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Notch Regulation of the Immune System pp 99–114Cite as

Canonical and Non-Canonical Notch Signaling in CD4+ T Cells

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 360))

Abstract

For T cells to become fully activated, they must integrate a myriad of signals, both extrinsic and intrinsic. External stimuli accrued through various cell surface receptors are transduced and amplified through a coordinated circuitry of signaling cascades that ultimately result in the transcription of new genes. Along the way, extracellular and intracellular signaling components function to impart a fully activated state. Evidence is accumulating to show that the Notch family of cell surface receptors, long known to function as transcriptional regulators through their interactions with the canonical nuclear binding protein CSL/RBP-J, may also be playing an as-yet-unappreciated role in T cell activation by virtue of its signaling via non-canonical as well as nonnuclear mechanisms. In this review we will discuss these and other better-known means by which Notch signaling influences T cell responses.

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Acknowledgments

We thank the members of the Minter and Osborne labs for their contributions and apologize to colleagues whose work was not cited in the interest of space. We particularly thank Richard Goldsby for his insightful comments. This work was supported by NIH AG025531.

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Authors and Affiliations

  1. Department of Veterinary and Animal Sciences, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA

    Lisa M. Minter & Barbara A. Osborne

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  1. Lisa M. Minter
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  2. Barbara A. Osborne
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Correspondence to Barbara A. Osborne .

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  1. , EPFL SV ISREC UPRAD, University of Lausanne, Lausanne, 1015, Switzerland

    Freddy Radtke

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Minter, L.M., Osborne, B.A. (2012). Canonical and Non-Canonical Notch Signaling in CD4+ T Cells. In: Radtke, F. (eds) Notch Regulation of the Immune System. Current Topics in Microbiology and Immunology, vol 360. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_233

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