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Transcriptional Control of Lineage Differentiation in Immune Cells pp 125–172Cite as

Transcriptional Regulatory Networks for CD4 T Cell Differentiation

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 381))

Abstract

CD4+ T cells play a central role in controlling the adaptive immune response by secreting cytokines to activate target cells. Naïve CD4+ T cells differentiate into at least four subsets, Th1 , Th2 , Th17 , and inducible regulatory T cells , each with unique functions for pathogen elimination. The differentiation of these subsets is induced in response to cytokine stimulation, which is translated into Stat activation, followed by induction of master regulator transcription factors . In addition to these factors, multiple other transcription factors, both subset specific and shared, are also involved in promoting subset differentiation. This review will focus on the network of transcription factors that control CD4+ T cell differentiation.

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Acknowledgment

The work is supported by the Division of Intramural Research, NIAID, National Institutes of Health, USA. The authors declare no competing financial interests.

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  1. Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Darah Christie & Jinfang Zhu

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  1. Darah Christie
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  2. Jinfang Zhu
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Correspondence to Darah Christie .

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  1. Medical University of Vienna, Division of Immunobiology, Institute of Immunology, Center of Pathophysiology,Infectiology and Immunology, Vienna, Wien, Austria

    Wilfried Ellmeier

  2. RIKEN Center for Integrative Medical Sciences, IMS,, Laboratory for Transcriptional Regulation,, Yokohama, Kanagawa, Japan

    Ichiro Taniuchi

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Christie, D., Zhu, J. (2014). Transcriptional Regulatory Networks for CD4 T Cell Differentiation. In: Ellmeier, W., Taniuchi, I. (eds) Transcriptional Control of Lineage Differentiation in Immune Cells. Current Topics in Microbiology and Immunology, vol 381. Springer, Cham. https://doi.org/10.1007/82_2014_372

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