Epidemiology and Pathogenicity of Zoonotic Streptococci

  • Marcus Fulde
  • Peter Valentin-WeigandEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 368)


Zoonotic infections caused by Streptococcus spp. have been neglected in spite of the fact that frequency and severity of outbreaks increased dramatically in recent years. This may be due to non-identification since respective species are often not considered in human medical diagnostic procedures. On the other hand, an expanding human population concomitant with an increasing demand for food and the increased number of companion animals favour conditions for host species adaptation of animal streptococci. This review aims to give an overview on streptococcal zoonoses with focus on epidemiology and pathogenicity of four major zoonotic species, Streptococcus canis, Streptococcus equi sub. zooepidemicus, Streptococcus iniae and Streptococcus suis.


Striped Bass Necrotising Fasciitis Zoonotic Infection Streptococcal Species Pyogenic Streptococcus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Our studies are supported by grants from the Deutsche Forschungsgemeinschaft (SFB587, DFG-SPP 1316), Bonn, Germany and Deutsches Zentrum für Infektionsforschung (DZIF).


  1. Abbott Y, Acke E, Khan S, Muldoon EG, Markey BK, Pinilla M, Leonard FC, Steward K, Waller A (2010) Zoonotic transmission of Streptococcus equi subsp. zooepidemicus from a dog to a handler. J Med Microbiol 59:120–123PubMedGoogle Scholar
  2. Agnew W, Barnes AC (2007) Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Vet Microbiol 122:1–15PubMedGoogle Scholar
  3. Akesson P, Moritz L, Truedsson M, Christensson B, Pawel-Rammingen U (2006) IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection. Infect Immun 74:497–503PubMedGoogle Scholar
  4. Akineden O, Alber J, Lammler C, Weiss R, Siebert U, Foster G, Tougaard S, Brasseur SM, Reijnders PJ (2007) Relatedness of Streptococcus equi subsp. zooepidemicus strains isolated from harbour seals (Phoca vitulina) and grey seals (Halichoerus grypus) of various origins of the North Sea during 1988–2005. Vet Microbiol 121:158–162PubMedGoogle Scholar
  5. Akineden O, Hassan AA, Alber J, El Sayed A, Estoepangestie AT, Lammler C, Weiss R, Siebert U (2005) Phenotypic and genotypic properties of Streptococcus equi subsp. zooepidemicus isolated from harbor seals (Phoca vitulina) from the German North Sea during the phocine distemper outbreak in 2002. Vet Microbiol 110:147–152PubMedGoogle Scholar
  6. Allgaier A, Goethe R, Wisselink HJ, Smith HE, Valentin-Weigand P (2001) Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits. J Clin Microbiol 39:445–453PubMedGoogle Scholar
  7. Amass SF, SanMiguel P, Clark LK (1997) Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting. J Clin Microbiol 35:1595–1596PubMedGoogle Scholar
  8. Arends JP, Hartwig N, Rudolphy M, Zanen HC (1984) Carrier rate of Streptococcus suis capsular type 2 in palatine tonsils of slaughtered pigs. J Clin Microbiol 20:945–947PubMedGoogle Scholar
  9. Arends JP, Zanen HC (1988) Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10:131–137PubMedGoogle Scholar
  10. Aubry P, Swor TM, Lohr CV, Tibary A, Barrington GM (2000) Septic orchitis in an alpaca. Can Vet J 41:704–706PubMedGoogle Scholar
  11. Baele M, Chiers K, Devriese LA, Smith HE, Wisselink HJ, Vaneechoutte M, Haesebrouck F (2001) The gram-positive tonsillar and nasal flora of piglets before and after weaning. J Appl Microbiol 91:997–1003PubMedGoogle Scholar
  12. Baiano JC, Barnes AC (2009) Towards control of Streptococcus iniae. Emerg Infect Dis 15:1891–1896PubMedGoogle Scholar
  13. Baiano JC, Tumbol RA, Umapathy A, Barnes AC (2008) Identification and molecular characterisation of a fibrinogen binding protein from Streptococcus iniae. BMC Microbiol 8:67Google Scholar
  14. Balter S, Benin A, Pinto SW, Teixeira LM, Alvim GG, Luna E, Jackson D, LaClaire L, Elliott J, Facklam R, Schuchat A (2000) Epidemic nephritis in Nova Serrana, Brazil. Lancet 355:1776–1780PubMedGoogle Scholar
  15. Bannister MF, Benson CE, Sweeney CR (1985) Rapid species identification of group C streptococci isolated from horses. J Clin Microbiol 21:524–526PubMedGoogle Scholar
  16. Barnham M, Cole G, Efstratiou A, Tagg JR, Skjold SA (1987a) Characterization of Streptococcus zooepidemicus (Lancefield group C) from human and selected animal infections. Epidemiol Infect 98:171–182PubMedGoogle Scholar
  17. Barnham M, Ljunggren A, McIntyre M (1987b) Human infection with Streptococcus zooepidemicus (Lancefield group C): three case reports. Epidemiol Infect 98:183–190PubMedGoogle Scholar
  18. Barnham M, Thornton TJ, Lange K (1983) Nephritis caused by Streptococcus zooepidemicus (Lancefield group C). Lancet 1:945–948PubMedGoogle Scholar
  19. Barquero N, Chanter N, Laxton R, Wood JL, Newton JR (2010) Molecular epidemiology of Streptococcus zooepidemicus isolated from the respiratory tracts of thoroughbred racehorses in training. Vet J 183:348–351PubMedGoogle Scholar
  20. Baums CG, Hermeyer K, Ohlemeyer S, Adamek M, Czerny CP, Hoerstgen-Schwark C, Valentin-Weigand P, Baumgärtner W, Steinhagen D (2012) Establishment of a model of Streptococcus iniae meningoencephalitis in Nile tilapia (Oreochromis niloticus). J Comp Pathol (in press)Google Scholar
  21. Baums CG, Kaim U, Fulde M, Ramachandran G, Goethe R, Valentin-Weigand P (2006) Identification of a novel virulence determinant with serum opacification activity in Streptococcus suis. Infect Immun 74:6154–6162PubMedGoogle Scholar
  22. Baums CG, Valentin-Weigand P (2009) Surface-associated and secreted factors of Streptococcus suis in epidemiology, pathogenesis and vaccine development. Anim Health Res Rev 10:65–83PubMedGoogle Scholar
  23. Baums CG, Verkuhlen GJ, Rehm T, Silva LM, Beyerbach M, Pohlmeyer K, Valentin-Weigand P (2007) Prevalence of Streptococcus suis genotypes in wild boars of Northwestern Germany. Appl Environ Microbiol 73:711–717PubMedGoogle Scholar
  24. Benga L, Friedl P, Valentin-Weigand P (2005) Adherence of Streptococcus suis to porcine endothelial cells. J Vet Med B Infect Dis Vet Public Health 52:392–395PubMedGoogle Scholar
