Skip to main content
SpringerLink
Log in
Book cover

Cellular and Biomolecular Mechanics and Mechanobiology pp 477–521Cite as

Adhesion and Signaling of Tumor Cells to Leukocytes and Endothelium in Cancer Metastasis

  • Chapter
  • First Online:

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 4))

Abstract

Heterotypic cell–cell adhesion in the near wall region under dynamic shear forces has been studied. In particular, we focus on neutrophil (PMN)–melanoma cell emboli formation in a non-linear shear flow and subsequent tethering to the vascular endothelium (EC) as a result of cell–cell aggregation. The extent of tumor cell adhesion to a vessel wall is governed by the kinetic formation/disruption of receptor–ligand bonds, soluble signaling proteins within the tumor microenvironment, and the hydrodynamic shear within the circulation. Upon tumor cell arrest on the endothelium, retraction of EC during tumor cell extravasation occurs due to the disruption of intercellular channels or disassembly of the vascular endothelial (VE)-cadherin homodimers that allow the passage of soluble proteins and cells. Preliminary studies have found tumor-elicited PMNs increase melanoma cell extravasation, which involves PMNs tethering on the EC and subsequently capturing/maintaining melanoma cells in close proximity to the EC. Results have indicated a novel finding that PMN-facilitated melanoma cell arrest on the EC is mediated by binding between the intercellular adhesion molecule (ICAM)-1 (expressing on both melanoma cells and ECs) and β2 integrins on PMNs, influenced by tumor-induced inflammatory cytokines, e.g., interleukin (IL)-8, and hydrodynamic shear rates. Furthermore, the adherens junctions in terms of VE-cadherin are regulated by endothelial mitogen activated protein kinases (MAPK) in response to tumor cell adhesion to the EC, as well as to IL-8 and several other soluble signaling proteins within the tumor microenvironment. These studies will yield new evidence for the complex role of hemodynamics, protein signaling, and heterotypic cell adhesion in the recruitment of metastatic cancer cells to the EC in the microcirculation during metastasis, which will be significant in fostering new cross-disciplinary approaches to cancer treatment.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Alon, R., Chen, S.Q., Puri, K.D., Finger, E.B., Springer, T.A.: The kinetics of L-selectin tethers and the mechanics of selectin-mediated Rolling. J. Cell Biol. 138, 1169–1180 (1997)

    Article  Google Scholar 

  2. Bar-Eli, M.: Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology 67, 12–18 (1999)

    Article  Google Scholar 

  3. Bell, G.I.: Models for the specific adhesion of cells to cells. Science 200, 618–627 (1978)

    Article  Google Scholar 

  4. Burdick, M.M., McCarty, O.J.T., Jadhav, S., Konstantopoulos, K.: Cell–cell interactions in inflammation and cancer metastasis. IEEE Eng. Med. Biol. Mag. 20, 86–89 (2001)

    Article  Google Scholar 

  5. Cao, J., Donell, B., Deaver, D.R., Lawrence, M.B., Dong, C.: In vitro side-view imaging technique and analysis of human T-leukemic cell adhesion to ICAM-1 in shear flow. Microvasc. Res. 55 , 124–137 (1998)

    Article  Google Scholar 

  6. Cassatella, M.A.: The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16, 21–6 (1995)

    Article  Google Scholar 

  7. Cassatella, M.A.: Neutrophil-derived proteins: selling cytokines by the pound, Adv. Immunol. 73, 369–509 (1999)

    Article  Google Scholar 

  8. Chambers, A.F., MacDonald, I.C., Schmidt, E.E., Morris, V.L., Groom, A.C.: Clinical targets for anti-metastasis therapy. Adv. Cancer Res. 79, 91–121 (2000)

    Article  Google Scholar 

  9. Crawford, S., Belajic, D., Wei, J., Riley, J.P., Dunford, P.J., Bembenek, S., Fourie, A., Edwards, J.P., Karlsson, L., Brunmark, A.: A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker. Mol. Cancer. Ther. 7, 492–499 (2008)

