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Tissue Engineering Approaches for Myocardial Bandage: Focus on Hydrogel Constructs

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Myocardial Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 6))

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Abstract

Myocardial tissue engineering ambitions to regenerate, repair or replace damaged cardiac muscle by combining cellular and engineering technologies. Several issues must be addressed before this approach may one day find clinical applications for cardiac disorders such as congenital diseases or ventricular dysfunction following myocardial infarction for example. The chance of the myocardial tissue engineering approach is nevertheless real. Indeed, on the one hand, several clinical studies have recently confirmed the positive effect of stem cell therapy in patients with heart failure. On the other hand, research from several laboratories have demonstrated over the past decade that engineered muscle tissues can be created and successfully applied in models of myocardial injury. Engineering a functional myocardial graft faces with many challenges, and various approaches have been investigated. In the current chapter, we focus our review on hydrogel-based engineered tissues for myocardial application. The literature on injectable and implantable hydrogel constructs is discussed and an overview of our own experience is presented. We emphasize important aspects on development of hydrogel constructs in particular the mechanical and electrical conditioning of the construct as well as smart hydrogels.

None of the authors have conflict of interest to disclose.

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Acknowledgments

We thank Ms Laura Graham for excellent assistance in manuscript preparation, Ms Concetina Receputo and amd Mr Gilles Godar for excellent technical assistance. The research investigations were support by grants from the Swiss National Science Foundation (3200B0-108417 and 122334)

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  1. Clinic for Cardiovascular Surgery, Inselspital Berne, Berne University Hospital and University of Berne, 3010, Berne, Switzerland

    Marie Noëlle Giraud & Hendrik Tevaearai

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  1. Marie Noëlle Giraud
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Correspondence to Marie Noëlle Giraud .

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  1. University of Erlangen-Nuremberg, Department of Materials Science and Engi, Institute of Biomaterials, Erlangen, 91058, Germany

    Aldo R. Boccaccini

  2. South Kensington Campus, Imperial College London, London, SW7 2AZ, United Kingdom

    Sian E. Harding

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Giraud, M.N., Tevaearai, H. (2010). Tissue Engineering Approaches for Myocardial Bandage: Focus on Hydrogel Constructs. In: Boccaccini, A., Harding, S. (eds) Myocardial Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_43

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