  25. Benga L, Fulde M, Neis C, Goethe R, Valentin-Weigand P (2008) Polysaccharide capsule and suilysin contribute to extracellular survival of Streptococcus suis co-cultivated with primary porcine phagocytes. Vet Microbiol 132:211–219PubMedGoogle Scholar
  26. Benga L, Goethe R, Rohde M, Valentin-Weigand P (2004) Non-encapsulated strains reveal novel insights in invasion and survival of Streptococcus suis in epithelial cells. Cell Microbiol 6:867–881PubMedGoogle Scholar
  27. Beres SB, Sesso R, Pinto SW, Hoe NP, Porcella SF, Deleo FR, Musser JM (2008) Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease. PLoS One 3:e3026Google Scholar
  28. Bergmann R, Dinkla K, Nitsche-Schmitz DP, Graham RM, Luttge M, Sanderson-Smith ML, Nerlich A, Rohde M, Chhatwal GS (2011) Biological functions of GCS3, a novel plasminogen-binding protein of Streptococcus dysgalactiae ssp. equisimilis. Int J Med Microbiol 301:157–164PubMedGoogle Scholar
  29. Bert F, Lambert-Zechovsky N (1997) Septicemia caused by Streptococcus canis in a human. J Clin Microbiol 35:777–779PubMedGoogle Scholar
  30. Berthelot-Herault F, Gottschalk M, Labbe A, Cariolet R, Kobisch M (2001) Experimental airborne transmission of Streptococcus suis capsular type 2 in pigs. Vet Microbiol 82:69–80PubMedGoogle Scholar
  31. Biberstein EL, Brown C, Smith T (1980) Serogroups and biotypes among beta-hemolytic streptococci of canine origin. J Clin Microbiol 11:558–561PubMedGoogle Scholar
  32. Blank LM, Hugenholtz P, Nielsen LK (2008) Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci. J Mol Evol 67:13–22PubMedGoogle Scholar
  33. Blum S, Elad D, Zukin N, Lysnyansky I, Weisblith L, Perl S, Netanel O, David D (2010) Outbreak of Streptococcus equi subsp. zooepidemicus infections in cats. Vet Microbiol 144:236–239PubMedGoogle Scholar
  34. Blunden AS, Hannant D, Livesay G, Mumford JA (1994) Susceptibility of ponies to infection with Streptococcus pneumoniae (capsular type 3). Equine Vet J 26:22–28PubMedGoogle Scholar
  35. Bonifait L, Grignon L, Grenier D (2008) Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. Appl Environ Microbiol 74:4969–4972PubMedGoogle Scholar
  36. Bordes-Benitez A, Sanchez-Onoro M, Suarez-Bordon P, Garcia-Rojas AJ, Saez-Nieto JA, Gonzalez-Garcia A, Alamo-Antunez I, Sanchez-Maroto A, Bolanos-Rivero M (2006) Outbreak of Streptococcus equi subsp. zooepidemicus infections on the island of Gran Canaria associated with the consumption of inadequately pasteurized cheese. Eur J Clin Microbiol Infect Dis 25:242–246PubMedGoogle Scholar
  37. Britton AP, Davies JL (2010) Rhinitis and meningitis in two shelter cats caused by Streptococcus equi subspecies zooepidemicus. J Comp Pathol 143:70–74PubMedGoogle Scholar
  38. Bromage ES, Thomas A, Owens L (1999) Streptococcus iniae, a bacterial infection in barramundi Lates calcarifer. Dis Aquat Organ 36:177–181PubMedGoogle Scholar
  39. Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V (2005) Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development. Infect Immun 73:6935–6944PubMedGoogle Scholar
  40. Butaye R (1956) De breed beta haemolytische streptococcen afkomstig van honden. Vlaams Diergeneeskd Tijdschr 15:127–131Google Scholar
  41. Byun JW, Yoon SS, Woo GH, Jung BY, Joo YS (2009) An outbreak of fatal hemorrhagic pneumonia caused by Streptococcus equi subsp. zooepidemicus in shelter dogs. J Vet Sci 10:269–271PubMedGoogle Scholar
  42. Chabot-Roy G, Willson P, Segura M, Lacouture S, Gottschalk M (2006) Phagocytosis and killing of Streptococcus suis by porcine neutrophils. Microb Pathog 41:21–32PubMedGoogle Scholar
  43. Chaffer M, Friedman S, Saran A, Younis A (2005) An outbreak of Streptococcus canis mastitis in a dairy herd in Israel. N Z Vet J 53:261–264Google Scholar
  44. Charland N, Harel J, Kobisch M, Lacasse S, Gottschalk M (1998) Streptococcus suis serotype 2 mutants deficient in capsular expression. Microbiology 144(Pt 2):325–332PubMedGoogle Scholar
  45. Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Gottschalk M (2000) Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun 68:637–643PubMedGoogle Scholar
  46. Chen C, Tang J, Dong W, Wang C, Feng Y, Wang J, Zheng F, Pan X, Liu D, Li M, Song Y, Zhu X, Sun H, Feng T, Guo Z, Ju A, Ge J, Dong Y, Sun W, Jiang Y, Wang J, Yan J, Yang H, Wang X, Gao GF, Yang R, Wang J, Yu J (2007) A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One 2: e315Google Scholar
  47. Clark C, Greenwood S, Boison JO, Chirino-Trejo M, Dowling PM (2008) Bacterial isolates from equine infections in western Canada (1998–2003). Can Vet J 49:153–160PubMedGoogle Scholar
  48. Clifton-Hadley FA (1983) Streptococcus suis type 2 infections. Br Vet J 139:1–5PubMedGoogle Scholar
  49. Clifton-Hadley FA, Alexander TJ (1980) The carrier site and carrier rate of Streptococcus suis type II in pigs. Vet Rec 107:40–41PubMedGoogle Scholar
  50. Corning BF, Murphy JC, Fox JG (1991) Group G streptococcal lymphadenitis in rats. J Clin Microbiol 29:2720–2723PubMedGoogle Scholar
  51. de Greeff A, Buys H, Verhaar R, Dijkstra J, Van Alphen L, Smith HE (2002) Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2. Infect Immun 70:1319–1325PubMedGoogle Scholar
  52. Devriese LA, Hommez J, Klipper-Balz R, Schleifer K-H (1986) Streptococcus canis sp. nov.: a species of group G Streptococci from Animals. Int J Syst Bacteriol 36:422–425Google Scholar
  53. DeWinter LM, Low DE, Prescott JF (1999) Virulence of Streptococcus canis from canine streptococcal toxic shock syndrome and necrotizing fasciitis. Vet Microbiol 70:95–110PubMedGoogle Scholar
  54. DeWinter LM, Prescott JF (1999) Relatedness of Streptococcus canis from canine streptococcal toxic shock syndrome and necrotizing fasciitis. Can J Vet Res 63: 90–95Google Scholar
  55. Dogan B, Schukken YH, Santisteban C, Boor KJ (2005) Distribution of serotypes and antimicrobial resistance genes among Streptococcus agalactiae isolates from bovine and human hosts. J Clin Microbiol 43:5899–5906PubMedGoogle Scholar
  56. Efstratiou A, Colman G, Hahn G, Timoney JF, Boeufgras JM, Monget D (1994) Biochemical differences among human and animal streptococci of Lancefield group C or group G. J Med Microbiol 41:145–148PubMedGoogle Scholar
