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Viruses, Genes, and Cancer pp 83–116Cite as

Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 407)

Abstract

Red meat and dairy products have frequently been suggested to represent risk factors for certain cancers, chronic neurodegenerative diseases, and autoimmune and cardiovascular disorders. This review summarizes the evidence and investigates the possible involvement of infectious factors in these diseases. The isolation of small circular single-stranded DNA molecules from serum and dairy products of Eurasian Aurochs (Bos taurus)-derived cattle, obviously persisting as episomes in infected cells, provides the basis for further investigations. Gene expression of these agents in human cells has been demonstrated, and frequent infection of humans is implicated by the detection of antibodies in a high percentage of healthy individuals. Epidemiological observations suggest their relationship to the development multiple sclerosis, to heterophile antibodies, and to N-glycolylneuraminic acid (Neu5Gc) containing cell surface receptors.

Keywords

  • Bovine zoonoses
  • Multiple sclerosis
  • Colon cancer
  • N-glycolylneuraminic acid
  • Hodgkin‘s disease

Dedication

This manuscript is dedicated to Dr. Peter Vogt, San Diego, whose pioneering studies stimulated, encouraged and influenced a large number of young scientists and greatly contributed to the progress of Virology and Cell Biology.

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Acknowledgements

We thank Prof. Dr. Hermann Müller (Veterinary Faculty, University of Leipzig, Germany) for providing the serum samples from cattle.

An unrestricted grant was provided by Oryx, München.

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  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Harald zur Hausen, Timo Bund & Ethel-Michele de Villiers

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  1. Harald zur Hausen
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Correspondence to Harald zur Hausen or Ethel-Michele de Villiers .

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  1. Emory Vaccine Center, Emory University, Atlanta, GA, USA

    Prof. Dr. Eric Hunter

  2. Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria

    Prof. Dr. Klaus Bister

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zur Hausen, H., Bund, T., de Villiers, EM. (2017). Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases. In: Hunter, E., Bister, K. (eds) Viruses, Genes, and Cancer. Current Topics in Microbiology and Immunology, vol 407. Springer, Cham. https://doi.org/10.1007/82_2017_3

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