The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

  • Naama Shoham
  • Natan T. Shaked
  • Dafna Benayahu
  • Amit GefenEmail author
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 16)


This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.


Adipose Tissue Brown Adipose Tissue White Adipose Tissue Subcutaneous Adipose Tissue Magnetic Resonance Elastography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research work is being supported by a Grant from the Israel Science Foundation (no. 611/12, A.G. and D.B.) and by the Israel Ministry of Science and Technology (Women in Science Scholarship awarded to N.S.).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Naama Shoham
    • 1
  • Natan T. Shaked
    • 1
  • Dafna Benayahu
    • 2
  • Amit Gefen
    • 1
    Email author
  1. 1.Department of Biomedical Engineering, Faculty of EngineeringTel Aviv UniversityTel AvivIsrael
  2. 2.Department of Cell and Developmental Biology, Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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