin, P.E., Science, 249 (1990) 404.

    Article  PubMed  CAS  Google Scholar 

  5. Scott, J.K. and Smith, G.P., Science, 249 (1990) 386.

    Article  PubMed  CAS  Google Scholar 

  6. Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M. and Knapp, R.J., Nature, 354 (1991) 82.

    Article  PubMed  CAS  Google Scholar 

  7. Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T. and Cuervo, J.H., Nature, 354 (1991) 84.

    Article  PubMed  CAS  Google Scholar 

  8. Thompson, L.A. and Ellman, J.A., Chem. Rev., 96 (1996) 555.

    Article  PubMed  CAS  Google Scholar 

  9. Merrifield, R.B., J. Am. Chem. Soc., 85 (1963) 2149.

    Google Scholar 

  10. Davis, EW., Hudson, D., Little, M., Sinaha, N.D., Usman, N., Weiss, M. and Wright, P, In Epton, R. (Ed.) Innovation and Perspectives in Solid Phase Synthesis, 2nd International Symposium, Intercept, Andover, U.K., 1992, pp. 63–75.

    Google Scholar 

  11. Beaucage, S.L. and Iyer, R.P., Tetrahedron, 48 (1992) 2223.

    Article  CAS  Google Scholar 

  12. Douglas, S.P., Whitfield, D.M. and Kerpinsky, J.J., J. Am. Chem. Soc., 113 (1991) 5095.

    Article  CAS  Google Scholar 

  13. Danishefsky, S.J., McClure, K.F., Randolph, J.T. and Ruggeri, R.B., Science, 260 (1993) 1307.

    Article  PubMed  CAS  Google Scholar 

  14. Leznoff, C.C., Acc. Chem, Res., 11 (1978) 327.

    Article  CAS  Google Scholar 

  15. Cheng, S., Corner, D.D., Williams, J.P., Myers, P.L. and Boger, D.L., J. Am. Chem. Soc., 118 (1996) 2567.

    Google Scholar 

  16. Cheng, S., Tarby, C.M., Corner, D.D., Williams, J.P., Caporale, L.H., Myers, P.L. and Boger, D.L., Bioorg. Med. Chem., 4 (1996) 727.

    Article  PubMed  CAS  Google Scholar 

  17. Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Ostresh, J.M. and Houghten, R.A., Drug Dev. Res., 33 (1994) 133.

    Article  CAS  Google Scholar 

  18. Rapp, W, In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 425–464.

    Book  Google Scholar 

  19. Vagner, J., KrchúSk, V, Sepetov, N.F., Strop, P., Lam, K.S., Barany, G. and Lebl, M., In Epton, R. (Ed.) Innovation and Perspectives in Solid Phase Synthesis, 3rd International Symposium, Mayflower, Birmingham, U.K., 1994, pp. 347–352.

    Google Scholar 

  20. Vagner, J., Barany, G., Lam, K.S., Krchiïík, V., Sepetov, N.F., Ostresm, J.A., Strop, E and Lebl, M., Proc. Natl. Acad. Sei. USA, 93 (1996) 8194.

    Article  CAS  Google Scholar 

  21. Singh, J., Allen, M.P., Ator, M.A., Gainor, J.A., Whipple, D.A., Solowiej, J.E., Treasurywala, A.M., Morgan, B.A., Gordon, T.D. and Upson, D.A., J. Med. Chem., 38 (1995) 217.

    Article  PubMed  CAS  Google Scholar 

  22. Meldal, M. and Svendsen, I., J. Chem. Soc. Perkin Trans. 1, (1995) 1591.

    Google Scholar 

  23. Buettner, J.A., Dadd, C.A., Baumbach, G.A., Masecar, B.L. and Hammond, D.J., Int. J. Pept. Protein Res., 47 (1996) 70.

    Article  PubMed  CAS  Google Scholar 

  24. Barany, G., Sole, N.A., Van Abel, R.J., Albericio, E. and Selsted, M.E., In Epton, R. (Ed.) Innovation and Perspectives in Solid Phase Synthesis, 2nd International Symposium, Intercept, Andover, U.K., 1992, pp. 29–38.

