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Illustrations of the HIV Life Cycle

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The Future of HIV-1 Therapeutics

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 389))

Abstract

Illustrations of the HIV Life Cycle. The illustrations include proteins, nucleic acids and membranes; small molecules and water are omitted for clarity. Host cell molecules are shown in shades of blue and green and blood plasma proteins are shown in shades of tan and brown. HIV proteins are shown in red and magenta, HIV RNA is in yellow and HIV DNA is in yellow-green. The 3D model of the mature virion was generated using CellPACK by Graham Johnson

Illustrations of the major steps of HIV life cycle are presented that integrate information from structural and biophysical studies. The illustrations depict HIV and its interaction with its cellular host at a magnification that reveals all macromolecules. This report describes the sources of scientific support for the structures and processes shown in the illustrations.

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Acknowledgments

This work was supported by NIH (P50GM-103368) to the HIV Interaction and Viral Evolution Center. I thank Stephen Hughes, John Coffin, Stefan Sarafianos, Alan Engelman and Arthur Olson for insightful discussions.

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Authors and Affiliations

  1. Department of Integrative Structural and Computational Biology and RCSB Protein Data Bank, The Scripps Research Institute, La Jolla, 92037, CA, USA

    David S. Goodsell

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  1. David S. Goodsell
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Correspondence to David S. Goodsell .

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Editors and Affiliations

  1. Departments of Molecular and Experimental Medicine and Immunology and Microbial Science (MEM 131), The Scripps Research Institute, La Jolla, California, USA

    Bruce E. Torbett

  2. Department of Integrative Structural and Computational Biology, and RCSB Protein Data Bank, The Scripps Research Institute, La Jolla, California, USA

    David S. Goodsell

  3. Department of Pathology, University of California, San Diego, La Jolla, California, USA

    Douglas D. Richman

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Goodsell, D.S. (2015). Illustrations of the HIV Life Cycle. In: Torbett, B., Goodsell, D., Richman, D. (eds) The Future of HIV-1 Therapeutics. Current Topics in Microbiology and Immunology, vol 389. Springer, Cham. https://doi.org/10.1007/82_2015_437

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