    Article  Google Scholar 

  10. Crissman, J.D., Hatfield, J., Schaldenbrand, M., Sloane, B.F., Honn, K.V.: Arrest and extravasation of B16 amelanotic melanoma in murine lungs: a light and EM study. Lab Invest 53, 470–478 (1985)

    Google Scholar 

  11. Dejana, E., Corada, M., Lampugnani, M.G.: Endothelial cell-to-cell junctions, FASEB J 9, 910–918 (1995)

    Google Scholar 

  12. Del Maschio, A., Zanetti, A., Corada, M., Rival, Y., Ruco, L., Lampugnani, M.G., Dejana, E.: Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J. Cell. Biol. 135, 497–510 (1996)

    Article  Google Scholar 

  13. Dembo, M., Torney, D.C., Saxaman, K., Hammer, D.: The reaction-limited kinetics of membrane-to surface adhesion and detachment. Proc. R. Soc. Lond. 234, 55–83 (1988)

    Article  Google Scholar 

  14. Dong, C., Aznavoorian, S., Liotta, L.A.: Two phases of pseudopod protrusion in tumor cells revealed by a micropipette. Microvasc. Res. 47, 55–67 (1994)

    Article  Google Scholar 

  15. Dong, C., Cao, J., Struble, E., Lipowsky, H.H.: Mechanics of leukocyte deformation and adhesion to endothelium in shear flow. Ann. Biomed. Eng.27, 298–312 (1999)

    Article  Google Scholar 

  16. Dong, C., Lei, X.: Biomechanics of cell rolling: Shear flow, cell-surface adhesion, and cell deformability. J. Biomechanics 33, 35–43 (2000)

    Article  Google Scholar 

  17. Dong, C., Robertson, G.P.: Immunoediting of leukocyte functions within the tumor microenvironment and cancer metastasis development. Biorheology 46, 265–279 (2009)

    Google Scholar 

  18. Dong, C., Skalak, R.: Leukocyte deformability: finite element modeling of large viscoelastic deformation. J. Theor. Biol. 158, 173–193 (1992)

    Article  Google Scholar 

  19. Dong, C., Skalak, R., Sung, K.L.P., Schmid-Schonbein, G.W., Chien, S.: Passive deformation analysis of human leukocytes. J. Biol. Eng. 110, 27–36 (1988)

    Google Scholar 

  20. Dong, C., Skalak, R., Sung, K.L.P.: Cytoplasmic rheology of passive neutrophils. Biorheology 28, 557–567 (1991)

    Google Scholar 

  21. Dong, C., Slattery, M.J., Liang, S., Peng, H.H.: Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8. Mol. Cell. Biomech. 2, 145–159 (2005)

    Google Scholar 

  22. Dong, C., Slattery, M.J., Rank, B.M., You, J.: In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation. Ann Biomed Eng 30, 344–355 (2002)

    Article  Google Scholar 

  23. Drury, J.L., Dembo, M.: Aspiration of human neutrophils: effects of shear thinning and cortical dissipation. Biophys. J. 81, 3166–3177 (2001)

    Article  Google Scholar 

  24. Esser, S., Lampugnani, M.G., Corada, M., Dejana, E., Risau, W.: Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci. 111, 1853–1865 (1998)

    Google Scholar 

  25. Frederick, M.J., Clayman, G.L.: Chemokines in cancer. Expert Rev Mol Med. 200, 1–18 (2001)

    Google Scholar 

  26. Giavazzi, R., Foppolo, M., Dossi, R., Remuzzi, A.: Rolling and adhesion of human tumor cells on vascular endothelium under physiological flow conditions. J. Clin. Invest. 92, 3038–3044 (1993)

    Article  Google Scholar 

  27. Gopalan, P.K., Smith, C.W., Lu, H., Berg, E.L., McIntire, L.V., Simon, S.I.: Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin. J. Immunol. 158, 367–375 (1997)

    Google Scholar 

  28. Grutkoski, P.S., Graeber, C.T., Ayala, A., Simms, H.H.: Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak, Shock 17, 47–54 (2002)