    Google Scholar 

  25. Gooding, O., Hoeprich, P.O.J., Labadie, J.W., Porco, J.A.J., Van Eikeren, P. and Wright, P., In Chai-ken, I.M. and Janda, K.D. (Eds.) Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, American Chemical Society, Washington, DC, U.S.A., 1996, pp. 199–206.

    Google Scholar 

  26. Kempe, M. and Barany, G., J. Am. Chem. Soc., 118 (1996) 7083.

    Article  CAS  Google Scholar 

  27. Maeji, N.J., Valerio, R.M., Bray, A.M., Campbell, R.A. and Geysen, H.M., React. Polym., 22 (1994) 203.

    Article  CAS  Google Scholar 

  28. Bunin, B.A., Plunkett, M.J. and Ellman, J.A., Proc. Natl. Acad. Sci. USA, 91 (1994) 4708.

    Article  CAS  Google Scholar 

  29. Frank, R., Heikens, W, Heisterberg-Moutsis, G. and Blöcker, H., Nucleic Acids Res., 11 (1983) 4365.

    Article  PubMed  CAS  Google Scholar 

  30. Kramer, A., Volkmer-Engert, R., Malin, R., Reineke, U. and Schneider-Mergener, J.. Pept. Res., 6 (1993) 314.

    PubMed  CAS  Google Scholar 

  31. Tegge, W, Frank, R., Hofmann, F. and Dostmann, W.R.G., Biochemistry, 34 (1995) 10569.

    Article  PubMed  CAS  Google Scholar 

  32. Berg, R.H., Almdal, K., Pedersen, W.B., Holm, A., Tam, J.P. and Merrifield, R.B., J. Am. Chem. Soc., 111 (1989) 8024.

    Article  CAS  Google Scholar 

  33. Stankova, M., Wade, S., Lam, K.S. and Lebl, M., Pept. Res., 7 (1994) 292.

    PubMed  CAS  Google Scholar 

  34. Fields, G.B., Tian, Z. and Barany, G., In Grant, G.A. (Ed.) Synthetic Peptides: A User’s Guide, Freeman, New York, NY, U.S.A., 1992, pp. 77–183.

    Google Scholar 

  35. Fruchtel, J.S. and Jung, G., In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 19–78.

    Book  Google Scholar 

  36. Winter, M., In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 465–510.

    Book  Google Scholar 

  37. Stankova, M. and Lebl, M., Mol. Div., 2 (1996) 75.

    Article  CAS  Google Scholar 

  38. Patek, M. and Lebl, M., Tetrahedron Lett., 32 (1991) 3891.

    Article  CAS  Google Scholar 

  39. Bray, A.M., Maeji, N.J. and Geysen, H.M., Tetrahedron Lett., 31 (1990) 5811.

    Article  CAS  Google Scholar 

  40. Hoffmann, S. and Frank, R., Tetrahedron Lett., 35 (1994) 7763.

    CAS  Google Scholar 

  41. Holmes, C.P. and Rybak, C.M., In Hodges, R.S. and Smith, J.A. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 13th American Peptide Symposium), ESCOM, Leiden, The Netherlands, 1994, pp. 992–994.

    Google Scholar 

  42. Lebl, M., Krchiïâk, V., Sepetov, N.F., Nikolaev, V., Stierandova, A., Safar, P., Seligman, B., Strop, P., Lam, K.S. and Salmon, S.E., In Epton, R. (Ed.) Innovation and Perspectives in Solid Phase Synthesis, 3rd International Symposium, Mayflower, Birmingham, U.K., 1994, pp. 233–238.

    Google Scholar 

  43. Kania, R.S., Zuckermann, R.N. and Marlowe, C.K., J. Am. Chem. Soc., 116 (1994) 8835.

    Article  CAS  Google Scholar 

  44. Kocis, P., Krchndk, V. and Lebl, M., Tetrahedron Lett., 34 (1993) 7251.

    Article  CAS  Google Scholar 

  45. Cardno, M. and Bradley, M., Tetrahedron Lett., 37 (1996) 135.

    Article  CAS  Google Scholar 

  46. Rivier, J.E., Jiang, G.-C., Simon, L., Koerber, S.C., Porter, J., Craig, A.G. and Hoeger, C.A., In Kau-maya, P.T.P. and Hodges, R.S. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 14th American Peptide Symposium), Mayflower, Birmingham, U.K., 1996, pp. 275–277.