  57. Egesten A, Frick IM, Morgelin M, Olin AI, Bjorck L (2011) Binding of albumin promotes bacterial survival at the epithelial surface. J Biol Chem 286:2469–2476PubMedGoogle Scholar
  58. Eldar A, Ghittino C (1999) Lactococcus garvieae and Streptococcus iniae infections in rainbow trout Oncorhynchus mykiss: similar, but different diseases. Dis Aquat Organ 36:227–231PubMedGoogle Scholar
  59. Enright MR, Alexander TJ, Clifton-Hadley FA (1987) Role of houseflies (Musca domestica) in the epidemiology of Streptococcus suis type 2. Vet Rec 121:132–133PubMedGoogle Scholar
  60. Erol E, Locke SJ, Donahoe JK, Mackin MA, Carter CN (2012) Beta-hemolytic Streptococcus spp. from horses: a retrospective study (2000–2010). J Vet Diagn Invest 24:142–147PubMedGoogle Scholar
  61. Esgleas M, Li Y, Hancock MA, Harel J, Dubreuil JD, Gottschalk M (2008) Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis. Microbiology 154:2668–2679PubMedGoogle Scholar
  62. Eyngor M, Chilmonczyk S, Zlotkin A, Manuali E, Lahav D, Ghittino C, Shapira R, Hurvitz A, Eldar A (2007) Transcytosis of Streptococcus iniae through skin epithelial barriers: an in vitro study. FEMS Microbiol Lett 277:238–248PubMedGoogle Scholar
  63. Eyngor M, Tekoah Y, Shapira R, Hurvitz A, Zlotkin A, Lublin A, Eldar A (2008) Emergence of novel Streptococcus iniae exopolysaccharide-producing strains following vaccination with nonproducing strains. Appl Environ Microbiol 74:6892–6897PubMedGoogle Scholar
  64. Facklam R (2002) What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev 15:613–630PubMedGoogle Scholar
  65. Facklam R, Elliott J, Shewmaker L, Reingold A (2005) Identification and characterization of sporadic isolates of Streptococcus iniae isolated from humans. J Clin Microbiol 43:933–937PubMedGoogle Scholar
  66. Fan H, Wang Y, Tang F, Lu C (2008) Determination of the mimic epitope of the M-like protein adhesin in swine Streptococcus equi subsp. zooepidemicus. BMC Microbiol 8: 170Google Scholar
  67. Feng Y, Zhang H, Ma Y, Gao GF (2010) Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol 18:124–131PubMedGoogle Scholar
  68. Finkelstein R, Oren I (2011) Soft tissue infections caused by marine bacterial pathogens: epidemiology, diagnosis, and management. Curr Infect Dis Rep 13:470–477PubMedGoogle Scholar
  69. Fittipaldi N, Segura M, Grenier D, Gottschalk M (2012) Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis. Future Microbiol 7:259–279PubMedGoogle Scholar
  70. Fittipaldi N, Sekizaki T, Takamatsu D, de la Dominguez-Punaro Cruz, Harel J, Bui NK, Vollmer W, Gottschalk M (2008a) Significant contribution of the pgdA gene to the virulence of Streptococcus suis. Mol Microbiol 70:1120–1135PubMedGoogle Scholar
  71. Fittipaldi N, Sekizaki T, Takamatsu D, Harel J, Dominguez-Punaro ML, Von Aulock S, Draing C, Marois C, Kobisch M, Gottschalk M (2008b) D-alanylation of lipoteichoic acid contributes to the virulence of Streptococcus suis. Infect Immun 76:3587–3594PubMedGoogle Scholar
  72. Flanagan J, Collin N, Timoney J, Mitchell T, Mumford JA, Chanter N (1998) Characterization of the haemolytic activity of Streptococcus equi. Microb Pathog 24:211–221PubMedGoogle Scholar
  73. Flock M, Karlstrom A, Lannergard J, Guss B, Flock JI (2006) Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse. Vaccine 24:4144–4151PubMedGoogle Scholar
  74. Francis AJ, Nimmo GR, Efstratiou A, Galanis V, Nuttall N (1993) Investigation of milk-borne Streptococcus zooepidemicus infection associated with glomerulonephritis in Australia. J Infect 27:317–323PubMedGoogle Scholar
  75. Fulde M, Rohde M, Hitzmann A, Preissner KT, Nitsche-Schmitz DP, Nerlich A, Chhatwal GS, Bergmann S (2011a) SCM, a novel M-like protein from Streptococcus canis, binds (mini)-plasminogen with high affinity and facilitates bacterial transmigration. Biochem J 434:523–535PubMedGoogle Scholar
  76. Fulde M, Willenborg J, de Greeff A, Benga L, Smith HE, Valentin-Weigand P, Goethe R (2011b) ArgR is an essential local transcriptional regulator of the arcABC operon in Streptococcus suis and is crucial for biological fitness in an acidic environment. Microbiology 157:572–582PubMedGoogle Scholar
  77. Fuller JD, Bast DJ, Nizet V, Low DE, de Azavedo JC (2001) Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun 69:1994–2000PubMedGoogle Scholar
  78. Gaede W, Reckling KF, Schliephake A, Missal D, Hotzel H, Sachse K (2010) Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. Vet Microbiol 142:440–444PubMedGoogle Scholar
  79. Galperine T, Cazorla C, Blanchard E, Boineau F, Ragnaud JM, Neau D (2007) Streptococcus canis infections in humans: retrospective study of 54 patients. J Infect 55:23–26PubMedGoogle Scholar
  80. Garnett NL, Eydelloth RS, Swindle MM, Vonderfecht SL, Strandberg JD, Luzarraga MB (1982) Hemorrhagic streptococcal pneumonia in newly procured research dogs. J Am Vet Med Assoc 181:1371–1374PubMedGoogle Scholar
  81. Gottschalk M, Petitbois S, Higgins R, Jacques M (1991) Adherence of Streptococcus suis capsular type 2 to porcine lung sections. Can J Vet Res 55:302–304Google Scholar
  82. Gottschalk M, Segura M (2000) The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions. Vet Microbiol 76:259–272PubMedGoogle Scholar
  83. Gottschalk M, Segura M, Xu J (2007) Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Anim Health Res Rev 8:29–45PubMedGoogle Scholar
  84. Gottschalk M, Xu J, Calzas C, Segura M (2010) Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol 5:371–391PubMedGoogle Scholar
  85. Gruening P, Fulde M, Valentin-Weigand P, Goethe R (2006) Structure, regulation, and putative function of the arginine deiminase system of Streptococcus suis. J Bacteriol 188:361–369PubMedGoogle Scholar
  86. Hamilton CA, Stark DM (1970) Occurrence and characterization of Lancefield group G streptococci in bovine mastitis. Am J Vet Res 31:397–398PubMedGoogle Scholar
  87. Hare T, Frye RM (1938) Preliminary observations of an infection of dogs by beta-haemolytic streptococci. Vet Rec 50:213–218Google Scholar