    Article  Google Scholar 

  29. Hentzen, E.R., Neelamegham, S., Kansas, G.S., Benanti, J.A., McIntire, L.V., Smith, C.W., Simon, S.I.: Sequential binding of CD11a/CD18 and CD11b/CD18 defines newtuophil capture and stable adhesion to intercellular adhesion molecule-1. Blood 95, 911–920 (2000)

    Google Scholar 

  30. Hodgson, L., Dong, C.: [Ca2+] as a potential down regulator of α2β1 integrin-mediated A2058 tumor cell migration to type IV collagen. Am. J. Physiol. Cell Physiol. 281, C106–C113 (2001)

    Google Scholar 

  31. Hodgson, L., Henderson, A.J., Dong, C.: Melanoma cell migration to type IV collagen requires activation of NF-kappaB. Oncogene 22, 98–108 (2003)

    Article  Google Scholar 

  32. Holmes, W.E., Lee, J., Kuang, W.J., Rice, G.C., Wood, W.I.: Structure and functional expression of human interleukin-8 receptor. Science 253, 1278–1280 (1991)

    Article  Google Scholar 

  33. Hoskins, M.H., Dong, C.: Kinetics analysis of binding between melanoma cells and neutrophils. Mol. Cell Biomech. 3, 79–87 (2006)

    MathSciNet  Google Scholar 

  34. Hoskins, M.H., Kunz, R.F., Bistline, J., Dong, C.: Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method. J. Fluids Struct. 25, 936–953 (2009)

    Article  Google Scholar 

  35. House, S., Lipowsky, H.: In vivo determination of the force of leukocyte-endothelium adhesion in the mesenteric microvasculature of the cat. Circ. Res. 63, 658–668 (1988)

    Google Scholar 

  36. Huh, S.J., Liang, S., Sharma, A., Dong, C., Robertson, G.P.: Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 70, 6071–6082 (2010)

    Article  Google Scholar 

  37. Jadhav, S., Eggleton, C.D., Konstantopoulos, K.: A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling. Biophys. J. 88, 96–104 (2005)

    Article  Google Scholar 

  38. Jadhav, S., Konstantopoulos, K.: Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas. Am. J. Physiol. Cell Physiol. 283, C1133–C1143 (2002)

    Google Scholar 

  39. Khanna, P., Yunkunis, T., Muddana, H.S., Peng, H.H., August, A., Dong, C.: p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly. Am. J. Physiol. Cell Physiol. 298, C1140–C1150 (2010)

    Article  Google Scholar 

  40. Khismatullin, D., Truskey, G.: Three-dimensional numerical simulation of receptor-mediated leukocyte adhesion to surfaces: Effects of cell deformability and viscoelasticity. Phys. Fluids. 17, 031505-1–21 (2005)

    Google Scholar 

  41. Konstantopoulos, K., Thomas, S.N.: Cancer cells in transit: the vascular interactions of tumor cells. Annu. Rev. Biomed. Eng. 11, 177–202 (2009)

    Article  Google Scholar 

  42. Kooijman, H.A.: A modification of the Stokes–Einstein equation for diffusivities in dilute binary mixtures. Ind. Eng. Chem. Res. 41, 3326–3328 (2002)

    Article  Google Scholar 

  43. Kramer, R.H., Nicolson, G.L.: Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion. Proc. Natl. Acad. Sci. USA 76, 5704–5708 (1979)

    Article  Google Scholar 

  44. Kunz, R.F., Yu, W.S., Antal, S.P., Ettorre, S.M.: An unstructured two-fluid method based on the coupled phasic exchange algorithm. AIAA Paper # AIAA-2001-2672. In: AIAA Computational Fluid Dynamics Conference, 15th, Anaheim, June 11–14, (2001)

    Google Scholar 

  45. Lampugnani, M.G., Corada, M., Caveda, L., Breviario, F., Ayalon, O., Geiger, B., Dejana, E.: The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J. Cell Biol. 129, 203–217 (1995)

    Article  Google Scholar 

  46. Lei, X., Lawrence, M.B., Dong, C.: Influence of cell deformation on leukocyte rolling adhesion in shear flow. J. Biomech. Eng. 121, 636–643 (1999)