    Google Scholar 

  47. O’Donnel, M.J., Zhou, C. and Scott, W.L., J. Am. Chem. Soc., 118 (1996) 6070.

    Article  Google Scholar 

  48. Schwesinger, R., Willaredt, J., Schlemper, H., Keller, M., Schmidt, D. and Fritz, H., Chem. Ber., 127 (1994) 2435.

    Google Scholar 

  49. Kates, S.A., Carpino, L.A. and Albericio, F., In Kaumaya, P.T.P. and Hodges, R.S. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 14th American Peptide Symposium), Mayflower, Birmingham, U.K., 1996, pp. 893–895.

    Google Scholar 

  50. Wijkmans, J.C.H.M., Blok, F.A.A., Van der Marel, G.A., Van Boom, J.H. and Bloemhoff, W, In Kaumaya, P.T.P. and Hodges, R.S. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 14th American Peptide Symposium), Mayflower, Birmingham, U.K., 1996, pp. 92–93.

    Google Scholar 

  51. Fuller, W.D., Cohen, M.P., Shabankareh, M., Blair, R.K., Goodman, M. and Naider, F.R., J. Am. Chem. Soc., 112 (1990) 7414.

    Article  CAS  Google Scholar 

  52. Zhu, Y.-F. and Fuller, W.D., Tetrahedron Lett., 36 (1995) 807.

    Article  CAS  Google Scholar 

  53. Dimaio, J. and Schiller, P.W., Proc. Natl. Acad. Sci. USA, 77 (1980) 7162.

    Article  CAS  Google Scholar 

  54. Sham, H.L., Bolis, G., Stein, H.H., Fesik, S.W., Marcotte, P.A., Plattner, J.J., Rempel, C.A. and Greer, J., J. Med. Chem., 31 (1988) 284.

    Article  PubMed  CAS  Google Scholar 

  55. Smith, D.D., Slaninova, V.J. and Hruby, V.J., J. Med. Chem., 35 (1992) 1558.

    Google Scholar 

  56. Al-Obeidi, E, Castrucci, A.M., Hadley, M.E. and Hruby, V.J., J. Med. Chem., 32 (1989) 2555.

    Google Scholar 

  57. Salmon, S.E., Lam, K.S., Lebl, M., Kandola, A., Khattri, P.S., Wade, S., Patek, M., Kocis, P., Krchnâk, V., Thorpe, D. and Felder, S., Proc. Natl. Acad. Sci. USA, 90 (1993) 11708.

    Article  CAS  Google Scholar 

  58. Eichler, J., Lucka, A.W., Pinilla, C. and Houghten, R.A., Mol. Div., 1 (1995) 233.

    Article  Google Scholar 

  59. Kramer, A., Schuster, A., Reineke, U., Malin, R., Volkmer-Engert, R., Landgraf, C. and SchneiderMergener, J., Methods (A Companion to Methods Enzymol.), 6 (1994) 388.

    Article  CAS  Google Scholar 

  60. Eichler, J., Lucka, A.W. and Houghten, R.A., Pept. Res., 7 (1994) 300.

    PubMed  CAS  Google Scholar 

  61. Bradshaw, C.G., Chollet, A.R. and Wells, T.N.C., In Schneider, C.H. and Eberle, A.N. (Eds.) Peptides 1992 (Proceedings of the 22nd European Peptide Symposium), ESCOM, Leiden, The Netherlands, 1993, pp. 318–319.

    Google Scholar 

  62. Darlak, K., Romanovskis, P. and Spatola, A.F., In Hodges, R.S. and Smith, J.A. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 13th American Peptide Symposium), ESCOM, Leiden, The Netherlands, 1994, pp. 981–983.

    Google Scholar 

  63. McBride, J.D., Freeman, N., Domingo, G.J. and Leatherbarrow, R.J., J. Mol. Biol., 259 (1996) 819.

    Article  PubMed  CAS  Google Scholar 

  64. Spatola, A.F. and Romanovskis, P., In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 327–347.

    Book  Google Scholar 

  65. DeWitt, S.H., Kiely, J.S., Stankovic, C.J., Schroeder, M.C., Cody, D.M.R. and Pavia, M.R., Proc. Natl. Acad. Sci. USA, 90 (1993) 6909.

