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Patient-Specific Modeling in Tomorrow's Medicine pp 281–334Cite as

A Decission Support System for Endoprosthetic Patient-Specific Surgery of the Human Trachea

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Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 09))

Abstract

This chapter presents a patient specific decision support system for helping surgeons in endoprosthetical tracheal surgery. The system is based on a set of 3D finite element numerical simulations of the human trachea during swallowing with and without prosthetic insertion. The associated code uses the constitutive behavior derived from a set of experimental and histological tests performed for its main components: smooth muscle and cartilage. A complete set of numerical results is derived from those simulations using a parametric approach relying on a robust design of experiments and on a automatic mesh adaptation process. These results feed a tool for statistical analysis of human swallowing without and with prosthesis that, together with the response surface method, allows getting a set of response functions for the most important variables of the problem (displacements and principal stresses) for every point of the trachea in terms of a set of patient-specific parameters that define the geometry of the trachea and prosthesis. This provides the thoracic surgeon a fast, accurate and simple tool for predicting the stress state of the trachea and the reduction in the ability to swallow after implantation thus helping in taking decisions during pre-operative planning of tracheal interventions. This tool is also useful for performing patient specific studies of pathological swallowing and for the design of new types of prostheses.

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References

  1. Ritt, M.J.P.F., Stuart, P.R., Naggar, L., Beckenbaugh, R.D.: The early history of arthroplasty of the wrist from amputation to total wrist implant. J. Hand Surg. Br. 19(6), 778–782 (1994)

    Article  Google Scholar 

  2. Fattori, R., Piva, T.: Drug-eluting stents in vascular intervention. Lancet 361(9353), 247–249 (2003)

    Article  Google Scholar 

  3. Zakaluzny, S.A., Lane, J.D., Mair, E.A.: Complications of tracheobronchial airway stents. Am. Acad. Otolaryngology-Head Neck Surg. 128, 478 (2003)

    Article  Google Scholar 

  4. Norwood, S., Vallina, V.L., Short, K., Saigusa, M., Fernandez, L.G., McLarty, J.W.: Incidence of Tracheal Stenosis and other late complications after percutaneous Tracheostomy. Ann. Surg. 232, 233–241 (2000)

    Article  Google Scholar 

  5. Fung, Y.C.: Biomechanics: Mechanical Properties of Living Tissues. 1st edn. Springer, Heidelberg/New York (1990)

    MATH  Google Scholar 

  6. Garzon Alvarado, D.A., Garcia, J.M., Doblare, M.: A Reaction-diffusion model for long bone growth. Biomed. Environ. Sci. 8(5), 381–395 (2009)

    Google Scholar 

  7. Hernandez, B., Pena, E., Pascual, G., Rodriguez, M., Calvo, B., Doblare, M., Bellon, J.: Mechanical and histological characterization of the abdominal muscle. A previous step to modelling hernia surgery. J. Mech. Behav. Biomed. Mater. 4(3), 392–404 (2011)

    Article  Google Scholar 

  8. Enderle, J., Blanchard, S.M., Bronzino, J.: Introduction to Biomedical Engineering. Biomedical Engineering, 1st edn. Elsevier, Amsterdam (2000)

    Google Scholar 

  9. Malve, M., Perez-del Palomar, A., Trabelsi, O., Lopez-Villalobos, J., Ginel, A., Doblare, M.: Modeling of the fluid structure interaction of a human trachea under different ventilation conditions. Int. Commun. Heat Mass Transf. 38(1), 10–15 (2011)

    Article  Google Scholar 

  10. Bayod, J., Losa-Iglesias, M., Becerrode Bengoa-Vallejo, R., Carlos Prados-Frutos, J., Jules, K., Doblare, M.: Advantages and Drawbacks of Proximal Interphalangeal Joint Fusion Versus Flexor Tendon Transfer in the Correction of Hammer and Claw Toe Deformity. A Finite-Element Study. J. Biomech. Eng. Trans. ASME 132(5), 051002, (2010)

    Article  Google Scholar 

  11. Trabelsi O., Pérez Del Palomar A., Mena Tobar A., López-Villalobos J.L., Ginel A., Doblaré M.: FE simulation of human trachea swallowing movement before and after the implantation of an endoprothesis. Appl. Math. Model. (2011)

