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Illustrations of the HIV Life Cycle

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 389)

Abstract

Illustrations of the HIV Life Cycle. The illustrations include proteins, nucleic acids and membranes; small molecules and water are omitted for clarity. Host cell molecules are shown in shades of blue and green and blood plasma proteins are shown in shades of tan and brown. HIV proteins are shown in red and magenta, HIV RNA is in yellow and HIV DNA is in yellow-green. The 3D model of the mature virion was generated using CellPACK by Graham Johnson

Illustrations of the major steps of HIV life cycle are presented that integrate information from structural and biophysical studies. The illustrations depict HIV and its interaction with its cellular host at a magnification that reveals all macromolecules. This report describes the sources of scientific support for the structures and processes shown in the illustrations.

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Acknowledgments

This work was supported by NIH (P50GM-103368) to the HIV Interaction and Viral Evolution Center. I thank Stephen Hughes, John Coffin, Stefan Sarafianos, Alan Engelman and Arthur Olson for insightful discussions.

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Correspondence to David S. Goodsell .

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Goodsell, D.S. (2015). Illustrations of the HIV Life Cycle. In: Torbett, B., Goodsell, D., Richman, D. (eds) The Future of HIV-1 Therapeutics. Current Topics in Microbiology and Immunology, vol 389. Springer, Cham. https://doi.org/10.1007/82_2015_437

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