    Article  CAS  Google Scholar 

  66. Maeji, N.J., Bray, A.M. and Geysen, H.M., J. Immunol. Methods, 134 (1990) 23.

    Article  PubMed  CAS  Google Scholar 

  67. Gammon, G., Geysen, H.M., Apple, R.J., Pickett, E., Palmer, M., Ametani, A. and Sercarz, E.E., J. Exp. Med., 173 (1991) 609.

    Article  PubMed  CAS  Google Scholar 

  68. Mutch, D.A., Rodds, S.J., Benstead, M., Valerio, R.M. and Geysen, H.M., Pept. Res., 4 (1991) 132.

    PubMed  CAS  Google Scholar 

  69. Wang, J.-X., Bray, A.M., DiPasquals, A.J., Maeji, N.J. and Geysen, H.M., Bioorg. Med. Chem. Lett., 3 (1993) 447.

    Article  CAS  Google Scholar 

  70. Wang, J.-X., DiPasquals, A.J., Bray, A.M., Maeji, N.J. and Geysen, H.M., Bioorg. Med. Chem. Lett., 3 (1993) 451.

    Article  Google Scholar 

  71. Spellmeyer, D.C., Brown, S., Stauber, G.B., Geysen, H.M. and Valerio, R., Bioorg. Med. Chem. Lett., 3 (1993) 519.

    Article  CAS  Google Scholar 

  72. Spellmeyer, D.C., Brown, S., Stauber, G.B., Geysen, H.M. and Valerio, R., Bioorg. Med. Chem, Lett., 3 (1993) 1253.

    Google Scholar 

  73. Bastos, M., Maeji, N.J. and Abeles, R.H., Proc. Natl. Acad. Sci. USA, 92 (1995) 6738.

    Article  CAS  Google Scholar 

  74. Maeji, N.J., Bray, A.M., Valerio, R.M. and Wang, W, Pept. Res., 8 (1995) 33.

    PubMed  CAS  Google Scholar 

  75. Frank, R., Tetrahedron, 48 (1992) 9217.

    Article  CAS  Google Scholar 

  76. Blankemeyer-Menge, B. and Frank, R., Tetrahedron Lett., 29 (1988) 5871.

    Article  CAS  Google Scholar 

  77. Frank, R. and Doring, R., Tetrahedron, 44 (1988) 6031.

    Article  CAS  Google Scholar 

  78. Frank, R., Bioorg. Med. Chem. Lett., 3 (1993) 425.

    Article  CAS  Google Scholar 

  79. Frank, R., Hoffmann, S., Kieß, M., Lahmann, H., Tegge, W, Behn, C. and Gausepohl, H., In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 363–386.

    Book  Google Scholar 

  80. Frank, R., J. Biotechnol., 41 (1995) 259.

    Article  PubMed  CAS  Google Scholar 

  81. Schneider-Mergener, J., Kramer, A. and Reineke, U., In Cortese, R. (Ed.) Combinatorial Libraries: Synthesis, Screening, and Application Potential, Walter de Gruyter, Berlin, Germany, 1996, pp. 53–68.

    Google Scholar 

  82. Kramer, A. and Schneider-Mergener, J., In Maia, H.L.S. (Ed.) Peptides 1994 (Proceedings of the 23rd European Peptide Symposium), ESCOM, Leiden, The Netherlands, 1995, pp. 475–476.

    Chapter  Google Scholar 

  83. Fodor, S.P.A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T. and Solas, D., Science, 251 (1991) 767.

    Article  PubMed  CAS  Google Scholar 

  84. Fodor, S.P.A., Rava, R.P., Huang, X.C., Pease, A.C., Holmes, C.P. and Adams, C.L., Nature, 364 (1993) 555.

    Article  PubMed  CAS  Google Scholar 

  85. Gallop, M.A., Barrett, R.W., Dower, W.J., Fodor, S.P.A. and Gordon, E.M., J. Med. Chem., 37 (1994) 1233.

    Google Scholar 

  86. Holmes, C.P., Adams, C.L., Kochersperger, L.M., Mortensen, R.B. and Aldwin, L.A., Biopolym. Pept. Sci. Sect., 37 (1995) 199.