    Google Scholar 

  12. Grillo, H.C., Donahue, D.M., Mathisen, D.J., Wain, J.C., Wright, C.D.: Postintubation tracheal stenosis, treatment and results. J. Thorac. Cardiovasc. Surg. 109(3), 486–492 (1995)

    Article  Google Scholar 

  13. Huang, C.J.: Use of the silicone T-tube to treat tracheal stenosis or tracheal injuty. Ann. Thorac. Cardiacovasc. Surg. 7, 192–196 (2001)

    Google Scholar 

  14. Rob, C., Bateman, G.: Reconstruction of the trachea and cervical oesophagus; preliminary report. Br. J. Surg. 37(146), 202–205 (1949)

    Article  Google Scholar 

  15. Belsey, R.: Resection and reconstruction of the intrathoracic trachea. Br. J. Surg. 38, 200–205 (1951)

    Article  Google Scholar 

  16. Grillo, H.C.: Tracheal replacement: a critical review. Ann. Thorac. Surg. 73, 1995–2004 (2002)

    Article  Google Scholar 

  17. Wahidi, M.M., Ernst, A.: The Montgomery T-tube tracheal stent. Clinics in Chest Med. 24(3), 437–443 (2003)

    Article  Google Scholar 

  18. Xavier, R.G., Stefani Sanches, P.R., VieradeMacedo Neto, A., Kuhl, G., Bianchi Vearick, S., Dall’Onder Michelon, M.: Development of a modified Dumon stent for tracheal applicatons: an experimental study in dogs. Jornal Brasileiro de Pneumologia 34, 21–26 (2008)

    Article  Google Scholar 

  19. Noppen, M., Meysman, M., Claes, I., D’Haese, J., Vincken, W.: Screw-thread vs Dumon endoprosthesis in the management of tracheal stenosis. Chest 115, 532–535 (1999)

    Article  Google Scholar 

  20. Madden, B.P., Datta, S., Charokopos, N.: Experience with ultraflex expandable metallic stents in the management of endobronchial pathology. Ann. Thorac. Surg. 73, 938–944 (2002)

    Article  Google Scholar 

  21. Noppen, M., Stratakos, G., D’Haese, J., Meysman, M., Vincken, W.: Removal of covered self-expandable matallic airway stents in benign disorders. Chest 127, 482–487 (2005)

    Article  Google Scholar 

  22. Freitag, L., Eicker, R., Linz, B., Greschuchna, D.: Theoretical and experimental basis for the development of a dynamic airway stent. Eur. Respirory J. 7, 2038–2045 (1994)

    Google Scholar 

  23. Mitsuoka, M., Sakuragi, T., Itoh, T.: Clinical benefits and complications of Dumon stent insertion for the treatment of severe central stenosis or airway fistula. Jpn. Assoc. Thorac. Surg. 55, 275–280 (2007)

    Google Scholar 

  24. Dumon, J.F., Cavaliere, S., Diaz-Gimenez, P., Vergnon, J.M.: Seven-year experience with the Dumon prosthesis. J. Bronchol. Interv. Pulmonol. 3, 1–82 (1996)

    Google Scholar 

  25. Dumon, J.F.: A dedicated tracheobronchial stent. Chest 97, 328–332 (1990)

    Article  Google Scholar 

  26. Pereszlenyi, A., Igaz, M., Majer, I., Harustiak, S.: Role of endotracheal stenting in tracheal reconstruction surgery-retrospective analysis. Eur. J. Cardio-Thorac. Surg. 25, 1059–1064 (2004)

    Article  Google Scholar 

  27. Holzhauser, U., Lambert, R.K.: Analysis of tracheal mechanics and applications. J. Appl. Physiol. 91, 290–297 (2001)

    Google Scholar 

  28. Costantino, M.L., Bagnoli, P., Dini, G., Fiore, G.B., Soncini, M., Corno, C., Acocella, F., Colombi, R.: A Medical Engineering & Physics numerical and experimental study of compliance and collapsibility of preterm lamb tracheae. J. Biomech. 37, 1837–1847 (2004)

    Article  Google Scholar 

  29. Gustin, B., G’Sell, C., Cochelin, B., Wourms, P., Potier-Ferry, M.: Finite element determination of the forces exerted by endotracheal tubes on the upper airways. Biomaterials 17, 1219–1225 (1996)

