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Diet History Is a Reliable Predictor of Suboptimal Docosahexaenoic Acid Levels in Adult Patients with Phenylketonuria

  • T. Bosdet
  • J. BranovEmail author
  • C. Selvage
  • M. Yousefi
  • S. Sirrs
Research Report
Part of the JIMD Reports book series (JIMD, volume 21)

Abstract

Background: Omega-3 long-chain polyunsaturated fatty acids (n3LCPUFA) levels are reduced in phenylketonuria (PKU). Recent care guidelines recommend essential fatty acid status is monitored in patients with PKU but access to such testing is limited. We hypothesized that information obtained on diet history would identify PKU adults with suboptimal levels of n3LCPUFA.

Methods: A 12-month single site prospective study was completed including 35 adults (age 18–46) attending a clinic for adults with inborn errors of metabolism. Levels of n3LCPUFA were correlated with estimated intake using a published food frequency questionnaire. n3LCPUFA levels were tested at a commercial laboratory and values > one SD below the laboratory mean value were considered suboptimal.

Results: Mean levels of docosahexaenoic acid (DHA) were lower and levels of eicosapentaenoic acid (EPA) and alpha-linoleic acid (ALA) higher in subjects with PKU than in laboratory controls. n3LCPUFA levels correlated with estimated intake (p <0.002). Diet history had a positive predictive value of 93% and negative predictive value of 90% to identify subjects with suboptimal n3LCPUFA levels.

Conclusions: Diet history is sufficient to predict adult subjects who may have low DHA levels and can be used to target testing or supplementation to those at risk. DHA levels are low despite high levels of ALA suggesting that supplementation, if indicated, should be with preformed DHA rather than with its precursors.

Keywords

Docosahexaenoic Acid Diet History Specialized Laboratory Testing Nutrition Screening Tool Kennedy Krieger Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© SSIEM and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • T. Bosdet
    • 1
  • J. Branov
    • 1
    Email author
  • C. Selvage
    • 1
  • M. Yousefi
    • 2
  • S. Sirrs
    • 1
  1. 1.Adult Metabolic Diseases Clinic, Vancouver HospitalVancouverCanada
  2. 2.Brain Research CenterUniversity of British ColumbiaVancouverCanada

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