  88. Hassan AA, Akineden O, Usleber E (2005) Identification of Streptococcus canis isolated from milk of dairy cows with subclinical mastitis. J Clin Microbiol 43:1234–1238PubMedGoogle Scholar
  89. Hassan AA, Khan IU, Abdulmawjood A, Lammler C (2003) Development of PCR assays for detection of Streptococcus canis. FEMS Microbiol Lett 219:209–214PubMedGoogle Scholar
  90. Hayashi M, Matsuzaki Y, Shimonaka M (2009) Impact of plasminogen on an in vitro wound healing model based on a perfusion cell culture system. Mol Cell Biochem 322:1–13PubMedGoogle Scholar
  91. Hewson J, Cebra CK (2001) Peritonitis in a llama caused by Streptococcus equi subsp. zooepidemicus. Can Vet J 42:465–467PubMedGoogle Scholar
  92. Hill JE, Gottschalk M, Brousseau R, Harel J, Hemmingsen SM, Goh SH (2005) Biochemical analysis, cpn60 and 16S rDNA sequence data indicate that Streptococcus suis serotypes 32 and 34, isolated from pigs, are Streptococcus orisratti. Vet Microbiol 107:63–69PubMedGoogle Scholar
  93. Hitzmann A, Bergmann S, Rohde M, Chhatwal GS, Fulde M (2012) Identification and characterization of the arginine deiminase system of Streptococcus canis (in press)Google Scholar
  94. Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Croucher NJ, Chieu TB, Mai NT, Diep TS, Chinh NT, Kehoe M, Leigh JA, Ward PN, Dowson CG, Whatmore AM, Chanter N, Iversen P, Gottschalk M, Slater JD, Smith HE, Spratt BG, Xu J, Ye C, Bentley S, Barrell BG, Schultsz C, Maskell DJ, Parkhill J (2009) Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLoS One 4:e6072Google Scholar
  95. Holden MT, Heather Z, Paillot R, Steward KF, Webb K, Ainslie F, Jourdan T, Bason NC, Holroyd NE, Mungall K, Quail MA, Sanders M, Simmonds M, Willey D, Brooks K, Aanensen DM, Spratt BG, Jolley KA, Maiden MC, Kehoe M, Chanter N, Bentley SD, Robinson C, Maskell DJ, Parkhill J, Waller AS (2009) Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog 5:e1000346Google Scholar
  96. Hong-Jie F, Fu-yu T, Ying M, Cheng-ping L (2009) Virulence and antigenicity of the szp-gene deleted Streptococcus equi ssp. zooepidemicus mutant in mice. Vaccine 27:56–61PubMedGoogle Scholar
  97. Hulting G, Flock M, Frykberg L, Lannergard J, Flock JI, Guss B (2009) Two novel IgG endopeptidases of Streptococcus equi. FEMS Microbiol Lett 298:44–50PubMedGoogle Scholar
  98. Iglauer F, Kunstyr I, Morstedt R, Farouq H, Wullenweber M, Damsch S (1991) Streptococcus canis arthritis in a cat breeding colony. J Exp Anim Sci 34:59–65PubMedGoogle Scholar
  99. Igwe EI, Shewmaker PL, Facklam RR, Farley MM, van Beneden C, Beall B (2003) Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans. FEMS Microbiol Lett 229:259–264PubMedGoogle Scholar
  100. Jacobs AA, Loeffen PL, van den Berg AJ, Storm PK (1994) Identification, purification, and characterization of a thiol-activated hemolysin (suilysin) of Streptococcus suis. Infect Immun 62:1742–1748PubMedGoogle Scholar
  101. Jensen A, Kilian M (2012) Delineation of Streptococcus dysgalactiae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenes. J Clin Microbiol 50:113–126PubMedGoogle Scholar
  102. Jones M, Miesner M, Grondin T (2009) Outbreak of Streptococcus equi ssp. zooepidemicus polyserositis in an alpaca herd. J Vet Intern Med 23:220–223PubMedGoogle Scholar
  103. Jonsson H, Lindmark H, Guss B (1995) A protein G-related cell surface protein in Streptococcus zooepidemicus. Infect Immun 63:2968–2975PubMedGoogle Scholar
  104. Kawamura Y, Hou XG, Sultana F, Miura H, Ezaki T (1995) Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus. Int J Syst Bacteriol 45:406–408PubMedGoogle Scholar
  105. Kim MK, Jee H, Shin SW, Lee BC, Pakhrin B, Yoo HS, Yoon JH, Kim DY (2007a) Outbreak and control of haemorrhagic pneumonia due to Streptococcus equi subspecies zooepidemicus in dogs. Vet. Rec. 161:528–530PubMedGoogle Scholar
  106. Kim MS, Choi SH, Lee EH, Nam YK, KimS K, KimK H (2007b) a-enolase, a plasmin(ogen) binding protein and cell wall associating protein from a fish pathogenic Streptococcus iniae strain. Aquaculture 265:55–60Google Scholar
  107. Kruger EF, Byrne BA, Pesavento P, Hurley KF, Lindsay LL, Sykes JE (2010) Relationship between clinical manifestations and pulsed-field gel profiles of Streptococcus canis isolates from dogs and cats. Vet Microbiol 146:167–171PubMedGoogle Scholar
  108. Kuusi M, Lahti E, Virolainen A, Hatakka M, Vuento R, Rantala L, Vuopio-Varkila J, Seuna E, Karppelin M, Hakkinen M, Takkinen J, Gindonis V, Siponen K, Huotari K (2006) An outbreak of Streptococcus equi subspecies zooepidemicus associated with consumption of fresh goat cheese. BMC Infect Dis 6: 36Google Scholar
  109. Lalonde M, Segura M, Lacouture S, Gottschalk M (2000) Interactions between Streptococcus suis serotype 2 and different epithelial cell lines. Microbiology 146(Pt 8):1913–1921PubMedGoogle Scholar
  110. Lam MM, Clarridge JE III, Young EJ, Mizuki S (2007) The other group G Streptococcus: increased detection of Streptococcus canis ulcer infections in dog owners. J Clin Microbiol 45:2327–2329PubMedGoogle Scholar
  111. Lamm CG, Ferguson AC, Lehenbauer TW, Love BC (2010) Streptococcal infection in dogs: a retrospective study of 393 cases. Vet Pathol 47:387–395PubMedGoogle Scholar
  112. Lammler C, Frede C, Gurturk K, Hildebrand A, Blobel H (1988) Binding activity of Streptococcus canis for albumin and other plasma proteins. J Gen Microbiol 134:2317–2323PubMedGoogle Scholar
  113. Lannergard J, Guss B (2006) IdeE, an IgG-endopeptidase of Streptococcus equi ssp. equi. FEMS Microbiol Lett 262:230–235PubMedGoogle Scholar
  114. Las HA, Vela AI, Fernandez E, Legaz E, Dominguez L, Fernandez-Garayzabal JF (2002) Unusual outbreak of clinical mastitis in dairy sheep caused by Streptococcus equi subsp. zooepidemicus. J Clin Microbiol 40:1106–1108Google Scholar
  115. Lau SK, Woo PC, Luk WK, Fung AM, Hui WT, Fong AH, Chow CW, Wong SS, Yuen KY (2006) Clinical isolates of Streptococcus iniae from Asia are more mucoid and beta-hemolytic than those from North America. Diagn Microbiol Infect Dis 54:177–181PubMedGoogle Scholar