    Article  CAS  Google Scholar 

  87. Pinilla, C., Appel, J.R. and Houghten, R.A., In Zegers, N., Boersma, W. and Claasen, E. (Eds.) Immunological Recognition of Peptides in Medicine and Biology, CRC Press, Boca Raton, FL, U.S.A., 1995, pp. 1–14.

    Google Scholar 

  88. Pinilla, C., Appel, J.R. and Houghten, R.A., Mol. Immunol., 30 (1993) 577.

    Article  PubMed  CAS  Google Scholar 

  89. Appel, J.R., Pinilla, C. and Houghten, R.A., Immunomethods, 1 (1992) 17.

    Article  CAS  Google Scholar 

  90. Pinilla, C., Appel, J.R. and Houghten, R.A., Gene, 128 (1993) 71.

    Article  PubMed  CAS  Google Scholar 

  91. Dooley, C.T., Kaplan, R.A., Chung, N.N., Schiller, P.W., Bidlack, J.M. and Houghten, R.A., Pept. Res., 8 (1995) 124.

    PubMed  CAS  Google Scholar 

  92. Dooley, C.T., Chung, N.N., Schiller, P.W. and Houghten, R.A., Proc. Natl. Acad. Sci. USA, 90 (1993) 10811.

    Article  CAS  Google Scholar 

  93. Blondelle, S.E. and Houghten, R.A., Annu. Rep. Med. Chem., 27 (1992) 159.

    Article  CAS  Google Scholar 

  94. Eichler, J. and Houghten, R.A., Biochemistry, 32 (1993) 11035.

    Article  PubMed  CAS  Google Scholar 

  95. Pinilla, C., Appel, J.R., Blanc, P. and Houghten, R.A., BioTechniques, 13 (1992) 901.

    PubMed  CAS  Google Scholar 

  96. Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Ostresh, J.M. and Houghten, R.A., Drug Dev. Res., 33 (1994) 133.

    Article  CAS  Google Scholar 

  97. Dooley, C.T. and Houghten, R.A., Life Sci., 52 (1993) 1509.

    Article  PubMed  CAS  Google Scholar 

  98. Pinilla, C., Appel, J.R., Milich, D. and Houghten, R.A., In Hodges, R.S. and Smith, J.A. (Eds.) Peptides: Chemistry, Structure and Biology (Proceedings of the 13th American Peptide Symposium), ESCOM, Leiden, The Netherlands, 1994, pp. 1016–1017.

    Google Scholar 

  99. Deprez, B., Williard, X., Bourel, L., Coste, H., Hyafil, F. and Tartar, A., J. Am. Chem. Soc., 117 (1995) 5405.

    Article  CAS  Google Scholar 

  100. Erb, E., Janda. K.D. and Brenner, S., Proc. Natl. Acad. Sci. USA, 91 (1994) 11422.

    Article  CAS  Google Scholar 

  101. Songyang, Z., Shoelson, S.E., Chandhuri, M., Gish, G., Pawson, T., Haser, W, King, E, Roberts, T., Ratnofsky, S., Lechteider, R.J., Neel, B.G., Birge, R.B., Fajardo, J.E., Chou, M.M., Hanafusa, H., Schaffhausen, B. and Cantley, L.C., Cell, 72 (1993) 767.

    Article  PubMed  CAS  Google Scholar 

  102. Songyang, Z., Carrway III, K.L., Eck, M.J., Harrison, S.C., Feldman, R.A., Modammadi, M., Schlessinger, J., Hubbard, S.R., Smith, D.P., Eng, C., Lorenzo, M.J., Ponder, B.A.J., Mayer, B.J. and Cantley, L.C., Nature, 373 (1995) 536.

    Article  PubMed  CAS  Google Scholar 

  103. Ellington, A.D. and Szostak, J.W., Nature, 346 (1990) 1104.

    Article  Google Scholar 

  104. Chu, Y.-H., Avila, L.Z., Biebuyck, H.A. and Whitesides, G.M., J. Org. Chem., 58 (1993) 648.

    Article  CAS  Google Scholar 

  105. Chu, Y-H., Dunayevskiy, Y.M., Kirby, D.P., Vouros, P. and Karger, B.L., J. Am. Chem. Soc., 118 (1996) 7827.

    Article  CAS  Google Scholar 

  106. Furka, A., Sebestyen, F., Asgedom, M. and Dibo, G., poster presented at the 14th International Congress of Biochemistry, Prague, Czechoslovakia, 1988.