    Article  Google Scholar 

  47. Leyton-Mange, J., Sung, Y., Henty, M., Kunz, R.F., Zahn, J., Dong, C.: Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies. J. Biomech. Eng 128, 271–278 (2006)

    Article  Google Scholar 

  48. Liang, S., Dong, C.: Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions. Am. J. Physiol. Cell. Physiol. 295, C701–707 (2008)

    Article  Google Scholar 

  49. Liang, S., Fu, C., Wagner, D., Guo, H., Zhan, D., Dong, C., Long, M.: 2D kinetics of β2 integrin-ICAM-1 bindings between neutrophils and melanoma cells. Am. J. Physiol. 294, C743–C753 (2008a)

    Article  Google Scholar 

  50. Liang, S., Hoskins, M.H., Dong, C.: Tumor cell extravasation mediated by leukocyte adhesion is shear rate-dependent on IL-8 signaling. Mol. Cell. Biomech. 7(2), 77–91 (2009)

    Google Scholar 

  51. Liang, S., Hoskins, M.H., Khanna, P., Kunz, R.F., Dong, C.: The tumor-leukocyte microenvironment in a shear flow and how it affects melanoma–neutrophil adhesion to the endothelium. Cell. Mol. Bioeng. 1, 189–200 (2008b)

    Article  Google Scholar 

  52. Liang, S., Sharma, A., Peng, H.H., Robertson, G., Dong, C.: Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Res 67, 5814–5820 (2007)

    Article  Google Scholar 

  53. Liang, S., Slattery, M., Dong, C.: Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion. Exp. Cell Res. 310, 282–292 (2005)

    Article  Google Scholar 

  54. Liang, S., Slattery, M.J., Wagner, D., Simon, S.I., Dong, C.: Hydrodynamic shear rate regulates melanoma–leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation. Ann. Biomed. Eng. 36, 661–671 (2008c)

    Article  Google Scholar 

  55. Liao, F., Doody, J.F., Overholser, J., Finnerty, B., Bassi, R., Wu, Y., Dejana, E., Kussie, P., Bohlen, P., Hicklin, D.J.: Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability. Cancer Res. 62, 2567–2575 (2002)

    Google Scholar 

  56. Liotta, L.A.: Cancer cell invasion and metastasis. Sci. Am. 266, 54–63 (1992)

    Article  Google Scholar 

  57. Lynam, E., Sklar, L.A., Taylor, A.D., Neelamegham, S., Edwards, B.S., Smith, C.W., Simon, S.I.: Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells. J. Leukoc. Biol. 64, 622–630 (1998)

    Google Scholar 

  58. Ma, Y.P., Wang, J., Liang, S., Dong, C., Du, Q.: Application of population dynamics to study heterotypic cell aggregations in the near-wall region of a shear flow. Cell. Mol. Bioeng. 3(1), 3–19 (2010)

    Article  Google Scholar 

  59. Marie, C., Roman-Roman, S., Rawadi, G.: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or mycoplasma fermentans membrane lipoproteins. Infect. Immun. 67, 688–693 (1999)

    Google Scholar 

  60. Miele, M.E., Bennett, C.F., Miller, B.E., Welch, D.R.: Enhanced metastatic ability of TNF-treated maliganant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1) antisense oligonucleotides. Exp. Cell Res. 214, 231–241 (1994)

    Article  Google Scholar 

  61. Migliorini, C., Qian, Y.H., Chen, H.D., Brown, E.B., Jain, R.K., Munn, L.L.: Red blood cells augment leukocyte rolling in a virtual blood vessel. Biophys. J. 83, 1834–1841 (2002)

    Article  Google Scholar 

  62. Moghe, P.V., Nelson, R.D., Tranquillo, R.T.: Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay. J. Immunol. Meth. 180, 193–211 (1995)

    Article  Google Scholar 

  63. Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S.N., Barrera, J.L., Mohar, A., Verastegui, E., Zlotnik, A.: Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50–6 (2001)

    Article  Google Scholar 

  64. Munn, L.L., Melder, R.J., Jain, R.K.: Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies. Biophys. J. 67, 889–895 (1994)