    Article  Google Scholar 

  30. Wiggs, B.R., Hrousis, C.A., Drazen, J.M., Kamm, R.D.: On the mechanism of mucosal folding in normal and asthmatic airways. J. Appl. Physiol. 83, 1814–1821 (1997)

    Google Scholar 

  31. Rains, J.K., Bert, J.L., Roberts, C.R., Pare, P.D.: Mechanical properties of human tracheal cartilage. J. Appl. Physiol. 72, 219–225 (1992)

    Google Scholar 

  32. Roberts, C.R., Rains, J.K., Paré, P.D., Walker, D.C., Wiggs, B., Bert, J.L.: Ultrastructure and tensile properties of human tracheal cartilage. J. Biomech. 31, 81–86 (1998)

    Article  Google Scholar 

  33. Zhongzhao, T., Ochoa, I., Bea, J.A., Doblare, M.: Theoretical and experimental studies on the nonlinear mechanical property of the tracheal cartilage. In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 1058–1061 (2007)

    Google Scholar 

  34. Yamada, H.: Mechanical Properties of Respiratory and Digestive Organs and Tissues. Williams & Wilkins, Bultimera (1970)

    Google Scholar 

  35. Lambert, R.K., Baile, E.M., Moreno, R.H., Bert, J., Pare, P.D.: A method for estimating the Young’s modulus of complete tracheal cartilage rings. J. Appl. Physiol. 70, 1152–1159 (1991)

    Google Scholar 

  36. Rains, J.: Mechanical properties of tracheal cartilage. Chemical and biological engineering theses and dissertations. University of British Columbia (1989)

    Google Scholar 

  37. Kempson G.E.: Mechanical properties of articular cartilage. In: Freeman, M.A.R. (eds.) 2nd edn. Pitman, London (1979)

    Google Scholar 

  38. Wang, Y.Q., Lin, Y. H., Teng, Z.Z.: A thin shell modeling for collapsible trachea. J. Fudan Univ. Natural Science 45, 141–150 (2006)

    MathSciNet  MATH  Google Scholar 

  39. Begis, D., Delpuech, C.L., Tallec, P., Loth, L., Thiriet, M., Vidrascu, M.: A finite-element model of tracheal collapse. J. Appl. Physiol. 64, 1359–1368 (1988)

    Google Scholar 

  40. Gunst, S.J., Wu, M.F.: Plasticity in skeletal, cardiac, and smooth muscle selected contribution: plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms. J. Appl. Physiol. 90, 741–749 (2001)

    Article  Google Scholar 

  41. Comín M., Peris J.L., Prat J.M., Dejoz R.J., Vera P.M., Hoyos J.V.: Biomecánica de la Fractura Ósea y Técnicas de Reparación, 2nd edn. Instituto de Biomecánica de Valencia (1999)

    Google Scholar 

  42. Stephens, N.L., Cardinal, R., Simmons, B.: Mechanical properties of tracheal smooth muscle: effects of temperature. Am. J. Physiol. Cell Physiol. 233, C92–C98 (1977)

    Google Scholar 

  43. Holzapfel, G.A., Gasser, T.C., Ogden, R.W.: A new constitutive framework for arterial wall mechanics and a comparative study of material models. J. Elast. 61, 1–48 (2000)

    Article  MathSciNet  MATH  Google Scholar 

  44. Williams P.L., Bannister L.H., Berry M.M., Collins P., Dyson M., Dussek J.E., Ferguson M.W.J.: Anatomía de Gray. 2. Spanish Edition (1998)

    Google Scholar 

  45. Holzapfel, G.A., Gasser, T.C., Ogden, R.W.: A new constitutive framework for arterial wall mechanics and a comparative study of material models. J. Elast. 61, 1–48 (2000)

    Article  MathSciNet  MATH  Google Scholar 

  46. Peña, E., Calvo, B., Martínez, M.A., Doblaré, M.: On finite-strain damage of viscoelastic-fibred materials. Application to soft biological tissues. Int. J. Numer. Methods Eng. 74, 1198–1218 (2008)