  116. Lefebure T, Richards VP, Lang P, Pavinski-Bitar P, Stanhope MJ (2012) Gene repertoire evolution of Streptococcus pyogenes inferred from phylogenomic analysis with Streptococcus canis and Streptococcus dysgalactiae. PLoS One 7:e37607Google Scholar
  117. Lewis MJ, Meehan M, Owen P, Woof JM (2008) A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system. J Biol Chem 283:17615–17623PubMedGoogle Scholar
  118. Lindmark H, Guss B (1999) SFS, a novel fibronectin-binding protein from Streptococcus equi, inhibits the binding between fibronectin and collagen. Infect Immun 67:2383–2388PubMedGoogle Scholar
  119. Lindmark H, Jacobsson K, Frykberg L, Guss B (1996) Fibronectin-binding protein of Streptococcus equi subsp. zooepidemicus. Infect Immun 64:3993–3999PubMedGoogle Scholar
  120. Literak O, Mraz O (1991) Streptococcus equi subsp. zooepidemicus as the cause of mass mortality among laboratory mice. Acta Vet Brno 60:51–60Google Scholar
  121. Ljungh A (2000) Helicobacter pylori interactions with plasminogen. Methods 21:151–157PubMedGoogle Scholar
  122. Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT (2008) Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. PLoS One 3:e2824Google Scholar
  123. Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT (2007a) Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol 189:1279–1287PubMedGoogle Scholar
  124. Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT (2007b) Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ 76:17–26PubMedGoogle Scholar
  125. Lowe BA, Marsh TL, Isaacs-Cosgrove N, Kirkwood RN, Kiupel M, Mulks MH (2011) Microbial communities in the tonsils of healthy pigs. Vet Microbiol 147:346–357PubMedGoogle Scholar
  126. Lowe BA, Miller JD, Neely MN (2007) Analysis of the polysaccharide capsule of the systemic pathogen Streptococcus iniae and its implications in virulence. Infect Immun 75:1255–1264PubMedGoogle Scholar
  127. Lun ZR, Wang QP, Chen XG, Li AX, Zhu XQ (2007) Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis 7:201–209PubMedGoogle Scholar
  128. Lyskova P, Vydrzalova M, Mazurova J (2007) Identification and antimicrobial susceptibility of bacteria and yeasts isolated from healthy dogs and dogs with otitis externa. J Vet Med A Physiol PatholClin Med 54:559–563Google Scholar
  129. Ma Z, Zhang H, Zheng J, Li Y, Yi L, Fan H, Lu C (2012) Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus. PLoS One 7:e32099Google Scholar
  130. Mai NT, Hoa NT, Nga TV, Linh lD, Chau TT, Sinh DX, Phu NH, Chuong LV, Diep TS, Campbell J, Nghia HD, Minh TN, Chau NV, de Jong MD, Chinh NT, Hien TT, Farrar J, Schultsz C (2008) Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis 46:659–667PubMedGoogle Scholar
  131. Martinez G, Harel J, Higgins R, Lacouture S, Daignault D, Gottschalk M (2000) Characterization of Streptococcus agalactiae isolates of bovine and human origin by randomly amplified polymorphic DNA analysis. J Clin Microbiol 38:71–78PubMedGoogle Scholar
  132. Matz-Rensing K, Winkelmann J, Becker T, Burckhardt I, Van der LM, Kondgen S, Leendertz F, Kaup FJ (2009) Outbreak of Streptococcus equi subsp. zooepidemicus infection in a group of rhesus monkeys (Macaca mulatta). J Med Primatol 38:328–334PubMedGoogle Scholar
  133. McDonald TJ, McDonald JS (1976) Streptococci isolated from bovine intramammary infections. Am J Vet Res 37:377–381PubMedGoogle Scholar
  134. Meehan M, Lynagh Y, Woods C, Owen P (2001) The fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi additionally binds IgG and contributes to virulence in a mouse model. Microbiology 147:3311–3322PubMedGoogle Scholar
  135. Messier S, Lacouture S, Gottschalk M (2008) Distribution of Streptococcus suis capsular types from 2001 to 2007. Can Vet J 49:461–462PubMedGoogle Scholar
  136. Miller CW, Prescott JF, Mathews KA, Betschel SD, Yager JA, Guru V, DeWinter L, Low DE (1996) Streptococcal toxic shock syndrome in dogs. J Am Vet Med Assoc 209:1421–1426PubMedGoogle Scholar
  137. Miller JD, Neely MN (2004) Zebrafish as a model host for streptococcal pathogenesis. Acta Trop 91:53–68PubMedGoogle Scholar
  138. Minces LR, Brown PJ, Veldkamp PJ (2011) Human meningitis from Streptococcus equi subsp. zooepidemicus acquired as zoonoses. Epidemiol Infect 139:406–410PubMedGoogle Scholar
  139. Mwaniki CG, Robertson ID, Hampson DJ (1994a) The prevalence of Streptococcus suis type 2 in Western Australian piggeries. Aust Vet J 71:385–386PubMedGoogle Scholar
  140. Mwaniki CG, Robertson ID, Trott DJ, Atyeo RF, Lee BJ, Hampson DJ (1994b) Clonal analysis and virulence of Australian isolates of Streptococcus suis type 2. Epidemiol Infect 113:321–334PubMedGoogle Scholar
  141. Nghia HD, Hoa NT, Linh lD, Campbell J, Diep TS, Chau NV, Mai NT, Hien TT, Spratt B, Farrar J, Schultsz C (2008) Human case of Streptococcus suis serotype 16 infection. Emerg Infect Dis 14:155–157PubMedGoogle Scholar
  142. Ngo TH, Tran TB, Tran TT, Nguyen VD, Campbell J, Pham HA, Huynh HT, Nguyen VV, Bryant JE, Tran TH, Farrar J, Schultsz C (2011) Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam. PLoS One 6:e17943Google Scholar
  143. Nicholson ML, Ferdinand L, Sampson JS, Benin A, Balter S, Pinto SW, Dowell SF, Facklam RR, Carlone GM, Beall B (2000) Analysis of immunoreactivity to a Streptococcus equi subsp. zooepidemicus M-like protein To confirm an outbreak of poststreptococcal glomerulonephritis, and sequences of M-like proteins from isolates obtained from different host species. J Clin Microbiol 38:4126–4130PubMedGoogle Scholar
  144. Nitsche DP, Johansson HM, Frick IM, Morgelin M (2006) Streptococcal protein FOG, a novel matrix adhesin interacting with collagen I in vivo. J Biol Chem 281:1670–1679PubMedGoogle Scholar
  145. Nitsche-Schmitz DP, Johansson HM, Sastalla I, Reissmann S, Frick IM, Chhatwal GS (2007) Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q. J Biol Chem 282:17530–17536PubMedGoogle Scholar
  146. O’Sullivan T, Friendship R, Blackwell T, Pearl D, McEwen B, Carman S, Slavic D, Dewey C (2011) Microbiological identification and analysis of swine tonsils collected from carcasses at slaughter. Can.J.Vet.Res. 75: 106-111Google Scholar