    Article  Google Scholar 

  65. Murphy, P.M., Tiffany, H.L.: Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253, 1280–1283 (1991)

    Article  Google Scholar 

  66. N’Dri, N.A., Shyy, W., Tran-Son-Tay, R.: Computational modeling of cell adhesion and movement using a continuum-kinetics approach. Biophys. J. 85, 2273–2286 (2003)

    Article  Google Scholar 

  67. Neelamegham, S.: Transport features, reaction kinetics and receptor biomechanics controlling selectin and integrin mediated cell adhesion. Cell Commun. Adhes. 1, 35–50 (2004)

    Article  Google Scholar 

  68. Neelamegham, S., Taylor, A.D., Burns, A.R., Smith, C.W., Simon, S.I.: Hydrodynamic shear shows distinct roles for LFA-1 and MAC-1 in neutrophil adhesion to intercellular adhesion molecule-1. Blood 72, 1626–1638 (1998)

    Google Scholar 

  69. Nwariaku, F.E., Chang, J., Zhu, X., Liu, Z., Duffy, S.L., Halaihel, N.H., Terada, L.: Turnage RH The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability. Shock 1, 82–5 (2002)

    Article  Google Scholar 

  70. Okamoto, M., Liu, W., Luo, Y., Tanaka, A., Cai, X., Norris, D.A., Dinarello, C.A., Fujita, M.: Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1β. J. Biol. Chem. 285, 6477–6488 (2010)

    Article  Google Scholar 

  71. Payne, A.S., Cornelius, L.A.: The role of chemokines in melanoma tumor growth and metastasis. J. Invest. Dermatol. 118, 915–922 (2002)

    Article  Google Scholar 

  72. Peng, H.H., Dong, C.: Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly. Cell. Mol. Bioeng. 2(3), 375–385 (2009)

    Article  Google Scholar 

  73. Peng, H.H., Hodgson, L., Henderson, A.J., Dong, C.: Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly. Frontiers Biosci. 10, 1597–1606 (2005)

    Article  Google Scholar 

  74. Peng, H.H., Liang, S., Henderson, A.J., Dong, C.:Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Exp. Cell Res. 313, 551–559 (2007)

    Article  Google Scholar 

  75. Qi, J., Chen, N., Wang, J., Siu, C.H.: Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway. Mol. Biol. Cell. 16, 4386–4397 (2005)

    Article  Google Scholar 

  76. Rinker, K.D., Prabhakar, V., Truskey, G.A.: Effect of contact time and force on monocyte adhesion to vascular endothelium. Biophys. J. 80, 1722–1732 (2001)

    Article  Google Scholar 

  77. Sandig, M., Voura, E.B., Kalnins, V.I., Siu, C.H.: Role of cadherins in the transendothelial migration of melanoma cells in culture. Cell Motil Cytoskelet. 38, 351–64 (1997)

    Article  Google Scholar 

  78. Schadendorf, D., Mohler, T., Haefele, J., Hunstein, W., Kelholz, U.: Serum interleuckin-8 is elevated in patients with metastatic melanoma and correlates with tumor load. Melanoma Res. 5, 179–181 (1995)

    Article  Google Scholar 

  79. Scherbarth, S., Orr, F.W.: Intravital video microscopic evidence for regulation of metastasis by the hepatic microvasculature: Effects of interleukin-1 on metastasis and the location of B16F1 melanoma cell arrest. Cancer Res. 57, 4105–4110 (1997)

    Google Scholar 

  80. Sharma, A., Tran, M., Liang, S., Sharma, A.K., Amin, S., Smith, C.D., Dong, C., Robertson, G.P.: Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res. 66, 8200–8209 (2006)

    Article  Google Scholar 

  81. Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., Resnick, N.: VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 99, 9462–9427 (2002)

    Article  Google Scholar 

  82. Simon, S.I., Green, C.E.: Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu. Rev. Biomed. Eng. 7, 151–185 (2005)

    Article  Google Scholar 

  83. Singh, R.K., Gutman, M., Radinsky, R., Bucana, C.D., Fidler, I.J.: Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res. 54, 3242–3247 (1994)