    Article  MATH  Google Scholar 

  47. Holzapfel, G.A., Sommer, G., Gasser, C.T., Regitnig, P.: Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling. Am. J. Physiol. Heart Circulatory Physiol. 289, H2048–H2058 (2005)

    Article  Google Scholar 

  48. Holzapfel, G.A., Gasser, T.C.: A viscoelastic for fiber-renforced composites at finite strains: continuum bases, computational aspects and applications. J. Computer Methods Appl. Mech. Eng. 190, 4379–4403 (2001)

    Article  Google Scholar 

  49. Korhonen, R.K., Laasanen, M.S., Töyräs, J., Rieppo, J., Hirvonen, J., Helminen, H.J., Jurvelin, J.S.: Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and identation. J. Biomech. 35, 903–909 (2002)

    Article  Google Scholar 

  50. Sarma, P.A., Pidaparti, R.M., Moulik, P.N., Meiss, R.A.: Non-linear material models for tracheal smooth muscle tissue. Bio-Med. Mater. Eng. 13, 235–245 (2003)

    Google Scholar 

  51. Sarma, P.A., Pidaparti, R.M., Meiss, R.A.: Anisotropic properties of tracheal smooth muscle tissue. J. Biomed. Mater. Res. 65(1), 1–8 (2003)

    Article  Google Scholar 

  52. Schaefer, G., Hassanien, A., Jiang, J.: Computational Intelligence in Medical Imaging. CRC Press, Boca Raton, FL (2009)

    Book  Google Scholar 

  53. MIMICS Guide. Materialise Technologielaan 15, 3001 Leuven. http://www.materialise.com/mimics

  54. McNeel R. Rhinoceros 4.0. http://www.rhino3d.com (2007)

  55. Guyton, A.C., Hall, J.E.: Tratado de Fisiología Médica. Edición 9. McGraw-Hill Interamericana, pp. 872–873 (1997)

    Google Scholar 

  56. Boston Medical Products. 117 Flander Rd., Westborough. http://www.trachs.com/home/trachbronch/pdf/ttubecat.pdf

  57. Herrero Jover J. ALMA IT Systems. Barcelona. http://www.alma3d.com (2005)

  58. Beekhof, F.: CVMLCPP Common Versatile Multi-purpose Library for C++. CUI University of Geneva (2010)

    Google Scholar 

  59. Trabelsi, O., Pérez Del Palomar, A., López-Villalobos, J.L., Ginel, A., Doblaré, M.: Experimental characterization and constitutive modeling of the mechanical behavior of the human trachea. Med. Eng. Phys. 32, 76–82 (2010)

    Article  Google Scholar 

  60. Wang, L., Pinder, K.L., Bert, J.L., Okazawa, M., Paré, P.D.: Mechanical properties of the tracheal mucosal membrane in the rabbit. II. Morphometric analysis. J. Appl. Physiol. 88, 1022–1028 (2000)

    Google Scholar 

  61. Bourgeois, C., Steinsland, E., Blanc, N., de Rooij, N.F.: Design of resonators for the determination of the temperature coefficients of elastic constants of monocrystalline silicon. Proceedings of the IEEE International Frequency Control Symposium (1997)

    Google Scholar 

  62. MEMS and Nanotechnology Exchange. Corporation for National Research Initiatives® (CNRI) (1999)

    Google Scholar 

  63. Verkerke, G.J., de Vries, M.P., Schutte, H.K., Van den Hoogen, F.J.A, Rakhorst, G.: Analysis of mechanical behavior of the Nijdam Voice prosthesis. Laryngoscope 107, 1656–1660 (1997)

    Article  Google Scholar 

  64. Sera, T., Satoh, S., Horinouchi, H., Kabayashi, K., Tanishita, K.: Respiratory flow in a realistic tracheostenosis model. J. Biomech. Eng. 125, 461–471 (2003)

    Article  Google Scholar 

  65. Logemann, J.A., Kahrilas, P.J., Cheng, J., Pauloski, B.R., Gibbons, P.J., Rademaker, A.W., Lin, S.: Closure mechamisms of laryngeal vestibule during swallow. Am. J. Physiol. 262, G338–G344 (1992)

    Google Scholar 

  66. Rademaker, A.W., Pauloski, B.R., Logemann, J.A., Shanahan, T.K.: Oropharyngeal swallow efficiency as a representative measure of swallowing function. J. Speech, Lang. Hear. Res. 37, 314–325 (1994)