    Google Scholar 

  107. Furka, A., Sebestyen, F., Asgedom, M. and Dibo, G., poster presented at the Xth International Symposium on Medicinal Chemistry, Budapest, Hungary, 1988.

    Google Scholar 

  108. Furka, A., Sebestyen, E, Asgedom, M. and Dibo, G., Int. J. Pept. Protein Res., 37 (1991) 487.

    Article  PubMed  CAS  Google Scholar 

  109. Lam, K.S. and Salmon, S.E., U.S. Patent 5510240, 1996.

    Google Scholar 

  110. Lebl, M., Krchnak, V., Sepetov, N.F., Seligmann, B., Strop, P., Felder, S. and Lam, K.S., Biopolym. Pept. Sci. Sect., 37 (1995) 177.

    Article  CAS  Google Scholar 

  111. Lam, K.S. and Lebl, M., In Jung, G. (Ed.) Combinatorial Peptide and Nonpeptide Libraries, A Handbook, VCH, Weinheim, Germany, 1996, pp. 173–201.

    Book  Google Scholar 

  112. Lam, K.S., Lebl, M. and Krchnak, V., Chem. Rev., (1997) in press.

    Google Scholar 

  113. Lam, K.S., Lake, D., Salmon, S.E., Smith, J., Chen, M.L., Wade, S., Abdul-Latif, E, Leblova, Z., Ferguson, R.D., Krchnak, V., Sepetov, N.F. and Lebl, M., Methods (A Companion to Methods Enzymol.), 9 (1996) 482.

    Article  CAS  Google Scholar 

  114. Mattioli, S., Imberti, L., Stellini, R. and Primi, D., J. Virol., 69 (1995) 5294.

    PubMed  CAS  Google Scholar 

  115. Steward, M.W., Stanley, C.M. and Obeid, O.E., J. Virol., 69 (1995) 7668.

    PubMed  CAS  Google Scholar 

  116. De Koster, H.S., Amons, R., Benckhuijsen, W.E., Feijlbrief, M., Schellekens, G.A. and Drijfhout, J.W., J. Immunol. Methods, 187 (1995) 179.

    Article  PubMed  Google Scholar 

  117. Lam, K.S., Lou, Q., Zhao, Z.G., Chen, M.L., Smith, J., Pleshko, E. and Salmon, S.E., Biomed. Pept. Protein Nucleic Acids, 1 (1995) 205.

    CAS  Google Scholar 

  118. Lam, K.S. and Lebl, M., Immunomethods, 1 (1992) 11.

    Article  CAS  Google Scholar 

  119. Smith, M.H., Lam, K.S., Hersh, E.M., Lebl, M. and Grimes, W.J., Mol. Immunol., 31 (1994) 1431.

    Google Scholar 

  120. Samson, I., Kerremans, L., Rozenski, J., Samyn, B., Van Beeumen, J., Van Aerschot, A. and Herdewijn, E, Bioorg. Med. Chem., 3 (1995) 257.

    Google Scholar 

  121. Lam, K.S., Wade, S., Abdul-Latif, E. and Lebl, M., J. Immunol. Methods, 180 (1995) 219.

    Article  PubMed  CAS  Google Scholar 

  122. Chen, J.K., Lane, W.S., Brauer, A.W., Tanaka, A. and Schreiber, S.L., J. Am. Chem. Soc., 115 (1993) 12519.

    Article  Google Scholar 

  123. Combs, A.P., Kapoor, T.M., Feng, S., Chen, J.K., Daude-Snow, L.F. and Schreiber, S.L., J. Am. Chem. Soc., 118 (1996) 287.

    Article  CAS  Google Scholar 

  124. Kassarjian, A., Schellenberger, V. and Truck, C.W., Pept. Res., 6 (1993) 129.

    PubMed  CAS  Google Scholar 

  125. Nestler, H.P., Wennemers, H., Sherlock, R. and Dong, D.L.Y., Bioorg. Med. Chem. Lett., 6 (1996) 1327.

    Google Scholar 

  126. Still, W.C., Acc. Chem. Res., 29 (1996) 155.

    Article  CAS  Google Scholar 

  127. Ohlmeyer, M.H.J., Swanson, R.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M. and Still, W.C., Proc. Natl. Acad. Sci. USA, 90 (1993) 10922.

