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Role of Lymphoid Structure in Skin Immunity

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Inducible Lymphoid Organs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 426))

Abstract

The skin is the outermost organ of the body and is exposed to many kinds of external pathogens. To manage this, the skin contains multiple types of immune cells. To achieve sufficient induction of cutaneous adaptive immune responses, the antigen presentation/recognition in the skin is an essential process. Recent studies have expanded our knowledge of how T cells survey their cognate antigens in the skin. In addition, the formation of a lymphoid cluster, named inducible skin-associated lymphoid tissue (iSALT), has been reported during skin inflammation. Although iSALT may not be classified as a typical tertiary lymphoid organ, it provides specific antigen presentation sites in the skin. In this article, we provide an overview of the antigen presentation mechanism in the skin, with a focus on the development of iSALT and its function.

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Abbreviations

APCs:

Antigen-presenting cells

cDCs:

Conventional dendritic cells

CHS:

Contact hypersensitivity

DCs:

Dendritic cells

FRC:

Follicular reticular cell

iSALT:

Inducible skin-associated lymphoid tissue

LCs:

Langerhans cells

LNs:

Lymph nodes

MALT:

Mucosa-associated lymphoid tissue

PCVs:

Post-capillary venules

pDCs:

Plasmacytoid DCs

PVMs:

Perivascular macrophages

SALT:

Skin-associated lymphoid tissue

SLO:

Secondary lymphoid organs

TLO:

Tertiary lymphoid organ

Tregs:

Regulatory T cells

TRM:

Resident memory T cells

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Authors and Affiliations

  1. Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Gyohei Egawa & Kenji Kabashima

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  1. Gyohei Egawa
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  2. Kenji Kabashima
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Correspondence to Gyohei Egawa .

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Editors and Affiliations

  1. Department of Dermatology, Kyoto University, Kyoto, Japan

    Kenji Kabashima

  2. Department of Dermatology, Kyoto University, Kyoto, Japan

    Gyohei Egawa

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Egawa, G., Kabashima, K. (2020). Role of Lymphoid Structure in Skin Immunity. In: Kabashima, K., Egawa, G. (eds) Inducible Lymphoid Organs. Current Topics in Microbiology and Immunology, vol 426. Springer, Cham. https://doi.org/10.1007/82_2020_206

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