    Google Scholar 

  67. Logemann, J.A., Pauloski, B.R., Rademaker, A.W., Kahrilas, P.J.: Oropharyngeal swallow in younger and older woman: Videofluoroscopic analysis. J. Speech, Lang. Hear. Res. 45, 434–445 (2002)

    Article  Google Scholar 

  68. Dantas, R.O., Dodds, W.J.: Effect of bolus volume and consistency on swallow-induced submental and infrahyoid electromyographic activity. Braz. J. Med. Biol. Res. 23, 37–44 (1990)

    Google Scholar 

  69. Mendell, D.A., Logemann, J.A.: Temporal sequence of swallow events during the oropharyngeal swallow. J. Speech, Lang. Hear. Res. 50(5), 1256–1271 (2007)

    Article  Google Scholar 

  70. Wilson, E.M., Green, J.R.: Coordinative organization of lingual propulsion during the normal adult swallow. Dysphagia 21(4), 226–236 (2006)

    Article  Google Scholar 

  71. Inagaki, D., Miyaoka, Y., Ashida, I., Ueda, K., Yamada, Y.: Influences of body posture on duration of oral swallowing in normal young adults. J. Oral Rehabil. 34(6), 414–421 (2007)

    Article  Google Scholar 

  72. Steele, C.M., Van Lieshout, P.H.: The dynamics of lingual-mandibular coordination during liquid swallowing. Dysphagia 23(1), 33–46 (2007)

    Article  Google Scholar 

  73. Terk, A.R., Leder, S.B., Burrell, M.I.: Hyoid bone and laryngeal movement dependent upon presence of a tracheotomy tube. Dysphagia 22(2), 89–93 (2007)

    Article  Google Scholar 

  74. Mendell, D.A., Logemann, J.A.: Temporal sequence of swallow events during the oropharyngeal swallow. J. Speech Lang. Hear. Res. 50(5), 1256–1271 (2007)

    Article  Google Scholar 

  75. Honda, Y., Hata, N.: Dynamic imaging of swallowing in a seated position using open-configuration MRI. J. Magn. Reson. Imaging 26(1), 172–176 (2007)

    Article  Google Scholar 

  76. Crary, M.A., Carnaby Mann, G.D., Groher, ME.: Identification of swallowing events from sEMG Signals Obtained from Healthy Adults. Dysphagia 22(2), 94–9 (2007)

    Article  Google Scholar 

  77. Aboofazeli, M., Moussavi, Z.: Analysis of temporal pattern of swallowing mechanism. Conf. Proc. IEEE Eng. Med. Biol. Soc. 1, 5591–5594 (2006)

    Article  Google Scholar 

  78. Afkari, S.: Measuring frequency of spontaneous swallowing. Australasian Phys. Eng. Sci. Med. 30(4), 313–7 (2007)

    Google Scholar 

  79. Moreno, M.C., Gil-Loyzaga, P., Gómez, F.R., Carcedo, C.F., Fernández, J.G., Martínez, E.P., Grande, A.H., Broto, J.P.: Magnetoelastic sensors as a new tool for laryngeal research. Acta Otolaryngology 127(11), 1182–1187 (2007)

    Article  Google Scholar 

  80. Robert, D.: Swallowing disorders following endotracheal intubation and tracheotomy. Reanimation 13, 417–430 (2004)

    Google Scholar 

  81. Philips Medical Systems Nederland B.V. Integris V with High-Speed DICOM Image Interface R1 (MCV 2971). DICOM Conformance Statement (1998)

    Google Scholar 

  82. Crow, K.: Robust Product Design through Design of Experiments. DRM Associates (1998)

    Google Scholar 

  83. Ashby, W.R.: Design for a Brain. 2nd edn. Chapman & Hall, London (1960)

    MATH  Google Scholar 

  84. Miranda V.J.C.: Product design: techniques for robustness, reliability and optimization. Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Toluca (2004)

    Google Scholar 

  85. Montgomery, D.C.: Design and Analysis of Experiments, 7th edn (2008)

    Google Scholar 

  86. Berger, P.D., Maurer, R.E.: Experimental design with applications in management, engineering and the sciences. Technometrics: J. Statist. Phys. Chem. Eng. Sci. 45(1), 105 (2003)