  147. Oikawa M, Kamada M, Yoshikawa Y, Yoshikawa T (1994) Pathology of equine pneumonia associated with transport and isolation of Streptococcus equi subsp. zooepidemicus. J Comp Pathol 111:205–212PubMedGoogle Scholar
  148. Oikawa M, Takagi S, Anzai R, Yoshikawa H, Yoshikawa T (1995) Pathology of equine respiratory disease occurring in association with transport. J Comp Pathol 113:29–43PubMedGoogle Scholar
  149. Okamoto S, Kawabata S, Terao Y, Fujitaka H, Okuno Y, Hamada S (2004) The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection. Infect Immun 72:6068–6075PubMedGoogle Scholar
  150. Oliveira IC, de Mattos MC, Pinto TA, Ferreira-Carvalho BT, Benchetrit LC, Whiting AA, Bohnsack JF, Figueiredo AM (2006) Genetic relatedness between group B streptococci originating from bovine mastitis and a human group B Streptococcus type V cluster displaying an identical pulsed-field gel electrophoresis pattern. Clin Microbiol Infect 12:887–893PubMedGoogle Scholar
  151. Paillot R, Darby AC, Robinson C, Wright NL, Steward KF, Anderson E, Webb K, Holden MT, Efstratiou A, Broughton K, Jolley KA, Priestnall SL, Marotti Campi MC, Hughes MA, Radford A, Erles K, Waller AS (2010) Identification of three novel superantigen-encoding genes in Streptococcus equi subsp. zooepidemicus, szeF, szeN, and szeP. Infect Immun 78:4817–4827PubMedGoogle Scholar
  152. Palmieri C, Varaldo PE, Facinelli B (2011) Streptococcus suis, an emerging drug-resistant animal and human pathogen. Front Microbiol 2:235PubMedGoogle Scholar
  153. Panchaud Y, Gerber V, Rossano A, Perreten V (2010) Bacterial infections in horses: a retrospective study at the University Equine Clinic of Bern. Schweiz Arch Tierheilkd 152:176–182PubMedGoogle Scholar
  154. Pancholi V, Chhatwal GS (2003) Housekeeping enzymes as virulence factors for pathogens. Int J Med Microbiol 293:391–401PubMedGoogle Scholar
  155. Pawel-Rammingen U (2012) Streptococcal IdeS and its impact on immune response and inflammation. J Innate Immun 4:132–140Google Scholar
  156. Pawel-Rammingen U, Johansson BP, Bjorck L (2002) IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J 21:1607–1615Google Scholar
  157. Perch B, Pedersen KB, Henrichsen J (1983) Serology of capsulated streptococci pathogenic for pigs: six new serotypes of Streptococcus suis. J Clin Microbiol 17:993–996PubMedGoogle Scholar
  158. Pereira UP, Mian GF, Oliveira IC, Benchetrit LC, Costa GM, Figueiredo HC (2010) Genotyping of Streptococcus agalactiae strains isolated from fish, human and cattle and their virulence potential in Nile tilapia. Vet Microbiol 140:186–192PubMedGoogle Scholar
  159. Pesavento PA, Hurley KF, Bannasch MJ, Artiushin S, Timoney JF (2008) A clonal outbreak of acute fatal hemorrhagic pneumonia in intensively housed (shelter) dogs caused by Streptococcus equi subsp. zooepidemicus. Vet Pathol 45:51–53PubMedGoogle Scholar
  160. Pier GB, Madin SH, Al-Nakeeb S (1978) Isolation and characterization of a second isolate of Streptococcus iniae. Int J Syst Bacteriol 28:311–314Google Scholar
  161. Pisoni G, Zadoks RN, Vimercati C, Locatelli C, Zanoni MG, Moroni P (2009) Epidemiological investigation of Streptococcus equi subspecies zooepidemicus involved in clinical mastitis in dairy goats. J Dairy Sci 92:943–951PubMedGoogle Scholar
  162. Poyart C, Quesne G, Coulon S, Berche P, Trieu-Cuot P (1998) Identification of streptococci to species level by sequencing the gene encoding the manganese-dependent superoxide dismutase. J Clin Microbiol 36:41–47PubMedGoogle Scholar
  163. Prescott JF, Mathews K, Gyles CL, Matsumiya L, Miller C, Rinkhardt N, Yager JA, Hylands RH, Low DE (1995) Canine streptococcal toxic shock syndrome in Ontario: an emerging disease. Can Vet J 36:486–487Google Scholar
  164. Priestnall S, Erles K (2011) Streptococcus zooepidemicus: an emerging canine pathogen. Vet J 188:142–148PubMedGoogle Scholar
  165. Proft T, Fraser JD (2007) Streptococcal superantigens. Chem Immunol Allergy 93:1–23PubMedGoogle Scholar
  166. Rojas M, Labrador I, Concepcion JL, Aldana E, Avilan L (2008) Characteristics of plasminogen binding to Trypanosoma cruzi epimastigotes. Acta Trop 107:54–58PubMedGoogle Scholar
  167. Rosenkranz M, Elsner HA, Sturenburg HJ, Weiller C, Rother J, Sobottka I (2003) Streptococcus suis meningitis and septicemia contracted from a wild boar in Germany. J Neurol 250:869–870PubMedGoogle Scholar
  168. Ryu SH, Koo HC, Lee YW, Park YH, Lee CW (2011) Etiologic and epidemiologic analysis of bacterial infectious upper respiratory disease in thoroughbred horses at the Seoul Race Park. J Vet Sci 12:195–197PubMedGoogle Scholar
  169. Schrager HM, Alberti S, Cywes C, Dougherty GJ, Wessels MR (1998) Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. J Clin Invest 101:1708–1716PubMedGoogle Scholar
  170. Schroeder B, Boyle MD, Sheerin BR, Asbury AC, Lottenberg R (1999) Species specificity of plasminogen activation and acquisition of surface-associated proteolytic activity by group C streptococci grown in plasma. Infect Immun 67:6487–6495PubMedGoogle Scholar
  171. Schwarz-Linek U, Hook M, Potts JR (2006) Fibronectin-binding proteins of gram-positive cocci. Microbes Infect 8:2291–2298PubMedGoogle Scholar
  172. Seele J, Singpiel A, Spoerry C, von Pawel-Rammingen U, Valentin-Weigand P, Baums CG Identification of a novel host-specific IgM protease in Streptococcus suis. J Bact (in revision)Google Scholar
  173. Segura M, Gottschalk M (2002) Streptococcus suis interactions with the murine macrophage cell line J774: adhesion and cytotoxicity. Infect Immun 70:4312–4322PubMedGoogle Scholar
  174. Segura M, Stankova J, Gottschalk M (1999) Heat-killed Streptococcus suis capsular type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages. Infect Immun 67:4646–4654PubMedGoogle Scholar
  175. Segura M, Vadeboncoeur N, Gottschalk M (2002) CD14-dependent and -independent cytokine and chemokine production by human THP-1 monocytes stimulated by Streptococcus suis capsular type 2. Clin Exp Immunol 127:243–254PubMedGoogle Scholar
  176. Segura M, Vanier G, Al Numani D, Lacouture S, Olivier M, Gottschalk M (2006) Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system. FEMS Immunol Med Microbiol 47:92–106PubMedGoogle Scholar
