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Corticosteroids in ARDS: back to the future

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Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.

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Abstract

The first descriptions of acute respiratory distress syndrome (ARDS) were published in 1967, when Ashbaugh et al. [1] described 12 patients with acute respiratory distress, cyanosis refractory to oxygen therapy, decreased lung compliance, and diffuse infiltrates evident on chest radiograph. ARDS is thought to be a uniform expression of a diffuse and overwhelming inflammatory reaction of the pulmonary parenchyma to a variety of serious underlying diseases. In 1994, the American- European Consensus Conference [2] defined two pathogenetic pathways leading to ARDS: a direct (‘primary’ or ‘pulmonary’) insult that directly affects lung parenchyma, and an indirect (‘secondary’ or ‘extrapulmonary’) insult that results from an acute systemic inflammatory response (Table 1).

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Author information

Authors and Affiliations

  1. Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    A. B. Souza-Fernandes & P. R. M. Rocco

  2. Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    W. A. Zin

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  1. A. B. Souza-Fernandes
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  2. W. A. Zin
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  3. P. R. M. Rocco
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Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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Souza-Fernandes, A.B., Zin, W.A., Rocco, P.R.M. (2006). Corticosteroids in ARDS: back to the future. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/88-470-0407-1_34

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  • DOI: https://doi.org/10.1007/88-470-0407-1_34

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