    Google Scholar 

  87. Roy, R.: The primer on the Taguchi method. Edition Van Nostrand Reinhold (1990)

    Google Scholar 

  88. Tsui, K.L.: An overview of Taguchi method and newly developed statistical methods for robust design. IIE Trans. 24(5), 44–57 (1992)

    Article  MathSciNet  Google Scholar 

  89. Griscom, N.T., Wohl, M.E.B.: Dimensions of the growing trachea related to age and gender. Am. Roentgen Ray Soc. 146, 233–237 (1986)

    Google Scholar 

  90. Rocabado B.J.L., Roldan T.R., Derosas A.C., Zuleta S.R., Hurtado S.G.: Manejo de la estenosis traqueal. Revista Chilena de Cirugía. 59(6):408-416. (2007)

    Google Scholar 

  91. Ragavan, A.J., Evrensel, C.A., Krumpe, P.: Interactions of airway oscillation, tracheal inclination and mucus elasticity. Significantly improve Simulated Cough clearance. Am. Coll. Chest Physicians 137, 355–361 (2010)

    Google Scholar 

  92. Perez del Palomar A., Trabelsi O., Mena A., Lopez-Villalobos J.L., Ginel A., Doblare M.: Patient-specific models of human trachea to predict mechanical consequences of endoprosthesis implantation. Phil. Trans. R. Soc. A Math. Phys. Eng. Sci. 368 (1921):2881–2896 (2010)

    Google Scholar 

  93. Neter, J., Kutner, M., Wasserman, W., Nachtsheim, C.: Applied Linear Statistical Models. McGraw-Hill, New York (1996)

    Google Scholar 

  94. Ryan, B.: Minitab Software. State College, Pensilvania (1972)

    Google Scholar 

  95. Darlington, R.B.: Regression and Linear Models. Mc Graw-Hill, New York (1990)

    Google Scholar 

  96. Hocking, R.R.: A biometrics invited paper. The analysis and selection of variables in linear regression. Biometrics 32(1), 1–49 (1976)

    Article  MathSciNet  MATH  Google Scholar 

  97. Lindeman, R.H., Merenda, P.F., Gold, R.Z.: Introduction to Bivariate and Multivariate Analysis. Scott, Foresman, Glenview (1980)

    MATH  Google Scholar 

  98. Sharma, M.K., Jain, C.K.: Fluoride modeling using best subset procedure. J. Appl. Hydrol. XVIII, 12–22 (2005)

    Google Scholar 

  99. Neter, J., Wasserman, W.: Applied Linear Statistical Models, 2nd edn. Professional Publishing, Irwin (1985)

    Google Scholar 

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Acknowledgments

The support of the Instituto de Salud Carlos III under the CIBER initiative is greatly acknowledged.

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Authors and Affiliations

  1. Group of Structural Mechanics and Materials Modelling (GEMM). Aragón Institute of Engineering Research (I3A), University of Zaragoza, Betancourt Bldg. María de Luna s/n, 50018, Zaragoza, Spain

    Olfa Trabelsi, Amaya Pérez-del Palomar & Manuel Doblaré

  2. Thoracic and Neumology Service, Hospital Virgen del Rocío, Av. Manuel Siurot s/n, 41013, Seville, Spain

    Angel Ginel & Jose L. López-Villalobos

  3. ALMA IT Systems , Vilana 4B, 4-1, 08022, Barcelona, Spain

    Miguel A González-Ballester

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  1. Olfa Trabelsi
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  2. Angel Ginel
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  3. Jose L. López-Villalobos
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  4. Miguel A González-Ballester
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  5. Amaya Pérez-del Palomar
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  6. Manuel Doblaré
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Correspondence to Manuel Doblaré .

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  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, 69978, Israel

    Amit Gefen

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Trabelsi, O., Ginel, A., López-Villalobos, J.L., González-Ballester , M.A., Pérez-del Palomar, A., Doblaré, M. (2011). A Decission Support System for Endoprosthetic Patient-Specific Surgery of the Human Trachea. In: Gefen, A. (eds) Patient-Specific Modeling in Tomorrow's Medicine. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 09. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_96

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