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Escherichia coli, a Versatile Pathogen pp 73–115Cite as

Modulation of Host Cell Processes by T3SS Effectors

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 416))

Abstract

Two of the enteric Escherichia coli pathotypes—enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)—have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target—the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection.

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  1. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, SW7 2AZ, London, UK

    Avinash R. Shenoy, R. Christopher D. Furniss, Philippa J. Goddard & Abigail Clements

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    Gad Frankel

  2. Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Eliora Z Ron

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Shenoy, A.R., Furniss, R.C.D., Goddard, P.J., Clements, A. (2018). Modulation of Host Cell Processes by T3SS Effectors. In: Frankel, G., Ron, E. (eds) Escherichia coli, a Versatile Pathogen. Current Topics in Microbiology and Immunology, vol 416. Springer, Cham. https://doi.org/10.1007/82_2018_106

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