    Article  CAS  Google Scholar 

  128. Boyce, R., Li, G., Nestler, H.P., Suenaga, T. and Still, W.C., J. Am. Chem. Soc., 116 (1994) 7955.

    Article  CAS  Google Scholar 

  129. Lam, K.S., Zhao, Z.G., Wade, S., Krchnak, V. and Lebl, M., Drug Dev. Res., 33 (1994) 157.

    Article  CAS  Google Scholar 

  130. Wennemers, H. and Still, W.C., Tetrahedron Lett., 35 (1994) 6413.

    Article  CAS  Google Scholar 

  131. Pennington, M.E., Lam, K.S. and Cress, A.E., Mol. Div., 2 (1996) 19.

    Article  CAS  Google Scholar 

  132. Sasaki, S., Takagi, M., Tanaka, Y. and Maeda, M., Tetrahedron Lett., 37 (1996) 85.

    Article  CAS  Google Scholar 

  133. Wu, J., Ma, Q.N. and Lam, K.S., Biochemistry, 33 (1994) 14825.

    Article  PubMed  CAS  Google Scholar 

  134. Lam, K.S. and Wu, J., Methods (A Companion to Methods Enzymol.), 6 (1994) 401.

    Article  CAS  Google Scholar 

  135. Lam, K.S., Wu, J. and Lou, Q., Int. J. Pept. Protein Res., 45 (1995) 587.

    Article  PubMed  CAS  Google Scholar 

  136. Lou, Q., Leftwich, M.E. and Lam, K.S., Bioorg. Med. Chem., 4 (1996) 677.

    Article  PubMed  CAS  Google Scholar 

  137. Meldal, M., Svendsen, I., Breddam, K. and Auzanneau, F.I., Proc. Natl. Acad. Sci. USA, 91 (1994) 3314.

    Article  CAS  Google Scholar 

  138. Meldal, M., Methods (A Companion to Methods Enzymol.), 6 (1994) 417.

    Article  CAS  Google Scholar 

  139. Meldal, M. and Svendsen, I., J. Chem. Soc. Perkin Trans. 1, (1995) 1591.

    Google Scholar 

  140. Lam, K.S., Salmon, S.E., Hruby, V.J., Hersh, E.M. and Al-Obeidi, F., WO PCT 92 /00091, 1992.

    Google Scholar 

  141. Jayawickreme, C.K., Graminski, G.F., Quillan, J.M. and Lerner, M.R., Proc. Natl. Acad. Sci. USA, 91 (1994) 1614.

    Article  PubMed  CAS  Google Scholar 

  142. Jayawickreme, C.K., Quillan, J.M., Graminski, G.F. and Lerner, M.R., J. Biol. Chem., 269 (1994) 29846.

    PubMed  CAS  Google Scholar 

  143. Salmon, S.E., Liu-Stevens, R.H., Zhao, Y., Lebl, M., Krchnak, V., Wertman, K., Sepetov, N. and Lam, K.S., Mol. Div., 2 (1996) 57.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Arizona Cancer Center, Department of Medicine and Department of Microbiology and Immunology, College of Medicine, The University of Arizona, 1515 North Campbell Avenue, Tucson, AZ, 85724, USA

    Zhan-Gong Zhao & Kit S. Lam

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  1. Zhan-Gong Zhao
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  2. Kit S. Lam
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Editors and Affiliations

  1. MitoKor, 92121, San Diego, CA, USA

    W. H. Moos

  2. Sphinx Pharmaceuticals, 02139, Cambridge, MA, USA

    M. R. Pavia

  3. University of North Carolina, 27599-3280, Chapel Hill, NC, USA

    B. K. Kay

  4. Indiana University, 47405, Bloomington, IN, USA

    A. D. Ellington

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Zhao, ZG., Lam, K.S. (1997). Synthetic peptide libraries. In: Moos, W.H., Pavia, M.R., Kay, B.K., Ellington, A.D. (eds) Annual Reports in Combinatorial Chemistry and Molecular Diversity. Annual Reports in Combinatorial Chemistry and Molecular Diversity, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-0-306-46904-6_14

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  • DOI: https://doi.org/10.1007/978-0-306-46904-6_14

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