New Approach in the Prevention of Atrial Fibrillation: Role of Angiotensin II Antagonists

  • P. Verdecchia
  • F. Angeli
  • M. G. Sardone
  • R. Gattobigio
Conference paper


Although lowering the blood pressure stands out as the fundamental mechanism for preventing any complication of hypertension, recent data suggest that ARBs might play an important and perhaps independent contribution in the prevention of AF. By inhibiting the effects of angiotensin II, ARBs reduce both blood pressure and myocardial fibrosis, with important potential implications for atrial and ventricular electric remodelling and atrial pressure and stretch. The LIFE study has shown the beneficial effect of losartan in reducing the risk of AF in hypertensive subjects in sinus rhythm. Further studies should clarify to what extent this effect applies to other ARBs.


Atrial Fibrillation Framingham Heart Study Rheumatic Heart Disease Hypertensive Subject Chronic Atrial Fibrillation 
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Copyright information

© Springer-Verlag Italia 2005

Authors and Affiliations

  • P. Verdecchia
    • 1
  • F. Angeli
    • 1
  • M. G. Sardone
    • 1
  • R. Gattobigio
    • 1
  1. 1.Dipartimento Malattie CardiovascolariOspedale R. SilvestriniPerugiaItaly

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