    Google Scholar 

  84. Singh, R.K., Varney, M.L.: Regulation of interleukin-8 expression in human malignant melanoma cells. Cancer Res. 58, 1532–1537 (1998)

    Google Scholar 

  85. Singh, S., Varney, M., Singh, R.K.: Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res. 69, 411–5 (2009)

    Article  Google Scholar 

  86. Slattery, M.J., Dong, C.: Neutrophils influence melanoma adhesion and migration under flow conditions. Int. J. Cancer 106, 713–722 (2003)

    Article  Google Scholar 

  87. Slattery, M.J., Liang, S., Dong, C.: Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Am. J. Physiol. Cell Physiol. 288(4), C831–839 (2005)

    Article  Google Scholar 

  88. Smith, M.J., Berg, E.L., Lawrence, M.B.: A direct comparison of selectin-mediated transient, adhesive events using high temporal resolution. Biophys. J. 77, 3371–3383 (1999)

    Article  Google Scholar 

  89. Springer, T.A.: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301–314 (1994)

    Article  Google Scholar 

  90. Starkey, J.R., Liggitt, H.D., Jones, W., Hosick, H.L.: Influence of migratory blood cells on the attachment of tumor cells to vascular endothelium. Int. J. Cancer 34, 535–543 (1984)

    Article  Google Scholar 

  91. Strieter, R.M., Kasahara, K., Allen, R.M., Standiford, T.J., Rolfe, M.W., Becker, F.S., Chensue, S.W., Kunkel, S.L.: Cytokine-induced neutrophil-derived interleukin-8. Am. J. Pathol. 141, 397–407 (1992)

    Google Scholar 

  92. Thorlacius, H., Pricto, J., Raud, J., Gautam, N., Patarroyuo, M., Hedqvist, P., Lindbom, L.: Tumor cell arrest in the microcirculation: lack of evidence for a leukocyte-like rolling adhesive interaction with vascular endothelium in vivo. Clin. Immunol. Immunopathol. 83, 68–76 (1997)

    Article  Google Scholar 

  93. Todaro, G.J., Fryling, C., De Larco, J.E.: Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc. Natl. Acad. Sci. USA 77, 5258–62 (1980)

    Article  Google Scholar 

  94. Tominaga, Y., Kita, Y., Satoh, A., Asai, S., Kato, K., Ishikawa, K., Horiuchi, T., Takashi, T.: Affinity and kinetic analysis of the molecular interaction of ICAM-1 and leukocyte function-associated antigen-1. J. Immunol. 161, 4016–4022 (1998)

    Google Scholar 

  95. Tremblay, P.L., Auger, F.A., Huot, J.: Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases. Oncogene 25, 6563–73 (2006)

    Article  Google Scholar 

  96. Van Wetering, S., van den Berk, N., van Buul, J.D., Mul, F.P., Lommerse, I., Mous, R., ten Klooster, J.P., Zwaginga, J.J., Hordijk, P.L.: VCAM-1-mediated Rac signaling controls endothelial cell–cell contacts and leukocyte transmigration. Am. J. Physiol. Cell Physiol. 285, 343–352 (2003)

    Google Scholar 

  97. Vitte, J., Pierres, A., Benoliel, A.M., Bongrand, P.: Direct quantification of the modulation of interaction between cell- or surface-bound LFA -1 and ICAM-1. J. Leukoc. Biol. 76, 1–9 (2004)

    Article  Google Scholar 

  98. Volberg, T., Zick, Y., Dror, R., Sabanay, I., Gilon, C., Levitzki, A., Geiger, B.: The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junction. EMBO J. 11, 1733–1742 (1992)

    Google Scholar 

  99. Voura, E.B., Sandig, M., Siu, C.H.: Cell–cell interactions during transendothelial migration of tumor cells. Microsc Res Tech. 43, 265–275 (Review) (1998)

    Google Scholar 

  100. Walz, A., Peveri, P., Aschauer, A.O., Baggiolini, M.: Purification and amino acid sequencing of NAF, a novel neutrophil activating factor produced by monocytes. Biochem. Biophys. Res. Commun 149, 755–761 (1987)