  177. Sesso R, Pinto SW (2005) Five-year follow-up of patients with epidemic glomerulonephritis due to Streptococcus zooepidemicus. Nephrol Dial Transplant 20:1808–1812PubMedGoogle Scholar
  178. Shoemaker CA, Klesius PH, Evans JJ (2001) Prevalence of Streptococcus iniae in tilapia, hybrid striped bass, and channel catfish on commercial fish farms in the United States. Am J Vet Res 62:174–177PubMedGoogle Scholar
  179. Silva LM, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P (2006) Virulence-associated gene profiling of Streptococcus suis isolates by PCR. Vet Microbiol 115:117–127PubMedGoogle Scholar
  180. Smeesters PR, Mardulyn P, Vergison A, Leplae R, Van Melderen L (2008) Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development. Vaccine 26:5835–5842PubMedGoogle Scholar
  181. Smith HE, Damman M, van d V, Wagenaar F, Wisselink HJ, Stockhofe-Zurwieden N, Smits MA (1999) Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor. Infect Immun 67:1750–1756PubMedGoogle Scholar
  182. Smith TC, Capuano AW, Boese B, Myers KP, Gray GC (2008) Exposure to Streptococcus suis among US swine workers. Emerg Infect Dis 14:1925–1927PubMedGoogle Scholar
  183. Soedarmanto I, Pasaribu FH, Wibawan IW, Lammler C (1996) Identification and molecular characterization of serological group C streptococci isolated from diseased pigs and monkeys in Indonesia. J Clin Microbiol 34:2201–2204PubMedGoogle Scholar
  184. Staats JJ, Feder I, Okwumabua O, Chengappa MM (1997) Streptococcus suis: past and present. Vet Res Commun 21:381–407PubMedGoogle Scholar
  185. Su Y, Yao W, Perez-Gutierrez ON, Smidt H, Zhu WY (2008a) 16S ribosomal RNA-based methods to monitor changes in the hindgut bacterial community of piglets after oral administration of Lactobacillus sobrius S1. Anaerobe 14:78–86PubMedGoogle Scholar
  186. Su Y, Yao W, Perez-Gutierrez ON, Smidt H, Zhu WY (2008b) Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach, jejunum and ileum of piglets after weaning. FEMS Microbiol Ecol 66:546–555PubMedGoogle Scholar
  187. Sukhnanand S, Dogan B, Ayodele MO, Zadoks RN, Craver MP, Dumas NB, Schukken YH, Boor KJ, Wiedmann M (2005) Molecular subtyping and characterization of bovine and human Streptococcus agalactiae isolates. J Clin Microbiol 43:1177–1186PubMedGoogle Scholar
  188. Sun H, Ringdahl U, Homeister JW, Fay WP, Engleberg NC, Yang AY, Rozek LS, Wang X, Sjobring U, Ginsburg D (2004) Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305:1283–1286PubMedGoogle Scholar
  189. Sun JR, Yan JC, Yeh CY, Lee SY, Lu JJ (2007) Invasive infection with Streptococcus iniae in Taiwan. J Med Microbiol 56:1246–1249PubMedGoogle Scholar
  190. Sundberg JP, Hill D, Wyand DS, Ryan MJ, Baldwin CH (1981) Streptococcus zooepidemicus as the cause of septicemia in racing greyhounds. Vet Med Small Anim Clin 76:839–842PubMedGoogle Scholar
  191. Swindle MM, Narayan O, Luzarraga M, Bobbie DL (1980) Contagious streptococcal lymphadenitis in cats. J Am Vet Med Assoc 177:829–830PubMedGoogle Scholar
  192. Takeda N, Kikuchi K, Asano R, Harada T, Totsuka K, Sumiyoshi T, Uchiyama T, Hosoda S (2001) Recurrent septicemia caused by Streptococcus canis after a dog bite. Scand J Infect Dis 33:927–928PubMedGoogle Scholar
  193. Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Luangsuk P, Khamisara K, Wongwan N, Areeratana P, Chiranairadul P, Lertchayanti S, Petcharat S, Yowang A, Chaiwongsaen P, Nakayama T, Akeda Y, Hamada S, Sawanpanyalert P, Dejsirilert S, Oishi K (2012) Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand. PLoS One 7:e31265Google Scholar
  194. Tang J, Wang C, Feng Y, Yang W, Song H, Chen Z, Yu H, Pan X, Zhou X, Wang H, Wu B, Wang H, Zhao H, Lin Y, Yue J, Wu Z, He X, Gao F, Khan AH, Wang J, Zhao GP, Wang Y, Wang X, Chen Z, Gao GF (2006) Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med 3:e151Google Scholar
  195. Tapp J, Thollesson M, Herrmann B (2003) Phylogenetic relationships and genotyping of the genus Streptococcus by sequence determination of the RNase P RNA gene, rnpB. Int J Syst Evol Microbiol 53:1861–1871PubMedGoogle Scholar
  196. Tenenbaum T, Adam R, Eggelnpohler I, Matalon D, Seibt A, GE KN, Galla HJ, Schroten H (2005) Strain-dependent disruption of blood-cerebrospinal fluid barrier by Streptoccocus suis in vitro. FEMS Immunol Med Microbiol 44:25–34PubMedGoogle Scholar
  197. Tenenbaum T, Papandreou T, Gellrich D, Friedrichs U, Seibt A, Adam R, Wewer C, Galla HJ, Schwerk C, Schroten H (2009) Polar bacterial invasion and translocation of Streptococcus suis across the blood-cerebrospinal fluid barrier in vitro. Cell Microbiol 11:323–336PubMedGoogle Scholar
  198. Tian Y, Aarestrup FM, Lu CP (2004) Characterization of Streptococcus suis serotype 7 isolates from diseased pigs in Denmark. Vet Microbiol 103:55–62PubMedGoogle Scholar
  199. Tikofsky LL, Zadoks RN (2005) Cross-infection between cats and cows: origin and control of Streptococcus canis mastitis in a dairy herd. J Dairy Sci 88:2707–2713PubMedGoogle Scholar
  200. Tillman PC, Dodson ND, Indiveri M (1982) Group G streptococcal epizootic in a closed cat colony. J Clin Microbiol 16:1057–1060PubMedGoogle Scholar
  201. Timoney JF (2004) The pathogenic equine streptococci. Vet Res 35:397–409PubMedGoogle Scholar
  202. Timoney JF, Artiushin SC, Boschwitz JS (1997) Comparison of the sequences and functions of Streptococcus equi M-like proteins SeM and SzPSe. Infect Immun 65:3600–3605PubMedGoogle Scholar
  203. Timoney JF, DeNegri R, Sheoran A, Forster N (2010) Affects of N-terminal variation in the SeM protein of Streptococcus equi on antibody and fibrinogen binding. Vaccine 28:1522–1527PubMedGoogle Scholar
  204. Timoney JF, Walker J, Zhou M, Ding J (1995) Cloning and sequence analysis of a protective M-like protein gene from Streptococcus equi subsp. zooepidemicus. Infect Immun 63:1440–1445PubMedGoogle Scholar
  205. Ullberg M, Karlsson I, Wiman B, Kronvall G (1992) Two types of receptors for human plasminogen on group G streptococci. APMIS 100:21–28PubMedGoogle Scholar
  206. Vadeboncoeur N, Segura M, Al Numani D, Vanier G, Gottschalk M (2003) Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2. FEMS Immunol Med Microbiol 35:49–58PubMedGoogle Scholar
