Host–Pathogen Interactions in Streptococcal Immune Sequelae

  • D. Patric Nitsche-SchmitzEmail author
  • Gursharan S. Chhatwal
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 368)


Otherwise uncomplicated infections with Streptococcus pyogenes can cause two insidious immune sequelae known as post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever (ARF). These diseases follow with a latency of a few weeks or months after primary infection and are responsible for high mortality and morbidity. PSGN has also been linked to infections with group C streptococci of the species S. equi ssp. zooepidemicus (SESZ). Moreover, there are some indications that infection with group C and G streptococci (GCGS) of the subspecies Streptococcus dysgalactiae ssp. equisimilis (SDSE) leads to ARF. Despite decades of research, the picture of the molecular pathogenesis of streptococcal immune sequelae resembles a jigsaw puzzle. Herein we try to put some of the puzzle bits together that have been collected till date.


Hyaluronic Acid Rheumatic Heart Disease Complement Factor Molecular Mimicry Acute Rheumatic Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • D. Patric Nitsche-Schmitz
    • 2
    Email author
  • Gursharan S. Chhatwal
    • 1
  1. 1.Department of Medical MicrobiologyHelmholtz Centre for Infection ResearchBraunschweigGermany
  2. 2.Helmholtz Centre for Infection ResearchBraunschweigGermany

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