    Article  Google Scholar 

  101. Welch, D.R., Bisi, J.E., Miller, B.E., Conaway, D., Seftor, E.A., Yohem, K.H., Gilmore, L.B., Seftor, R.E.B., Nakajima, M., Hendrix, M.J.C.: Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int. J. Cancer 47, 227–237 (1991)

    Article  Google Scholar 

  102. Welch, D.R., Schissel, D.J., Howrey, R.P., Aeed, P.A.: Tumor-elicited polymorphonuclear cells, in contrast to “normal” circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adnocardinoma cells. Proc. Natl. Acad. Sci. USA 86, 5859–5863 (1989)

    Article  Google Scholar 

  103. Yamada, K.M.: Introduction: Adhesion molecules in cancer. Part I. Semin. Cancer Biol. 4, 215–218 (1993)

    Google Scholar 

  104. Yeung, A., Evans, E.: Cortical shell-liquid core model for passive flow of liquid-like spherical cells into micropipets. Biophys. J. 56, 139–149 (1989)

    Article  Google Scholar 

  105. You, J., Mastro, A.M., Dong, C.: Application of the dual micropipette technique to the measurement of tumor cell locomotion. Exp. Cell Res. 248, 160–171 (1999)

    Article  Google Scholar 

  106. You, J., Miele, M.E., Dong, C., Welch, D.R.: Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility but not invasion. Biochem. Biophys. Res. Commun. 208, 476–484 (1995)

    Article  Google Scholar 

  107. Young, M.E., Carroad, P.A., Bell, R.L.: Estimation of diffusion coefficients of proteins. Biotechnol. Bioeng. 22, 947–955 (1980)

    Article  Google Scholar 

  108. Zetter, B.R.: Adhesion molecules in tumor metastasis. Semin. Cancer Biol. 4, 219–229 (1993)

    Google Scholar 

  109. Zhang, X.H., Wojcikiewicz, E., Moy, V.: Force spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. Biophys. J. 83, 2270–2279 (2002)

    Article  Google Scholar 

  110. Zhu, C., Yago, T., Lou, J., Zarnitsyna, V.I., McEver, R.P.: Mechanisms for flow-enhanced cell adhesion. Ann. Biomed. Eng. 36, 604–621 (2008)

    Article  Google Scholar 

Download references

Acknowledgment

The author thanks his former and current graduate students for their outstanding contributions to the work presented in this chapter, especially Dr. Margret Slattery, Dr. Shile Liang, Dr. Hsin H. Peng, Dr. Meghan Hoskins, Ms. Payal Khanna and Ms. Tara Yunkunis. He greatly acknowledges Dr. Gavin Robertson, Dr. Arati Sharma, Dr. Avery August, and Dr. Robert Kunz (all from Penn State University), who have contributed significant collaboration to the work. Gratitude also extends to Dr. Meenhard Herlyn (Wistar Institute, Philadelphia, PA, USA), Dr. Danny Welch (University of Alabama, Birmingham), and Dr. Scott Simon (UC Davis, CA, USA) for kindly providing cell lines and reagents. This work was supported in part by the National Institutes of Health grants CA97306 and CA-125707, the National Science Foundation grant CBET-0729091, the Johnson & Johnson Innovative Technology, and the PA Dept. of Health Research Fund SAP #41000-26343.

Author information

Authors and Affiliations

  1. Department of Bioengineering, The Pennsylvania State University, University Park, PA, 16802, USA

    Cheng Dong

Authors
  1. Cheng Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cheng Dong .

Editor information

Editors and Affiliations

  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, 69978, Israel

    Amit Gefen

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dong, C. (2010). Adhesion and Signaling of Tumor Cells to Leukocytes and Endothelium in Cancer Metastasis. In: Gefen, A. (eds) Cellular and Biomolecular Mechanics and Mechanobiology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_21

Download citation

  • DOI: https://doi.org/10.1007/8415_2010_21

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-14217-8

  • Online ISBN: 978-3-642-14218-5

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation