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Mathematical Models of Adipose Tissue Dynamics

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The Mechanobiology of Obesity and Related Diseases

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 16))

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Abstract

Adipose tissue is the main organ for long term storage of energy in the body. Adipose cells store excess energy by enlarging and/or increasing in number, while they provide energy by releasing fat and shrinking as needed. The regulation of energy storage capacity is not a simple problem considering the uncertainty of following food intakes and physical activities. In this Chapter, we introduce the inference of adipose tissue dynamics from adipose cell-size distributions using mathematical modeling and Bayesian inference. We examine recruitment of new adipose cells, growth/shrinkage and death of existing cells under positive/negative energy balance. A comprehensive understanding of adipose tissue dynamics can provide new insights into metabolic disorders such as obesity and diabetes.

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Author information

Authors and Affiliations

  1. Asia Pacific Center for Theoretical Physics, Hogil Kim Memorial Building #542 POSTECH, Pohang, Korea

    Junghyo Jo

  2. Diabetes, Endocrinology and Obesity Branch, NIDDK, NIH, Bethesda, MD, USA

    Matilde Arroyo & Samuel W. Cushman

  3. Laboratory of Biological Modeling, NIDDK, NIH, Bethesda, MD, USA

    Zeina Shreif, Jonathan R. Gaillard & Vipul Periwal

Authors
  1. Junghyo Jo
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  2. Zeina Shreif
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  3. Jonathan R. Gaillard
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  4. Matilde Arroyo
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  5. Samuel W. Cushman
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  6. Vipul Periwal
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Corresponding author

Correspondence to Junghyo Jo .

Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, Tel Aviv University Faculty of Engineering, Tel Aviv, Israel

    Amit Gefen

  2. Dept. of Cell and Developmental Biology Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

    Dafna Benayahu

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Jo, J., Shreif, Z., Gaillard, J.R., Arroyo, M., Cushman, S.W., Periwal, V. (2013). Mathematical Models of Adipose Tissue Dynamics. In: Gefen, A., Benayahu, D. (eds) The Mechanobiology of Obesity and Related Diseases. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 16. Springer, Cham. https://doi.org/10.1007/8415_2013_170

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  • DOI: https://doi.org/10.1007/8415_2013_170

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09335-2

  • Online ISBN: 978-3-319-09336-9

  • eBook Packages: EngineeringEngineering (R0)

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