Models of Viral Population Dynamics
Models of viral population dynamics have contributed enormously to our understanding of the pathogenesis and transmission of several infectious diseases, the coevolutionary dynamics of viruses and their hosts, the mechanisms of action of drugs, and the effectiveness of interventions. In this chapter, we review major advances in the modeling of the population dynamics of the human immunodeficiency virus (HIV) and briefly discuss adaptations to other viruses.
KeywordsHuman Immunodeficiency Virus Human Immunodeficiency Virus Infection Human Immunodeficiency Virus Replication Viral Dynamic Human Immunodeficiency Virus Protease
This work was supported by the Department of Science and Technology, Government of India.
- Boerlijst MC, Bonhoeffer S, Nowak MA (1996) Viral quasi-species and recombination. Proc R Soc Lond B 263:1577–1584Google Scholar
- Eigen M, McCaskill J, Schuster P (1989) The molecular quasi-species. Adv Chem Phys 75:149–263Google Scholar
- Hartl DL, Clark AG (2007) Principles of Population Genetics. Sinauer Associates Inc., SunderlandGoogle Scholar
- Nowak MA, May RM (2000) Virus dynamics: mathematical principles of immunology and virology. Oxford University Press, New YorkGoogle Scholar
- Rong L, Dahari H, Ribeiro RM et al (2010) Rapid emergence of protease inhibitor resistance in hepatitis C virus. Sci Transl Med 2:30ra32Google Scholar
- Shen L, Rabi SA, Sedaghat AR et al. (2011) A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs. Sci Transl Med 3:91ra63Google Scholar
- Simek MD, Rida W, Priddy FH et al (2009) Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol 83:7337–7348PubMedPubMedCentralCrossRefGoogle Scholar