  207. Valentin-Weigand P, Chhatwal GS, Blobel H (1988) Adherence of streptococcal isolates from cattle and horses to their respective host epithelial cells. Am J Vet Res 49:1485–1488PubMedGoogle Scholar
  208. Valentin-Weigand P, Traore MY, Blobel H, Chhatwal GS (1990) Role of alpha 2-macroglobulin in phagocytosis of group A and C streptococci. FEMS Microbiol Lett 58:321–324PubMedGoogle Scholar
  209. Van der LM, Al Lahham A, Nicklas W, Reinert RR (2009) Molecular characterization of pneumococcal isolates from pets and laboratory animals. PLoS One 4:e8286Google Scholar
  210. Vanier G, Segura M, Friedl P, Lacouture S, Gottschalk M (2004) Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2. Infect Immun 72:1441–1449PubMedGoogle Scholar
  211. Vanier G, Segura M, Gottschalk M (2007) Characterization of the invasion of porcine endothelial cells by Streptococcus suis serotype 2. Can J Vet Res 71:81–89Google Scholar
  212. Wada A (2012) Streptococcus pneumoniae infection and drug resistance in Japan. Nihon Rinsho 70:221–225PubMedGoogle Scholar
  213. Walker JA, Timoney JF (1998) Molecular basis of variation in protective SzP proteins of Streptococcus zooepidemicus. Am J Vet Res 59:1129–1133PubMedGoogle Scholar
  214. Waller AS, Jolley KA (2007) Getting a grip on strangles: recent progress towards improved diagnostics and vaccines. Vet J 173:492–501PubMedGoogle Scholar
  215. Webb K, Barker C, Harrison T, Heather Z, Steward KF, Robinson C, Newton JR, Waller AS (2012) Detection of Streptococcus equi subspecies equi using a triplex qPCR assay (in press)Google Scholar
  216. Webb K, Jolley KA, Mitchell Z, Robinson C, Newton JR, Maiden MC, Waller A (2008) Development of an unambiguous and discriminatory multilocus sequence typing scheme for the Streptococcus zooepidemicus group. Microbiology 154:3016–3024PubMedGoogle Scholar
  217. Weinstein MR, Litt M, Kertesz DA, Wyper P, Rose D, Coulter M, McGeer A, Facklam R, Ostach C, Willey BM, Borczyk A, Low DE (1997) Invasive infections due to a fish pathogen, Streptococcus iniae. S. iniae study group. N Engl J Med 337:589–594Google Scholar
  218. Wertheim HF, Nghia HD, Taylor W, Schultsz C (2009a) Streptococcus suis: an emerging human pathogen. Clin Infect Dis 48:617–625PubMedGoogle Scholar
  219. Wertheim HF, Nguyen HN, Taylor W, Lien TT, Ngo HT, Nguyen TQ, Nguyen BN, Nguyen HH, Nguyen HM, Nguyen CT, Dao TT, Nguyen TV, Fox A, Farrar J, Schultsz C, Nguyen HD, Nguyen KV, Horby P (2009) Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam. PLoS One 4: e5973Google Scholar
  220. Whatmore AM, Engler KH, Gudmundsdottir G, Efstratiou A (2001) Identification of isolates of Streptococcus canis infecting humans. J Clin Microbiol 39:4196–4199PubMedGoogle Scholar
  221. Wibawan IW, Pasaribu FH, Utama IH, Abdulmawjood A, Lammler C (1999) The role of hyaluronic acid capsular material of Streptococcus equi subsp. zooepidemicus in mediating adherence to HeLa cells and in resisting phagocytosis. Res Vet Sci 67:131–135PubMedGoogle Scholar
  222. Willenborg J, Fulde M, de Greeff A, Rohde M, Smith HE, Valentin-Weigand P, Goethe R (2011) Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis. Microbiology 157:1823–1833PubMedGoogle Scholar
  223. Williams AE, Blakemore WF, Alexander TJ (1988) A murine model of Streptococcus suis type 2 meningitis in the pig. Res Vet Sci 45:394–399PubMedGoogle Scholar
  224. Winterhoff N, Goethe R, Gruening P, Rohde M, Kalisz H, Smith HE, Valentin-Weigand P (2002) Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the Arginine Deiminase system of Streptococcus pyogenes. J Bacteriol 184:6768–6776PubMedGoogle Scholar
  225. Wisselink HJ, Smith HE, Stockhofe-Zurwieden N, Peperkamp K, Vecht U (2000) Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries. Vet Microbiol 74:237–248PubMedGoogle Scholar
  226. Wistedt AC, Ringdahl U, Muller-Esterl W, Sjobring U (1995) Identification of a plasminogen-binding motif in PAM, a bacterial surface protein. Mol Microbiol 18:569–578PubMedGoogle Scholar
  227. Ye C, Zheng H, Zhang J, Jing H, Wang L, Xiong Y, Wang W, Zhou Z, Sun Q, Luo X, Du H, Gottschalk M, Xu J (2009) Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis. J Infect Dis 199:97–107PubMedGoogle Scholar
  228. Ye C, Zhu X, Jing H, Du H, Segura M, Zheng H, Kan B, Wang L, Bai X, Zhou Y, Cui Z, Zhang S, Jin D, Sun N, Luo X, Zhang J, Gong Z, Wang X, Wang L, Sun H, Li Z, Sun Q, Liu H, Dong B, Ke C, Yuan H, Wang H, Tian K, Wang Y, Gottschalk M, Xu J (2006) Streptococcus suis sequence type 7 outbreak, Sichuan China. Emerg Infect Dis 12:1203–1208PubMedGoogle Scholar
  229. Younan M, Estoepangestie AT, Cengiz M, Alber J, El Sayed A, Lammler C (2005) Identification and molecular characterization of Streptococcus equi subsp. zooepidemicus isolated from camels (Camelus dromedarius) and camel milk in Kenya and Somalia. J Vet Med B Infect Dis Vet Public Health 52:142–146PubMedGoogle Scholar
  230. Yu H, Jing H, Chen Z, Zheng H, Zhu X, Wang H, Wang S, Liu L, Zu R, Luo L, Xiang N, Liu H, Liu X, Shu Y, Lee SS, Chuang SK, Wang Y, Xu J, Yang W (2006) Human Streptococcus suis outbreak, Sichuan China. Emerg Infect Dis 12:914–920PubMedGoogle Scholar
  231. Yuen KY, Seto WH, Choi CH, Ng W, Ho SW, Chau PY (1990) Streptococcus zooepidemicus (Lancefield group C) septicaemia in Hong Kong. J Infect 21:241–250PubMedGoogle Scholar
  232. Zhao Y, Liu G, Li S, Wang M, Song J, Wang J, Tang J, Li M, Hu F (2011) Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. J Infect Dis 204:274–281PubMedGoogle Scholar
  233. Zlotkin A, Chilmonczyk S, Eyngor M, Hurvitz A, Ghittino C, Eldar A (2003) Trojan horse effect: phagocyte-mediated Streptococcus iniae infection of fish. Infect Immun 71:2318–2325PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Medizinische Hochschule Honnover Institut für Medizinische Mikrobiologie und KrankenhaushygieneHannoverGermany
  2. 2.Institut für Mikrobiologie, Zentrum für Infektionsmedizin, Stiftung Tierärztliche Hochschule HannoverHannoverGermany

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